PALO ALTO, Calif.--(BUSINESS WIRE)--Curio Bioscience today announced the worldwide availability of Curio Trekker, a new single-cell spatial mapping kit that converts single-cell genomics measurements into tissue-specific spatial data. More than 80 early access customers have already validated this powerful new tool to advance discovery research in cancer biology, neuroscience, developmental sciences and beyond.

加利福尼亚州帕洛阿尔托（商业新闻短讯）--Curio Bioscience今天宣布在全球范围内推出Curio Trekker，这是一种新的单细胞空间作图试剂盒，可将单细胞基因组学测量结果转换为组织特定的空间数据。80多名早期访问客户已经验证了这一强大的新工具，以推进癌症生物学，神经科学，发育科学等领域的发现研究。

Making spatial omics more accessible, Curio Trekker delivers true single-cell spatial resolution to scientists, regardless of organism or tissue type..

Curio Trekker为科学家提供了真正的单细胞空间分辨率，使空间组学更容易获得，无论生物或组织类型如何。。

Conor Liston, Professor of Neuroscience and Psychiatry, Weill Cornell Medicine (New York), has hands-on experience with Curio Trekker, stating: “Curio Trekker adds valuable spatial information to single-nucleus transcriptomics data without compromising on cellular resolution or transcriptome coverage.

威尔·康奈尔医学（纽约）的神经科学和精神病学教授康纳·利斯顿（Conor Liston）拥有《古玩迷航记》的实践经验，他表示：“古玩迷航记在不影响细胞分辨率或转录组覆盖率的情况下，为单核转录组学数据添加了有价值的空间信息。

The protocol fits seamlessly into standard workflows, making it easy and time-efficient to add spatial information to our projects. Within weeks of starting our work with the Curio Trekker system, my lab members were generating high-quality data that has completely transformed two projects and opened new avenues to mechanistic insights that we are currently testing.

该协议无缝地融入标准工作流程，使向我们的项目添加空间信息变得简单且省时。在开始使用Curio Trekker系统的几周内，我的实验室成员生成了高质量的数据，这些数据彻底改变了两个项目，并为我们目前正在测试的机械见解开辟了新的途径。

The Curio Bioscience team was also outstanding in supporting us in our efforts to set this up. We couldn’t be happier with our experience and would enthusiastically recommend this platform to colleagues and collaborators.”.

古玩生物科学团队在支持我们建立这一平台方面也表现出色。我们对自己的经验非常满意，并将热情地向同事和合作者推荐这个平台。”。

Researchers use Curio Trekker with single-cell and single-nuclei analyses to carry out precise tissue reconstruction at single-cell resolution. The first of its kind, Curio’s novel kit enables researchers to routinely capture the spatial context of cell populations in an easy-to-use, one-hour workflow without specialized instrumentation or personnel.

研究人员使用Curio Trekker进行单细胞和单核分析，以单细胞分辨率进行精确的组织重建。Curio的新型试剂盒是同类产品中的第一个，它使研究人员能够在不需要专门仪器或人员的情况下，以易于使用的一小时工作流程定期捕获细胞群的空间背景。

This spatial biology solution simply plugs into existing standard single-cell sequencing workflows, preserving the high sensitivity of single-cell data..

这种空间生物学解决方案只需插入现有的标准单细胞测序工作流程，即可保持单细胞数据的高灵敏度。。

Brian Kalish, Director of Research in Neonatology, The Hospital for Sick Children (Toronto, Canada) and now a professor at Harvard University, is another customer with first-hand experience with Curio Trekker. He shared his perspective: “We have been able to seamlessly integrate Curio Trekker into our experiments.

布莱恩·卡利什（BrianKalish）是加拿大多伦多病童医院新生儿科研究主任，现为哈佛大学教授，他是另一位拥有古玩徒步旅行第一手经验的客户。他分享了自己的观点：“我们已经能够将古玩旅行者无缝地整合到我们的实验中。

The wet lab protocol is straightforward and highly reliable and integrates nicely with traditional single-cell platforms. The data quality is superb, and both precise spatial location and whole transcriptome results can be reliably obtained on tens of thousands of cells from a single tissue section.

湿实验室协议简单明了且高度可靠，并且与传统的单细胞平台很好地集成。数据质量非常好，可以从单个组织切片的数万个细胞上可靠地获得精确的空间位置和整个转录组结果。

We have computationally integrated the Trekker data with other data modalities, such as imaging-based in situ spatial transcriptomics, allowing for even greater biological insight. Trekker has become my ‘go-to’ single cell and spatial platform for all experiments, as the ease of performance and analysis, combined with the quality of data, is superior to any other spatial platform on the market.”.

我们已经将Trekker数据与其他数据模式进行了计算集成，例如基于成像的原位空间转录组学，从而可以获得更大的生物学见解。Trekker已经成为我所有实验的“go-to”单细胞和空间平台，因为它易于执行和分析，再加上数据质量，优于市场上任何其他空间平台。”。

Christina Fan, PhD, Co-founder and CTO of Curio Bioscience, said, “Trekker is the first true single-cell spatial biology solution designed specifically for the single-cell genomics market. It enables single-cell researchers to obtain spatial data with a simple protocol addition that sits directly upstream of their existing single-cell sequencing workflows.

Curio Bioscience联合创始人兼首席技术官Christina Fan博士说：“Trekker是第一个专门为单细胞基因组学市场设计的真正的单细胞空间生物学解决方案。它使单细胞研究人员能够通过直接位于其现有单细胞测序工作流程上游的简单协议添加来获得空间数据。

We are thrilled with the positive feedback from customers participating in our Trekker Early Access program and are excited to extend access globally. We believe the use of Trekker will become routine and transform how researchers conduct single-cell studies.”.

我们对参加Trekker早期访问计划的客户的积极反馈感到兴奋，并对在全球范围内扩展访问感到兴奋。我们相信Trekker的使用将成为常规，并改变研究人员进行单细胞研究的方式。”。

Designed as a simple reagent kit, Curio Trekker builds upon the Slide-tags technology, which was developed by Curio co-founders at the Broad Institute of MIT and Harvard and published in Nature last December. Curio Bioscience introduced Trekker through an early access program earlier in 2024, with top research organizations as participants..

作为一个简单的试剂盒，Curio Trekker以幻灯片标签技术为基础，该技术由麻省理工学院和哈佛大学布罗德研究所的Curio联合创始人开发，并于去年12月在《自然》杂志上发表。Curio Bioscience于2024年初通过一项早期访问计划引入了Trekker，顶尖研究机构作为参与者。。

The Trekker solution works by tagging each nucleus within its native tissue environment with spatial barcodes. These spatial barcodes are read using next-generation sequencing (NGS), allowing each nucleus to be bioinformatically positioned to its spatial coordinates. The result is a spatial map with true single-cell resolution, without the use of complex instrumentation, cell-type deconvolution, or cell segmentation..

Trekker解决方案通过用空间条形码标记其天然组织环境中的每个细胞核来工作。这些空间条形码是使用下一代测序（NGS）读取的，允许每个核在生物信息学上定位到其空间坐标。结果是一个具有真正单细胞分辨率的空间图，无需使用复杂的仪器，细胞类型反卷积或细胞分割。。

For more information about Curio Trekker, click here.

有关古玩旅行者的更多信息，请单击此处。

About Curio Bioscience

关于古玩生物科学

Curio Bioscience is advancing a new generation of high-precision tools for the life sciences industry. The company has developed innovative spatial biology capabilities to map the whole transcriptome at high resolution using existing sequencing workflows and instrumentation. The founding team has a strong track record of bringing genomic solutions to market.

Curio Bioscience正在为生命科学行业推进新一代高精度工具。该公司开发了创新的空间生物学功能，可以使用现有的测序工作流程和仪器以高分辨率绘制整个转录组。创始团队在将基因组解决方案推向市场方面有着良好的记录。

Based in Palo Alto, California, Curio Bioscience is a privately held company.

Curio Bioscience总部位于加利福尼亚州帕洛阿尔托，是一家私营公司。