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register hereBackground: T cell receptor (TCR)-T cell therapy is an innovative form of cancer immunotherapy that genetically modifies patients' T cells to target and destroy cancer cells. However, the current status of clinical trials of TCR-T cell therapy for the treatment of cancer remains unclear.

背景：T细胞受体（TCR）-T细胞疗法是一种创新的癌症免疫疗法，可以通过基因修饰患者的T细胞来靶向和破坏癌细胞。然而，TCR-T细胞疗法治疗癌症的临床试验的现状仍不清楚。

This study aimed to comprehensively analyze the registration trials related to TCR-T cell therapy for the treatment of cancer. Methods: A comprehensive search was conducted in the Trialtrove database for all clinical trials related to TCR-T cell therapy registered by August 1, 2024. Inclusion criteria focused on trials targeting TCR-T cell therapy for oncology, and excluded observational studies and incomplete data.

本研究旨在全面分析与TCR-T细胞治疗癌症相关的注册试验。方法：在Trialtrove数据库中对2024年8月1日登记的所有与TCR-T细胞治疗相关的临床试验进行全面搜索。纳入标准侧重于针对肿瘤TCR-T细胞治疗的试验，排除了观察性研究和不完整数据。

Statistical analysis was performed on key trial characteristics, with between-group comparisons utilizing chi-square or Fisher’s exact tests. Results: Analysis of 174 eligible clinical trials revealed that TCR-T cell therapy exhibits significant efficacy across various tumor types, particularly in refractory hematologic malignancies and certain solid tumors.

对关键试验特征进行统计分析，利用卡方检验或Fisher精确检验进行组间比较。结果：对174项符合条件的临床试验的分析显示，TCR-T细胞疗法在各种肿瘤类型中表现出显着的疗效，特别是在难治性血液系统恶性肿瘤和某些实体瘤中。

Additionally, combining TCR-T cell therapy with other immunotherapies enhanced these anti-tumor effects. Conclusion: TCR-T cell therapy holds substantial promise for cancer treatment. Future research should focus on optimizing treatment protocols, enhancing efficacy, and minimizing prices to fully realize the potential of this therapy..

另外，将TCR-T细胞疗法与其他免疫疗法相结合增强了这些抗肿瘤作用。结论：TCR-T细胞疗法对癌症治疗具有重大前景。未来的研究应侧重于优化治疗方案，提高疗效，并将价格降至最低，以充分发挥这种疗法的潜力。。