PALO ALTO, Calif.--(BUSINESS WIRE)--Arc Institute, the research organization pioneering a new model for pursuing scientific breakthroughs, announced today the addition of seven leading scientists to its Investigator Program and Ignite Award cohorts.

加利福尼亚州帕洛阿尔托市——（商业新闻短讯）——Arc研究所是一家开创追求科学突破新模式的研究机构，今天宣布在其研究项目和Ignite奖团队中增加七名顶尖科学家。

The new Investigators join Arc’s growing community of scientists pushing the boundaries of research into complex human disease, from cancer to neurodegeneration to immune dysfunction. By converging expertise from disciplines including systems biology, chemical biology, genetics, disease physiology, and neurobiology, this cohort will play a key role in advancing biomedical progress through cutting-edge, collaborative scientific exploration.

新的研究人员加入了Arc不断壮大的科学家群体，将研究的范围扩展到复杂的人类疾病，从癌症到神经退行性疾病再到免疫功能障碍。通过汇集系统生物学，化学生物学，遗传学，疾病生理学和神经生物学等学科的专业知识，该队列将通过尖端的合作科学探索在推进生物医学进步方面发挥关键作用。

Their contributions will further power Arc’s ongoing work at the interface of biomedicine and machine learning..

他们的贡献将进一步推动power Arc在生物医学和机器学习界面上正在进行的工作。。

Arc's Investigator Programs support ambitious and collaborative research across disciplines and provide scientists with multi-year, unrestricted funding. This allows Arc researchers to pursue curiosity-driven research into their boldest ideas at a level often not possible in traditional academic settings.

Arc的研究者项目支持跨学科的雄心勃勃的合作研究，并为科学家提供多年无限制的资金。这使得Arc研究人员能够在传统学术环境中不可能达到的水平上，对他们最大胆的想法进行好奇心驱动的研究。

All Investigators and Ignite Award recipients can hold faculty positions at Arc’s partner universities, which are nexuses of talent and discovery: Stanford University, the University of California, Berkeley, and the University of California, San Francisco. This year, one of Arc’s new Core Investigators, Dr.

所有研究人员和Ignite奖获得者都可以在Arc的合作大学担任教员职位，这些大学是人才和发现的纽带：斯坦福大学、加利福尼亚大学伯克利分校和加利福尼亚大学旧金山分校。今年，Arc的新核心研究员之一Dr。

Isha Jain, holds an Investigator position with the Gladstone Institutes in addition to her UCSF faculty position..

伊莎·贾恩（IshaJain）除了在加州大学旧金山分校（UCSF）担任教师职位外，还在格莱斯顿研究所（Gladstone Institutes）担任研究员职位。。

“Scientific breakthroughs in biology’s toughest open problems are increasingly collaborative and interdisciplinary,” said Dr. Silvana Konermann, Arc Co-Founder, Executive Director, and Core Investigator. “By bringing together scientists across key disciplines at Arc under one roof, and giving researchers the resources to do their best work, we aim to catalyze fundamental progress in understanding and eventually treating complex diseases.”.

Arc联合创始人、执行董事和核心研究员席尔瓦娜·科内曼博士说：“生物学最棘手的开放问题的科学突破越来越具有协作性和跨学科性。”。“通过将Arc各关键学科的科学家聚集在一起，并为研究人员提供尽可能好的工作所需的资源，我们的目标是促进在理解和最终治疗复杂疾病方面取得根本性进展。”。

“Our newly hired investigators are field-leading researchers who are tackling bold, frontier biology questions. They deploy powerful biotechnologies to illuminate the genetic and environmental contributions that underlie complex physiological interactions,” added Dr. Patrick Hsu, Arc Co-Founder and Core Investigator..

Arc联合创始人兼核心研究员Patrick Hsu博士补充道：“我们新聘用的研究人员是领域领先的研究人员，他们正在解决大胆的前沿生物学问题。他们部署了强大的生物技术来阐明复杂生理相互作用背后的遗传和环境贡献。”。。

“We are proud of Isha’s contributions to biomedical science and thrilled to partner with Arc in supporting her groundbreaking research,” said Dr. Deepak Srivastava, President of Gladstone Institutes.

格莱斯顿研究院院长迪帕克·斯里瓦斯塔瓦博士说：“我们为伊莎对生物医学科学的贡献感到骄傲，很高兴与Arc合作支持她的开创性研究。”。

Core Investigators are at the forefront of research at Arc

核心研究人员处于Arc研究的前沿

Arc’s Core Investigators are the bedrock of research at Arc’s headquarters. They are appointed for renewable eight-year terms and receive unrestricted funding to pursue creative, bold research with complete autonomy. Core Investigators maintain their labs at Arc and can also hold faculty positions at one of Arc’s partner universities, remaining connected to major hubs of scientific advancement..

Arc的核心调查员是Arc总部研究的基石。他们被任命为可续任的八年任期，并获得不受限制的资金，以完全自主地进行创造性、大胆的研究。核心研究人员在Arc维持实验室，也可以在Arc的合作大学之一担任教员职位，保持与主要科学进步中心的联系。。

This year, Arc has appointed three new Core Investigators, two of whom are joining Arc via coordinated searches with the Departments of Pathology and Genetics at Stanford University. With these appointments, Arc now has seven Core Investigators and aims to add up to eight more over time.

今年，Arc任命了三名新的核心研究人员，其中两名通过与斯坦福大学病理学和遗传学系的协调搜索加入了Arc。有了这些任命，Arc现在拥有7名核心调查员，并计划随着时间的推移再增加8名。

Felix Horns, Ph.D.

Felix Horns博士。

Partner University affiliation: Assistant Professor of Genetics at Stanford University

Dr. Felix Horns creates and uses new technologies to understand and manipulate cells. His lab aims to discover the fundamental principles governing how cells and tissues operate and to harness these insights to improve human health. His work unites molecular engineering, synthetic biology, and genomics to answer questions and solve problems in immunology, neuroscience, cancer, and aging.

费利克斯·霍恩斯博士创造并使用新技术来理解和操纵细胞。他的实验室旨在发现细胞和组织如何运作的基本原理，并利用这些见解来改善人类健康。他的工作结合了分子工程、合成生物学和基因组学，以回答免疫学、神经科学、癌症和衰老方面的问题和解决问题。

He has recently been developing novel RNA export technology to understand how cells change over time in living animals and how to deliver therapeutics precisely to human cells, addressing some of the most significant challenges in biomedicine..

他最近一直在开发新的RNA输出技术，以了解活体动物中细胞如何随时间变化，以及如何将治疗方法精确地传递给人类细胞，从而解决生物医学中一些最重大的挑战。。

Felix received his Ph.D. in Biophysics from Stanford and performed postdoctoral studies at the California Institute of Technology. His research has been recognized by the Burroughs Wellcome Fund Career Award at the Scientific Interface, the Chen Foundation fellowship, and the Helen Hay Whitney Foundation fellowship..

费利克斯在斯坦福大学获得生物物理学博士学位，并在加州理工学院进行博士后研究。他的研究获得了科学界面巴勒斯惠康基金职业奖、陈基金会奖学金和海伦·海伊·惠特尼基金会奖学金的认可。。

Isha Jain, Ph.D.

我是Jain博士。

Partner affiliation: Investigator at Gladstone Institutes and Assistant Professor of Biochemistry and Biophysics at UCSF

合作伙伴：格莱斯顿研究所研究员、加州大学旧金山分校生物化学和生物物理学助理教授

Dr. Isha Jain investigates how the body responds to changes in “what we breathe” and “what we eat.” More specifically, she and her lab are studying how variations in oxygen levels in the atmosphere and vitamin levels in the diet can affect disease progression. They are using this information to “turn the oxygen and vitamin dials” to treat a wide range of metabolic disorders from rare genetic diseases to age-associated degeneration..

Isha Jain博士研究了身体对“我们呼吸的东西”和“我们吃的东西”的变化是如何反应的。更具体地说，她和她的实验室正在研究大气中氧气水平和饮食中维生素水平的变化如何影响疾病进展。他们正在利用这些信息来“转换氧气和维生素的转盘”，以治疗从罕见的遗传疾病到与年龄相关的退化等多种代谢紊乱。。

Isha earned her Ph.D. in Computer Science and Systems Biology from the Harvard-MIT Program in Health Sciences and Technology. Prior to Gladstone, Isha was a UCSF Sandler Fellow. She has received several awards throughout her career, including the NIH Early Independence Award, Glenn Award for Aging Research, and the Harold M.

Isha从哈佛-麻省理工学院健康科学与技术项目获得了计算机科学和系统生物学博士学位。在格莱斯顿之前，伊莎是加州大学旧金山分校桑德勒分校的研究员。在她的职业生涯中，她获得了多项奖项，包括美国国立卫生研究院早期独立奖、格伦衰老研究奖和哈罗德·M。

Weintraub Award..

温特劳布奖。。

Christoph Thaiss, Ph.D.

Christoph Thaiss博士。

Proposed Partner University affiliation: Christoph is being recommended for appointment as Assistant Professor of Pathology at Stanford University, anticipated January 2025.

拟议的合作大学附属机构：Christoph被推荐担任斯坦福大学病理学助理教授，预计2025年1月。

Dr. Christoph Thaiss investigates how interactions between environment, body, and brain shape how neurodegeneration, inflammatory disease, cancer, and metabolic disorders arise in the human body. His research explores how environmental factors—like diet, chemicals, temperature, social interactions, the daily cycle of light and dark, and physical activity—shape body-brain communication and health at the molecular level.

Christoph Thaiss博士研究了环境、身体和大脑之间的相互作用如何影响人体神经退行性疾病、炎症性疾病、癌症和代谢紊乱的产生。他的研究探讨了诸如饮食、化学物质、温度、社交互动、每日明暗循环以及身体活动等环境因素如何在分子水平上影响身心沟通和健康。

He’s particularly interested in the aging brain, sensory neuron biology, and gut-brain communication..

他对衰老的大脑、感觉神经元生物学和肠脑沟通特别感兴趣。。

Christoph received his Ph.D. from the Weizmann Institute of Science. His research has been recognized by the Pew Biomedical Scholars Award, NIH Director's New Innovator Award, NIDDK Catalyst Award, McKnight Brain Research Foundation Innovator Award, and the Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease Award..

克里斯托夫获得了魏茨曼科学研究所的博士学位。他的研究获得了皮尤生物医学学者奖、NIH主任新创新者奖、NIDDK催化剂奖、McKnight大脑研究基金会创新者奖和Burroughs Wellcome基金会传染病发病机制研究者奖的认可。。

Science Fellows Program bridges a critical gap for early-career researchers

科学研究员计划弥补了早期职业研究人员的关键差距

Arc’s Science Fellows are outstanding early-career scientists who transition into principal investigator roles immediately after doctoral training. These exceptional scientists lead independent labs at Arc that pursue innovative high-risk, high-reward research. The Science Fellows Program was designed to accelerate careers and address the fact that many scientists wait until their early 40s for their first independent funding.

。这些杰出的科学家领导着Arc的独立实验室，从事创新的高风险、高回报研究。科学研究员计划旨在加速职业发展，并解决许多科学家等到40出头才获得第一笔独立资助的事实。

Fellows receive full funding for a small research group and are appointed for a five-year term..

研究员为一个小型研究小组获得全额资金，任期五年。。

Uche Medoh, Ph.D.

Uche Medoh博士。

Dr. Uche Medoh delves into the molecular basis of metabolism and aging to develop treatments inspired by metabolites, which are small molecules produced during metabolism that play crucial roles in cellular processes. His work leverages chemistry, biochemistry, multi-omics, and cellular and organismal metabolism to understand how anti-aging metabolites maintain cellular and whole-body health.

Uche Medoh博士深入研究代谢和衰老的分子基础，以开发受代谢物启发的治疗方法，代谢物是代谢过程中产生的小分子，在细胞过程中起着至关重要的作用。。

The Medoh lab discovers and characterizes a vast landscape of unknown metaboproteins—proteins that interact with or are modified by metabolites—to uncover new therapeutics for aging and age-related diseases..

Medoh实验室发现并表征了大量未知代谢物蛋白质，这些蛋白质与代谢物相互作用或被代谢物修饰，以发现衰老和年龄相关疾病的新疗法。。

Uche earned his M.Sc. in Medicine and his Ph.D. in Biochemistry from the Stanford University School of Medicine. While there, he was recognized as a Stanford ChEM-H O'Leary-Thiry Graduate Fellow and as an Adelson Scholar. Uche earned his bachelor's degree in Chemistry and in Molecular, Cellular, & Developmental Biology from Yale University..

Uche在斯坦福大学医学院获得医学硕士学位和生物化学博士学位。在那里，他被公认为斯坦福大学化学H O'Leary-Thiry研究生研究员和阿德尔森学者。Uche获得了耶鲁大学化学和分子、细胞与发育生物学学士学位。。

Innovation Investigator Program and Ignite Award fund pioneering research at partner universities

创新研究者计划和Ignite奖励基金合作大学的开创性研究

Arc’s Innovation Investigators and Ignite Award recipients are the intellectual bridges between Arc and its partner universities. Innovation Investigators conduct breakthrough research as faculty at partner universities and receive funding from Arc to support work that may not receive funding through traditional grant processes.

Arc的创新调查员和Ignite奖获得者是Arc与其合作大学之间的知识桥梁。创新研究人员作为合作大学的教员进行突破性研究，并从Arc获得资金，以支持可能无法通过传统拨款流程获得资金的工作。

Ignite Award recipients are scientists selected for their visionary research exploration and distinct perspectives, opening up additional channels for discovery and impact. This year, Arc is announcing two Innovation Investigators and one Ignite Awardee..

Ignite奖获得者是因其富有远见的研究探索和独特的观点而被选中的科学家，为发现和影响开辟了额外的渠道。。。

Maayan Levy, Ph.D.

。

Investigator Program: Innovation Investigator in Residence

调查员计划：常驻创新调查员

Proposed Partner University affiliation: Maayan is being recommended for appointment as Assistant Professor of Pathology at Stanford University, anticipated January 2025.

拟议的合作伙伴大学关系：马扬被推荐担任斯坦福大学病理学助理教授，预计2025年1月。

Dr. Maayan Levy’s scientific mission is to understand, develop, and apply the concept of metabotherapy—the use of metabolites as vehicles and targets to prevent and treat disease. Her lab's primary focus is on inflammatory diseases, neurological diseases, and cancer. Maayan is particularly interested in the metabolite landscape of the gastrointestinal tract, which serves as a major metabolite source for many other tissues and as an ideal entry point for the introduction of new metabolites into the organism.

Maayan Levy博士的科学使命是理解、发展和应用代谢疗法的概念，即使用代谢物作为预防和治疗疾病的载体和靶标。她的实验室主要研究炎症性疾病、神经系统疾病和癌症。Maayan对胃肠道的代谢物景观特别感兴趣，胃肠道是许多其他组织的主要代谢物来源，也是将新代谢物引入生物体的理想切入点。

She is exploring the repertoire of these intestinal metabolites, their impact on whole-body physiology, and the possibility of targeting them for therapeutic interventions..

她正在探索这些肠道代谢物的组成，它们对全身生理的影响，以及将其用于治疗干预的可能性。。

Maayan received her Ph.D. in Immunology from the Weizmann Institute of Science. Among the recognitions her work has received are the NIH Director’s New Innovator Award, Pew Biomedical Scholar Award, Searle Scholar Award, and Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease Award..

Maayan在魏茨曼科学研究所获得免疫学博士学位。她的工作获得的认可包括NIH主任新创新者奖、皮尤生物医学学者奖、塞尔学者奖和Burroughs Wellcome基金传染病发病机制研究者奖。。

Theo Roth, M.D., Ph.D.

西奥·罗斯，医学博士，博士。

Investigator Program: Innovation Investigator

调查员计划：创新调查员

Proposed Partner University affiliation: Theo is being recommended for appointment as Assistant Professor of Pathology at Stanford University, anticipated January 2025.

拟议的合作伙伴大学关系：西奥被推荐担任斯坦福大学病理学助理教授，预计2025年1月。

Dr. Theo Roth develops and applies genetic manipulation technologies for human cells and complex tissues. Working with a diverse team spanning bioengineering, genetics, immunology, oncology, and pathology, he and his lab created CRISPR-All, a unified genetic perturbation tool. This innovation enables examination of various genetic alterations across scales in human cells.

西奥·罗斯博士为人类细胞和复杂组织开发并应用基因操作技术。他和他的实验室与跨越生物工程，遗传学，免疫学，肿瘤学和病理学的多元化团队合作，创建了CRISPR All，这是一种统一的遗传扰动工具。这项创新使得能够检查人类细胞中各种规模的遗传改变。

Applications of CRISPR-All have revealed surprising capacities to engineer cells beyond their naturally evolved states. He aims to understand the potential of building new genes to optimize the genome of specific cells for specific environments, enabling novel therapeutic functions previously thought inaccessible..

CRISPR的应用都显示出令人惊讶的能力，可以将细胞设计成超越其自然进化状态的细胞。他旨在了解构建新基因的潜力，以针对特定环境优化特定细胞的基因组，从而实现以前认为无法实现的新型治疗功能。。

Theo earned his MD and Ph.D. in the Medical Scientist Training Program at UCSF, and completed his residency in Pathology at Stanford. He co-founded and was the first Chief Scientific Officer of ArsenalBio. He has received multiple awards throughout his career, including the Burroughs Wellcome Fund Career Award for Medical Scientists, an NIH Mentored Clinical Scientist Development Award, and the Arsenal Biosciences Mission Award, as well as mentorship awards from nominations by his trainees..

西奥在加州大学旧金山分校的医学科学家培训项目中获得了医学博士和博士学位，并在斯坦福大学完成了病理学实习。他是ArsenalBio的联合创始人，也是该公司的第一任首席科学官。在整个职业生涯中，他获得了多项奖项，包括Burroughs Wellcome基金医学科学家职业奖、NIH指导临床科学家发展奖和阿森纳生物科学使命奖，以及受训人员提名的导师奖。。

Will Allen, Ph.D.

威尔·艾伦博士。

Investigator Program: Ignite Award

调查员计划：点火奖

Partner University affiliation: Assistant Professor of Developmental Biology, Stanford University School of Medicine

合作大学附属机构：斯坦福大学医学院发育生物学助理教授

Dr. Will Allen unravels the mysteries of how living systems, from tiny cells to entire organisms, maintain their balance and function over time. His research explores the intricate homeostatic balancing acts that maintain cellular and tissue function throughout an animal's life. Will and his lab aim to elucidate how these mechanisms work in various types of cells and tissues, and what goes wrong in age-related diseases like chronic inflammation and brain degeneration.

威尔·艾伦博士揭开了从微小细胞到整个生物体的生命系统如何随着时间的推移保持平衡和功能的奥秘。他的研究探索了在动物一生中维持细胞和组织功能的复杂稳态平衡行为。威尔和他的实验室旨在阐明这些机制如何在各种类型的细胞和组织中发挥作用，以及在与年龄相关的疾病（如慢性炎症和脑变性）中出现了什么问题。

Their ultimate goal is to engineer cells in living animals to restore homeostasis, replace lost functionality, and even rejuvenate aged or damaged tissues..

。。

Will received his Ph.D. in Neuroscience from Stanford, and was subsequently appointed an independent Junior Fellow in the Society of Fellows at Harvard University. He is the recipient of multiple fellowships and awards, including the Churchill Scholarship, Hertz Foundation Fellowship, Nemko Prize in Cellular or Molecular Neuroscience, Weintraub Graduate Student Award, Science & SciLifeLab Prize for Young Scientists, and the Burroughs-Wellcome Fund Career Award at the Scientific Interface..

威尔在斯坦福大学获得神经科学博士学位，随后被任命为哈佛大学研究员协会的独立初级研究员。他获得了多项奖学金和奖项，包括丘吉尔奖学金、赫兹基金会奖学金、Nemko细胞或分子神经科学奖、Weintraub研究生奖、青年科学家科学与科学生命实验室奖以及Burroughs Wellcome Fund Scientific Interface职业奖。。

2025 searches now open

2025搜索现已打开

Arc has now opened its 2025 round of faculty, investigator, and awardee searches.

Arc现已开始2025年的教员、研究员和获奖者搜索。

The Institute looks to welcome additional Core Investigators, including two through coordinated searches with partner universities.

该研究所希望欢迎更多的核心调查人员，包括两名通过与合作大学协调搜索的核心调查人员。

With UCSF’s Department of Neurology, Arc is seeking a scientist who aspires to groundbreaking research in neurobiology or neuroimmunology.

加州大学旧金山分校神经病学系正在寻找一位渴望在神经生物学或神经免疫学领域进行开创性研究的科学家。

With Stanford’s Department of Bioengineering, Arc will soon be launching a search for a senior faculty member leading the field in computational biology or machine learning, neurobiology, or immunology.

随着斯坦福大学生物工程系（Stanford's Department of Bioengineering），Arc将很快开始寻找一名在计算生物学或机器学习、神经生物学或免疫学领域领先的高级教员。

Arc also plans to welcome an early-career scientist (a Ph.D. or MD who graduated from 2023 to 2025) ready to launch their own lab at Arc in neurobiology or immunology as a Science Fellow.

Arc还计划欢迎一位职业生涯早期的科学家（2023年至2025年毕业的博士或医学博士）准备在Arc神经生物学或免疫学实验室作为科学研究员启动自己的实验室。

For current faculty at Stanford, UCSF, or UC Berkeley with a focus on neurobiology or immunology, Arc is accepting applications for its Innovation Investigator program, which provides funding over five years for faculty to pursue bold research from their home universities.

对于斯坦福大学、加州大学旧金山分校或加州大学伯克利分校目前专注于神经生物学或免疫学的教师来说，Arc正在接受其创新研究者计划的申请，该计划为教师提供五年以上的资金，以从其母校进行大胆的研究。

Arc also continues to accept applications from faculty at affiliated universities Stanford, UCSF, and UC Berkeley to its Core Investigator program.

Arc还继续接受斯坦福大学、加州大学旧金山分校和加州大学伯克利分校附属大学教师向其核心研究员项目提出的申请。

About Arc Institute

关于Arc研究所

Arc Institute is an independent nonprofit research organization located in Palo Alto, California, that aims to accelerate scientific progress and understand the root causes of complex diseases. Arc’s model gives scientists complete freedom to pursue curiosity-driven research agendas and fosters deep interdisciplinary collaboration.

Arc研究所是一个独立的非营利研究组织，位于加利福尼亚州帕洛阿尔托，旨在加速科学进步，了解复杂疾病的根本原因。Arc的模型为科学家提供了追求好奇心驱动的研究议程的完全自由，并促进了深入的跨学科合作。

The Institute operates in close partnership with Stanford University, the University of California, Berkeley, and the University of California, San Francisco. Arc was founded in 2021 by Silvana Konermann, Patrick Hsu, and Patrick Collison..

该研究所与斯坦福大学、加利福尼亚大学伯克利分校和加利福尼亚大学旧金山分校密切合作。Arc于2021年由席尔瓦娜·科内曼（SilvanaKonermann）、帕特里克·徐（PatrickHsu）和帕特里克·科利森（PatrickCollison）创立。。