AbstractThe aim of this study was to investigate whether triglyceride glucose-body mass index (TyG-BMI) plays a mediating role between obstructive sleep apnoea syndrome (OSAS) and hypertension. The study analyzed clinical data from a total of 840 OSAS patients at Wuhan Union Hospital between January 2020 to December 2023.

摘要本研究的目的是调查甘油三酯-葡萄糖体重指数（TyG-BMI）是否在阻塞性睡眠呼吸暂停综合征（OSAS）和高血压之间起中介作用。该研究分析了2020年1月至2023年12月期间武汉协和医院840名OSAS患者的临床数据。

The association between TyG-BMI and hypertension was examined using restricted cubic spline regression and logistic regression. Mediation effect analysis was conducted to explore the relationship between OSAS, TyG-BMI, and the risk of hypertension. Severe OSAS was associated with a significantly increased risk of hypertension compared to mild OSAS (OR = 1.752, p = 0.013).

使用限制性三次样条回归和逻辑回归检查了TyG BMI与高血压之间的关联。进行中介效应分析以探讨OSAS，TyG BMI与高血压风险之间的关系。与轻度OSAS相比，严重OSAS与高血压风险显着增加相关（OR=1.752，p=0.013）。

There was a positive linear relationship between TyG-BMI and the risk of hypertension (P-non-linear = 0.535). The risk of hypertension increased with increasing TyG-BMI, with a significantly higher risk of hypertension in the fourth quartile (OR = 3.407, p < 0.001) than in the third quartile (OR = 2.457, p < 0.001) and in the second quartile (OR = 1.576, p = 0.043).

TyG BMI与高血压风险之间存在正线性关系（P-非线性=0.535）。高血压风险随着TyG BMI的增加而增加，第四四分位数（OR=3.407，p<0.001）的高血压风险显着高于第三四分位数（OR=2.457，p<0.001）和第二四分位数（OR=1.576，p<0.043）。

TyG-BMI mediated the association between OSAS and hypertension with a mediation effect of 41.3% (p < 0.001). TyG-BMI is important for assessing the risk of hypertension in patients with OSAS..

TyG BMI介导OSAS与高血压之间的关联，中介作用为41.3%（p<0.001）。TyG BMI对于评估OSAS患者的高血压风险很重要。。

IntroductionObstructive sleep apnoea syndrome (OSAS) is a clinical disorder characterized by recurrent apnoea and hypoventilation events during sleep, which may be complicated by nocturnal hypoxaemia. Prolonged nocturnal hypoxia leads to autonomic dysfunction, activation of oxidative stress, and chronic inflammatory responses1.

简介阻塞性睡眠呼吸暂停综合征（OSAS）是一种临床疾病，其特征是睡眠期间反复出现呼吸暂停和通气不足事件，可能伴有夜间低氧血症。长期夜间缺氧导致自主神经功能障碍，氧化应激激活和慢性炎症反应1。

With the obesity epidemic, the prevalence of OSAS is increasing every year2, but it is usually overlooked by patients and physicians because its clinical features are not clearly specific. Its main clinical manifestations are disrupted sleep structure, snoring or breath-holding at night, and daytime drowsiness.

随着肥胖的流行，OSAS的患病率每年都在增加2，但由于其临床特征不明确，通常被患者和医生忽视。其主要临床表现为睡眠结构紊乱，夜间打鼾或屏气，白天嗜睡。

Undetected and untreated OSAS patients are highly susceptible to cardiovascular, neurological, and endocrine diseases3. Studies have reported that OSAS is strongly associated with a number of cardiovascular conditions, including coronary heart disease, heart failure, arrhythmias and stroke4,5,6. Studies have shown that OSAS can increase the risk of hypertension and that positive pressure ventilation therapy has a significant clinical benefit in patients with OSAS combined with hypertension7,8.

未被发现和未经治疗的OSAS患者极易患心血管，神经和内分泌疾病3。研究报道，OSAS与许多心血管疾病密切相关，包括冠心病，心力衰竭，心律失常和中风4,5,6。研究表明，OSAS可增加高血压的风险，正压通气治疗对OSAS合并高血压患者具有显着的临床益处7,8。

Intermittent hypoxia in OSAS is independently associated with insulin resistance, and the prevalence of OSAS is significantly higher in patients with type 2 diabetes9,10. Studies have revealed that the metabolic disorders associated with insulin resistance are linked to hypertension and other cardiovascular diseases11.There is an established relationship between OSAS and hypertension, but few studies have investigated the mediators of this relationship.

OSAS间歇性缺氧与胰岛素抵抗独立相关，2型糖尿病患者OSAS患病率显着升高9,10。研究表明，与胰岛素抵抗相关的代谢紊乱与高血压和其他心血管疾病有关11。OSAS与高血压之间存在既定关系，但很少有研究调查这种关系的介质。

Based on the above research evidence, the present study proposes the following hypothesis: insulin resistance may be a mediator of the association between OSAS and hypertension. The triglyceride-gluco.

基于上述研究证据，本研究提出以下假设：胰岛素抵抗可能是OSAS与高血压之间关联的介质。甘油三酯葡萄糖。

Data availability

数据可用性

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

本研究中使用和/或分析的数据集可根据合理要求从通讯作者处获得。

AbbreviationsOSAS:

缩写OSAS：

Obstructive sleep apnoea syndrome

阻塞性睡眠呼吸暂停综合征

TyG-BMI:

TyG BMI：

Triglyceride glucose-body mass index

甘油三酯葡萄糖体重指数

TyG:

面料：

Triglyceride-glucose

甘油三酯葡萄糖

BMI:

体重指数：

Body mass index

体重指数

AHI:

在那里：

Apnoea-hypopnoea index

呼吸暂停低通气指数

NLR:

NLR：

Neutrophil-lymphocyte ratio

中性粒细胞淋巴细胞比率

ODI:

对外直接投资

Oxygen desaturation index

氧去饱和指数

RCS:

RCS：

Restricted cubic spline

受限三次样条

ORs:

OR：

Odds Ratio

优势比

95% CI:

95%置信区间：

95% confidence interval

95%置信区间

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Download referencesAcknowledgementsWe would like to express our sincere gratitude to all the members of the research team and all the participants who took part in this study.FundingNo funding.Author informationAuthors and AffiliationsGeneral Practice Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, ChinaLiping Wang, Jingfeng Zou, Shaotian Li, Chunhui Tian, Jiajia Ran, Xin Yang, Yiting Liu, Guqiao Nie, Lei Jiang & Wen PengAuthorsLiping WangView author publicationsYou can also search for this author in.

下载参考文献致谢我们要向研究团队的所有成员以及参与本研究的所有参与者表示衷心的感谢。资金没有资金。作者信息作者和附属机构华中科技大学同济医学院联合医院综合实践部，武汉市江汉区解放大道1277号，王丽萍，邹景峰，李少田，田春晖，冉佳佳，杨欣，刘怡婷，聂古桥，蒋磊和彭文作者王丽萍观点作者出版物您也可以在中搜索这位作者。

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PubMed Google ScholarContributionsLW was responsible for study design, statistical software operation, data analysis, and manuscript writing. LW, JZ, SL and CT were involved in project management and data collection. JR, XY, YL were involved in data collection and verification.

。LW、JZ、SL和CT参与了项目管理和数据收集。JR，XY，YL参与了数据收集和验证。

GN reviewed and revised the manuscript. LJ and WP supervised the research project and guided the methodological and conceptual components.Corresponding authorsCorrespondence to.

GN审查并修订了手稿。LJ和WP监督研究项目，并指导方法和概念组成部分。通讯作者通讯。

Lei Jiang or Wen Peng.Ethics declarations

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Competing interests

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The authors declare no competing interests.

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Ethics approval and consent to participate

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This study was approved by the Ethics Committee of Wuhan Union Medical College Hospital (UHCT-IEC-SOP-016-03-01) and informed consent was waived.

这项研究得到了武汉协和医科大学医院伦理委员会（UHCT-IEC-SOP-016-03-01）的批准，并放弃了知情同意。

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Reprints and permissionsAbout this articleCite this articleWang, L., Zou, J., Li, S. et al. Triglyceride glucose-body mass index as a mediator of hypertension risk in obstructive sleep apnoea syndrome: a mediation analysis study.

转载和许可本文引用本文Wang，L.，Zou，J.，Li，S。等人。甘油三酯-葡萄糖体重指数作为阻塞性睡眠呼吸暂停综合征高血压风险的中介：中介分析研究。

Sci Rep 14, 25910 (2024). https://doi.org/10.1038/s41598-024-76378-xDownload citationReceived: 26 May 2024Accepted: 14 October 2024Published: 29 October 2024DOI: https://doi.org/10.1038/s41598-024-76378-xShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

Sci Rep 1425910（2024）。https://doi.org/10.1038/s41598-024-76378-xDownload引文收到日期：2024年5月26日接受日期：2024年10月14日发布日期：2024年10月29日OI：https://doi.org/10.1038/s41598-024-76378-xShare本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

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KeywordsObstructive sleep apnoea syndrome (OSAS)Triglyceride glucose-body mass index (TyG-BMI)HypertensionInsulin resistance

关键词结构性睡眠呼吸暂停综合征（OSAS）甘油三酯葡萄糖体重指数（TyG BMI）高血压胰岛素抵抗