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含益生菌、益生元、合生元的配方奶粉对足月婴儿生长的有效性和安全性研究——随机对照研究的系统评价和荟萃分析

Effectiveness and safety study of formula containing probiotics, prebiotics, synbiotics on fullterm infants’ growth - a systematic review and meta-analysis of randomized controlled study

Nature 等信源发布 2024-10-24 15:58

可切换为仅中文

AbstractBackground and ObjectiveProbiotics, prebiotics, and synbiotics, are hot topics of research and have been shown to improve the body’s disease state and promote health. Analysis of whether infant formula containing probiotcs, prebiotics, synbiotics is beneficial to infant and child growth.MethodsWe systematically searched multiple electronic databases (PubMed, Web of Science, The Cochrane Library, Embase) to identify eligible studies published from 1966 to December 25, 2022.

摘要背景和目的益生菌，益生元和合生元是研究的热点，已被证明可以改善身体的疾病状态并促进健康。分析含有益生菌、益生元、合生元的婴儿配方奶粉是否有利于婴儿和儿童的生长。方法我们系统地搜索了多个电子数据库（PubMed，Web of Science，Cochrane图书馆，Embase），以确定1966年至2022年12月25日发表的符合条件的研究。

Included studies were randomized controlled trials (RCTs) studying the influence of milk powder containing probiotcs, prebiotics, synbiotics on infants and children’s growth. RevMan 5.4 was used to analyze the data.ResultsA total of 55 RCTs with a total sample size of 8868 participants met the inclusion criteria.

纳入的研究是随机对照试验（RCT），研究含有益生菌，益生元，合生元的奶粉对婴儿和儿童生长的影响。RevMan 5.4用于分析数据。结果共有55项随机对照试验，总样本量为8868名参与者符合纳入标准。

Milk powder with probiotics, prebiotics, synbiotics does not significantly improve the growth of infants and children (Weight, height, BMI, and Head Circumference); The incidence of minor adverse events (OR 0.88, 95% CI 0.70–1.11 P = 0.28) and serious adverse events (OR 0.92, 95% CI 0.62–1.36 P = 0.67) was also comparable to the control group; The intestinal microbial diversity of infants consuming probiotcs, prebiotics, synbiotics supplemented formula was lower than that of infants consuming formula without probiotcs, prebiotics, synbiotics (SMD –0.88, 95% CI –1.66- –0.1 P = 0.03), but the abundance of individual beneficial flora was increased.

含有益生菌，益生元，合生元的奶粉不会显着改善婴儿和儿童的生长（体重，身高，BMI和头围）；轻微不良事件（OR 0.88，95%CI 0.70-1.11 P=0.28）和严重不良事件（OR 0.92，95%CI 0.62-1.36 P=0.67）的发生率也与对照组相当；食用益生菌、益生元、合生元补充配方奶粉的婴儿的肠道微生物多样性低于食用不含益生菌、益生元、合生元的配方奶粉的婴儿（SMD–0.88，95%CI–1.66–0.1 P =0.03），但个体有益菌群的丰度增加。

(SMD 1.62, 95%CI 0.61–2.62 P = 0.002). In particular, the abundance of Lactobacillus (SMD 1.62, 95% CI 0.61–2.62 P = 0.002). For metabolites, synbiotics increased fecal antibody concentrations (SMD 0.47, 95% CI 0.08-0.86 P = 0.02), but fecal short-chain fatty acid concentrations remained balanced in both groups (SMD 0.05 95% CI –0.17–0.28 P = .

（SMD 1.62，95%可信区间0.61-2.62，P=0.002）。特别是乳酸杆菌的丰度（SMD 1.62，95%CI 0.61-2.62，P=0.002）。。

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Fig. 1Fig. 2: Meta-analysis of influence of probiotics, prebiotics, synbiotics on infants’  safety.Fig. 3: Meta-analysis of influence of probiotics, prebiotics, synbiotics on the count of Lactobacillus.Fig. 4: Meta-analysis of influence of prebiotic on Stool frequency.Fig. 5: Meta-analysis of influence of prebiotic on Stool consistency.Fig.

图1图。2： 益生菌，益生元，合生元对婴儿安全性影响的荟萃分析。图3：益生菌，益生元，合生元对乳酸杆菌计数影响的荟萃分析。图4：益生元对粪便频率影响的荟萃分析。图5：益生元对粪便稠度影响的荟萃分析。图。

6: Meta-analysis of influence of prebiotic on Stool pH..

6： 益生元对粪便pH影响的荟萃分析。。

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Download referencesAuthor informationAuthor notesThese authors contributed equally: Jiafen Qian, Zongwei Fang, Sijie Chang.Authors and AffiliationsDepartment of Pharmacy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaJiafen Qian, Zongwei Fang, Sijie Chang, Zhiwei Zeng & Jinhua ZhangAuthorsJiafen QianView author publicationsYou can also search for this author in.

下载参考文献作者信息作者注意到这些作者做出了同样的贡献：钱家芬，方宗伟，常四杰。作者和附属机构福建医科大学妇产科与儿科临床医学院福建妇幼保健院药学系，中国福州钱家芬，方宗伟，常四杰，曾志伟和张金华作者钱家芬观点作者出版物你也可以在中搜索这位作者。

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PubMed Google ScholarContributionsJZ initiated the study. JQ, ZF performed data extraction and analyses, JQ drafted the first version of the manuscript. JZ, SC and ZF critically reviewed the manuscript and revised it. ZZ, SC Performed all verification work. All authors made a substantial contribution to the concept and design of the study, interpreted the data, and reviewed the manuscript.

PubMed Google ScholarContributionsJZ发起了这项研究。JQ，ZF进行了数据提取和分析，JQ起草了手稿的第一版。JZ，SC和ZF严格审查了手稿并对其进行了修订。ZZ，SC进行了所有验证工作。所有作者都对研究的概念和设计做出了重大贡献，解释了数据，并审查了手稿。

Sijie Chang, Zongwei Fang and Jiafen Qian contributed equally to the article.Corresponding authorCorrespondence to.

张四杰、方宗伟和钱家芬对这篇文章的贡献相同。对应作者对应。

Jinhua Zhang.Ethics declarations

。道德宣言

Competing interests

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The authors declare no competing interests.

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Additional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Supplementary informationSupplementary material figures.Appendix1 Search strategyAppendix2 Study population characteristicsAppendix3 ROB 2_IRPG_2018_beta_v6_25Jun2019Appendix4 Forest plot of subgroupAppendix5 stata17-Risk of bias assessmentAppendix6 growth characteristicsAppendix7 SafetyAppendix8 Gut microbiomeAppendix8 Gut microbiomeAppendix10 Gut microbiome and metabolitesRights and permissionsSpringer Nature or its licensor (e.g.

。补充信息补充材料数字。。

a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.Reprints and permissionsAbout this articleCite this articleQian, J., Fang, Z., Chang, S.

协会或其他合作伙伴）根据与作者或其他权利持有人的出版协议对本文拥有专有权；本文接受稿件版本的作者自行存档仅受此类出版协议和适用法律的条款管辖。转载和许可本文引用本文Qian，J.，Fang，Z.，Chang，S。

et al. Effectiveness and safety study of formula containing probiotics, prebiotics, synbiotics on fullterm infants’ growth - a systematic review and meta-analysis of randomized controlled study..

等。含有益生菌、益生元、合生元的配方奶粉对足月婴儿生长的有效性和安全性研究——随机对照研究的系统综述和荟萃分析。。

Eur J Clin Nutr (2024). https://doi.org/10.1038/s41430-024-01506-9Download citationReceived: 25 June 2023Revised: 29 August 2024Accepted: 02 September 2024Published: 24 October 2024DOI: https://doi.org/10.1038/s41430-024-01506-9Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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