Farnesyl pyrophosphate (FPP), an intermediate of cholesterol biosynthesis in the mevalonate pathway, prolongs the survival of migratory dendritic cells (mig-DCs) by remodelling mitochondrial structure and metabolism. Treating a mouse model of systemic lupus erythematosus with simvastatin (an inhibitor of this pathway) led to recovery from dysregulation in mig-DCs and ameliorated systemic autoimmune pathogenesis..

法尼基焦磷酸（FPP）是甲羟戊酸途径中胆固醇生物合成的中间体，通过重塑线粒体结构和代谢来延长迁移性树突状细胞（mig-DC）的存活。用辛伐他汀（该途径的抑制剂）治疗系统性红斑狼疮的小鼠模型导致mig DC失调的恢复，并改善了系统性自身免疫发病机制。。

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Fig. 1: Migratory DCs with aberrant cholesterol metabolism are enriched in lesional skin in SLE.

图1：具有异常胆固醇代谢的迁移性DC在SLE的病变皮肤中富集。

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Download referencesAdditional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.This is a summary of: Zhang, X. et al. Farnesyl pyrophosphate potentiates dendritic cell migration in autoimmunity through mitochondrial remodelling.

下载参考其他信息出版商的注释Springer Nature对于已发布地图和机构隶属关系中的管辖权主张保持中立。这是Zhang，X。等人的总结。法尼基焦磷酸盐通过线粒体重塑增强自身免疫中的树突状细胞迁移。

Nat. Metab. https://doi.org/10.1038/s42255-024-01149-x (2024).Rights and permissionsReprints and permissionsAbout this articleCite this article Farnesyl pyrophosphate modulates dendritic cell migration in lupus autoimmunity..

自然代谢。https://doi.org/10.1038/s42255-024-01149-x（2024年）。权利和许可打印和许可本文引用本文法尼基焦磷酸盐调节狼疮自身免疫中的树突状细胞迁移。。

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