AbstractFatigue is one of the common symptoms in individuals with diseases or disorders, significantly affecting quality of life (QoL) and the prognosis of diseases. This study aimed to comprehensively compare the features of fatigue across a wide range of diseases. We systematically searched the PubMed and Cochrane Library databases from inception to March 31st, 2021, and conducted a meta-analysis to generate precise estimates.

摘要疲劳是疾病或障碍患者的常见症状之一，严重影响生活质量（QoL）和疾病的预后。这项研究旨在全面比较各种疾病的疲劳特征。我们从开始到2021年3月31日系统地搜索了PubMed和Cochrane图书馆数据库，并进行了荟萃分析以产生精确的估计。

The analyses were stratified by classification of diseases, gender, and severity of fatigue (moderate and severe), and study quality was assessed using the Newcastle–Ottawa Scale (NOS). In total, 214 articles (233 prevalence data) met our eligibility criteria, covering 102,024 participants (mean 438 ± 1,421) across 88 diseases.

分析按疾病分类，性别和疲劳严重程度（中度和重度）进行分层，并使用纽卡斯尔-渥太华量表（NOS）评估研究质量。总共有214篇文章（233份流行率数据）符合我们的资格标准，涵盖88种疾病的102024名参与者（平均4381421名）。

Among these, seventy-eight data sets (52,082 participants) and thirty-nine data sets (10,389 participants) reported gender- and severity-related fatigue prevalence. The overall prevalence among subjects with 88 diseases was 49.4% [95% CI 46.9–52.1]. According to the International Classification of Diseases-10 (ICD-10) classification, the highest prevalence of fatigue (65.9% [95% CI 54.9–79.6]) was observed in patients with mental/behavioral diseases, whereas the lowest prevalence (34.7% [95% CI 24.5–49.2]) was found among those with circulatory system diseases.

其中，78个数据集（52082名参与者）和39个数据集（10389名参与者）报告了与性别和严重程度相关的疲劳患病率。患有88种疾病的受试者的总体患病率为49.4%[95%CI 46.9-52.1]。。

A slight female dominance (43.5% vs. 49.8%) was observed in the total data, with the most notable female predominance (1.8-fold) seen in patients with low back pain. The top disease groups with a moderate to severe level of fatigue included gastroparesis (92.3%), pulmonary hypertension (90.0%), chronic obstructive pulmonary disease (COPD, 83.2%), and multiple sclerosis (80.0%).

在总数据中观察到轻微的女性优势（43.5%比49.8%），在腰痛患者中女性优势最为明显（1.8倍）。中度至重度疲劳程度最高的疾病组包括胃轻瘫（92.3%），肺动脉高压（90.0%），慢性阻塞性肺病（COPD，83.2%）和多发性硬化症（80.0%）。

These results are the first to comprehensively show the comparative features of fatigue .

这些结果首次全面展示了疲劳的比较特征。

IntroductionFatigue is one of the most frequent complaints not only among subjects with diseases, like 50% of cancer patients1, but also in the general population, approximately 16%2. Short-term fatigue can be a predictable physiological response to intense activity and typically does not affect daily life3.

引言疲劳是最常见的投诉之一，不仅在患有疾病的受试者中，如50%的癌症患者1，而且在一般人群中，约占16%2。短期疲劳可能是对剧烈活动的可预测的生理反应，通常不会影响日常生活3。

However, pathological fatigue, especially when chronic and uncontrolled, leads to a poor quality of life (QoL) and impairs daily efficiency4,5.Many factors affect the prevalence of fatigue, including age, sex, ethnicity, occupation, and psychological condition5,6,7,8. For example, females are known to be more susceptible to cancer-related fatigue (CRF), with a prevalence about 2.1 times higher than that of males9.

。例如，已知女性更容易患癌症相关疲劳（CRF），患病率约为男性的2.1倍9。

Health-related factors such as sleep quality, obesity, nutritional status, stress, and illness further influence the frequency and severity of fatigue10,11,12. Among these, the presence of a disorder or disease is the primary determinants of the prevalence and severity of fatigue; for instance, approximately 70% and 82% of individuals with irritable bowel syndrome (IBS) and fibromyalgia, respectively, experience fatigue13,14.

睡眠质量，肥胖，营养状况，压力和疾病等健康相关因素进一步影响疲劳的频率和严重程度10,11,12。其中，疾病或疾病的存在是疲劳患病率和严重程度的主要决定因素；例如，大约70%和82%的肠易激综合征（IBS）和纤维肌痛患者分别经历疲劳13,14。

Additionally, other disease-related factors, such as malnutrition in patients with inflammatory bowel disease (IBD), also affect prevalence of fatigue15.Disease-related fatigue is not only a primary symptom of many disorders but also a factor that influences the clinical course of the disease, including its outcomes.

此外，其他与疾病相关的因素，如炎症性肠病（IBD）患者的营养不良，也会影响疲劳的患病率15。与疾病相关的疲劳不仅是许多疾病的主要症状，也是影响疾病临床进程的因素，包括其结果。

Increased fatigue has been associated with the progression of dialysis initiation in patients with chronic kidney disease16, and with increased mortality in individuals with chronic obstructive pulmonary disease (COPD)17. Moreover, fatigue has been linked to the prognosis of diseases, with potentially higher recurrence ra.

疲劳增加与慢性肾脏病患者透析开始的进展16以及慢性阻塞性肺疾病（COPD）患者的死亡率增加17有关。此外，疲劳与疾病的预后有关，ra的复发率可能更高。

Availability of data and materials

数据和材料的可用性

Data and materials are available from the corresponding author upon reasonable request.

根据合理的要求，通讯作者可以提供数据和材料。

ReferencesKang, Y. E. et al. Prevalence of cancer-related fatigue based on severity: a systematic review and meta-analysis. Sci. Rep. 13(1), 12815 (2023).Article

参考文献Kang，Y.E.等人。基于严重程度的癌症相关疲劳患病率：系统评价和荟萃分析。科学。代表13（1），12815（2023）。文章

ADS

广告

CAS

中科院

Google Scholar

谷歌学者

Yoon, J. H. et al. The demographic features of fatigue in the general population worldwide: a systematic review and meta-analysis. Front. Public Health. 11, 1192121 (2023).Article

Yoon，J.H.等人，《全球普通人群疲劳的人口统计学特征：系统综述和荟萃分析》。正面。公共卫生。111192121（2023）。文章

Google Scholar

谷歌学者

Kluger, B. M., Krupp, L. B. & Enoka, R. M. Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy. Neurology. 80(4), 409–416 (2013).Article

Kluger，B.M.，Krupp，L.B。＆Enoka，R.M。神经系统疾病中的疲劳和疲劳：统一分类的建议。神经病学。80（4），409–416（2013）。文章

Google Scholar

谷歌学者

Landmark-Hoyvik, H. et al. The genetics and epigenetics of fatigue. PM R. 2(5), 456–465 (2010).Article

Landmark Hoyvik，H.等人，《疲劳的遗传学和表观遗传学》。PM R.2（5），456–465（2010）。文章

Google Scholar

谷歌学者

Ghajarzadeh, M. et al. Fatigue in multiple sclerosis: relationship with disease duration, physical disability, disease pattern, age and sex. Acta Neurol. Belg. 113(4), 411–414 (2013).Article

Ghajarzadeh，M.等人，《多发性硬化症中的疲劳：与疾病持续时间、身体残疾、疾病模式、年龄和性别的关系》。神经学报。贝尔格。113（4），411-414（2013）。文章

Google Scholar

谷歌学者

Zielinski, M. R., Systrom, D. M. & Rose, N. R. Fatigue, sleep, and autoimmune and related disorders. Front. Immunol. 10, 1827 (2019).Article

Zielinski，M.R.，Systrom，D.M。和Rose，N.R。疲劳，睡眠，自身免疫和相关疾病。正面。免疫。101827（2019）。文章

CAS

中科院

Google Scholar

谷歌学者

Bazazan, A. et al. Physical and psychological job demands and fatigue experience among offshore workers. Heliyon. 9(6), e16441 (2023).Article

Bazazan，A.等人，《海上作业人员的身心工作需求和疲劳体验》。海伦。9（6），e16441（2023）。文章

Google Scholar

谷歌学者

Dinos, S. et al. A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping. Int. J. Epidemiol. 38(6), 1554–1570 (2009).Article

Dinos，S.等人，《慢性疲劳及其综合征和种族的系统综述：患病率、严重程度、合并症和应对》。国际流行病学杂志。38（6），1554–1570（2009）。文章

Google Scholar

谷歌学者

Ma, Y. et al. Prevalence and risk factors of cancer-related fatigue: A systematic review and meta-analysis. Int. J. Nurs. Stud. 111, 103707 (2020).Article

Ma，Y.等。癌症相关疲劳的患病率和危险因素：系统综述和荟萃分析。。螺柱111103707（2020）。文章

Google Scholar

谷歌学者

Doerr, J. M. et al. Reciprocal relationship between acute stress and acute fatigue in everyday life in a sample of university students. Biol. Psychol. 110, 42–49 (2015).Article

Doerr，J.M.等人。大学生样本中日常生活中急性压力与急性疲劳之间的相互关系。生物心理学。110,42-49（2015）。文章

Google Scholar

谷歌学者

Fortier-Brochu, E., Beaulieu-Bonneau, S., Ivers, H. & Morin, C. M. Relations between sleep, fatigue, and health-related quality of life in individuals with insomnia. J. Psychosom. Res. 69(5), 475–483 (2010).Article

Fortier Brochu，E.，Beaulieu-Bonneau，S.，Ivers，H.＆Morin，C.M。失眠患者睡眠，疲劳与健康相关生活质量之间的关系。J、 精神病。。文章

Google Scholar

谷歌学者

Resnick, H. E., Carter, E. A., Aloia, M. & Phillips, B. Cross-sectional relationship of reported fatigue to obesity, diet, and physical activity: results from the third national health and nutrition examination survey. J. Clin. Sleep Med. 2(2), 163–169 (2006).Article

Resnick，H.E.，Carter，E.A.，Aloia，M。＆Phillips，B。报告的疲劳与肥胖，饮食和身体活动的横断面关系：第三次全国健康和营养调查的结果。J、 临床。睡眠医学2（2），163-169（2006）。文章

Google Scholar

谷歌学者

Frandemark, A., Jakobsson Ung, E., Tornblom, H., Simren, M. & Jakobsson, S. Fatigue: a distressing symptom for patients with irritable bowel syndrome. Neurogastroenterol. Motil. https://doi.org/10.1111/nmo.12898 (2017).Article

Frandemark，A.，Jakobsson Ung，E.，Tornblom，H.，Simren，M。＆Jakobsson，S。疲劳：肠易激综合征患者的痛苦症状。神经胃肠道。运动型。https://doi.org/10.1111/nmo.12898（2017年）。文章

Google Scholar

谷歌学者

Overman, C. L., Kool, M. B., Da Silva, J. A. & Geenen, R. The prevalence of severe fatigue in rheumatic diseases: an international study. Clin. Rheumatol. 35(2), 409–415 (2016).Article

Overman，C.L.，Kool，M.B.，Da Silva，J.A。＆Geenen，R。风湿性疾病中严重疲劳的患病率：一项国际研究。临床。风湿病。35（2），409-415（2016）。文章

Google Scholar

谷歌学者

Borren, N. Z., van der Woude, C. J. & Ananthakrishnan, A. N. Fatigue in IBD: Epidemiology, pathophysiology and management. Nat. Rev. Gastroenterol. Hepatol. 16(4), 247–259 (2019).Article

Borren，N.Z.，van der Woude，C.J。和Ananthakrishnan，A.N。IBD疲劳：流行病学，病理生理学和管理。。。16（4），247-259（2019）。文章

CAS

中科院

Google Scholar

谷歌学者

Gregg, L. P. et al. Fatigue in nondialysis chronic kidney disease: Correlates and association with kidney outcomes. Am. J. Nephrol. 50(1), 37–47 (2019).Article

Gregg，L.P.等人，《非透析慢性肾脏疾病中的疲劳：与肾脏结局的相关性和关联》。Am.J.Nephrol。50（1），37-47（2019）。文章

CAS

中科院

Google Scholar

谷歌学者

Andersson, M., Stridsman, C., Ronmark, E., Lindberg, A. & Emtner, M. Physical activity and fatigue in chronic obstructive pulmonary disease - A population based study. Respir. Med. 109(8), 1048–1057 (2015).Article

Andersson，M.，Stridsman，C.，Ronmark，E.，Lindberg，A。＆Emtner，M。慢性阻塞性肺病的体力活动和疲劳-一项基于人群的研究。呼吸。医学109（8），1048-1057（2015）。文章

Google Scholar

谷歌学者

Glader, E. L., Stegmayr, B. & Asplund, K. Poststroke fatigue: a 2-year follow-up study of stroke patients in Sweden. Stroke. 33(5), 1327–1333 (2002).Article

Glader，E.L.，Stegmayr，B。＆Asplund，K。中风后疲劳：瑞典中风患者的2年随访研究。笔划。33（5），1327–1333（2002）。文章

Google Scholar

谷歌学者

Ruiz-Casado, A., Alvarez-Bustos, A., de Pedro, C. G., Mendez-Otero, M. & Romero-Elias, M. Cancer-related fatigue in breast cancer survivors: A review. Clin. Breast Cancer. 21(1), 10–25 (2021).Article

Ruiz-Casado，A.，Alvarez-Bustos，A.，de Pedro，C.G.，Mendez-Otero，M。和Romero-Elias，M。乳腺癌幸存者的癌症相关疲劳：综述。临床。乳腺癌。21（1），10-25（2021）。文章

Google Scholar

谷歌学者

Krupp, L. B., LaRocca, N. G., Muir-Nash, J. & Steinberg, A. D. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch. Neurol. 46(10), 1121–1123 (1989).Article

Krupp，L.B.，LaRocca，N.G.，Muir-Nash，J。＆Steinberg，A.D。疲劳严重程度量表。应用于多发性硬化症和系统性红斑狼疮患者。拱门。神经病学。46（10），1121-1123（1989）。文章

CAS

中科院

Google Scholar

谷歌学者

Langston, B., Armes, J., Levy, A., Tidey, E. & Ream, E. The prevalence and severity of fatigue in men with prostate cancer: a systematic review of the literature. Support Care Cancer. 21(6), 1761–1771 (2013).Article

Langston，B.，Armes，J.，Levy，A.，Tidey，E。＆Ream，E。前列腺癌男性疲劳的患病率和严重程度：文献的系统综述。支持护理癌症。21（6），1761-1771（2013）。文章

Google Scholar

谷歌学者

Maqbali. M. A. Cancer-related fatigue: An overview. Br. J. Nurs. (2021).Ma, Y. et al. Prevalence and risk factors of cancer-related fatigue: A systematic review and meta-analysis. Int. J. Nurs. Stud. https://doi.org/10.1016/j.ijnurstu.2020.103707 (2020).Article

马卡巴里。M、 A.癌症相关疲劳：概述。Br.J.努斯。（2021年）。Ma，Y.等。癌症相关疲劳的患病率和危险因素：系统综述和荟萃分析。。螺柱。https://doi.org/10.1016/j.ijnurstu.2020.103707（2020年）。文章

Google Scholar

谷歌学者

Barbi, C. et al. Brain structural and functional alterations in multiple sclerosis-related fatigue: A systematic review. Neurol. Int. 14(2), 506–535 (2022).Article

Barbi，C.等人，《多发性硬化症相关疲劳的大脑结构和功能改变：系统综述》。神经病学。内景14（2），506-535（2022）。文章

CAS

中科院

Google Scholar

谷歌学者

Siciliano, M. et al. Fatigue in Parkinson’s disease: A systematic review and meta-analysis. Mov. Disord. 33(11), 1712–1723 (2018).Article

Siciliano，M。等。帕金森病的疲劳：系统综述和荟萃分析。莫夫。混乱。33（11），1712-1723（2018）。文章

Google Scholar

谷歌学者

Lim, E. J. & Son, C. G. Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). J. Transl. Med. 18(1), 289 (2020).Article

Lim，E.J.＆Son，C.G。回顾肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的病例定义。J、 。医学杂志18（1），289（2020）。文章

Google Scholar

谷歌学者

Wong, T. L. & Weitzer, D. J. Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-A systemic review and comparison of clinical presentation and symptomatology. Medicina (Kaunas). 57(5), 418 (2021).Article

Wong，T。L。＆Weitzer，D。J。Long-COVID和肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）-临床表现和症状的系统评价和比较。麦地那（考纳斯）。57（5），418（2021）。文章

Google Scholar

谷歌学者

Arponen, H., Waltimo-Siren, J., Valta, H. & Makitie, O. Fatigue and disturbances of sleep in patients with osteogenesis imperfecta - a cross-sectional questionnaire study. BMC Musculoskelet. Disord. 19(1), 3 (2018).Article

Arponen，H.，Waltimo-Siren，J.，Valta，H。＆Makitie，O。成骨不全症患者的疲劳和睡眠障碍-横断面问卷研究。BMC肌肉骨骼。混乱。19（1），3（2018）。文章

Google Scholar

谷歌学者

Molvaer, A. K. et al. Metabolic predictors of pain, fatigue, depression and quality of life in people with long-term type 1 diabetes-the Dialong study. Diabet. Med. 40(3), e15009 (2023).Article

Molvaer，A.K.等人，《长期1型糖尿病患者疼痛、疲劳、抑郁和生活质量的代谢预测因素——Dialong研究》。暗黑破坏神。。文章

CAS

中科院

Google Scholar

谷歌学者

Wohland, H., Aringer, M. & Leuchten, N. Physical exercise is associated with less fatigue, less pain and better sleep in patients with systemic lupus erythematosus. Clin. Exp. Rheumatol. https://doi.org/10.55563/clinexprheumatol/az3pkn (2023).Article

Wohland，H.，Aringer，M。＆Leuchten，N。体育锻炼与系统性红斑狼疮患者的疲劳减轻，疼痛减轻和睡眠改善有关。临床。实验风湿病。https://doi.org/10.55563/clinexprheumatol/az3pkn（2023年）。文章

Google Scholar

谷歌学者

McClune, T., Burton, A. K. & Waddell, G. Whiplash associated disorders: A review of the literature to guide patient information and advice. Emerg. Med. J. 19(6), 499–506 (2002).Article

McClune，T.，Burton，A.K。＆Waddell，G。挥鞭样相关疾病：文献综述，以指导患者信息和建议。《急诊医学杂志》19（6），499-506（2002）。文章

CAS

中科院

Google Scholar

谷歌学者

Mandarino, F. V. et al. Imaging in gastroparesis: exploring innovative diagnostic approaches, symptoms, and treatment. Life (Basel). 13(8), 1743 (2023).ADS

Mandarino，F.V.等。胃轻瘫的影像学：探索创新的诊断方法，症状和治疗。人寿保险（巴塞尔）。13（8），1743（2023）。广告

CAS

中科院

Google Scholar

谷歌学者

Reyes-Gibby, C. C., Aday, L. A., Anderson, K. O., Mendoza, T. R. & Cleeland, C. S. Pain, depression, and fatigue in community-dwelling adults with and without a history of cancer. J. Pain Symptom Manage. 32(2), 118–128 (2006).Article

Reyes Gibby，C.C.，Aday，L.A.，Anderson，K.O.，Mendoza，T.R。＆Cleeland，C.S。有或没有癌症史的社区居住成年人的疼痛，抑郁和疲劳。J、 疼痛症状管理。32（2），118-128（2006）。文章

Google Scholar

谷歌学者

Baek, Y., Jung, K., Kim, H. & Lee, S. Association between fatigue, pain, digestive problems, and sleep disturbances and individuals’ health-related quality of life: A nationwide survey in South Korea. Health Qual. Life Outcomes. 18(1), 159 (2020).Article

Baek，Y.，Jung，K.，Kim，H。＆Lee，S。疲劳，疼痛，消化问题和睡眠障碍与个人健康相关生活质量之间的关联：韩国的一项全国性调查。健康质量。生活成果。18（1），159（2020）。文章

Google Scholar

谷歌学者

Goertz, Y. M. J. et al. Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study. Sci. Rep. 11(1), 20977 (2021).Article

Goertz，Y.M.J.等人，《慢性病患者的疲劳：基于人群的生命线队列研究的结果》。科学。代表11（1），20977（2021）。文章

ADS

广告

CAS

中科院

Google Scholar

谷歌学者

Menting, J. et al. Is fatigue a disease-specific or generic symptom in chronic medical conditions?. Health Psychol. 37(6), 530–543 (2018).Article

Menting，J。等人。疲劳是慢性疾病中的疾病特异性或通用症状吗？。健康心理学。37（6），530-543（2018）。文章

Google Scholar

谷歌学者

Hu, Y. et al. Progress in pathological and therapeutic research of HIV-related neuropathic pain. Cell. Mol. Neurobiol. 43(7), 3343–3373 (2023).Article

。细胞。分子神经生物学。43（7），3343-3373（2023）。文章

Google Scholar

谷歌学者

Godfrey, C., Harrison, M. B., Medves, J. & Tranmer, J. E. The symptom of pain with heart failure: a systematic review. J. Card. Fail. 12(4), 307–313 (2006).Article

Godfrey，C.，Harrison，M.B.，Medves，J。＆Tranmer，J.E。心力衰竭疼痛的症状：系统评价。J、 卡片。失败。12（4），307-313（2006）。文章

Google Scholar

谷歌学者

Norris, T., Hawton, K., Hamilton-Shield, J. & Crawley, E. Obesity in adolescents with chronic fatigue syndrome: an observational study. Arch. Dis. Child. 102(1), 35–39 (2017).Article

Norris，T.，Hawton，K.，Hamilton Shield，J。＆Crawley，E。慢性疲劳综合征青少年的肥胖：一项观察性研究。拱门。Dis。孩子。102（1），35-39（2017）。文章

CAS

中科院

Google Scholar

谷歌学者

Lim, W., Hong, S., Nelesen, R. & Dimsdale, J. E. The association of obesity, cytokine levels, and depressive symptoms with diverse measures of fatigue in healthy subjects. Arch Intern. Med. 165(8), 910–915 (2005).Article

Lim，W.，Hong，S.，Nelesen，R。＆Dimsdale，J.E。肥胖，细胞因子水平和抑郁症状与健康受试者疲劳程度的关系。首席实习生。医学杂志165（8），910-915（2005）。文章

Google Scholar

谷歌学者

Gu, M. et al. Obesity and poststroke fatigue: A 2-year longitudinal study. Neurol. Ther. 10(2), 955–969 (2021).Article

Gu，M.等人，《肥胖与卒中后疲劳：一项为期2年的纵向研究》。神经病学。他们。10（2），955-969（2021）。文章

Google Scholar

谷歌学者

Kang, Y. E. et al. Prevalence of cancer-related fatigue based on severity: a systematic review and meta-analysis. Sci. Rep. https://doi.org/10.1038/s41598-023-39046-0 (2023).Article

Kang，Y.E.等人。基于严重程度的癌症相关疲劳患病率：系统综述和荟萃分析。科学。代表。https://doi.org/10.1038/s41598-023-39046-0（2023年）。文章

Google Scholar

谷歌学者

Salvetti Mde, G., Pimenta, C. A., Braga, P. E. & McGillion, M. Prevalence of fatigue and associated factors in chronic low back pain patients. Rev. Lat. Am. Enfermagem. 21, 12–19 (2013).Article

Salvetti Mde，G.，Pimenta，C.A.，Braga，P.E。＆McGillion，M。慢性腰痛患者疲劳和相关因素的患病率。版次：Lat.Am.Enfermagem。21,12-19（2013）。文章

Google Scholar

谷歌学者

Tan, J. S. Q., Fong, W., Kwan, Y. H. & Leung, Y. Y. Prevalence and variables associated with fatigue in psoriatic arthritis: a cross-sectional study. Rheumatol. Int. 40(11), 1825–1834 (2020).Article

Tan，J.S.Q.，Fong，W.，Kwan，Y.H。和Leung，Y.Y。银屑病关节炎的患病率和与疲劳相关的变量：一项横断面研究。风湿病。Int.40（11），1825–1834（2020）。文章

CAS

中科院

Google Scholar

谷歌学者

Coates, L. C. et al. Sex-specific differences in patients with psoriatic arthritis: A systematic review. J. Rheumatol. 50(4), 488–496 (2023).Article

Coates，L.C.等人，《银屑病关节炎患者的性别差异：系统综述》。J、 。50（4），488-496（2023）。文章

Google Scholar

谷歌学者

Wang, X. S. et al. Prevalence and characteristics of moderate to severe fatigue: a multicenter study in cancer patients and survivors. Cancer. 120(3), 425–432 (2014).Article

Wang，X.S.等人，《中度至重度疲劳的患病率和特征：癌症患者和幸存者的多中心研究》。癌症。120（3），425-432（2014）。文章

Google Scholar

谷歌学者

Hagemans, M. L. et al. Fatigue: an important feature of late-onset Pompe disease. J. Neurol. 254(7), 941–945 (2007).Article

Hagemans，M.L.等人，《疲劳：迟发性庞贝病的重要特征》。J、 神经病学。254（7），941-945（2007）。文章

Google Scholar

谷歌学者

Tartavoulle, T. M. et al. Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors. ERJ Open Res. https://doi.org/10.1183/23120541.00079-2017 (2018).Article

Tartavoulle，T.M.等人，《肺动脉高压的多维疲劳：患病率、严重程度和预测因素》。ERJ开放资源。https://doi.org/10.1183/23120541.00079-2017（2018年）。文章

Google Scholar

谷歌学者

Kim, Y. J., Lee, S. G., Lee, J. S., Choi, Y. J. & Son, C. G. Comparative characteristics of fatigue in irritable bowel syndrome and inflammatory bowel disease: A systematic review and meta-analysis. J. Psychosom. Res. 177, 111589 (2024).Article

Kim，Y.J.，Lee，S.G.，Lee，J.S.，Choi，Y.J.＆Son，C.G.肠易激综合征和炎症性肠病疲劳的比较特征：系统评价和荟萃分析。J、 精神病。第177111589号决议（2024年）。文章

Google Scholar

谷歌学者

Pae, C. U. et al. Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants. Expert Opin. Pharmacother. 10(10), 1561–1570 (2009).Article

Pae，C.U.等人。慢性疲劳综合征的药物治疗：关注抗抑郁药的作用。专家意见。药剂师。10（10），1561–1570（2009）。文章

CAS

中科院

Google Scholar

谷歌学者

Passik, S. D. et al. Patient-related barriers to fatigue communication: initial validation of the fatigue management barriers questionnaire. J. Pain Symptom Manage. 24(5), 481–493 (2002).Article

Passik，S.D.等人，《与患者相关的疲劳沟通障碍：疲劳管理障碍问卷的初步验证》。J、 疼痛症状管理。。文章

Google Scholar

谷歌学者

Poort, H. et al. cognitive behavioral therapy for treatment-related fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitors: A mixed-method study. J. Clin. Psychol. Med. Settings. 26(4), 440–448 (2019).Article

认知行为疗法治疗酪氨酸激酶抑制剂治疗慢性粒细胞白血病患者治疗相关疲劳：一项混合方法研究。J、 临床。心理学。医学设置。26（4），440-448（2019）。文章

Google Scholar

谷歌学者

NCGC. Pharmacological interventions: Myalgic encephalomyelitis (or encephalopathy) / chronic fatigue syndrome: diagnosis and management: Evidence review F. London (2021).Download referencesFundingThis research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2018R1A6A1A03025221) and Bio&Medical Technology Development Program (NRF-2022M3A9E4095338).Author informationAuthors and AffiliationsKorean Medical College of Daejeon University, 62, Daehak-ro, Dong-gu, Daejeon, Republic of KoreaNa-Hyun Park, Ye-Eun Kang, Ji-Hae Yoon & Byung-Jin ParkDepartment of Health Service Management, Daejeon University, 96-3 Yongun-dong, Dong-gu, Daejeon, 300-716, Republic of KoreaYo-Chan AhnDepartment of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daedeok-daero 176, Seo-gu, Daejeon, 35235, Republic of KoreaEun-Jung LeeResearch Center for CFS/ME, Daejeon Oriental Hospital of Daejeon University, 176 Daedeok-daero, Seo-gu, Daejeon, 35235, Republic of KoreaChang-Gue SonAuthorsNa-Hyun ParkView author publicationsYou can also search for this author in.

NCGC。药物干预：肌痛性脑脊髓炎（或脑病）/慢性疲劳综合征：诊断和管理：证据综述F.London（2021）。下载参考文献资助这项研究得到了韩国国家研究基金会（NRF）的支持，该基金会由科学，ICT和未来规划部（NRF-2018R1A6A1A03025221）和生物与医学技术发展计划（NRF-2022M3A9E4095338）资助。作者信息作者和所属机构大田大学韩国医学院，62岁，大田东固大哈罗，大田韩国玄园，叶恩康，海永和秉真公园大田大学卫生服务管理系，96-3 Yongun Dong，Dong gu，Daejeon，300-716，大韩民国陈安韩国康复医学系，大田大学韩国医学院，大田大德大罗176，Seo gu，大田，35235，大韩民国大田东方医院CFS/ME研究中心大田大学，176 Daedeok daero，Seo gu，Daejeon，35235，大韩民国Gue SonAuthorsNa Hyun ParkView作者出版物您也可以在中搜索这位作者。

PubMed Google ScholarYe-Eun KangView author publicationsYou can also search for this author in

PubMed Google ScholarJi-Hae YoonView author publicationsYou can also search for this author in

PubMed Google ScholarJi Hae YoonView作者出版物您也可以在

PubMed Google ScholarYo-Chan AhnView author publicationsYou can also search for this author in

PubMed Google ScholarYo Chan AhnView作者出版物您也可以在

PubMed Google ScholarEun-Jung LeeView author publicationsYou can also search for this author in

PubMed Google ScholarEun Jung LeeView作者出版物您也可以在

PubMed Google ScholarByung-Jin ParkView author publicationsYou can also search for this author in

PubMed Google ScholarChang-Gue SonView author publicationsYou can also search for this author in

PubMed Google ScholarChang Gue SonView作者出版物您也可以在

PubMed Google ScholarContributionsNHP, YEK and JHY had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. YCA conducted statistical analysis. NHP, EJL and CGS designed the study and drafted the manuscript.

PubMed谷歌学术贡献SNHP，YEK和JHY可以完全访问研究中的所有数据，并对数据的完整性和数据分析的准确性负责。YCA进行了统计分析。NHP，EJL和CGS设计了这项研究并起草了手稿。

BJP contributed to manuscript revisions and submission process. CGS obtained the funding and supervised the whole process of this study. All authors read and approved the final manuscript.Corresponding authorCorrespondence to.

BJP为稿件修订和提交过程做出了贡献。CGS获得了资金并监督了这项研究的整个过程。所有作者都阅读并批准了最终稿件。对应作者对应。

Chang-Gue Son.Ethics declarations

常古子。道德宣言

Competing interests

相互竞争的利益

The authors declare no competing interests.

作者声明没有利益冲突。

Additional informationPublisher’s noteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Supplementary InformationSupplementary Information.Rights and permissions

Additional informationPublisher的noteSpringer Nature在已发布地图和机构隶属关系中的管辖权主张方面保持中立。补充信息补充信息。权限和权限

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material.

开放获取本文是根据知识共享署名非商业性NoDerivatives 4.0国际许可证授权的，该许可证允许以任何媒介或格式进行任何非商业性使用，共享，分发和复制，只要您对原始作者和来源给予适当的信任，提供知识共享许可证的链接，并指出您是否修改了许可材料。

You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

根据本许可证，您无权共享源自本文或其部分的改编材料。本文中的图像或其他第三方材料包含在文章的知识共享许可证中，除非该材料的信用额度中另有说明。如果材料未包含在文章的知识共享许可中，并且您的预期用途不受法律法规的许可或超出许可用途，则您需要直接获得版权所有者的许可。

To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/..

要查看此许可证的副本，请访问http://creativecommons.org/licenses/by-nc-nd/4.0/..

Reprints and permissionsAbout this articleCite this articlePark, NH., Kang, YE., Yoon, JH. et al. Comparative study for fatigue prevalence in subjects with diseases: a systematic review and meta-analysis.

转载和许可本文引用本文新罕布什尔州帕克。，康，叶，尹，JH。等。疾病患者疲劳患病率的比较研究：系统综述和荟萃分析。

Sci Rep 14, 23348 (2024). https://doi.org/10.1038/s41598-024-74683-zDownload citationReceived: 05 April 2024Accepted: 27 September 2024Published: 07 October 2024DOI: https://doi.org/10.1038/s41598-024-74683-zShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

科学报告1423348（2024）。https://doi.org/10.1038/s41598-024-74683-zDownload引文接收日期：2024年4月5日接受日期：2024年9月27日发布日期：2024年10月7日OI：https://doi.org/10.1038/s41598-024-74683-zShare。复制到剪贴板。

Provided by the Springer Nature SharedIt content-sharing initiative

由Springer Nature SharedIt内容共享计划提供

KeywordsClassification of diseasesFatiguePrevalenceSystematic reviewMeta-analysis

关键词疾病分类患病率系统评价Meta分析

CommentsBy submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

评论通过提交评论，您同意遵守我们的条款和社区指南。如果您发现有虐待行为或不符合我们的条款或准则，请将其标记为不合适。