柠檬酸能拯救受种植体周围炎影响的牙种植体吗？-动脉网

Could citric acid save dental implants affected by peri-implantitis?

Dental Tribune 等信源发布 2024-09-23 21:41

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Anisha Hall Hoppe, Dental Tribune International

Anisha Hall Hoppe，《国际牙科论坛报》

Mon. 23. September 2024

周一。2024年9月23日

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MADRID, Spain: New research provides compelling evidence that citric acid-based treatments, particularly those combined with collagen and magnesium, are effective in enhancing the surface properties of titanium dental implants after implantoplasty. These treatments not only improve cell proliferation and tissue regeneration but also offer significant antibacterial benefits.

西班牙马德里：新研究提供了令人信服的证据，表明基于柠檬酸的治疗方法，特别是与胶原蛋白和镁结合的治疗方法，可有效增强种植体成形术后钛牙种植体的表面性能。这些治疗不仅可以改善细胞增殖和组织再生，还可以提供显着的抗菌益处。

The findings suggest that such solutions could be developed into practical applications, such as mouthwashes, to support the long-term success of implants by promoting tissue regeneration and preventing bacterial recolonisation..

研究结果表明，这些解决方案可以开发成实际应用，如漱口水，通过促进组织再生和防止细菌再聚集来支持植入物的长期成功。。

Current peri-implantitis treatments focus on decontaminating the implant surface to inhibit biofilm formation and encourage tissue regeneration. Among these treatments, implantoplasty, which involves mechanically smoothing the implant surface, is commonly used. However, this process often reduces the surface roughness of the titanium, making it less conducive to cell adhesion and tissue growth.

目前的种植体周围炎治疗侧重于净化种植体表面以抑制生物膜形成并促进组织再生。在这些治疗中，通常使用植入成形术，其涉及机械平滑植入物表面。然而，该过程通常会降低钛的表面粗糙度，使其不利于细胞粘附和组织生长。

The researchers sought therefore to investigate the effects of citric acid-based decontamination solutions on titanium surfaces to enhance cell viability and inhibit bacterial colonisation..

因此，研究人员试图研究基于柠檬酸的去污溶液对钛表面的影响，以增强细胞活力并抑制细菌定植。。

After subjecting 80 titanium discs to an implantoplasty protocol, the researchers treated the discs with four different solutions: 25% citric acid, 25% citric acid with 0.25 g/l collagen, 25% citric acid with 0.50 g/l collagen, and 25% citric acid with 0.50 g/l collagen and 1% magnesium nitrate. The surfaces were analysed for roughness, wettability, fibroblast adhesion, osteoblast proliferation and bactericidal behaviour against the common oral bacteria Streptococcus sanguinis, Streptococcus gordonii and Pseudomonas aeruginosa..

在对80个钛椎间盘进行植入成形术后，研究人员用四种不同的溶液处理椎间盘：25%柠檬酸，25%柠檬酸和0.25 g/l胶原蛋白，25%柠檬酸和0.50 g/l胶原蛋白，25%柠檬酸和0.50 g/l胶原蛋白和1%硝酸镁。分析表面的粗糙度，润湿性，成纤维细胞粘附，成骨细胞增殖和对常见口腔细菌血链球菌，戈登链球菌和铜绿假单胞菌的杀菌行为。。

The researchers found that citric acid increased the roughness of the titanium surfaces slightly and made them super-hydrophilic, significantly reducing the contact angle from 78° to 13°. This change was deemed beneficial for cell adhesion, as it creates a better environment for cell proliferation.

研究人员发现，柠檬酸略微增加了钛表面的粗糙度，使其具有超亲水性，从而将接触角从78°显着降低到13°。这种变化被认为有利于细胞粘附，因为它为细胞增殖创造了更好的环境。

Additionally, fibroblast and osteoblast proliferation greatly improved on surfaces treated with the citric acid solution containing collagen and magnesium. This solution showed the highest cytocompatibility and contributed to a rapid increase in cell numbers within 24 hours, indicating that it may support tissue regeneration on the implant surface.

此外，在用含有胶原蛋白和镁的柠檬酸溶液处理的表面上，成纤维细胞和成骨细胞的增殖大大改善。该溶液显示出最高的细胞相容性，并有助于在24小时内细胞数量的快速增加，表明它可能支持植入物表面的组织再生。

The presence of magnesium appeared to further stimulate cell adhesion and differentiation..

镁的存在似乎进一步刺激细胞粘附和分化。。

The citric acid solutions displayed a clear bactericidal effect, especially against Gram-positive bacteria like S. sanguinis and S. gordonii. The solution containing magnesium showed the lowest levels of bacterial adhesion, indicating its superior ability to resist bacterial colonisation. However, the bactericidal effect was less obvious against the Gram-negative strain P. aeruginosa..

柠檬酸溶液显示出明显的杀菌作用，特别是对革兰氏阳性菌如血球链球菌和戈登链球菌。含有镁的溶液显示出最低水平的细菌粘附，表明其抵抗细菌定植的优越能力。然而，对革兰氏阴性菌株铜绿假单胞菌的杀菌效果不太明显。。

All treatments were found to be cytocompatible, and no significant cytotoxic effects were observed. This suggests that such treatments could be safely used in clinical applications to aid in the recovery from peri-implantitis and the maintenance of implants.

发现所有治疗均具有细胞相容性，未观察到明显的细胞毒性作用。这表明这种治疗可以安全地用于临床应用，以帮助从种植体周围炎中恢复和维持种植体。

The authors recommended that the same study be carried out in vivo with soft tissue to rule out the risk of tissue irritability. Doing so could also determine whether bone tissue is able to regenerate such that re-osseointegration can occur. The researchers further recommended culturing biofilm to evaluate how well citric acid solutions cope with the full variety of bacterial strains present in the oral cavity.

作者建议在体内用软组织进行同样的研究，以排除组织过敏的风险。这样做还可以确定骨组织是否能够再生，从而可以发生再骨整合。研究人员进一步建议培养生物膜，以评估柠檬酸溶液如何应对口腔中存在的各种细菌菌株。

Such an assessment would also be useful in determining necessary concentrations for an effective mouthwash..

。。

The study, titled “Surface decontamination of titanium dental implants subjected to implantoplasty by treatment with citric acid solutions”, was published online on 27 August 2024 in Coatings.

该研究题为“用柠檬酸溶液处理种植体成形术后钛牙种植体的表面去污”，于2024年8月27日在线发表在《涂层》杂志上。

Topics:

主题：

Dental Implantology

牙科种植学

Tags:

标签：

Bacterial contamination

细菌污染

Dental implant

牙科植入物

Peri-implantitis

种植体周围炎

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