AbstractInflammatory bowel diseases (IBD) are a group of chronic, non-specific intestinal diseases that could comorbid with varieties of negative emotional constructs, including pain-related negative emotions and trait negative emotions; however, the link between brain functions and different dimensions of negative emotions remains largely unknown.

摘要炎症性肠病（IBD）是一组慢性非特异性肠道疾病，可能与多种负面情绪结构共存，包括与疼痛相关的负面情绪和特质负面情绪；。

Ninety-eight patients with IBD and forty-six healthy subjects were scanned using a 3.0-T functional magnetic resonance imaging scanner. The amplitudes of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC) were used to assess resting-state brain activity. Partial least squares (PLS) correlation was employed to assess the relationship among abnormal brain activities, pain-related and trait negative emotions.

使用3.0-T功能磁共振成像扫描仪扫描了98名IBD患者和46名健康受试者。低频波动（ALFF），区域同质性（ReHo）和程度中心性（DC）的幅度用于评估静息状态的大脑活动。偏最小二乘（PLS）相关性用于评估异常大脑活动，疼痛相关和特质负面情绪之间的关系。

Compared to controls, patients with IBD exhibited higher values of ALFF in the right anterior cingulate cortex (ACC), lower values of ALFF in the left postcentral gyrus, and higher values of DC in the bilateral ACC. Multivariate PLS correlation analysis revealed the brain scores of the ACC were correlated with pain-related negative emotions, the brain salience in the left postcentral gyrus was associated with the higher-order trait depression.

与对照组相比，IBD患者右前扣带回（ACC）的ALFF值较高，左中央后回的ALFF值较低，双侧ACC的DC值较高。多变量PLS相关分析显示ACC的大脑评分与疼痛相关的负面情绪相关，左中央后回的大脑显着性与高阶特质抑郁有关。

These findings can enhance our comprehension of how pain-related negative emotion and trait negative emotion affect the brains of patients with IBD in distinct ways..

这些发现可以增强我们对疼痛相关负面情绪和特质负面情绪如何以不同方式影响IBD患者大脑的理解。。

IntroductionInflammatory bowel diseases (IBD) are a group of chronic, non-specific intestinal diseases that mostly comprise Crohn’s disease and ulcerative colitis1. They typically occur alternately in episodes and remissions and are difficult to cure2,3. Patients with IBD may have a variety of negative emotional behaviors, primarily characterized by heightened physical discomfort, excessive concern with the possibility of disease recurrence, and apprehension over exacerbating their condition4, and experiences of anxiety and depression5.

引言炎症性肠病（IBD）是一组慢性非特异性肠道疾病，主要包括克罗恩病和溃疡性结肠炎1。它们通常在发作和缓解期间交替发生，难以治愈2,3。IBD患者可能有多种负面情绪行为，主要表现为身体不适加剧，过度担心疾病复发的可能性，担心病情恶化4，以及焦虑和抑郁的经历5。

Lower-order pain-related psychological constructs (such as pain catastrophizing, pain-related anxiety, and pain-related fear) and higher-order personality traits (such as trait anxiety and depression) have been demonstrated to have different impacts on pain in healthy humans6. Despite the close association between negative feelings and repeated symptoms, few studies have considered the different impacts of pain-related negative emotions and trait negative emotions in patients with IBD.The brain-gut axis is commonly utilized to describe the intricate interactions among neuroendocrine pathways, the peripheral, central, and autonomic neural systems, and the gastrointestinal tract7.

低阶疼痛相关的心理结构（如疼痛灾难，疼痛相关的焦虑和疼痛相关的恐惧）和高阶人格特征（如特质焦虑和抑郁）已被证明对健康人的疼痛有不同的影响6。尽管负面情绪与反复症状之间存在密切联系，但很少有研究考虑IBD患者疼痛相关负面情绪和特质负面情绪的不同影响。脑-肠轴通常用于描述神经内分泌途径，外周，中枢和自主神经系统以及胃肠道之间复杂的相互作用7。

These interconnected pathways might be bidirectional8. For example, there have been strong connections between gastrointestinal disorders and pain-related fear9, pain-related anxiety10, and pain catastrophizing11. Negative emotions, a higher-order trait associated with negative feelings, cognitions, and self-concept, are also linked to the intensity of symptoms in some chronically gastrointestinal conditions12,13.

这些相互关联的途径可能是双向的8。例如，胃肠道疾病与疼痛相关的恐惧9，疼痛相关的焦虑10和疼痛灾难11之间有很强的联系。负面情绪是与负面情绪，认知和自我概念相关的高阶特征，也与某些慢性胃肠道疾病的症状强度有关12,13。

Neuroimaging techniques provide a valuable tool for investigating the maladaptive plastic changes of the human brain and their association with psychol.

神经影像学技术为研究人脑适应不良的可塑性变化及其与心理的关系提供了有价值的工具。

Data availability

数据可用性

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

在当前研究期间生成和/或分析的数据集可根据合理要求从通讯作者处获得。

ReferencesRosen, M. J., Dhawan, A. & Saeed, S. A. Inflammatory bowel disease in children and adolescents. JAMA Pediatr. 169, 1053–1060. https://doi.org/10.1001/jamapediatrics.2015.1982 (2015).Article

参考文献Rosen，M.J.，Dhawan，A。＆Saeed，S.A。儿童和青少年的炎症性肠病。JAMA儿科。1691053-1060年。https://doi.org/10.1001/jamapediatrics.2015.1982（2015年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Baumgart, D. C. & Sandborn, W. J. Crohn’s disease. Lancet 380, 1590–1605. https://doi.org/10.1016/s0140-6736(12)60026-9 (2012).Article

Baumgart，D.C。和Sandborn，W.J。克罗恩病。柳叶刀3801590-1605。https://doi.org/10.1016/s0140-6736（12） 60026-9（2012）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Danese, S. & Fiocchi, C. Ulcerative colitis. N. Engl. J. Med. 365, 1713–1725. https://doi.org/10.1056/NEJMra1102942 (2011).Article

Danese，S.和Fiocchi，C.溃疡性结肠炎。N.Engl。《医学杂志》，第365期，1713-1725页。https://doi.org/10.1056/NEJMra1102942(2011).文章

PubMed

PubMed

Google Scholar

谷歌学者

Hyphantis, T. N. et al. Psychological distress, somatization, and defense mechanisms associated with quality of life in inflammatory bowel disease patients. Dig. Dis. Sci. 55, 724–732. https://doi.org/10.1007/s10620-009-0762-z (2010).Article

Hyphantis，T.N.等人。与炎症性肠病患者生活质量相关的心理困扰，躯体化和防御机制。挖掘。Dis。科学。55724-732。https://doi.org/10.1007/s10620-009-0762-z（2010年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Farrokhyar, F., Marshall, J. K., Easterbrook, B. & Irvine, E. J. Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: prevalence and impact on health. Inflamm. Bowel Dis. 12, 38–46. https://doi.org/10.1097/01.mib.0000195391.49762.89 (2006).Article .

Farrokhyar，F.，Marshall，J.K.，Easterbrook，B。＆Irvine，E.J。非活动性炎症性肠病患者的功能性胃肠道疾病和情绪障碍：患病率和对健康的影响。发炎。肠病。12，38-46。https://doi.org/10.1097/01.mib.0000195391.49762.89（2006年）。文章。

PubMed

PubMed

Google Scholar

谷歌学者

Lee, J. E., Watson, D. & Frey Law, L. A. Lower-order pain-related constructs are more predictive of cold pressor pain ratings than higher-order personality traits. J. Pain 11, 681–691. https://doi.org/10.1016/j.jpain.2009.10.013 (2010).Article

Lee，J.E.，Watson，D。＆Frey-Law，L.A。低阶疼痛相关结构比高阶人格特征更能预测冷加压疼痛评分。J、 疼痛11681-691。https://doi.org/10.1016/j.jpain.2009.10.013（2010年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Bonaz, B. L. & Bernstein, C. N. Brain-gut interactions in inflammatory bowel disease. Gastroenterology 144, 36–49. https://doi.org/10.1053/j.gastro.2012.10.003 (2013).Article

Bonaz，B.L。和Bernstein，C.N。炎症性肠病中的脑肠相互作用。胃肠病学144,36-49。https://doi.org/10.1053/j.gastro.2012.10.003（2013年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Gracie, D. J., Guthrie, E. A., Hamlin, P. J. & Ford, A. C. Bi-directionality of brain-gut interactions in patients with inflammatory bowel disease. Gastroenterology 154, 1635–1646. https://doi.org/10.1053/j.gastro.2018.01.027 (2018).Article

Gracie，D.J.，Guthrie，E.A.，Hamlin，P.J。＆Ford，A.C。炎症性肠病患者脑肠相互作用的双向性。胃肠病学1541635-1646。https://doi.org/10.1053/j.gastro.2018.01.027（2018年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Icenhour, A. et al. Neural circuitry of abdominal pain-related fear learning and reinstatement in irritable bowel syndrome. Neurogastroenterol. Motil. 27, 114–127. https://doi.org/10.1111/nmo.12489 (2015).Article

Icenhour，A。等人。肠易激综合征中与腹痛相关的恐惧学习和恢复的神经回路。神经胃肠道。运动型。27114-127。https://doi.org/10.1111/nmo.12489（2015年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Murray, H. B. et al. Frequency of eating disorder pathology among patients with chronic constipation and contribution of gastrointestinal-specific anxiety. Clin. Gastroenterol. Hepatol. 18, 2471–2478. https://doi.org/10.1016/j.cgh.2019.12.030 (2020).Article

Murray，H.B.等人。慢性便秘患者进食障碍病理的频率和胃肠道特异性焦虑的贡献。临床。胃肠道。肝病。182471-2478。https://doi.org/10.1016/j.cgh.2019.12.030（2020年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Wojtowicz, A. A., Greenley, R. N., Gumidyala, A. P., Rosen, A. & Williams, S. E. Pain severity and pain catastrophizing predict functional disability in youth with inflammatory bowel disease. J. Crohns Colitis 8, 1118–1124. https://doi.org/10.1016/j.crohns.2014.02.011 (2014).Article .

Wojtowicz，A.A.，Greenley，R.N.，Gumidyala，A.P.，Rosen，A。＆Williams，S.E。疼痛严重程度和疼痛灾难预测炎症性肠病青少年的功能障碍。J、 。https://doi.org/10.1016/j.crohns.2014.02.011（2014年）。文章。

PubMed

PubMed

Google Scholar

谷歌学者

Black, C. J., Drossman, D. A., Talley, N. J., Ruddy, J. & Ford, A. C. Functional gastrointestinal disorders: advances in understanding and management. Lancet 396, 1664–1674. https://doi.org/10.1016/s0140-6736(20)32115-2 (2020).Article

Black，C.J.，Drossman，D.A.，Talley，N.J.，Ruddy，J。＆Ford，A.C。功能性胃肠疾病：理解和管理的进展。柳叶刀3961664-1674。https://doi.org/10.1016/s0140-6736（20） 32115-2（2020年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Zhu, F., Tu, H. & Chen, T. The microbiota-gut-brain axis in depression: the potential pathophysiological mechanisms and microbiota combined antidepression effect. Nutrients 14. https://doi.org/10.3390/nu14102081 (2022).Elsenbruch, S. et al. Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study.

Zhu，F.，Tu，H。＆Chen，T。抑郁症中的微生物群-肠-脑轴：潜在的病理生理机制和微生物群联合抗抑郁作用。营养素14。https://doi.org/10.3390/nu14102081（2022年）。Elsenbruch，S.等人。情感障碍调节肠易激综合征内脏疼痛刺激的神经处理：功能磁共振成像研究。

Gut 59, 489–495. https://doi.org/10.1136/gut.2008.175000 (2010).Article .

很好，59489-495。https://doi.org/10.1136/gut.2008.175000(2010).第条。

PubMed

PubMed

Google Scholar

谷歌学者

Chen, Y. et al. Differential responses from the left postcentral gyrus, right middle frontal gyrus, and precuneus to meal ingestion in patients with functional dyspepsia. Front. Psychiatry 14, 1184797. https://doi.org/10.3389/fpsyt.2023.1184797 (2023).Article

Chen，Y.等人。功能性消化不良患者左侧中央后回、右侧额中回和楔前叶对进食的不同反应。正面。精神病学141184797。https://doi.org/10.3389/fpsyt.2023.1184797（2023年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Fan, Y. et al. Altered functional connectivity of the amygdala in Crohn’s disease. Brain Imaging Behav. 14, 2097–2106. https://doi.org/10.1007/s11682-019-00159-8 (2020).Article

Fan，Y.等人改变了克罗恩病中杏仁核的功能连接。脑成像行为。142097-2106年。https://doi.org/10.1007/s11682-019-00159-8（2020年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Huang, M. et al. Alterations of Regional Homogeneity in Crohn’s Disease with Psychological disorders: a resting-state fMRI study. Front. Neurol. 13, 817556. https://doi.org/10.3389/fneur.2022.817556 (2022).Article

Huang，M.等。伴有心理障碍的克罗恩病区域同质性的改变：静息状态fMRI研究。正面。神经病学。13817556页。https://doi.org/10.3389/fneur.2022.817556（2022年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Wold, H. Path models with latent variables: the NIPALS approach. Quant. Sociol. 307–357 (1975).Zöller, D. et al. Disentangling resting-state BOLD variability and PCC functional connectivity in 22q11.2 deletion syndrome. Neuroimage 149, 85–97. https://doi.org/10.1016/j.neuroimage.2017.01.064 (2017).Article .

Wold，H。具有潜在变量的路径模型：NIPALS方法。数量。社会学。307-357（1975）。Zöller，D。等人。解开22q11.2缺失综合征中静息状态BOLD变异性和PCC功能连接。神经影像149,85-97。https://doi.org/10.1016/j.neuroimage.2017.01.064（2017年）。文章。

PubMed

PubMed

Google Scholar

谷歌学者

Wiebels, K., Waldie, K. E., Roberts, R. P. & Park, H. R. Identifying grey matter changes in schizotypy using partial least squares correlation. Cortex 81, 137–150. https://doi.org/10.1016/j.cortex.2016.04.011 (2016).Article

Wiebels，K.，Waldie，K.E.，Roberts，R.P。＆Park，H.R。使用偏最小二乘相关识别分裂型中的灰质变化。皮质81137-150。https://doi.org/10.1016/j.cortex.2016.04.011（2016年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Kong, N., Gao, C., Xu, M. & Gao, X. Changes in the anterior cingulate cortex in Crohn’s disease: a neuroimaging perspective. Brain Behav. 11, e02003. https://doi.org/10.1002/brb3.2003 (2021).Article

Kong，N.，Gao，C.，Xu，M。＆Gao，X。克罗恩病前扣带回皮层的变化：神经影像学观点。大脑行为。2003年10月11日。https://doi.org/10.1002/brb3.2003（2021年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Kong, N. et al. Neurophysiological effects of the Anterior Cingulate Cortex on the exacerbation of Crohn’s Disease: a combined fMRI-MRS study. Front. Neurosci. 16, 840149. https://doi.org/10.3389/fnins.2022.840149 (2022).Article

Kong，N.等人。前扣带回皮层对克罗恩病恶化的神经生理学影响：一项联合fMRI-MRS研究。正面。神经科学。16840149。https://doi.org/10.3389/fnins.2022.840149（2022年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Zhuo, M. Cortical plasticity as synaptic mechanism for chronic pain. J. Neural Transm. (Vienna) 127, 567–573. https://doi.org/10.1007/s00702-019-02071-3 (2020).Article

Zhuo，M。皮质可塑性作为慢性疼痛的突触机制。J、 神经传输。（维也纳）127567-573。https://doi.org/10.1007/s00702-019-02071-3（2020年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Bao, C. et al. Difference in regional neural fluctuations and functional connectivity in Crohn’s disease: a resting-state functional MRI study. Brain Imaging Behav. 12, 1795–1803. https://doi.org/10.1007/s11682-018-9850-z (2018).Article

Bao，C.等。克罗恩病局部神经波动和功能连接性的差异：静息状态功能MRI研究。脑成像行为。121795年至1803年。https://doi.org/10.1007/s11682-018-9850-z（2018年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Kim, J. et al. Somatotopically specific primary somatosensory connectivity to salience and default mode networks encodes clinical pain. Pain 160, 1594–1605. https://doi.org/10.1097/j.pain.0000000000001541 (2019).Article

Kim，J.等人。躯体特异性初级躯体感觉连接到显着性和默认模式网络编码临床疼痛。疼痛1601594-1605。https://doi.org/10.1097/j.pain.0000000000001541（2019年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Gingold, S. I., Greenspan, J. D. & Apkarian, A. V. Anatomic evidence of nociceptive inputs to primary somatosensory cortex: relationship between spinothalamic terminals and thalamocortical cells in squirrel monkeys. J. Comp. Neurol. 308, 467–490. https://doi.org/10.1002/cne.903080312 (1991).Article .

Gingold，S.I.，Greenspan，J.D。和Apkarian，A.V。初级躯体感觉皮层伤害性输入的解剖学证据：松鼠猴脊髓丘脑终末和丘脑皮层细胞之间的关系。J、 公司。神经病学。308467-490。https://doi.org/10.1002/cne.903080312（1991年）。文章。

PubMed

PubMed

Google Scholar

谷歌学者

Su, C. et al. Abnormal resting-state local spontaneous functional activity in irritable bowel syndrome patients: a meta-analysis. J. Affect. Disord. 302, 177–184. https://doi.org/10.1016/j.jad.2022.01.075 (2022).Article

Su，C.等人。肠易激综合征患者静息状态局部自发功能活动异常：荟萃分析。J、 影响。混乱。302177-184。https://doi.org/10.1016/j.jad.2022.01.075（2022年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Bao, C. et al. Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease. Sci. Rep. 6, 36636. https://doi.org/10.1038/srep36636 (2016).Article

Bao，C.等人。克罗恩病患者对电针和艾灸治疗的不同大脑反应。科学。代表636636。https://doi.org/10.1038/srep36636（2016年）。文章

ADS

广告

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Hakamata, Y. et al. Basolateral amygdala connectivity with Subgenual Anterior Cingulate Cortex represents enhanced fear-related memory encoding in anxious humans. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 5, 301–310. https://doi.org/10.1016/j.bpsc.2019.11.008 (2020).Article

Hakamata，Y。等人。基底外侧杏仁核与膝下前扣带回皮层的连接代表了焦虑症患者恐惧相关记忆编码的增强。生物精神病学认知。神经科学。神经影像学5301-310。https://doi.org/10.1016/j.bpsc.2019.11.008（2020年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Thibodeau, M. A., Welch, P. G., Katz, J. & Asmundson, G. J. G. Pain-related anxiety influences pain perception differently in men and women: a quantitative sensory test across thermal pain modalities. Pain 154, 419–426. https://doi.org/10.1016/j.pain.2012.12.001 (2013).Article

Thibodeau，M.A.，Welch，P.G.，Katz，J。＆Asmundson，G.J.G。疼痛相关焦虑对男性和女性疼痛感知的影响不同：跨热痛模式的定量感觉测试。疼痛154419-426。https://doi.org/10.1016/j.pain.2012.12.001（2013年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Xiao, X. & Zhang, Y. Q. A new perspective on the anterior cingulate cortex and affective pain. Neurosci. Biobehav. Rev. 90, 200–211. https://doi.org/10.1016/j.neubiorev.2018.03.022 (2018).Article

Xiao，X。＆Zhang，Y.Q。关于前扣带回皮层和情感性疼痛的新观点。神经科学。生物行为。修订版90200–211。https://doi.org/10.1016/j.neubiorev.2018.03.022（2018年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Bush, G., Luu, P. & Posner, M. I. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn. Sci. 4, 215–222. https://doi.org/10.1016/s1364-6613(00)01483-2 (2000).Article

Bush，G.，Luu，P。＆Posner，M.I。前扣带回皮层的认知和情绪影响。趋势认知。科学。4215-222。https://doi.org/10.1016/s1364-6613（00）01483-2（2000）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Koyama, T., Kato, K., Tanaka, Y. Z. & Mikami, A. Anterior cingulate activity during pain-avoidance and reward tasks in monkeys. Neurosci. Res. 39, 421–430. https://doi.org/10.1016/s0168-0102(01)00197-3 (2001).Article

Koyama，T.，Kato，K.，Tanaka，Y.Z。和Mikami，A。猴子在避免疼痛和奖励任务期间的前扣带回活动。神经科学。第39421-430号决议。https://doi.org/10.1016/s0168-0102（01）00197-3（2001）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Koyama, T., Kato, K. & Mikami, A. During pain-avoidance neurons activated in the macaque anterior cingulate and caudate. Neurosci. Lett. 283, 17–20. https://doi.org/10.1016/s0304-3940(00)00894-6 (2000).Article

Koyama，T.，Kato，K。＆Mikami，A。在避免疼痛期间，猕猴前扣带回和尾状核中激活的神经元。神经科学。利特。283，17-20。https://doi.org/10.1016/s0304-3940（00）00894-6（2000）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Koyama, T., Tanaka, Y. Z. & Mikami, A. Nociceptive neurons in the macaque anterior cingulate activate during anticipation of pain. Neuroreport 9, 2663–2667. https://doi.org/10.1097/00001756-199808030-00044 (1998).Article

Koyama，T.，Tanaka，Y.Z。＆Mikami，A。猕猴前扣带回中的伤害感受神经元在预期疼痛期间激活。神经报告92663-2667。https://doi.org/10.1097/00001756-199808030-00044（1998年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Cao, B., Zhang, X., Yan, N., Chen, S. & Li, Y. Cholecystokinin enhances visceral pain-related affective memory via vagal afferent pathway in rats. Mol. Brain 5, 19. https://doi.org/10.1186/1756-6606-5-19 (2012).Article

Cao，B.，Zhang，X.，Yan，N.，Chen，S。＆Li，Y。胆囊收缩素通过迷走神经传入途径增强大鼠内脏疼痛相关的情感记忆。分子大脑5,19。https://doi.org/10.1186/1756-6606-5-19（2012年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Yan, N. et al. Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats. Neurobiol. Learn. Mem. 97, 156–164. https://doi.org/10.1016/j.nlm.2011.11.003 (2012).Article

Yan，N。等人。前扣带回皮层的谷氨酸能激活介导大鼠内脏疼痛记忆的情感成分。神经生物学。学习。成员。97156-164。https://doi.org/10.1016/j.nlm.2011.11.003（2012年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Hurt, R. W. & Ballantine, H. T. Jr. Stereotactic anterior cingulate lesions for persistent pain: a report on 68 cases. Clin. Neurosurg. 21, 334–351. https://doi.org/10.1093/neurosurgery/21.cn_suppl_1.334 (1974).Article

Hurt，R.W。＆Ballantine，H.T.Jr。立体定向前扣带回病变治疗持续性疼痛：68例报告。临床。神经外科21334-351。https://doi.org/10.1093/neurosurgery/21.cn_suppl_1.334（1974年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Ballantine, H. T. Jr., Cassidy, W. L., Flanagan, N. B. & Marino, R. Jr. Stereotaxic anterior cingulotomy for neuropsychiatric illness and intractable pain. J. Neurosurg. 26, 488–495. https://doi.org/10.3171/jns.1967.26.5.0488 (1967).Article

Ballantine，H。T。Jr.，Cassidy，W。L.，Flanagan，N。B。＆Marino，R。Jr。立体定向前扣带回切开术治疗神经精神疾病和顽固性疼痛。J、 神经外科26488-495。https://doi.org/10.3171/jns.1967.26.5.0488（1967年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Rainville, P., Duncan, G. H., Price, D. D., Carrier, B. & Bushnell, M. C. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 277, 968–971. https://doi.org/10.1126/science.277.5328.968 (1997).Article

Rainville，P.，Duncan，G.H.，Price，D.D.，Carrier，B。＆Bushnell，M.C。疼痛影响编码在人类前扣带回，但不编码体感皮层。科学277968-971。https://doi.org/10.1126/science.277.5328.968（1997年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Weaver, K. R., Sherwin, L. B., Walitt, B., Melkus, G. D. & Henderson, W. A. Neuroimaging the brain-gut axis in patients with irritable bowel syndrome. World J. Gastrointest. Pharmacol. Ther. 7, 320–333. https://doi.org/10.4292/wjgpt.v7.i2.320 (2016).Article

Weaver，K.R.，Sherwin，L.B.，Walitt，B.，Melkus，G.D。＆Henderson，W.A。对肠易激综合征患者的脑肠轴进行神经成像。世界J.Gastrointest。药理学。他们。。https://doi.org/10.4292/wjgpt.v7.i2.320（2016年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Kropf, E., Syan, S. K., Minuzzi, L. & Frey, B. N. From anatomy to function: the role of the somatosensory cortex in emotional regulation. Braz. J. Psychiatry 41, 261–269. https://doi.org/10.1590/1516-4446-2018-0183 (2019).Article

Kropf，E.，Syan，S.K.，Minuzzi，L。＆Frey，B.N。从解剖学到功能：体感皮层在情绪调节中的作用。钎焊。J、 精神病学41261-269。https://doi.org/10.1590/1516-4446-2018-0183（2019年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Schmaal, L. et al. Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA major depressive disorder Working Group. Mol. Psychiatry 22, 900–909. https://doi.org/10.1038/mp.2016.60 (2017).Article

Schmaal，L.等人。根据ENIGMA重度抑郁症工作组全球20个队列的脑部扫描，患有重度抑郁症的成年人和青少年的皮质异常。摩尔精神病学22900-909。https://doi.org/10.1038/mp.2016.60（2017年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Syan, S. K. et al. Brain structure and function in women with comorbid bipolar and premenstrual dysphoric disorder. Front. Psychiatry 8, 301. https://doi.org/10.3389/fpsyt.2017.00301 (2017).Article

Syan，S.K.等人。患有双相情感障碍和经前期烦躁不安障碍的女性的大脑结构和功能。正面。精神病学8301。https://doi.org/10.3389/fpsyt.2017.00301（2017年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Francis, C. Y., Morris, J. & Whorwell, P. J. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment. Pharmacol. Ther. 11, 395–402. https://doi.org/10.1046/j.1365-2036.1997.142318000.x (1997).Article

Francis，C.Y.，Morris，J。＆Whorwell，P.J。肠易激综合征严重程度评分系统：监测肠易激综合征及其进展的简单方法。食物。药理学。他们。11395-402。https://doi.org/10.1046/j.1365-2036.1997.142318000.x（1997年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Eypasch, E. et al. Gastrointestinal quality of Life Index: development, validation and application of a new instrument. Br. J. Surg. 82, 216–222. https://doi.org/10.1002/bjs.1800820229 (1995).Article

Eypasch，E。等。胃肠道生活质量指数：新仪器的开发，验证和应用。Br.J.外科杂志82216-222。https://doi.org/10.1002/bjs.1800820229（1995年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

McNeil, D. W. & Rainwater, A. J. 3rd. Development of the Fear of Pain Questionnaire–III. J. Behav. Med. 21, 389–410 (1998). https://doi.org/10.1023/a:1018782831217McCracken, L. M., Zayfert, C. & Gross, R. T. The Pain anxiety symptoms Scale: development and validation of a scale to measure fear of pain.

麦克尼尔，D.W。和雨水，A.J。第三。疼痛恐惧问卷的编制–III。J、 行为。医学21389-410（1998）。https://doi.org/10.1023/a:1018782831217McCracken，L.M.，Zayfert，C。＆Gross，R.T。疼痛焦虑症状量表：测量疼痛恐惧的量表的开发和验证。

Pain 50, 67–73. https://doi.org/10.1016/0304-3959(92)90113-p (1992).Article .

Pain 50, 67–73. https://doi.org/10.1016/0304-3959(92)90113-p (1992).Article .

PubMed

PubMed

Google Scholar

谷歌学者

Sullivan, M., Bishop, S. R. & Pivik, J. The Pain Catastrophizing Scale: Development and Validation. Psychol. Assess. 7, 524–532 (1996).Article

Sullivan，M.，Bishop，S.R。＆Pivik，J。疼痛灾难量表：开发和验证。心理学。评估。7524-532（1996）。文章

Google Scholar

谷歌学者

Ruscheweyh, R., Marziniak, M., Stumpenhorst, F., Reinholz, J. & Knecht, S. Pain sensitivity can be assessed by self-rating: development and validation of the pain sensitivity questionnaire. Pain 146, 65–74. https://doi.org/10.1016/j.pain.2009.06.020 (2009).Article

Ruscheweyh，R.，Marziniak，M.，Stumpenhorst，F.，Reinholz，J。＆Knecht，S。疼痛敏感性可以通过自评来评估：疼痛敏感性问卷的开发和验证。疼痛146，65-74。https://doi.org/10.1016/j.pain.2009.06.020（2009年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

McCracken, L. M. Attention to pain in persons with chronic pain: a behavioral approach. Behav. Ther. 28, 271–284. https://doi.org/10.1016/S0005-7894(97)80047-0 (1997).Article

McCracken，L.M。关注慢性疼痛患者的疼痛：行为方法。行为。他们。28271-284。https://doi.org/10.1016/S0005-7894（97）80047-0（1997）。文章

Google Scholar

谷歌学者

Julian, L. J. Measures of anxiety: state-trait anxiety inventory (STAI), Beck anxiety inventory (BAI), and hospital anxiety and depression scale-anxiety (HADS-A). Arthritis Care Res. (Hoboken) 63(Suppl 11), S467–472. https://doi.org/10.1002/acr.20561 (2011).Article

。关节炎护理研究（霍博肯）63（补充11），S467-472。https://doi.org/10.1002/acr.20561（2011年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Beck, A. T., Steer, R. A. & Carbin, M. G. Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin. Psychol. Rev. 8, 77–100 (1988).Article

Beck，A.T.，Steer，R.A。＆Carbin，M.G。贝克抑郁量表的心理测量特性：二十五年的评估。临床。心理学。第8版，77-100（1988）。文章

Google Scholar

谷歌学者

Power, J. D. et al. Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage 84, 320–341. https://doi.org/10.1016/j.neuroimage.2013.08.048 (2014).Article

Power，J.D.等人，《静息态功能磁共振成像中检测、表征和去除运动伪影的方法》。神经影像84320–341。https://doi.org/10.1016/j.neuroimage.2013.08.048（2014年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Chao-Gan, Y. & Yu-Feng, Z. D. P. A. R. S. F. A MATLAB Toolbox for Pipeline Data Analysis of resting-state fMRI. Front. Syst. Neurosci. 4, 13. https://doi.org/10.3389/fnsys.2010.00013 (2010).Article

Chao Gan，Y。＆Yu Feng，Z.D.P.A.R.S.F。用于静息状态fMRI管道数据分析的MATLAB工具箱。Front。系统。神经科学。4，13。https://doi.org/10.3389/fnsys.2010.00013（2010年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Zang, Y., Jiang, T., Lu, Y., He, Y. & Tian, L. Regional homogeneity approach to fMRI data analysis. Neuroimage 22, 394–400. https://doi.org/10.1016/j.neuroimage.2003.12.030 (2004).Article

Zang，Y.，Jiang，T.，Lu，Y.，He，Y。＆Tian，L。功能磁共振成像数据分析的区域同质性方法。神经影像22394-400。https://doi.org/10.1016/j.neuroimage.2003.12.030（2004年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Zang, Y. F. et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev. 29, 83–91. https://doi.org/10.1016/j.braindev.2006.07.002 (2007).Article

Zang，Y.F.等人，《静息状态功能MRI显示ADHD儿童基线大脑活动的改变》。大脑发展29，83-91。https://doi.org/10.1016/j.braindev.2006.07.002（2007年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Zuo, X. N. et al. Network centrality in the human functional connectome. Cereb. Cortex 22, 1862–1875. https://doi.org/10.1093/cercor/bhr269 (2012).Article

Zuo，X.N.等人。人类功能连接组中的网络中心性。塞雷布。皮质221862-1875。https://doi.org/10.1093/cercor/bhr269（2012年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Banissy, M. J. et al. Suppressing sensorimotor activity modulates the discrimination of auditory emotions but not speaker identity. J. Neurosci. 30, 13552–13557. https://doi.org/10.1523/jneurosci.0786-10.2010 (2010).Article

Banissy，M.J。等人。抑制感觉运动活动调节听觉情绪的辨别，但不调节说话人身份。J、 神经科学。3013552-13557。https://doi.org/10.1523/jneurosci.0786-10.2010（2010年）。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Krishnan, A., Williams, L. J., McIntosh, A. R. & Abdi, H. Partial least squares (PLS) methods for neuroimaging: a tutorial and review. Neuroimage 56, 455–475. https://doi.org/10.1016/j.neuroimage.2010.07.034 (2011).Article

Krishnan，A.，Williams，L.J.，McIntosh，A.R。＆Abdi，H。神经影像学的偏最小二乘（PLS）方法：教程和评论。神经影像56455-475。https://doi.org/10.1016/j.neuroimage.2010.07.034（2011年）。文章

PubMed

PubMed

Google Scholar

谷歌学者

Download referencesAcknowledgementsThe authors thank Jishu Xiao for excellent support for recruitment of subjects.Author informationAuthors and AffiliationsDepartment of Radiology Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No.

下载参考文献致谢作者感谢肖季舒对招募受试者的出色支持。作者信息作者和附属机构重庆医科大学儿童医院放射科，国家儿童健康与疾病临床研究中心，教育部儿童发育与疾病重点实验室，第号。

136, Zhongshan Second Road, Yuzhong District, Chongqing, 400000, ChinaLing Yang & Jinhua CaiRadiology Department, Chongqing General Hospital, Chongqing University, No.118, Xingguang Avenue, Liangjiang New Area, Chongqing, 401147, ChinaLing Yang, Lingqin Zhang & Kang LiChongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, ChinaLing Yang & Jinhua CaiSchool of Life Science and Technology, Center for Brain Imaging, Xidian University, Xi’an, ChinaJixin LiuGastroenterology Department, Chong Qing General Hospital, Chongqing University, Chongqing, ChinaYan LiuAuthorsLing YangView author publicationsYou can also search for this author in.

重庆市渝中区中山二路136号，400000，重庆大学重庆总医院放射科，重庆市两江新区星光大道118号，重庆市401147，重庆市杨凌勤，张凌勤，康李崇庆儿童代谢与炎症性疾病重点实验室，重庆市，西安西安西安西安西安西安西安西安西安西安西安西安西安西安西安重庆总医院消化内科，重庆重庆大学重庆总医院，中国Yan Liu作者Ling YangView作者出版物您也可以在中搜索这位作者。

PubMed Google ScholarLingqin ZhangView author publicationsYou can also search for this author in

PubMed Google ScholarLingqin ZhangView作者出版物您也可以在

PubMed Google ScholarYan LiuView author publicationsYou can also search for this author in

PubMed Google ScholarYan LiuView作者出版物您也可以在

PubMed Google ScholarJixin LiuView author publicationsYou can also search for this author in

PubMed Google ScholarJixin LiuView作者出版物您也可以在

PubMed Google ScholarKang LiView author publicationsYou can also search for this author in

PubMed Google ScholarKang LiView作者出版物您也可以在

PubMed Google ScholarJinhua CaiView author publicationsYou can also search for this author in

PubMed谷歌学者金华CaiView作者出版物您也可以在

PubMed Google ScholarContributionsL.Y. contributed to study conception, data acquisition, image inspection, statistical analysis and manuscript drafting. L.Z. contributed to study design, data acquisition and manuscript drafting. Y.L. contributed to disease diagnosis. J.L. contributed to study conception and design, statistical analysis, manuscript drafting, and critical revision and final approval.

PubMed谷歌学术贡献l。Y、 为研究概念，数据采集，图像检查，统计分析和手稿起草做出了贡献。五十、 。Y、 L.有助于疾病诊断。J、 L.为研究概念和设计，统计分析，手稿起草以及关键修订和最终批准做出了贡献。

K.L. and J.C. were responsible for study conception and design, image inspection and diagnosis, manuscript drafting, critical revision and final approval. All authors reviewed the manuscript.Corresponding authorsCorrespondence to.

K、 L.和J.C.负责研究概念和设计，图像检查和诊断，手稿起草，关键修订和最终批准。。通讯作者通讯。

Kang Li or Jinhua Cai.Ethics declarations

康丽或金华菜。道德宣言

Competing interests

相互竞争的利益

The authors declare no competing interests.

作者声明没有利益冲突。

Additional informationPublisher’s noteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Rights and permissions

Additional informationPublisher的noteSpringer Nature在已发布地图和机构隶属关系中的管辖权主张方面保持中立。权限和权限

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material.

开放获取本文是根据知识共享署名非商业性NoDerivatives 4.0国际许可证授权的，该许可证允许以任何媒介或格式进行任何非商业性使用，共享，分发和复制，只要您对原始作者和来源给予适当的信任，提供知识共享许可证的链接，并指出您是否修改了许可材料。

You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

根据本许可证，您无权共享源自本文或其部分的改编材料。本文中的图像或其他第三方材料包含在文章的知识共享许可证中，除非该材料的信用额度中另有说明。如果材料未包含在文章的知识共享许可中，并且您的预期用途不受法律法规的许可或超出许可用途，则您需要直接获得版权所有者的许可。

To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/..

要查看此许可证的副本，请访问http://creativecommons.org/licenses/by-nc-nd/4.0/..

Reprints and permissionsAbout this articleCite this articleYang, L., Zhang, L., Liu, Y. et al. The different impacts of pain-related negative emotion and trait negative emotion on brain function in patients with inflammatory bowel disease.

转载和许可本文引用本文Yang，L.，Zhang，L.，Liu，Y。等人。疼痛相关负性情绪和特质负性情绪对炎症性肠病患者脑功能的不同影响。

Sci Rep 14, 23897 (2024). https://doi.org/10.1038/s41598-024-75237-zDownload citationReceived: 25 March 2024Accepted: 03 October 2024Published: 12 October 2024DOI: https://doi.org/10.1038/s41598-024-75237-zShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

《科学报告》1423897（2024）。https://doi.org/10.1038/s41598-024-75237-zDownload引文接收日期：2024年3月25日接受日期：2024年10月3日发布日期：2024年10月12日OI：https://doi.org/10.1038/s41598-024-75237-zShare本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

Provided by the Springer Nature SharedIt content-sharing initiative

由Springer Nature SharedIt内容共享计划提供

KeywordsInflammatory bowel diseasesFunctional magnetic resonance imagingNegative emotionsAnterior cingulate cortexAmplitudes of low-frequency fluctuationDegree centrality

关键词炎症性肠病功能性磁共振成像阴性情绪扣带回皮层低频波动幅度程度中心性