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register hereBackground: Infertility is increasingly recognized as a global health issue affecting couples of reproductive age, with male factors contributing to approximately 50% of infertility cases. However, the association between depression and anxiety-two of the most prevalent mental health conditions-and impaired male fertility remains a subject of ongoing debate.

背景：不孕症越来越被认为是影响育龄夫妇的全球健康问题，男性因素约占不孕症病例的50%。然而，抑郁和焦虑这两种最普遍的心理健康状况与男性生育能力受损之间的关联仍然是一个持续争论的话题。

Methods: In this cross-sectional study, male participants seeking fertility counseling at an IVF clinic were recruited. Symptoms of depression and anxiety were assessed using the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 (GAD-7), respectively. Generalized linear regression models (GLMs) were employed to investigate the relationships between mental health status and semen parameters.

方法：在这项横断面研究中，招募了在IVF诊所寻求生育咨询的男性参与者。分别使用患者健康问卷-9（PHQ-9）和广泛性焦虑症-7（GAD-7）评估抑郁和焦虑症状。采用广义线性回归模型（GLMs）研究心理健康状况与精液参数之间的关系。

Results: Status of depression was negatively associated with semen quality parameters, whereas no statistically significant association was recognized between anxiety and semen quality except that sperm concentration was decreased by 25.60 (95% CI, 1.226 to 49.965, P=0.040) ×10 6 /ml in moderate to severe anxiety group referring to normal group.

结果：抑郁状态与精液质量参数呈负相关，而焦虑与精液质量之间无统计学显着相关性，但中重度焦虑组精子浓度下降25.60（95%CI，1.226〜49.965，P=0.040）×10 6/ml。

Furthermore, when stratified by sleep duration, moderate to severe depression group showed a great decrease in progressive motility (PR), total motility, concentration and total sperm count (TSC) as referred to normal group in participants with sleep duration less than 7 hours. Conclusion: The present study revealed that depression rather than anxiety was a negative factor that affected semen quality, especially in individuals with shorter sleep duration..

此外，当按睡眠时间分层时，中度至重度抑郁症组在睡眠时间少于7小时的参与者中，与正常组相比，进行性运动（PR），总运动，浓度和总精子计数（TSC）显着降低。结论：本研究表明，抑郁而非焦虑是影响精液质量的负面因素，尤其是睡眠时间较短的个体。。