BOSTON--(BUSINESS WIRE)--Patients with depression experienced a clinically significant reduction in symptoms after using a research-based mobile application for just eight weeks, according to new findings from Hedonia’s clinical trial run at Massachusetts General Hospital (MGH). This is the first study to use a therapeutic app based on Facilitating Thought ProgressionTM (FTP), a novel approach to mood disorders that disrupts cyclical, repetitive patterns of rigid thinking common in depression and anxiety..

波士顿-（商业新闻）-根据马萨诸塞州总医院（MGH）Hedonia临床试验的新发现，抑郁症患者在使用基于研究的移动应用程序仅八周后，症状在临床上显着减轻。这是第一项使用基于促进思维进步TM（FTP）的治疗应用程序的研究，FTP是一种治疗情绪障碍的新方法，它破坏了抑郁症和焦虑症中常见的周期性重复性僵化思维模式。。

“The change we saw in the trial participants was remarkable,” said Moshe Bar, PhD, who developed FTP while at Harvard Medical School and was part of the study team. “Many participants moved from moderate to mild depression. That can be the difference between being able to get out of bed in the morning and not.”.

“我们在试验参与者身上看到的变化是显着的，”Moshe Bar博士说，他在哈佛医学院（Harvard Medical School）期间开发了FTP，也是研究团队的一员。“许多参与者从中度抑郁转变为轻度抑郁。这可能是早上能够起床与不能够起床之间的区别。”。

The randomized controlled trial, conducted from November 2022 through July 2023, involved 101 participants with a diagnosis of mild-to-moderate depression. About a third of the participants were also diagnosed with anxiety. All participants continued their ongoing conventional treatment (medication, therapy, or both), if they were already on any, during the study.

这项随机对照试验于2022年11月至2023年7月进行，涉及101名诊断为轻度至中度抑郁症的参与者。大约三分之一的参与者也被诊断出患有焦虑症。在研究期间，所有参与者都继续进行正在进行的常规治疗（药物治疗，治疗或两者兼而有之），如果他们已经接受了任何治疗。

The intervention group engaged with the mobile application for at least 15 minutes a day for four days a week over eight weeks..

干预组在八周内每周四天每天至少15分钟使用移动应用程序。。

The study used a total of nine different validated clinical measurement tools to determine depression levels and other related symptoms such as anxiety and rumination before, during, and after the study. Significant improvement was shown across all relevant measures.

该研究使用了总共九种不同的经过验证的临床测量工具来确定研究之前、期间和之后的抑郁水平和其他相关症状，如焦虑和反刍。所有相关措施均显示出显着改善。

On the Montgomery-Asberg Depression Rating Scale (MADRS), a clinician-administered assessment, the depression severity scores of participants in the intervention group dropped by 43%, while the control group’s scores dropped by 18%. A decrease in scores indicates an improvement in symptoms. Similarly, in the Patient Health Questionnaire-9 (PHQ-9), a self-administered assessment, the intervention group’s depression scores dropped by 45% while the control group’s scores went down by 16%.

在蒙哥马利-阿斯伯格抑郁评定量表（MADRS）上，干预组参与者的抑郁严重程度评分下降了43%，而对照组的评分下降了18%。分数下降表明症状有所改善。同样，在自我管理评估的患者健康问卷-9（PHQ-9）中，干预组的抑郁评分下降了45%，而对照组的评分下降了16%。

“Even four weeks after the conclusion of the study, we continued to see symptom improvement, which could suggest a long-lasting effect,” said Dr. Bar.

巴尔博士说：“即使在研究结束四周后，我们仍能看到症状改善，这可能意味着长期的效果。”。

“Evidence-based games could be an invaluable new tool for patients with depression, as this research conducted at Massachusetts General Hospital shows participants improving significantly with a minimal investment of time,” said Maurizio Fava, MD, Chair of the Department of Psychiatry at MGH. “This novel, game-based approach to depression builds upon decades of statistically and clinically meaningful research by Dr.

MGH精神病学系主任Maurizio Fava医学博士说：“循证游戏对于抑郁症患者来说可能是一种非常宝贵的新工具，因为在马萨诸塞州总医院进行的这项研究表明，参与者只需花费很少的时间就能显着改善。”。“这种新颖的，基于游戏的抑郁症治疗方法建立在Dr。

Bar and his team, representing a potential new avenue for all of us who treat individuals with depression.”.

Bar和他的团队，代表了我们所有治疗抑郁症患者的潜在新途径。”。

Prolonged depression and repetitive thought patterns result in a loss of neuronal volume in critical brain structures such as the hippocampus. FTP disrupts such maladaptive thought patterns by making thought processes faster and more flexible, associative, and global. By gradually reconstructing cognitive patterns and their underlying neural networks that have been lost, FTP helps improve and maintain mental health..

长时间的抑郁和重复的思维模式会导致关键大脑结构（如海马）的神经元体积减少。FTP通过使思维过程更快、更灵活、更具关联性和全局性，破坏了这种不适应的思维模式。通过逐步重建已经丢失的认知模式及其潜在的神经网络，FTP有助于改善和维持心理健康。。

The FTP-based app used in the study (then called Moodville and now available as Mood Bloom) includes word association, speed reading, and other cognitive activities shown to facilitate the progression of thought.

该研究中使用的基于FTP的应用程序（当时称为Moodville，现在可用作Mood Bloom）包括单词联想、快速阅读和其他认知活动，这些活动可以促进思维的发展。

This approach reflects an innovative collaboration between researchers and app developers. Dr. Bar partnered with Samuel Keret, one of the founding members of the navigation app Waze. Together with entrepreneur Adi Pundak-Mintz, they founded Hedonia with the mission of bringing symptom relief for people with depression and anxiety through science-based therapeutic apps..

这种方法反映了研究人员和应用程序开发人员之间的创新合作。Bar博士与导航应用程序Waze的创始成员之一SamuelKeret合作。他们与企业家阿迪·蓬达克·明茨（Adi Pundak Mintz）共同创立了Hedonia，其使命是通过基于科学的治疗应用程序为抑郁症和焦虑症患者缓解症状。。

“In our scientific research, we developed cognitive paradigms that we have shown could help with anxiety and depression, but we faced a challenge: How do we get people to engage in these tasks regularly to get the clinical benefit?” said Dr. Bar. “That’s where Samuel and the product developers came in, using a game-based format to ensure adherence.”.

巴尔博士说：“在我们的科学研究中，我们开发了认知范式，我们已经证明这些范式可以帮助缓解焦虑和抑郁，但我们面临着一个挑战：我们如何让人们定期参与这些任务以获得临床益处？”。“这就是Samuel和产品开发人员的用武之地，他们使用基于游戏的格式来确保遵守。”。

The result was Mood Bloom, which encourages users to engage repeatedly over time, with features common in other popular mobile games: ample use of color, attractive characters, daily goals, and rewards.

其结果是情绪爆发，它鼓励用户随着时间的推移反复参与，其特点在其他流行的手机游戏中很常见：大量使用颜色、吸引人的角色、日常目标和奖励。

“Depression can often drain people of the motivation to continue with treatment. The idea of a game that keeps people coming back for therapeutic play—in conjunction with necessary therapy and medication—is very exciting,” says Dr. Fava.

法瓦博士说：“抑郁症通常会耗尽人们继续治疗的动机。一个游戏的想法是让人们在必要的治疗和药物治疗的同时回来进行治疗，这是非常令人兴奋的。”。

The researchers emphasized that this is the first study to examine the delivery of FTP using a mobile application. Future studies will assess the long-term benefits on symptom reduction.

研究人员强调，这是第一项使用移动应用程序检查FTP交付的研究。未来的研究将评估减轻症状的长期益处。

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About Hedonia

关于Hedonia

Hedonia offers an entirely new, clinically-proven tool for the treatment of depression and anxiety. Our mission is to bring real relief from depression and anxiety to as many people as possible, delivered through mobile games based on Facilitating Thought Progression™ (FTP). Grounded in years of neuroscientific research, FTP improves mood through quick, daily exercises that disrupt unhealthy thinking patterns and rebuild neural networks.

Hedonia为治疗抑郁症和焦虑症提供了一种全新的，经临床验证的工具。我们的使命是通过基于促进思维发展的手机游戏，为尽可能多的人带来真正的抑郁和焦虑缓解™（FTP）。基于多年的神经科学研究，FTP通过快速的日常锻炼来改善情绪，这些锻炼可以破坏不健康的思维模式并重建神经网络。

Hedonia’s unique clinician-designed activities are packed inside an entertaining game that keeps players engaged and receiving the right dose of FTP-based therapy. For more information, visit https://hedonia.io..

Hedonia独特的临床医生设计的活动被包装在一个有趣的游戏中，让玩家保持参与并接受正确剂量的基于FTP的治疗。有关更多信息，请访问https://hedonia.io..