未吸毒青少年非自杀性自伤局部脑活动和相应脑回路的变化-动脉网

Alterations of regional brain activity and corresponding brain circuits in drug-naïve adolescents with nonsuicidal self-injury

Nature 等信源发布 2024-10-23 17:37



可切换为仅中文







AbstractNonsuicidal self-injury (NSSI) is one of the major public health problems endangering adolescents. However, the neural mechanisms of NSSI is still unclear. The purpose of this study was to explore regional brain activity and corresponding brain circuits in drug-naïve adolescents with NSSI using amplitude of low-frequency fluctuations (ALFF) combined with functional connectivity (FC) analysis.

摘要非自杀性自伤（NSSI）是危害青少年的主要公共卫生问题之一。然而，NSSI的神经机制仍不清楚。这项研究的目的是使用低频波动幅度（ALFF）结合功能连接性（FC）分析来探索患有NSSI的未吸毒青少年的区域大脑活动和相应的大脑回路。

Thirty-two drug-naïve adolescents with NSSI (NSSI group) and 29 healthy controls matched for sex, age, and level of education (HC group) were enrolled in this study. ALFF and seed-based FC analyses were used to examine the alterations in regional brain activity and corresponding brain circuits. The correlation between ALFF or FC values of aberrant brain regions and clinical characteristics were detected by Pearson correlation analysis.

本研究纳入了32名患有NSSI的未服用药物的青少年（NSSI组）和29名与性别，年龄和教育水平相匹配的健康对照（HC组）。使用ALFF和基于种子的FC分析来检查区域大脑活动和相应大脑回路的变化。通过Pearson相关分析检测异常大脑区域的ALFF或FC值与临床特征之间的相关性。

The NSSI group showed increased ALFF in the left inferior and middle occipital gyri, lingual gyrus, and fusiform gyrus; additionally, decreased ALFF in the right medial cingulate gyrus, left anterior cingulate gyrus, and left medial superior frontal gyrus compared to those in the HC group. With the left inferior occipital gyrus as seed, the NSSI group showed increased FC between the left inferior occipital gyrus and the bilateral superior parietal gyrus, right inferior parietal angular gyrus, right inferior frontal gyrus of the insular region, and left precuneus relative to that the HC group.

NSSI组左下枕叶和中枕叶，舌回和梭状回的ALFF增加；此外，与HC组相比，右内侧扣带回，左前扣带回和左内侧额上回的ALFF降低。以左枕下回为种子，相对于HC组，NSSI组显示左枕下回与双侧顶叶上回，右顶叶下角回，岛状区右额下回和左楔前叶之间的FC增加。

With the left anterior cingulate gyrus as seed, the NSSI group showed increased FC between the left anterior cingulate gyrus and right dorsolateral superior frontal gyrus. With the left lingual gyrus as seed, the NSSI group showed increased FC between the left lingual gyrus and right middle frontal gyrus, and decreased FC between the left lingual gyrus a.

以左前扣带回为种子，NSSI组显示左前扣带回和右背外侧额上回之间的FC增加。以左舌回为种子，NSSI组显示左舌回和右额中回之间的FC增加，左舌回a之间的FC减少。

IntroductionNonsuicidal self-injury (NSSI) refers to intentional and direct injury to body tissues in a socially unacceptable way without suicidal intention1. NSSI often occurs in the context of psychiatric disorders, such as major depressive disorder (MDD) and borderline personality disorder2. In addition, it can occur also without accompanying psychopathology3.

引言非自杀性自伤（NSSI）是指以社会不可接受的方式对身体组织进行故意和直接伤害，而没有自杀意图1。NSSI通常发生在精神疾病的背景下，如重度抑郁症（MDD）和边缘性人格障碍2。此外，它也可能在没有伴随精神病理学的情况下发生3。

Self-injury behaviors are usually adopted by adolescents with repetitive self-injury as an emotion regulation strategy to relieve negative emotions such as anxiety, guilt, loneliness, alienation or self-hatred4,5. The most commonly recognized ways of self-injury include cutting and scratching the skin, hitting the body or a wall6.

自我伤害行为通常被反复自我伤害的青少年用作情绪调节策略，以缓解焦虑，内疚，孤独，疏远或自怨自艾等负面情绪4,5。最常见的自伤方式包括割伤和抓挠皮肤，撞击身体或墙壁6。

The lifetime prevalence of NSSI among adolescents has been reported to be 13–17%7, while the rate among adolescents in China has risen to 23%8. Adolescents who repeatedly self-injury are more likely to develop mental disorders or suicidal behavior9. With the rising prevalence of NSSI10, the disorder has been included in the Diagnostic and Statistical Manual of Mental Disorders (5th edition) draft diagnosis (DSM-5).

据报道，青少年中NSSI的终生患病率为13-17%7，而中国青少年的患病率已上升至23%8。。随着NSSI10患病率的上升，该疾病已被纳入《精神障碍诊断和统计手册》（第5版）诊断草案（DSM-5）。

Although NSSI has attracted attention due to its high incidence and potential risk of suicide, its neural mechanisms remain unclear.In recent years, functional magnetic resonance (fMRI) has played an important role in the diagnosis of mental disorders due to its non-invasiveness and high spatial and temporal resolution11.

尽管NSSI由于其高发病率和潜在的自杀风险而引起了人们的关注，但其神经机制仍不清楚。近年来，功能磁共振（fMRI）由于其无创性和高时空分辨率，在精神障碍的诊断中发挥了重要作用11。

Previous studies on NSSI were mostly based on task-fMRI12,13,14,15, which provided a considerable amount of evidence for the exploration of NSSI mechanisms. However, it is difficult to obtain consistent results due to differences in paradigms or experimental schemes used. Resting-state functional magnetic resonance imaging (rs-fMRI) as a relatively simple .

以前对NSSI的研究大多基于task-fMRI12,13,14,15，这为探索NSSI机制提供了大量证据。然而，由于所使用的范式或实验方案的差异，很难获得一致的结果。静息状态功能磁共振成像（rs-fMRI）作为一种相对简单的方法。

Availability of data and materials

数据和材料的可用性

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

本研究中使用和/或分析的数据集可根据合理要求从通讯作者处获得。

AbbreviationsNSSI:

缩写NSSI：

Nonsuicidal self-injury

非自杀性自伤

HC:

本币：

Healthy controls

健康对照

MDD:

MDD：

Major depressive disorder

重度抑郁症

ALFF:

阿尔夫：

Amplitude of low-frequency fluctuations

低频波动幅度

FC:

FC公司：

Functional connectivity

功能连接

rs-fMRI:

rs功能磁共振成像：

Resting-state functional magnetic resonance imaging

静息状态功能磁共振成像

SAS:

The self-rating anxiety scale

焦虑自评量表

BSSI:

BSSI：

The beck scale for suicidal ideations

贝克自杀意念量表

GRF:

GRF：

Gaussian random field

高斯随机场

IOG:

IOG：

Inferior occipital gyrus

枕下回

MOG:

MOG：

Middle occipital gyrus

枕中回

LG:

LG公司：

Lingual gyrus

舌回

FFG:

FFG：

Fusiform gyrus

梭状回

ACG:

ACG：

Anterior cingulate gyrus

前扣带回

SFGmed:

SFGmed：

Medial superior frontal gyrus

额内侧上回

MCG:

MCG：

Median cingulate gyrus

中扣带回

ReferencesRodríguez-Blanco, L., Carballo-Belloso, J. J., de León, S. & Baca-García, E. A longitudinal study of adolescents engaged in non-suicidal self injury (NSSI): Clinical follow-up from adolescence to young adulthood. Psychiatry Res. 297, 113711 (2021).Article

参考文献Rodríguez-Blanco，L.，Carballo-Belloso，J.J.，de León，S。＆Baca-García，E。对青少年进行非自杀性自伤（NSSI）的纵向研究：从青春期到成年期的临床随访。精神病学研究297113711（2021）。文章

PubMed

Google Scholar

谷歌学者

Nitkowski, D. & Petermann, F. Non-suicidal self-injury and comorbid mental disorders: A review. Fortschr. Neurol. Psychiatr. 79(1), 9–20 (2011).Article

Nitkowski，D。和Petermann，F。非自杀性自伤和共病精神障碍：综述。Fortschr公司。神经病学。精神病医生。79（1），9-20（2011）。文章

CAS

中科院

PubMed

Google Scholar

谷歌学者

Stanford, S. & Jones, M. P. Psychological subtyping finds pathological, impulsive, and “normal” groups among adolescents who self-harm. J. Child Psychol. Psychiatry Allied Discip. 50(7), 807–815 (2009).Article

。J、儿童心理学。精神病学联合学科。50（7），807–815（2009）。文章

Google Scholar

谷歌学者

Lloyd-Richardson, E. E., Perrine, N., Dierker, L. & Kelley, M. L. Characteristics and functions of non-suicidal self-injury in a community sample of adolescents. Psychol. Med. 37(8), 1183–1192 (2007).Article

Lloyd Richardson，E.E.，Perrine，N.，Dierker，L。＆Kelley，M.L。青少年社区样本中非自杀性自伤的特征和功能。心理学。医学杂志37（8），1183-1192（2007）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Dawkins, J. C., Hasking, P. A., Boyes, M. E., Greene, D. & Passchier, C. Applying a cognitive-emotional model to nonsuicidal self-injury. Stress Health J. Int. Soc. Investig. Stress 35(1), 39–48 (2019).Article

Dawkins，J.C.，Hasking，P.A.，Boyes，M.E.，Greene，D。＆Passchier，C。将认知情绪模型应用于非自杀性自伤。压力健康J.Int.Soc.Investig。。文章

Google Scholar

谷歌学者

Zetterqvist, M. The dsm-5 diagnosis of nonsuicidal self-injury disorder: A review of the empirical literature. Child Adolesc. Psychiatry Ment. Health 9, 31 (2015).Article

Zetterqvist，M。dsm-5诊断非自杀性自伤障碍：经验文献综述。儿童青少年。精神病学。健康9,31（2015）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Swannell, S. V., Martin, G. E., Page, A., Hasking, P. & St John, N. J. Prevalence of nonsuicidal self-injury in nonclinical samples: Systematic review, meta-analysis and meta-regression. Suicide Life Threat. Behav. 44(3), 273–303 (2014).Article

Swannell，S.V.，Martin，G.E.，Page，A.，Hasking，P。＆St John，N.J。非临床样本中非自杀性自伤的患病率：系统评价，荟萃分析和荟萃回归。自杀生命威胁。行为。44（3），273–303（2014）。文章

PubMed

Google Scholar

谷歌学者

Liang, S. et al. Differences between non-suicidal self injury and suicide attempt in chinese adolescents. Asian J. Psychiatry 8, 76–83 (2014).Article

Liang，S。等。中国青少年非自杀性自伤与自杀未遂的差异。亚洲J.精神病学8,76-83（2014）。文章

Google Scholar

谷歌学者

Hamza, C. A., Stewart, S. L. & Willoughby, T. Examining the link between nonsuicidal self-injury and suicidal behavior: A review of the literature and an integrated model. Clin. Psychol. Rev. 32(6), 482–495 (2012).Article

Hamza，C.A.，Stewart，S.L。和Willoughby，T。研究非自杀性自伤与自杀行为之间的联系：文献综述和综合模型。临床。心理学。修订版32（6），482–495（2012）。文章

PubMed

Google Scholar

谷歌学者

Zhang, L. et al. Assessment of mental health of Chinese primary school students before and after school closing and opening during the covid-19 pandemic. JAMA Netw. Open 3(9), e2021482 (2020).Article

Zhang，L.等人。新型冠状病毒肺炎期间中国小学生在学校关闭和开放前后的心理健康评估。JAMA网络。公开3（9），e2021482（2020）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Canario, E., Chen, D. & Biswal, B. A review of resting-state fMRI and its use to examine psychiatric disorders. Psychoradiology 1(1), 42–53 (2021).Article

Canario，E.，Chen，D。和Biswal，B。静息状态功能磁共振成像及其用于检查精神疾病的综述。心理放射学1（1），42-53（2021）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Plener, P. L., Bubalo, N., Fladung, A. K., Ludolph, A. G. & Lulé, D. Prone to excitement: Adolescent females with non-suicidal self-injury (NSSI) show altered cortical pattern to emotional and NSS-related material. Psychiatry Res. 203(2–3), 146–152 (2012).Article

。精神病学研究203（2-3），146-152（2012）。文章

PubMed

Google Scholar

谷歌学者

Osuch, E., Ford, K., Wrath, A., Bartha, R. & Neufeld, R. Functional MRI of pain application in youth who engaged in repetitive non-suicidal self-injury vs. psychiatric controls. Psychiatry Res. 223(2), 104–112 (2014).Article

Osuch，E.，Ford，K.，Wrath，A.，Bartha，R。＆Neufeld，R。功能性MRI在重复性非自杀性自伤与精神病对照的青少年中的疼痛应用。精神病学第223（2）号决议，104-112（2014）。文章

PubMed

Google Scholar

谷歌学者

In-Albon, T., Ruf, C. & Schmid, M. Facial emotion recognition in adolescents with nonsuicidal self-injury. Psychiatry Res. 228(3), 332–339 (2015).Article

在Albon，T.，Ruf，C。＆Schmid，M。非自杀性自伤青少年的面部情绪识别。精神病学第228（3）号决议，332-339（2015）。文章

PubMed

Google Scholar

谷歌学者

Otto, A. et al. Stress-induced alterations in resting-state functional connectivity among adolescents with non-suicidal self-injury. J. Affect. Disord. 339, 162–171 (2023).Article

Otto，A。等人。压力引起的非自杀性自伤青少年静息状态功能连接的改变。J、影响。混乱。339162-171（2023）。文章

PubMed

Google Scholar

谷歌学者

Chen, X. et al. Functional connectivity alterations in reward-related circuits associated with non-suicidal self-injury behaviors in drug-naïve adolescents with depression. J. Psychiatr. Res. 163, 270–277 (2023).Article

Chen，X。等人。未服用药物的抑郁症青少年中与非自杀性自伤行为相关的奖励相关回路的功能连接性改变。J、精神病医生。第163270-277号决议（2023年）。文章

PubMed

Google Scholar

谷歌学者

Huang, Q. et al. Disruption of neural activity and functional connectivity in adolescents with major depressive disorder who engage in non-suicidal self-injury: A resting-state fmri study. Front. Psychiatry 12, 571532 (2021).Article

Huang，Q.等人。参与非自杀性自我伤害的重度抑郁症青少年的神经活动和功能连接中断：静息状态fmri研究。。精神病学12571532（2021）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Zhou, Y. et al. A resting state functional magnetic resonance imaging study of unmedicated adolescents with non-suicidal self-injury behaviors: Evidence from the amplitude of low-frequency fluctuation and regional homogeneity indicator. Front. Psychiatry 13, 925672 (2022).Article

Zhou，Y。等。非自杀性自伤行为未服药青少年的静息状态功能磁共振成像研究：来自低频波动幅度和区域同质性指标的证据。。精神病学13925672（2022）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Yan, R. et al. Alterations of regional spontaneous neuronal activity and corresponding brain circuits related to non-suicidal self-injury in young adults with major depressive disorder. J. Affect. Disord. 305, 8–18 (2022).Article

Yan，R.等人。与重度抑郁症年轻人非自杀性自伤相关的局部自发性神经元活动和相应脑回路的改变。J、影响。混乱。305，8-18（2022）。文章

PubMed

Google Scholar

谷歌学者

Tadayonnejad, R., Yang, S., Kumar, A. & Ajilore, O. Clinical, cognitive, and functional connectivity correlations of resting-state intrinsic brain activity alterations in unmedicated depression. J Affect. Disord. 172, 241–250 (2015).Article

Tadayonnejad，R.，Yang，S.，Kumar，A。＆Ajilore，O。静息状态内在大脑活动改变在非药物抑郁症中的临床，认知和功能连接性相关性。J影响。混乱。172241-250（2015）。文章

PubMed

Google Scholar

谷歌学者

Guo, W. et al. Reversal alterations of amplitude of low-frequency fluctuations in early and late onset, first-episode, drug-naive depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 40, 153–159 (2013).Article

郭，W。等。早期和晚期发作，首次发作，未经药物治疗的抑郁症低频波动幅度的逆转改变。程序。神经精神药理学。生物精神病学40153-159（2013）。文章

PubMed

Google Scholar

谷歌学者

O’Reilly, J. X., Woolrich, M. W., Behrens, T. E. J., Smith, S. M. & Johansen-Berg, H. Tools of the trade: Psychophysiological interactions and functional connectivity. Soc. Cogn. Affect. Neurosci. 7(5), 604–609 (2012).Article

O'Reilly，J.X.，Woolrich，M.W.，Behrens，T.E.J.，Smith，S.M。＆Johansen-Berg，H。贸易工具：心理生理相互作用和功能连接。社会认知。影响。神经科学。7（5），604-609（2012）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Martin, J. et al. Psychometric properties of the functions and addictive features scales of the ottawa self-injury inventory: A preliminary investigation using a university sample. Psychol. Assess 25(3), 1013–1018 (2013).Article

Martin，J.等人，《渥太华自伤量表的功能和成瘾特征量表的心理测量特性：使用大学样本进行的初步调查》。心理学。评估25（3），1013–1018（2013）。文章

PubMed

Google Scholar

谷歌学者

Zung, W. W. A rating instrument for anxiety disorders. Psychosomatics 12, 371–379 (1971).Article

Zung，W.W。焦虑症评定工具。心身学12371-379（1971）。文章

CAS

中科院

PubMed

Google Scholar

谷歌学者

Beck, A. T., Kovacs, M. & Weissman, A. Assessment of suicidal intention: The scale for suicide ideation. J. Consult. Clin. Psychol. 47(2), 343–352 (1979).Article

Beck，A.T.，Kovacs，M。＆Weissman，A。自杀意图评估：自杀意念量表。J、咨询。临床。心理学。47（2），343-352（1979）。文章

CAS

中科院

PubMed

Google Scholar

谷歌学者

Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. & Turner, R. Movement-related effects in fMRI time-series. Magn Reson. Med. 35(3), 346–355 (1996).Article

Friston，K.J.，Williams，S.，Howard，R.，Frackowiak，R.S。＆Turner，R。功能磁共振成像时间序列中的运动相关效应。Magn Reson公司。医学杂志35（3），346-355（1996）。文章

CAS

中科院

PubMed

Google Scholar

谷歌学者

Fox, M. D. & Raichle, M. E. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat. Rev. Neurosci. 8(9), 700–711 (2007).Article

Fox，M.D。＆Raichle，M.E。通过功能磁共振成像观察到大脑活动的自发波动。神经科学杂志。8（9），700–711（2007）。文章

CAS

中科院

PubMed

Google Scholar

谷歌学者

Teng, C. et al. Abnormal resting state activity of left middle occipital gyrus and its functional connectivity in female patients with major depressive disorder. BMC Psychiatry 18(1), 370 (2018).Article

Teng，C.等人。女性重度抑郁症患者左枕中回静息状态活动异常及其功能连接。。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Cao, J. et al. Resting-state functional MRI of abnormal baseline brain activity in young depressed patients with and without suicidal behavior. J. Affect. Disord. 205, 252–263 (2016).Article

Cao，J.等人。有和没有自杀行为的年轻抑郁症患者基线大脑活动异常的静息状态功能MRI。J、影响。混乱。205252-263（2016）。文章

PubMed

Google Scholar

谷歌学者

Bogousslavsky, J., Miklossy, J., Deruaz, J. P., Assal, G. & Regli, F. Lingual and fusiform gyri in visual processing: A clinico-pathologic study of superior altitudinal hemianopia. J. Neurol. Neurosurg. Psychiatry 50(5), 607–614 (1987).Article

Bogousslavsky，J.，Miklossy，J.，Deruaz，J.P.，Assal，G。＆Regli，F。视觉处理中的舌回和梭形回：高度偏盲的临床病理研究。J、神经病学。神经外科。精神病学50（5），607-614（1987）。文章

CAS

中科院

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Jung, J. et al. Impact of lingual gyrus volume on antidepressant response and neurocognitive functions in major depressive disorder: A voxel-based morphometry study. J. Affect. Disord. 169, 179–187 (2014).Article

Jung，J.等人。舌回体积对重度抑郁症抗抑郁反应和神经认知功能的影响：基于体素的形态计量学研究。J、影响。混乱。169179–187（2014）。文章

PubMed

Google Scholar

谷歌学者

Palejwala, A. H. et al. Anatomy and white matter connections of the lingual gyrus and cuneus. World Neurosurg 151, e426–e437 (2021).Article

Palejwala，A.H.等人。舌回和楔骨的解剖学和白质连接。世界神经外科杂志151，e426–e437（2021）。文章

PubMed

Google Scholar

谷歌学者

Grill-Spector, K., Knouf, N. & Kanwisher, N. The fusiform face area subserves face perception, not generic within-category identification. Nat. Neurosci. 7, 555–562 (2004).Article

Grill Spector，K.，Knouf，N。＆Kanwisher，N。梭形面部区域用于面部感知，而不是通用的类别内识别。自然神经科学。7555-562（2004）。文章

CAS

中科院

PubMed

Google Scholar

谷歌学者

Palejwala, A. H. et al. Anatomy and white matter connections of the fusiform gyrus. Sci. Rep. 10(1), 13489 (2020).Article

Palejwala，A.H.等人。梭状回的解剖学和白质连接。科学。代表10（1），13489（2020）。文章

ADS

CAS

中科院

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Demers, L. A. et al. Alexithymia is associated with neural reactivity to masked emotional faces in adolescents who self-harm. J. Affect. Disord. 249, 253–261 (2019).Article

Demers，L.A。等人，述情障碍与自残青少年对掩饰情绪面孔的神经反应有关。J、影响。混乱。249253-261（2019）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Blasco-Fontecilla, H. et al. The addictive model of self-harming (non-suicidal and suicidal) behavior. Front. Psychiatry 7, 8 (2016).Article

Blasco Fontecilla，H.等人。自残（非自杀和自杀）行为的成瘾模型。。精神病学7,8（2016）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Pettorruso, M. et al. Exploring dopaminergic transmission in gambling addiction: A systematic translational review. Neurosci. Biobehav. Rev. 119, 481–511 (2020).Article

Pettorruso，M.等人，《探索赌博成瘾中的多巴胺能传播：系统转化综述》。神经科学。生物行为。修订版119481-511（2020）。文章

CAS

中科院

PubMed

Google Scholar

谷歌学者

Haber, S. N. & Knutson, B. The reward circuit: Linking primate anatomy and human imaging. Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol. 35(1), 4–26 (2010).Article

Haber，S.N。＆Knutson，B。奖励回路：连接灵长类解剖学和人类成像。神经精神药理学。关闭。公开。美国科罗拉多州。神经精神药理学。35（1），4-26（2010）。文章

Google Scholar

谷歌学者

Cooper, S., Robison, A. J. & Mazei-Robison, M. S. Reward circuitry in addiction. Neurother. J. Am. Soc. Exp. Neurother. 14(3), 687–697 (2017).CAS

Cooper，S.，Robison，A.J。和Mazei Robison，M.S。成瘾的奖励电路。神经质。J、美国社会经验神经症。14（3），687-697（2017）。中科院

Google Scholar

谷歌学者

Martz, M. E., Hart, T., Heitzeg, M. M. & Peltier, S. J. Neuromodulation of brain activation associated with addiction: A review of real-time fMRI neurofeedback studies. Neuroimage Clin. 27, 102350 (2020).Article

Martz，M.E.，Hart，T.，Heitzeg，M.M。＆Peltier，S.J。与成瘾相关的大脑激活的神经调节：实时fMRI神经反馈研究的综述。神经影像临床。27102350（2020）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Rolls, E. T. The cingulate cortex and limbic systems for emotion, action, and memory. Brain Struct. Funct. 224(9), 3001–3018 (2019).Article

Rolls，E.T。情绪，动作和记忆的扣带皮层和边缘系统。大脑结构。函数。224（9），3001-3018（2019）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Westlund Schreiner, M. et al. Multi-modal neuroimaging of adolescents with non-suicidal self-injury: Amygdala functional connectivity. J. Affect. Disord. 221, 47–55 (2017).Article

Westlund-Schreiner，M.等人。非自杀性自伤青少年的多模式神经影像学：杏仁核功能连接。J、影响。混乱。221,47-55（2017）。文章

PubMed

Google Scholar

谷歌学者

Brown, T. I., Rissman, J., Chow, T. E., Uncapher, M. R. & Wagner, A. D. Differential medial temporal lobe and parietal cortical contributions to real-world autobiographical episodic and autobiographical semantic memory. Sci. Rep. 8(1), 6190 (2018).Article

Brown，T.I.，Rissman，J.，Chow，T.E.，Uncapher，M.R。＆Wagner，A.D。内侧颞叶和顶叶皮层对现实世界自传体情节和自传体语义记忆的贡献。科学。代表8（1），6190（2018）。文章

ADS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Passarotti, A. M., Sweeney, J. A. & Pavuluri, M. N. Neural correlates of incidental and directed facial emotion processing in adolescents and adults. Soc. Cogn. Affect. Neurosci. 4(4), 387–398 (2009).Article

。社会认知。影响。神经科学。4（4），387-398（2009）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Seymour, K. E. et al. Emotional face recognition in adolescent suicide attempters and adolescents engaging in non-suicidal self-injury. Eur. Child Adolesc. Psychiatry 25, 247–259 (2016).Article

Seymour，K.E.等人。青少年自杀未遂者和非自杀性自伤青少年的情绪面孔识别。欧洲儿童青少年。精神病学25247-259（2016）。文章

PubMed

Google Scholar

谷歌学者

Nock, M. K. Self-injury. Annu. Rev. Clin. Psychol. 6, 339–363 (2010).Article

Nock，M.K。自伤。年。修订临床。心理学。6339-363（2010）。文章

PubMed

Google Scholar

谷歌学者

Zhang, L. et al. Gray matter volume of the lingual gyrus mediates the relationship between inhibition function and divergent thinking. Front. Psychol. 7, 1532 (2016).Article

Zhang，L。等人。舌回的灰质体积介导抑制功能和发散思维之间的关系。。心理学。71532（2016）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Filevich, E., Kühn, S. & Haggard, P. Negative motor phenomena in cortical stimulation: Implications for inhibitory control of human action. Cortex A J. Devoted Study Nerv. Syst. Behav. 48(10), 1251–1261 (2012).Article

Filevich，E.，Kühn，S。＆Haggard，P。皮质刺激中的负面运动现象：对人类行为抑制控制的影响。Cortex A J.专门研究神经。系统。行为。48（10），1251–1261（2012）。文章

Google Scholar

谷歌学者

Hamza, C. A., Willoughby, T. & Heffer, T. Impulsivity and nonsuicidal self-injury: A review and meta-analysis. Clin. Psychol. Rev. 38, 13–24 (2015).Article

Hamza，C.A.，Willoughby，T。＆Heffer，T。冲动性和非自杀性自伤：综述和荟萃分析。临床。心理学。第38版，第13-24页（2015年）。文章

PubMed

Google Scholar

谷歌学者

Armey, M. F., Crowther, J. H. & Miller, I. W. Changes in ecological momentary assessment reported affect associated with episodes of nonsuicidal self-injury. Behav. Ther. 42(4), 579–588 (2011).Article

Armey，M.F.，Crowther，J.H。＆Miller，I.W。生态瞬时评估的变化报告了与非自杀性自伤发作相关的影响。行为。他们。42（4），579-588（2011）。文章

PubMed

Google Scholar

谷歌学者

Herold, D., Spengler, S., Sajonz, B., Usnich, T. & Bermpohl, F. Common and distinct networks for self-referential and social stimulus processing in the human brain. Brain Struct. Funct. 221(7), 3475–3485 (2016).Article

Herold，D.，Spengler，S.，Sajonz，B.，Usnich，T。＆Bermpohl，F。人脑中自我参照和社会刺激处理的常见和独特网络。大脑结构。函数。221（7），3475–3485（2016）。文章

PubMed

Google Scholar

谷歌学者

Hu, B. et al. Emotion regulating attentional control abnormalities in major depressive disorder: An event-related potential study. Sci. Rep. 7(1), 13530 (2017).Article

胡，B。等。重性抑郁障碍的情绪调节注意控制异常：事件相关电位研究。科学。代表7（1），13530（2017）。文章

ADS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Renier, L. A. et al. Preserved functional specialization for spatial processing in the middle occipital gyrus of the early blind. Neuron 68(1), 138–148 (2010).Article

Renier，L.A.等人保留了早期盲人枕中回空间处理的功能特化。神经元68（1），138-148（2010）。文章

CAS

中科院

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Kropf, E., Syan, S. K., Minuzzi, L. & Frey, B. N. From anatomy to function: The role of the somatosensory cortex in emotional regulation. Rev. Bras. Psiquiatr. (Sao Paulo, Brazil) 41(3), 261–269 (2019).Article

Kropf，E.，Syan，S.K.，Minuzzi，L。＆Frey，B.N。从解剖学到功能：体感皮层在情绪调节中的作用。修订版Bras。普西奎特。（巴西圣保罗）41（3），261–269（2019）。文章

Google Scholar

谷歌学者

Phillips, M. L., Drevets, W. C., Rauch, S. L. & Lane, R. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol. Psychiatry 54(5), 515–528 (2003).Article

Phillips，M.L.，Drevets，W.C.，Rauch，S.L。和Lane，R。情绪感知的神经生物学II：对主要精神疾病的影响。。文章

PubMed

Google Scholar

谷歌学者

Kirtley, O. J., O’Carroll, R. E. & O’Connor, R. C. Pain and self-harm: A systematic review. J. Affect. Disord. 203, 347–363 (2016).Article

Kirtley，O.J.，O'Carroll，R.E。和O'Connor，R.C。疼痛和自我伤害：系统评价。J、影响。混乱。203347-363（2016）。文章

PubMed

Google Scholar

谷歌学者

Liu, R. T. Characterizing the course of non-suicidal self-injury: A cognitive neuroscience perspective. Neurosci. Biobehav. Rev. 80, 159–165 (2017).Article

Liu，R.T。描述非自杀性自伤的过程：认知神经科学的观点。神经科学。生物行为。第80159-165版（2017）。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Stanley, B. et al. Non-suicidal self-injurious behavior, endogenous opioids and monoamine neurotransmitters. J. Affect. Disord. 124(1–2), 134–140 (2010).Article

Stanley，B.等人。非自杀性自残行为，内源性阿片类药物和单胺类神经递质。J、影响。混乱。124（1-2），134-140（2010）。文章

CAS

中科院

PubMed

Google Scholar

谷歌学者

Download referencesAcknowledgementsThe authors are grateful to all participants in the study for their support.FundingThis study was funded by the Bureau of Science & Technology and Intellectual Property Nanchong City (22SXQT0305), the Opening Project of Functional and Molecular Imaging Key Laboratory of Sichuan Province (SCU-HM-202307001), and the Chinese Government Guidance Fund on Local Science and Technology Development of Sichuan Province (24ZYRGZN0018).Author informationAuthor notesThese authors contributed equally: Kaike Liao and Rui Yu.Authors and AffiliationsDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, ChinaKaike Liao, Rui Yu, Yuwei Chen, Xinyue Chen, Xinyan Wu, Xiaohua Huang & Nian LiuFunctional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu, 610041, ChinaNian LiuAuthorsKaike LiaoView author publicationsYou can also search for this author in.

下载参考文献致谢作者感谢研究中所有参与者的支持。资助本研究由南充市科学技术和知识产权局（22SXQT0305），四川省功能与分子成像重点实验室开放项目（SCU-HM-202307001）和中国政府四川省地方科技发展指导基金（24ZYRGZN0018）资助。作者信息作者注意到这些作者做出了同样的贡献：廖凯科和于睿。作者和附属机构川北医学院附属医院放射科，南充，637000，中国廖凯科，芮宇，陈玉伟，陈新月，吴新燕，黄晓华和刘年华四川省功能与分子影像重点实验室，成都，610041，刘年华作者廖凯科观点作者出版物您也可以在中搜索作者。

PubMed Google ScholarRui YuView author publicationsYou can also search for this author in

PubMed Google ScholarRui YuView作者出版物您也可以在

PubMed Google ScholarYuwei ChenView author publicationsYou can also search for this author in

PubMed Google ScholarYuwei ChenView作者出版物您也可以在

PubMed Google ScholarXinyue ChenView author publicationsYou can also search for this author in

PubMed Google ScholarXinyue ChenView作者出版物您也可以在

PubMed Google ScholarXinyan WuView author publicationsYou can also search for this author in

PubMed Google ScholarXinyan WuView作者出版物您也可以在

PubMed Google ScholarXiaohua HuangView author publicationsYou can also search for this author in

PubMed谷歌学者黄晓华查看作者出版物您也可以在

PubMed Google ScholarNian LiuView author publicationsYou can also search for this author in

PubMed Google ScholarNian LiuView作者出版物您也可以在

PubMed Google ScholarContributionsN.L. and K.L. contributed to the conception and design of the research. K.L. and R.Y. collected samples, analyzed data, and wrote the original manuscript. Y.C., X.C., X.W., and X.H. collected samples and gave some advice. N.L. supervised the research, provided funding, and revised the manuscript.

PubMed谷歌学术贡献。五十、 K.L.为研究的概念和设计做出了贡献。K、 L.和R.Y.收集样本，分析数据并撰写原始手稿。Y、 C.，X.C.，X.W。和X.H.收集了样本并给出了一些建议。N、 L.监督研究，提供资金，并修改手稿。

All authors contributed to the article and approved the submitted version.Corresponding authorCorrespondence to.

所有作者都为文章做出了贡献，并批准了提交的版本。对应作者对应。

Nian Liu.Ethics declarations

。道德宣言

Competing interests

相互竞争的利益

The authors declare no competing interests.

作者声明没有利益冲突。

Ethics approval and consent to participate

道德批准和同意参与

This study was approved by the Ethics Committee of the Affiliated Hospital of North Sichuan Medical College [2022ER406-1]. All of the participants were given the written informed consent.

本研究经川北医学院附属医院伦理委员会批准[2022ER406-1]。所有参与者均获得了书面知情同意书。

Additional informationPublisher’s noteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Rights and permissions

Additional informationPublisher的noteSpringer Nature在已发布地图和机构隶属关系中的管辖权主张方面保持中立。权限和权限

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material.

开放获取本文是根据知识共享署名非商业性NoDerivatives 4.0国际许可证授权的，该许可证允许以任何媒介或格式进行任何非商业性使用，共享，分发和复制，只要您对原始作者和来源给予适当的信任，提供知识共享许可证的链接，并指出您是否修改了许可材料。

You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/..

要查看此许可证的副本，请访问http://creativecommons.org/licenses/by-nc-nd/4.0/..

Reprints and permissionsAbout this articleCite this articleLiao, K., Yu, R., Chen, Y. et al. Alterations of regional brain activity and corresponding brain circuits in drug-naïve adolescents with nonsuicidal self-injury.

。

Sci Rep 14, 24997 (2024). https://doi.org/10.1038/s41598-024-75714-5Download citationReceived: 13 February 2024Accepted: 08 October 2024Published: 23 October 2024DOI: https://doi.org/10.1038/s41598-024-75714-5Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

《科学报告》1424997（2024）。https://doi.org/10.1038/s41598-024-75714-5Download引文接收日期：2024年2月13日接受日期：2024年10月8日发布日期：2024年10月23日OI：https://doi.org/10.1038/s41598-024-75714-5Share本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

Provided by the Springer Nature SharedIt content-sharing initiative

由Springer Nature SharedIt内容共享计划提供

KeywordsNonsuicidal self-injuryAdolescentsAmplitude of low-frequency fluctuationsFunctional connectivityResting-state functional magnetic resonance imaging

关键词非致命性自我伤害青少年低频波动功能连接状态功能磁共振成像

全球产业链接平台

重庆市渝北区金星科技大厦A区5楼512室

联系电话：023-67139735（重庆）

关于我们

产品服务