Ancestral sequence reconstruction enables the identification and synthesis of ReChb, an ancient form of CRISPR–Cas12a with a highly versatile functionality. ReChb can target any nucleic acid, with minimal restrictions, making it a multipurpose tool for genome editing and genetic diagnostics.

。ReChb可以以最小的限制靶向任何核酸，使其成为基因组编辑和遗传诊断的多用途工具。

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Fig. 1: ReChb, a resurrected ancestor of Cas12a nucleases.

图1:ReChb，Cas12a核酸酶的复活祖先。

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Download referencesAdditional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.This is a summary of: Jabalera, Y. et al. A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection.

下载参考其他信息出版商的注释Springer Nature对于已发布地图和机构隶属关系中的管辖权主张保持中立。这是Jabalera，Y.等人的总结。Cas12a的复活祖先扩展了核酸编辑和检测的靶标访问和底物识别。

Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02461-3 (2024).Rights and permissionsReprints and permissionsAbout this articleCite this article Ancient and versatile CRISPR–Cas nuclease created with ancestral sequence reconstruction..

美国国家生物技术公司。https://doi.org/10.1038/s41587-024-02461-3（2024年）。权利和许可打印和许可本文引用本文通过祖先序列重建创建的古老而通用的CRISPR-Cas核酸酶。。

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