Human induced pluripotent stem cell-derived models are a well-established preclinical tool, with the ability to retain the genetics of the individual from which they are derived. Here we comment on the global representation and accessibility of such cellular tools from African population groups.

人类诱导的多能干细胞衍生模型是一种成熟的临床前工具，能够保留其衍生个体的遗传学。在这里，我们评论了来自非洲人口群体的这种细胞工具的全球代表性和可及性。

The equitable representation of global genetic diversity in preclinical cellular models such as human induced pluripotent stem cells (hiPSCs) has been advocated for by many in recent years1,2,3. This has been driven by the recognition of extraordinary genetic diversity across the globe, especially within historically underrepresented population groups, including those on the African continent.

近年来，许多人提倡在临床前细胞模型（如人类诱导多能干细胞（hiPSC））中公平代表全球遗传多样性1,2,3。这是由于全球范围内对非凡遗传多样性的认识，特别是在历史上代表性不足的人群中，包括非洲大陆的人群。

This genetic diversity must be translated into physiologically relevant models to realise equitable benefits from advances in preclinical research for all population groups. Since the (a) efficacy of treatments from vaccines to gene therapies (both ex vivo and in vivo), (b) preclinical testing of small molecules, (c) diagnostic systems, and (d) deconvolution of the molecular basis of disease, could all be dependent on individual genetic background, the impact for healthcare is bound to be expansive.Whilst not yet market-approved, over 100 clinical trials for hiPSC-based cellular therapies are ongoing4.

这种遗传多样性必须转化为生理相关模型，以实现所有人群临床前研究进展的公平收益。由于（a）从疫苗到基因疗法（离体和体内）的治疗效果，（b）小分子的临床前测试，（c）诊断系统，以及（d）疾病分子基础的解卷积，都可能取决于个体的遗传背景，因此对医疗保健的影响必然是巨大的。虽然尚未获得市场批准，但仍有100多项基于hiPSC的细胞疗法的临床试验正在进行中4。

In addition, as a cellular and disease modelling resource, hiPSC technologies are being utilized to advance preclinical research across myriad fields within drug discovery and regenerative medicine, allowing for the functional investigation of individual donor genetics as they relate to specific diseases and treatment outcomes.

此外，作为一种细胞和疾病建模资源，hiPSC技术正被用于推进药物发现和再生医学中无数领域的临床前研究，从而可以对与特定疾病和治疗结果相关的个体供体遗传学进行功能研究。

Africa’s extensive genetic diversity is associated with a unique disease burden which could be repositioned to instead offer a rich resource for the development of therapeutics related to human leucocyte antigen (HLA) matching. Allogeneic strategies represent a significant proportion of current hiPSC clinical trials, yet few studies are actively taking this into consideration (as an example here by Japan5) to expand broader population applications.

非洲广泛的遗传多样性与独特的疾病负担有关，可以重新定位，为开发与人类白细胞抗原（HLA）匹配相关的治疗方法提供丰富的资源。同种异体策略在目前的hiPSC临床试验中占很大比例，但很少有研究积极考虑到这一点（如日本的例子5），以扩大更广泛的人群应用。

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Download referencesAcknowledgementsThe authors acknowledge the following funding, Department of Science and Innovation, V6YBG65, J.S. We also thank Marc Leo Felix for permission to reproduce the “Language Families Felix” dataset using WorldMap.Author informationAuthor notesThese authors contributed equally: Tracey Hurrell, Jerolen Naidoo.Authors and AffiliationsBioengineering and Integrated Genomics Group, Council for Scientific and Industrial Research, Pretoria, South AfricaTracey Hurrell, Jerolen Naidoo, Tiro Ntlhafu & Janine ScholefieldDepartment of Human Biology, University of Cape Town, Cape Town, South AfricaJerolen Naidoo & Janine ScholefieldDivision of Human Genetics, University of the Witwatersrand, Johannesburg, South AfricaJanine ScholefieldAuthorsTracey HurrellView author publicationsYou can also search for this author in.

下载参考文献致谢作者感谢以下资金，科学与创新部，V6YBG65，J.S。我们也感谢Marc Leo Felix允许使用WorldMap复制“语言家族Felix”数据集。作者信息作者注意到这些作者做出了同样的贡献：Tracey Hurrell，Jerolen Naidoo。作者和附属机构比勒陀利亚科学与工业研究委员会生物工程与综合基因组学小组南非约翰内斯堡威特沃特斯兰德大学人类遗传学系Jerolen Naidoo Jerolen Naidoo Tiro Ntlhafu＆Janine Schollefield作者Tracey HurrellView作者出版物您也可以在中搜索这位作者。

PubMed Google ScholarJerolen NaidooView author publicationsYou can also search for this author in

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PubMed Google ScholarContributionsConception and writing: J.S., T.H., and J.N. Data analysis: J.S. and T.N.Corresponding authorCorrespondence to

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Reprints and permissionsAbout this articleCite this articleHurrell, T., Naidoo, J., Ntlhafu, T. et al. An African perspective on genetically diverse human induced pluripotent stem cell lines.

转载和许可本文引用本文Hurrell，T.，Naidoo，J.，Ntlhafu，T。等人对遗传多样性人类诱导多能干细胞系的非洲观点。

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