AbstractObjectivesTo compare optical coherence tomography (OCT) biomarkers in eyes converting from non-neovascular (nnAMD) to exudative age-related macular degeneration (eAMD) based on the status of fellow eye.MethodsRetrospective analysis of one year of pre-conversion data of fellow eyes of patients with nnAMD and eAMD which converted to eAMD, defined as converting eyes (CE) with fellow nnAMD and CE with fellow eAMD respectively.

摘要目的比较基于对侧眼状态的非新生血管（nnAMD）转化为渗出性年龄相关性黄斑变性（eAMD）的眼睛中的光学相干断层扫描（OCT）生物标志物。方法回顾性分析nnAMD和eAMD患者转换为eAMD的对侧眼一年的转换前数据，分别定义为将对侧nnAMD转换为对侧眼（CE），将CE转换为对侧eAMD。

Demographics, best corrected visual acuity (BCVA), and OCT biomarkers including drusen type, iRORA/cRORA, subfoveal ellipsoid zone (SFEZ) disruption, central macular thickness (CMT), subfoveal choroidal thickness (SFCT), Haller vascular thickness (HVT) were evaluated. Chi-square and t-tests were employed, confidence interval of 95% and p < 0.05.Results72 eyes of 72 patients were included: 31 CE with fellow nnAMD and 41 CE with fellow eAMD.

人口统计学，最佳矫正视力（BCVA）和OCT生物标志物，包括drusen型，iRORA/cRORA，中心凹下椭球区（SFEZ）破坏，中央黄斑厚度（CMT），中心凹下脉络膜厚度（SFCT），Haller血管厚度（HVT）进行了评估。采用卡方检验和t检验，置信区间为95%，p<0.05。结果72例患者的72只眼包括：31例CE伴nnAMD，41例CE伴eAMD。

Mean age was 81.8 ± 9.9 years, with 62.5% females. Subfoveal iRORA was more frequent in CE with fellow nnAMD (26%) compared to CE with fellow eAMD (6%) 44 weeks before conversion (p = 0.058). SFCT and HVT were higher in CE with fellow nnAMD compared to CE with fellow eAMD 19 weeks prior to conversion (213 ± 82 vs.

平均年龄为81.8±9.9岁，女性为62.5%。。与转换前19周的eAMD患者相比，CE患者的SFCT和HVT更高（213±82 vs。

174 ± 63 µm, p = 0.052; 121 ± 44 vs. 104 ± 50 µm, p = 0.084 respectively). BCVA was significantly higher in CE with fellow eAMD compared to CE with fellow nnAMD every time frame (p < 0.05).ConclusionsAlthough subtle distinctions, no significant differences were observed between the groups. Further research is needed to understand the influence of one eye’s status on progression from nnAMD to eAMD in fellow eye..

174±63µm，p=0.052；121±44比104±50μm，分别为p=0.084）。在每个时间范围内，与同组nnAMD的CE相比，同组eAMD的CE的BCVA显着更高（p<0.05）。结论尽管有细微的区别，但两组之间没有显着差异。需要进一步的研究来了解一只眼睛的状态对另一只眼睛从nnAMD到eAMD进展的影响。。

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The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

本研究中使用和/或分析的数据集可根据合理要求从通讯作者处获得。

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Download referencesFundingThis research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectorsAuthor informationAuthors and AffiliationsDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USANicola Valsecchi, Stavan Shah, Arman Zarnegar, Anthony Tang, Shiva Yagobian & Jay ChhablaniOphthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, ItalyNicola Valsecchi, Luigi Fontana & Danilo IannettaIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyNicola Valsecchi, Luigi Fontana & Danilo IannettaAuthorsNicola ValsecchiView author publicationsYou can also search for this author in.

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PubMed Google ScholarContributionsNV conceptualization, collecting data, statistical analysis, and writing; SS conceptualization, collecting data; AZ collecting data; AT collecting data; SY collecting; LF supervision; DI supervision; JC conceptualization, collecting data, supervision, writing, and editing.

PubMed谷歌学术贡献SNV概念化，收集数据，统计分析和写作；SS概念化，收集数据；AZ收集数据；在收集数据时；SY收集；LF监督；DI监督；JC概念化，收集数据，监督，写作和编辑。

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The authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.

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Additional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Supplementary informationReporting ChecklistRights and permissionsSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.Reprints and permissionsAbout this articleCite this articleValsecchi, N., Shah, S., Zarnegar, A.

Additional informationPublisher的注释Springer Nature在已发布的地图和机构隶属关系中的管辖权主张方面保持中立。补充信息报告清单权利和许可Pringer Nature或其许可方（例如协会或其他合作伙伴）根据与作者或其他权利持有人的出版协议对本文拥有专有权；本文接受稿件版本的作者自行存档仅受此类出版协议和适用法律的条款管辖。转载和许可本文引用本文Valsecchi，N.，Shah，S.，Zarnegar，A。

et al. Assessment of optical coherence tomography biomarkers in patients with non-neovascular age-related macular degeneration (AMD) converting to exudative AMD according to the status of the fellow eye..

等。根据对侧眼的状态评估非新生血管性年龄相关性黄斑变性（AMD）转化为渗出性AMD患者的光学相干断层扫描生物标志物。。

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