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2010年3月至2024年3月，中国吉林省水痘带状疱疹病毒包膜上9种糖蛋白核苷酸位点变异的初步调查和分析

Preliminary investigation and analysis of nucleotide site variability of nine glycoproteins on varicella-zoster virus envelope, Jilin Province, China, 2010-March 2024

Nature 等信源发布 2024-10-01 12:50

可切换为仅中文

AbstractVaricella is endemic worldwide. In China, varicella has not yet been included in the list of legal infectious diseases, nor has a unified national surveillance program been established. And the live attenuated varicella vaccine has not been included in routine immunization. In this study, we analyzed for the first time the varicella epidemiology in Jilin Province in the past 20 years, and the nucleotide site, amino acid site and N-glycosylation site variation of glycoprotein in varicella-zoster virus (VZV) surface 9 in the past 15 years.

摘要水痘在世界范围内流行。。水痘减毒活疫苗尚未纳入常规免疫。在这项研究中，我们首次分析了吉林省过去20年的水痘流行病学，以及过去15年水痘带状疱疹病毒（VZV）表面9糖蛋白的核苷酸位点，氨基酸位点和N-糖基化位点变化。

The results showed that the reported incidence of varicella in Jilin Province in the last 20 years was fluctuating above and below 20/100,000, especially after the epidemic of the COVID-19, and fatal cases appeared in individual years. The genotypic branching of VZV was monitored as Clade 2 in the last 15 years.

结果表明，吉林省近20年水痘报告发病率在20/10万以上和20/10万以下波动，特别是新型冠状病毒（COVID-19）流行后，个别年份出现致命病例。在过去的15年中，VZV的基因型分支被监测为进化枝2。

9 glycogen nucleotide sites of VZV had different degrees of variability, and the variability had specificity. Therefore, it gives us the idea that in order to reduce the incidence of varicella and herpes zoster, a provincial or even national surveillance program should be introduced as early as possible, and the dynamic monitoring of the variability of the nucleotide sites of VZV should be strengthened at the same time as the vaccine immunization strategy is introduced..

VZV的9个糖原核苷酸位点具有不同程度的变异性，变异性具有特异性。因此，我们认为，为了降低水痘和带状疱疹的发病率，应尽早引入省级甚至国家监测计划，并在引入疫苗免疫策略的同时加强对VZV核苷酸位点变异性的动态监测。。

IntroductionVaricella-zoster virus (VZV) belongs to the Herpesviridae family, subfamily Herpesviridae alpha, and human herpesvirus type 3 (HHV-3)1. VZV possesses a genome of approximately 125 kb, consisting of 71 open reading frames (ORFs) and five repeat regions (R1–R5)2,3. It is an enveloped virus containing nine known glycoproteins in nine ORFs, namely gK (ORF5), gN (ORF9A), gC (ORF14), gB (ORF31), gH (ORF37), gM (ORF50), gL (ORF60), gI (ORF67) and gE (ORF68)4,5.

。VZV拥有大约125 kb的基因组，由71个开放阅读框（ORF）和五个重复区（R1-R5）2,3组成。它是一种包膜病毒，在9个ORF中含有9种已知的糖蛋白，即gK（ORF5），gN（ORF9A），gC（ORF14），gB（ORF31），gH（ORF37），gM（ORF50），gL（ORF60），gI（ORF67）和gE（ORF68）4,5。

These glycoproteins fulfill a variety of roles including viral entry, efflux, cell spreading, attachment, replication and envelopment6,7,8,9,10,11,12,13,14,15,16,17,18. It causes infections with two main clinical conditions: varicella and herpes zoster. Primary infection usually manifests as varicella and develops a latent phase in sensory ganglia.VZV reactivation can lead to herpes zoster, which is usually accompanied by neuralgia and postherpetic neuralgia (PHN)19,20.

这些糖蛋白具有多种作用，包括病毒进入，流出，细胞扩散，附着，复制和包膜6,7,8,9,10,11,12,13,14,15,16,17,18。它会导致两种主要临床症状的感染：水痘和带状疱疹。原发感染通常表现为水痘，并在感觉神经节中形成潜伏期。VZV再激活可导致带状疱疹，通常伴有神经痛和带状疱疹后神经痛（PHN）19,20。

Although the clinical manifestations are typical, there is still a report showing that no VZV-induced rash manifestations were found in fatal cases21, suggesting that new variants may exist. With the wide application of real-time PCR detection technology and the advancement of whole genome sequencing technology, the monitoring of VZV has become more convenient.The World Health Organization (WHO) recommended countries to establish a comprehensive disease surveillance system in its 2014 Position Paper22.

尽管临床表现很典型，但仍有报道显示在致命病例中未发现VZV引起的皮疹表现21，这表明可能存在新的变异。随着实时PCR检测技术的广泛应用和全基因组测序技术的进步，VZV的监测变得更加方便。世界卫生组织（WHO）在其2014年的立场文件22中建议各国建立一个全面的疾病监测系统。

In China, we have been monitoring the incidence of varicella since 2005, and molecular biology surveillance of VZV was started in Jilin Province in 2010.Jilin Province lies in the northeast corner of China. Jilin Province lies in the northwest of the country of North Korea. The current total population of Jilin Province is 24 million.In this st.

。吉林省位于朝鲜国的西北部。吉林省目前总人口为2400万。在这个圣。

Data availability

数据可用性

The datasets used and analyzed during the present study are available from the corresponding author on reasonable request.Sequence data of gK, gN, gB, gH, gM, gL, gI, gE and gC which support the findings of this study have been deposited in the Genbank with the accession Number: PQ039870 - PQ039907, PQ039908 - PQ039945, PQ039946 - PQ039983, PQ039984 - PQ040021, PQ040022 - PQ040059, PQ040060 - PQ040097, PQ040098 - PQ040135, PQ040136 - PQ040173, PQ040174 - PQ040211, respectively..

本研究中使用和分析的数据集可根据合理要求从通讯作者处获得。支持本研究结果的gK，gN，gB，gH，gM，gL，gI，gE和gC的序列数据已保存在Genbank中，登录号分别为：PQ039870-PQ039907，PQ039908-PQ039945，PQ039946-PQ039983，PQ039984-PQ040021，PQ040022-PQ040059，PQ040060-PQ040097，PQ040098-PQ040135，PQ040136-PQ040173，PQ040174-PQ040211。。

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Download referencesAcknowledgementsThe authors thank the epidemiologists for collection and integration of the epidemiological data. This work was supported by the Key Laboratory of Viruses of Jilin Provincial Health Commission (2023GW005), the Vaccination and Immunization Youth Talent Elevation Program of Chinese Preventive Medicine Association (20190206) and Horizontal joint project of Jilin University (2021YX0547).Author informationAuthors and AffiliationsChina-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin, ChinaLi XiranDepartment of Biobank, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin, ChinaSun HongyanDepartment of Tuberculosis Meningitis Diagnosis and Treatment Center, Changchun Infectious Disease Hospital, Changchun, 130123, Jilin, ChinaQin GuixiangDepartment of Dermatology, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 130021, Jilin, ChinaSun YingDepartment of Viral Disease, Jilin Provincial Center for Disease Control and Prevention, Changchun, 130062, Jilin, ChinaLi XiangDepartment of EMO, Jilin Provincial Center for Disease Control and Prevention, Changchun, 130062, Jilin, ChinaTian XinDepartment of Infectious Diseases, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin, ChinaHan Mengying & Ji ShangweiDepartment of Pediatrics, The Second Hospital of Jilin University, Changchun, 130022, Jilin, ChinaWang JiAuthorsLi XiranView author publicationsYou can also search for this author in.

下载参考文献致谢作者感谢流行病学家收集和整合流行病学数据。。作者信息作者和所属单位吉林大学中日联合医院，长春，130033，吉林，中国吉林吉林吉林大学中日联合医院生物库系，长春，130033吉林大学中日联合医院传染病科，吉林长春130033，中国王家作家李希兰评论作者出版物您也可以在中搜索这位作者。

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PubMed Google ScholarContributionsL.X. and L.X. performed experiments and wrote the main manuscript text. S.H., Q.G. and S.Y. collected samples. T.X. and H.M. analyzed study data. W.J. and J.S. designed the experiment, revised the paper, collected samples and participated in experiments.All authors reviewed the manuscript.Corresponding authorsCorrespondence to.

PubMed谷歌学术贡献l。十、 和L.X.进行了实验并撰写了主要手稿文本。S、 H.，Q.G.和S.Y.收集了样本。T、 X.和H.M.分析了研究数据。W、 J.和J.S.设计了实验，修改了论文，收集了样本并参加了实验。所有作者都审阅了手稿。通讯作者通讯。

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Reprints and permissionsAbout this articleCite this articleXiran, L., Hongyan, S., Guixiang, Q. et al. Preliminary investigation and analysis of nucleotide site variability of nine glycoproteins on varicella-zoster virus envelope, Jilin Province, China, 2010-March 2024.

转载和许可本文引用本文Xiran，L.，Hongyan，S.，Guixiang，Q。等人。中国吉林省水痘带状疱疹病毒包膜上9种糖蛋白核苷酸位点变异性的初步调查和分析，2010年3月至2024年3月。

Sci Rep 14, 22758 (2024). https://doi.org/10.1038/s41598-024-73072-wDownload citationReceived: 23 May 2024Accepted: 13 September 2024Published: 01 October 2024DOI: https://doi.org/10.1038/s41598-024-73072-wShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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KeywordsVaricella zoster virusEnvelope glycoproteinMutation site

关键词带状疱疹病毒包膜糖蛋白突变位点

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