AbstractObjectiveTo assess clinical factors leading to recurrent retinal detachment (RD) and characteristics of recurrence in patients with Stickler Syndrome.MethodsRetrospective case series study of patients with clinical diagnosis of Stickler Syndrome who underwent rhegmatogenous RD repair. Recurrent RD after initial surgery was categorized as “early” if the recurrence was within 1 year or “late” if greater than 1 year.ResultsThirty eyes from 22 patients underwent rhegmatogenous RD repair.

目的探讨Stickler综合征患者复发性视网膜脱离（RD）的临床因素及复发特点。。如果复发在1年内，则初次手术后复发的RD被分类为“早期”，如果复发大于1年，则被分类为“晚期”。结果22例30只眼行孔源性RD修复术。

For initial repair, 13 eyes underwent pars plana vitrectomy combined with scleral buckling (PPV/SB), 16 eyes underwent primary scleral buckling (SB), and 1 eye underwent pneumatic retinopexy (PnR). Recurrent RD occurred in 6 (46%) PPV/SB eyes (5 early and 1 late), 10 (63%) SB eyes (3 early and 7 late), and 0 (0%) PnR eyes (p = 0.61).

对于初次修复，13只眼接受了玻璃体切除联合巩膜扣带术（PPV/SB），16只眼接受了原发性巩膜扣带术（SB），1只眼接受了充气视网膜固定术（PnR）。复发性RD发生在6只（46%）PPV/SB眼（5只早期和1只晚期），10只（63%）SB眼（3只早期和7只晚期）和0只（0%）PnR眼（p=0.61）。

PPV/SB was preferred for eyes presenting with total detachment (82%), giant retinal tears (100%), and proliferative vitreoretinopathy (PVR) (80%). For eyes with early recurrent RD, 6 (75%) had PVR leading to recurrence. For eyes with late recurrent RD, 7 (87.5%) developed a new retinal break leading to recurrence, including 4 with a break posterior to the buckle indentation apex.

PPV/SB对于出现完全脱离（82%），巨大视网膜撕裂（100%）和增生性玻璃体视网膜病变（PVR）（80%）的眼睛是首选。对于早期复发性RD的眼睛，有6只（75%）患有PVR导致复发。对于晚期复发性RD的眼睛，有7只（87.5%）出现了新的视网膜破裂，导致复发，其中4只在屈曲压痕顶点后方破裂。

At last follow-up, median LogMAR visual acuity was 0.68 for eyes with recurrent RD compared to 0.29 for eyes without recurrence (p = 0.27).ConclusionsEarly recurrent RD was mostly caused by PVR, while late recurrent RD was mostly due to new retinal breaks. Eyes with seemingly uncomplicated rhegmatogenous RD repair with primary SB remained at high risk for late re-detachment..

在最后一次随访中，复发性RD眼的中位LogMAR视力为0.68，而无复发眼的中位LogMAR视力为0.29（p=0.27）。结论严重复发性RD主要由PVR引起，而晚期复发性RD主要由新的视网膜裂孔引起。原发性SB看似简单的孔源性RD修复的眼睛仍然存在晚期再脱离的高风险。。

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Fig. 1: Kaplan-Meier survival curve for sustained retinal reattachment after initial rhegmatogenous retinal detachment repair compared by procedure (p = 0.61, log-rank test).Fig. 2: Visual acuity at last follow-up compared by presence of recurrent retinal detachment.

图1：通过手术比较初始孔源性视网膜脱离修复后持续视网膜再附着的Kaplan-Meier生存曲线（p=0.61，对数秩检验）。图2：与复发性视网膜脱离的存在相比，最后一次随访的视力。

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The data that supports the findings of this study are available from the corresponding author upon reasonable request.

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ReferencesCarroll C, Papaioannou D, Rees A, Kaltenthaler E. The clinical effectiveness and safety of prophylactic retinal interventions to reduce the risk of retinal detachment and subsequent vision loss in adults and children with Stickler syndrome: a systematic review. Health Technol Assess. 2011;15:1–62.Article .

参考文献Carroll C，Papaioannou D，Rees A，Kaltenthaler E.预防性视网膜干预的临床有效性和安全性，以降低Stickler综合征成人和儿童视网膜脱离和随后视力丧失的风险：系统评价。健康技术评估。2011年；15： 1-62条。

CAS

中科院

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Snead MP, McNinch AM, Poulson AV, Bearcroft P, Silverman B, Gomersall P, et al. Stickler syndrome, ocular-only variants and a key diagnostic role for the ophthalmologist. Eye. 2011;25:1389–400.Article

Snead MP，McNinch AM，Poulson AV，Bearcroft P，Silverman B，Gomersall P等。Stickler综合征，仅眼部变异和眼科医生的关键诊断作用。眼睛。2011年；25:1389–400.文章

CAS

中科院

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Coussa RG, Sears J, Traboulsi EI. Stickler syndrome: exploring prophylaxis for retinal detachment. Curr Opin Ophthalmol. 2019;30:306.Article

库萨RG，西尔斯J，特拉布尔西EI。Stickler综合征：探索视网膜脱离的预防措施。Curr Opin Ophthalmol。2019年；30:306.文章

PubMed

PubMed

Google Scholar

谷歌学者

Yonekawa Y, Reddy D, Thomas B, Nudleman E, Williams G. Long-term surgical outcomes of retinal detachment in patients with Stickler syndrome. Clin Ophthalmol. 2016;10:1531–4.Article

Yonekawa Y，Reddy D，Thomas B，Nudleman E，Williams G.Stickler综合征患者视网膜脱离的长期手术结果。临床眼科。2016年；10： 1531-4.文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Day AC, Donachie PHJ, Sparrow JM, Johnston RL. The Royal College of Ophthalmologists National Ophthalmology Database study of cataract surgery: report 1, visual outcomes and complications. Eye. 2015;29:552–60.Article

Day AC，Donachie PHJ，Sparrow JM，Johnston RL。皇家眼科医师学院国家眼科数据库白内障手术研究：报告1，视力结果和并发症。眼睛。2015年；29:552–60.文章

CAS

中科院

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Ryan EH, Ryan CM, Forbes NJ, Yonekawa Y, Wagley S, Mittra RA, et al. Primary retinal detachment outcomes study report number 2. Ophthalmology. 2020;127:1077–85.Article

Ryan EH，Ryan CM，Forbes NJ，Yonekawa Y，Wagley S，Mittra等。原发性视网膜脱离结局研究报告2号。眼科学。2020年；127:1077–85.文章

PubMed

PubMed

Google Scholar

谷歌学者

Starr MR, Boucher N, Sharma C, Wakabayashi T, Sivalingam M, Klufas MA, et al. The state of pediatric retinal detachment surgery in the United States: a nationwide aggregated health record analysis. Retina. 2023;43:717.Article

Starr MR，Boucher N，Sharma C，Wakabayashi T，Sivalingam M，Klufas MA等。美国小儿视网膜脱离手术状况：全国汇总健康记录分析。视网膜。2023年；43:717.文章

PubMed

PubMed

Google Scholar

谷歌学者

Abdi F, Aghajani A, Hemmati S, Moosavi D, Gordiz A, Chaibakhsh S, et al. Pediatric rhegmatogenous retinal detachment: a meta-analysis of clinical features, surgical success rate, and prognostic factors. Indian J Ophthalmol. 2023;71:717.Article

Abdi F，Aghajani A，Hemmati S，Moosavi D，Gordiz A，Chaibakhsh S等。小儿孔源性视网膜脱离：临床特征，手术成功率和预后因素的荟萃分析。印度J眼科。2023年；71:717.文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Abeysiri P, Bunce C, da Cruz L. Outcomes of surgery for retinal detachment in patients with Stickler syndrome: a comparison of two sequential 20-year cohorts. Graefes Arch Clin Exp Ophthalmol. 2007;245:1633–8.Article

Abeysiri P，Bunce C，da Cruz L.Stickler综合征患者视网膜脱离手术的结果：两个连续20年队列的比较。Graefes Arch Clin Exp Ophthalmol。2007年；245:1633–8.文章

PubMed

PubMed

Google Scholar

谷歌学者

Al Rashaed S, Alshahrani S, Ghazi N. Rhegmatogenous retinal detachments associated to Stickler syndrome in a tertiary eye care center in Saudi Arabia. Clin Ophthalmol. 2015;10:1–6.Taylor K, Su M, Richards Z, Mamawalla M, Rao P, Chang E. Outcomes in retinal detachment repair and laser prophylaxis for syndromes with optically empty vitreous.

Al Rashaed S，Alshahrani S，Ghazi N.沙特阿拉伯三级眼科护理中心与Stickler综合征相关的孔源性视网膜脱离。临床眼科。2015年；10： 1-6.Taylor K，Su M，Richards Z，Mamawalla M，Rao P，Chang E.视网膜脱离修复和激光预防光学空玻璃体综合征的结果。

Ophthalmol Retin. 2023;7:848–56.Article .

眼科视网膜蛋白。2023年；7： 848-56条。

Google Scholar

谷歌学者

Errera MH, Liyanage SE, Moya R, Wong SC, Ezra E. Primary scleral buckling for pediatric rhegmatogenous retinal detachment. Retina. 2015;35:1441–9.Article

Errera MH，Liyanage SE，Moya R，Wong SC，Ezra E.儿童孔源性视网膜脱离的原发性巩膜扣带术。视网膜。2015年；35:1441–9.文章

PubMed

PubMed

Google Scholar

谷歌学者

Lincoff H, Kreissig I. Extraocular repeat surgery of retinal detachment: a minimal approach. Ophthalmology.1996;103:1586–92.Article

Lincoff H，Kreissig I.视网膜脱离的眼外重复手术：一种最小的方法。眼科学.1996；103:1586–92.文章

CAS

中科院

PubMed

PubMed

Google Scholar

谷歌学者

Fincham GS, Pasea L, Carroll C, McNinch AM, Poulson AV, Richards AJ, et al. Prevention of retinal detachment in stickler syndrome: the Cambridge prophylactic cryotherapy protocol. Ophthalmology. 2014;121:1588–97.Article

Fincham GS，Pasea L，Carroll C，McNinch AM，Poulson AV，Richards AJ等。stickler综合征视网膜脱离的预防：剑桥预防性冷冻治疗方案。眼科学。2014年；121:1588–97.文章

PubMed

PubMed

Google Scholar

谷歌学者

Linton E, Jalil A, Sergouniotis P, Moussa G, Black G, Charles S, et al. Laser prophylaxis in stickler syndrome: the Manchester protocol. Retina. 2023;43:88–93.Article

。视网膜。2023年；43:88–93.文章

PubMed

PubMed

Google Scholar

谷歌学者

Download referencesFundingThis work was supported by NIH CORE Grant P30 EY08098 to the Department of Ophthalmology, the Eye and Ear Foundation of Pittsburgh, the Children’s Foundation, and an unrestricted grant from Research to Prevent Blindness, New York, NY.Author informationAuthors and AffiliationsDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USATimothy H.

下载参考文献资助这项工作得到了美国国立卫生研究院（NIH）核心拨款P30 EY08098的支持，该拨款由匹兹堡眼耳基金会（the Eye and Ear Foundation of Pittsburgh）儿童基金会（the Children's Foundation）眼科资助，以及纽约州纽约市预防失明研究（Research to Prevent Blindness，New York，NY）的无限制拨款资助。作者信息作者和附属机构美国宾夕法尼亚州匹兹堡市匹兹堡大学眼科系Timothy H。

Chen, Marjan Imani Fooladi, Michelle Alabek, Hannah L. Scanga, Kelly S. Tripi, Ken K. Nischal & Joseph N. MartelUPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USAMarjan Imani Fooladi, Hannah L. Scanga, Kelly S. Tripi & Ken K. NischalAuthorsTimothy H. ChenView author publicationsYou can also search for this author in.

Chen，Marjan Imani-Foodadi，Michelle Alabek，Hannah L.Scanga，Kelly S.Tripi，Ken K.Nischal＆Joseph N.MartelUPMC匹兹堡儿童医院，宾夕法尼亚州匹兹堡，USAMarjan Imani-Foodadi，Hannah L.Scanga，Kelly S.Tripi＆Ken K.NischalAuthorsTimothy H.ChenView作者出版物您也可以在中搜索这位作者。

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PubMed Google ScholarContributionsConception and design: THC, MF, KKN, and JNM. Data Collection: THC, MA, HLS, and KST. Analysis and interpretation: THC, MF, MA, HLS, KST, KKN, and JNM. Overall Responsibility: THC, MF, MA, HLS, KST, KKN, and JNM.Corresponding authorCorrespondence to.

PubMed谷歌学术贡献概念和设计：THC，MF，KKN和JNM。数据收集：THC，MA，HLS和KST。分析和解释：THC，MF，MA，HLS，KST，KKN和JNM。总体责任：THC、MF、MA、HLS、KST、KKN和JNM。对应作者对应。

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et al. Recurrent retinal detachment in Stickler Syndrome..

Stickler综合征复发性视网膜脱离。。

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