For the 4 in 10 U.S. adults living with obesity, and therefore at increased risk of heart disease,1 Optifast is a non-invasive option to potentially lose weight and preserve heart health

对于每10名美国成年人中就有4名患有肥胖症，因此患心脏病的风险增加，1 Optifast是一种非侵入性的选择，可以潜在地减肥和保护心脏健康

LAUSANNE, Switzerland, Dec. 15, 2023 /PRNewswire/ -- Nestlé Health Science today announced the publication of positive clinical trial results in the journal Diabetes, Obesity, and Metabolism showing that the Optifast® meal replacement program led to significantly greater reductions in weight, blood pressure, cholesterol, and projected cardiovascular (CV) disease risk than a low-calorie food-based diet plan.2.

瑞士洛桑，2023年12月15日/PRNewswire/--雀巢健康科学今天宣布在《糖尿病、肥胖和新陈代谢》杂志上发表了积极的临床试验结果，表明Optifast®膳食替代计划可以显著降低体重、血压、胆固醇，并且预测心血管（CV）疾病的风险比基于低热量食物的饮食计划要高。

The manuscript is based on secondary and exploratory analyses of the year-long OPTIWIN study, a multicenter, randomized, controlled trial involving 273 U.S. adults with obesity, defined as having a body mass index (BMI) ≥30. Study participants who followed a partial or total Optifast meal replacement program experienced double-digit weight loss, down an average of 12.4% of their total body weight at week 26 and maintaining at 10.5% at week 52, which were the study's primary endpoints.

这份手稿是基于长达一年的OPTIWIN研究的二次和探索性分析，这是一项多中心，随机，对照试验，涉及273名美国肥胖成年人，定义为体重指数（BMI）≥30。接受部分或全部Optifast膳食替代计划的研究参与者体重减轻了两位数，在第26周平均下降了总体重的12.4%，在第52周保持在10.5%，这是该研究的主要终点。

By comparison, participants who followed a low-calorie food-based dietary plan experienced significantly less weight loss, down 6.0% at week 26 and 5.5% at week 52..

相比之下，遵循低热量食物饮食计划的参与者体重减轻明显减少，第26周下降6.0%，第52周下降5.5%。。

The new analyses showed the Optifast program also led to significantly greater improvements in LDL-cholesterol, HDL-cholesterol, and triglyceride levels at both 26 weeks and 52 weeks, compared to the food-based diet group. Additionally, the Optifast group had greater reductions in blood pressure, without an accompanying increase in heart rate, and a greater proportion of the Optifast group achieved blood pressures at or below the threshold for hypertension,3 though these effects were no longer significant at week 52.

新的分析显示，与以食物为基础的饮食组相比，Optifast计划在26周和52周时也能显着改善LDL胆固醇，HDL胆固醇和甘油三酯水平。此外，Optifast组的血压下降幅度更大，而心率没有随之增加，并且Optifast组的血压达到或低于高血压阈值的比例更高，3尽管这些影响在第52周不再显着。

At the end of the year-long study period, the Optifast group had a significantly reduced 10-year risk for atherosclerotic CV disease, which was unchanged for the food-based diet group. The positive CV effects of Optifast were most pronounced among those at highest risk of CV disease: people 60 years of age and older and people who had high systolic blood pressure at the start of the study.4.

在为期一年的研究期结束时，Optifast组动脉粥样硬化性心血管疾病的10年风险显着降低，而食物饮食组则没有变化。Optifast的积极心血管效应在心血管疾病风险最高的人群中最为明显：60岁及以上的人群以及研究开始时收缩压高的人群。

'These clinical results show that Optifast meal replacement products can not only deliver double-digit weight loss, but also reduce CV risk burden in people with overweight or obesity. Given the increased CV risk associated with obesity, and up until now the lack of insights into how quality meal replacement programs can modulate this, these are important results,' said Hans-Juergen Woerle, MD, Chief Scientific & Medical Officer of Nestlé Health Science..

“这些临床结果表明，Optifast膳食替代产品不仅可以实现两位数的体重减轻，还可以减轻超重或肥胖人群的心血管风险负担。雀巢健康科学首席科学与医学官Hans Juergen Woerle医学博士说，鉴于与肥胖相关的心血管疾病风险增加，以及到目前为止缺乏对优质膳食替代计划如何调节这一风险的见解，这些都是重要的结果。。

Both groups in the OPTIWIN study participated in individual and group behavioral counselling sessions and received prescriptions for physical activity, with a graduated target of 150-180 minutes/week of moderate-to-vigorous exercise. Both groups also recorded their daily food and exercise.

OPTIWIN研究中的两组都参加了个人和团体行为咨询会议，并接受了体育锻炼处方，每周进行150-180分钟的中度至剧烈运动。两组还记录了他们每天的食物和运动。

Based on food diary data, people in the Optifast group tended to get a greater proportion of their daily calories from protein, which is important for preserving lean muscle mass during weight loss.5 There were no significant differences between the two groups in terms of reported physical activity..

根据食物日记数据，Optifast组的人倾向于从蛋白质中获得更大比例的日常卡路里，这对于在减肥过程中保持瘦肌肉质量很重要。5在报告的体育锻炼方面，两组之间没有显着差异。。

About OptifastThe Optifast program is a non-surgical weight-management option designed for people with a body mass index (BMI) greater than 30. The program, which is available at weight loss clinics across the U.S., is a medically supervised intervention that closely monitors and assesses progress towards better health and emotional well-being.

关于Optifast Optifast计划是一种非手术体重管理选项，专为体重指数（BMI）大于30的人设计。该计划可在美国各地的减肥诊所获得，是一项由医学监督的干预措施，密切监测和评估在改善健康和情绪健康方面的进展。

The program utilizes a meal replacement plan that transitions to self-prepared 'everyday' meals, in conjunction with comprehensive patient education and support to help people lose weight, which can in turn reduce weight-related health risks. Clinical supervision is a key component of the program. Patients in the Optifast program met regularly with their medical provider for monitoring and counselling..

该计划利用膳食替代计划，过渡到自备的“日常”膳食，结合全面的患者教育和支持，帮助人们减肥，从而减少与体重相关的健康风险。临床监督是该计划的关键组成部分。Optifast计划的患者定期与医疗服务提供者会面，以进行监测和咨询。。

The Optifast program was launched in 1976 to fill the growing need to address obesity in a safe and effective way, with medical monitoring as a key component. As diseases related to obesity became more prevalent, the Optifast program was introduced as a sensible option for lifestyle transformation. The Optifast program is offered by Nestlé Health Science and is available in key markets worldwide.

Optifast计划于1976年启动，以满足以安全有效的方式解决肥胖问题的日益增长的需求，医疗监测是关键组成部分。随着与肥胖相关的疾病变得越来越普遍，Optifast计划被引入作为改变生活方式的明智选择。Optifast计划由雀巢健康科学提供，并在全球主要市场提供。

For more information, to see patient stories or to find a weight loss clinic, visit www.optifast.com. .

有关更多信息，请访问www.optifast.com查看患者故事或寻找减肥诊所。

About Nestlé Health Science (NHSc)Nestlé Health Science, a leader in the science of nutrition, is a globally managed business unit of Nestlé. We are committed to redefining the management of health, offering an extensive portfolio of science-based consumer health, medical nutrition, pharmaceutical therapies, and vitamin and supplement brands. Our extensive research network provides the foundation for products that empower healthier lives through nutrition.

关于雀巢健康科学（NHSc）雀巢健康科学是营养科学的领导者，是雀巢全球管理的业务部门。我们致力于重新定义健康管理，提供基于科学的消费者健康、医学营养、药物疗法以及维生素和补充剂品牌的广泛组合。 我们广泛的研究网络为通过营养增强健康生活的产品奠定了基础。

Headquartered in Switzerland, we have more than 12,000 employees around the world, with products available in more than 140 countries. www.nestlehealthscience.com .

总部位于瑞士，我们在全球拥有12000多名员工，产品遍布140多个国家。www.nestlehealthscience.com。

Media contact:[email protected]

媒体联系人：[受电子邮件保护]

1 Centers for Disease Control and Prevention. Adult obesity facts. Accessed on December 8, 2023. Available at: https://www.cdc.gov/obesity/data/adult.html2 Ard, JD, Neeland, IJ, Rothberg, AE, et al. The OPTIFAST total and partial meal replacement programme reduces cardiometabolic risk in adults with obesity: Secondary and exploratory analysis of the OPTIWIN study.

1疾病控制和预防中心。成人肥胖事实。2023年12月8日访问。网址：https://www.cdc.gov/obesity/data/adult.html2Ard，JD，Neeland，IJ，Rothberg，AE等。OPTIFAST全餐和部分膳食替代计划可降低肥胖成年人的心脏代谢风险：OPTIWIN研究的二次和探索性分析。

Diabetes Obes Metab. 2023; 1-11. doi:10.1111/dom.153923 American Heart Association. Understanding blood pressure readings. Accessed on December 8, 2023. Available at: https://www.heart.org/en/health-topics/high-blood-pressure/understanding-blood-pressure-readings4 Centers for Disease Control and Prevention.

糖尿病Obes代谢。2023年；1-11。doi:10.1111/dom.153923美国心脏协会。了解血压读数。2023年12月8日访问。网址：https://www.heart.org/en/health-topics/high-blood-pressure/understanding-blood-pressure-readings4疾病控制和预防中心。

Know your risk for heart disease. Accessed on December 11, 2023. Available at: https://www.cdc.gov/heartdisease/risk_factors.htm5 Josse AR, et al. Increased consumption of dairy foods and protein during diet- and exercise-induced weight loss promotes fat mass loss and lean mass gain in overweight and obese premenopausal women.

了解你患心脏病的风险。2023年12月11日访问。网址：https://www.cdc.gov/heartdisease/risk_factors.htm5Josse AR等人。饮食和运动引起的体重减轻期间乳制品和蛋白质的消耗增加会促进超重和肥胖绝经前女性的脂肪量减少和瘦体重增加。

J Nutr 2011; 141: 1626-34..

《营养杂志》2011；141:1626-34。。

SOURCE Nestlé Health Science

来源雀巢健康科学