WEDNESDAY, Oct. 16, 2024 -- The International Ovarian Tumour Analysis consortium (IOTA) Assessment of Different Neoplasias in the Adnexa (ADNEX) at 10 percent is more sensitive, but less specific, for diagnosing ovarian cancer compared with Risk of Malignancy 1 (RMI1) at 250, according to a study published in the October issue of The Lancet Oncology.Sudha Sundar, from the Institute of Cancer and Genomic Sciences at the University of Birmingham in the United Kingdom, and colleagues conducted a multicenter, prospective diagnostic accuracy study involving newly presenting female patients aged 16 to 90 years with nonspecific symptoms and elevated CA125, abnormal ultrasound results, or both.

2024年10月16日，星期三——根据发表在《柳叶刀肿瘤学》10月刊上的一项研究，国际卵巢肿瘤分析协会（IOTA）对附件（ADNEX）中10%的不同肿瘤形成的评估，与250%的恶性肿瘤风险1（RMI1）相比，对诊断卵巢癌更敏感，但特异性较低。英国伯明翰大学癌症与基因组科学研究所的Sudha Sundar及其同事进行了一项多中心前瞻性诊断准确性研究，涉及新出现的16至90岁女性患者，其非特异性症状和CA125升高，超声检查结果异常或两者兼有。

The analysis included only postmenopausal participants. Participants completed a symptom questionnaire, provided a blood sample, and underwent transabdominal and transvaginal ultrasounds. Data were included from 1,076 participants to examine diagnostic accuracy at predicting primary invasive ovarian cancer versus benign or normal histology.The researchers found that compared with RMI1 at a threshold of 250 (sensitivity, 82.9 percent; specificity, 87.4 percent), IOTA ADNEX at 10 percent was more sensitive but less specific (difference of −13.9 and 28.5 percent, respectively).

该分析仅包括绝经后参与者。参与者完成了症状问卷，提供了血液样本，并接受了经腹和经阴道超声检查。纳入1076名参与者的数据，以检查预测原发性浸润性卵巢癌与良性或正常组织学的诊断准确性。研究人员发现，与阈值为250（敏感性为82.9%；特异性为87.4%）的RMI1相比，10%的物联网附件更敏感，但特异性较低（分别为-13.9%和28.5%）。

Similar sensitivity and lower specificity were seen with the Risk of Malignancy Algorithm at 29.9 (difference of −3.6 and 5.2 percent, respectively). Similar sensitivity and lower specificity were seen for RMI1 at 200 (difference of −2.1 and 3.0 percent, respectively) and for the IOTA Simple Rules Risk model at 10 percent (difference of −4.3 and 16.2 percent, respectively).

恶性肿瘤算法的风险为29.9（分别为-3.6%和5.2%），具有相似的敏感性和较低的特异性。RMI1在200（分别为-2.1%和3.0%）和IOTA简单规则风险模型在10%（分别为-4.3%和16.2%）时具有相似的敏感性和较低的特异性。

IOTA Simple Rules had similar sensitivity and specificity (difference of −1.6 and −2.2 percent, respectively). CA125 at 35 IU/mL had similar sens.

IOTA简单规则具有相似的敏感性和特异性（分别为-1.6%和-2.2%）。35 IU/mL的CA125具有相似的敏感性。