MANHASSET, N.Y.--(BUSINESS WIRE)--Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that causes painful inflammation throughout the body. To study the therapeutic potential of non-invasive vagus nerve stimulation (VNS) to curb lupus-related pain and fatigue, Cynthia Aranow, MD, professor in the Institute of Molecular Medicine at The Feinstein Institutes for Medical Research, has been awarded the Lupus Research Alliance (LRA) inaugural Translational Bridge Award for $450,000 over two years.

纽约曼哈塞特（商业新闻短讯）--系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，会导致全身疼痛性炎症。为了研究无创迷走神经刺激（VNS）抑制狼疮相关疼痛和疲劳的治疗潜力，范斯坦医学研究所分子医学研究所教授辛西娅·阿拉诺（CynthiaAranow）医学博士在两年内获得了狼疮研究联盟（LRA）首届转化桥奖，奖金为45万美元。

This new project builds upon her previous clinical trial, which showed promising results for using transcutaneous, through the ear, VNS to reduce pain and fatigue in lupus patients..

这个新项目建立在她之前的临床试验的基础上，该试验显示了使用经皮，经耳，VNS减轻狼疮患者疼痛和疲劳的有希望的结果。。

“Joint and muscle pain, as well as fatigue, are common and debilitating symptoms of systemic lupus erythematosus that significantly affect quality of life,” said Dr. Aranow. “Our previous research showed that vagus nerve stimulation significantly reduced pain and fatigue associated with lupus, and this new grant from the LRA will allow us to build on our work and move bioelectronic medicine therapy closer to patients who urgently need new treatment options.”.

“关节和肌肉疼痛以及疲劳是系统性红斑狼疮的常见和衰弱症状，严重影响生活质量，”Aranow博士说。“我们之前的研究表明，迷走神经刺激可显着减轻与狼疮相关的疼痛和疲劳，LRA的这项新资助将使我们能够在工作的基础上进一步发展，并将生物电子药物治疗更接近迫切需要新治疗选择的患者。”。

The pilot, single-site trial will involve 18 participants who will receive daily, brief stimulation to the vagus nerve for a period of 28 days. The study will evaluate changes in pain levels and fatigue and explore how this type of stimulation might work to reduce these symptoms. Participants will be monitored for an additional 28 days after the stimulation period to assess the treatment's lasting effects.

这项试点的单点试验将涉及18名参与者，他们将每天接受迷走神经的短暂刺激，持续28天。这项研究将评估疼痛程度和疲劳程度的变化，并探讨这种刺激如何减轻这些症状。在刺激期结束后，将对参与者进行另外28天的监测，以评估治疗的持久效果。

Researchers will monitor blood biomarkers and the effects of stimulation on the gut microbiome and function, including its impact on intestinal permeability (leaky gut), which is linked to the vagus nerve, also known as the gut-brain axis..

研究人员将监测血液生物标志物以及刺激对肠道微生物组和功能的影响，包括其对肠道通透性（肠道渗漏）的影响，肠道通透性与迷走神经（也称为肠脑轴）有关。。

“Bioelectronic medicine holds the unique potential to treat many debilitating and painful autoimmune and inflammatory diseases,” said Kevin J. Tracey, MD, president and CEO of the Feinstein Institutes and Karches Family Distinguished Chair in Medical Research. “Dr. Aranow’s new clinical trial, building off her previous work, explores vagus nerve stimulation to relieve the symptoms of lupus.

“生物电子医学在治疗许多衰弱和痛苦的自身免疫性和炎症性疾病方面具有独特的潜力，”Feinstein Institutes总裁兼首席执行官Kevin J.Tracey医学博士和Karches家族医学研究杰出主席说道。“Aranow博士在之前工作的基础上进行的新临床试验探索了迷走神经刺激以缓解狼疮症状。

This research is much needed and offers hope to millions of people seeking relief.”.

这项研究非常必要，为数百万寻求救济的人带来了希望。”。

Dr. Aranow’s VNS research adds to the growing number of clinical trials being offered at the Feinstein Institutes in the field of bioelectronic medicine including those looking at VNS to treat inflammatory bowel disease in children and adults, post-traumatic stress disorder, and hemorrhaging and bleeding disorders, among others.

Aranow博士的VNS研究增加了Feinstein研究所在生物电子医学领域提供的越来越多的临床试验，包括那些研究VNS治疗儿童和成人炎症性肠病，创伤后应激障碍，出血和出血性疾病等。

Her work has the potential to help change the way lupus pain and fatigue are managed, offering renewed hope for improved quality of life for countless individuals..

她的工作有可能帮助改变狼疮疼痛和疲劳的管理方式，为无数人提高生活质量提供新的希望。。

The Feinstein Institutes for Medical Research is the global scientific leader in bioelectronic medicine and vagus nerve stimulation, where medical researchers use modern technology to develop new device-based therapies to treat disease and injury. Built on decades of research, the field of bioelectronic medicine integrates insights from neuroscience, molecular medicine, and biomedical engineering, and researchers at the Feinstein Institutes leverage the connection between the brain and the immune system to develop bioelectronic medicine interventions..

范斯坦医学研究院（Feinstein Institutes for Medical Research）是生物电子医学和迷走神经刺激领域的全球科学领导者，医学研究人员利用现代技术开发新的基于设备的疗法来治疗疾病和损伤。基于数十年的研究，生物电子医学领域整合了神经科学，分子医学和生物医学工程的见解，范斯坦研究所的研究人员利用大脑和免疫系统之间的联系来开发生物电子医学干预措施。。

The discovery that initiated the field of bioelectronic medicine – called the “inflammatory reflex” – was made more than 20 years ago by Dr. Tracey. This discovery emerged from studies on vagus nerve signaling and showed that the brain and body communicate to regulate inflammation and that, if uncontrolled, inflammation could lead to disease.

20多年前，特雷西博士发现了开创生物电子医学领域的新发现，即“炎症反射”。这一发现来自迷走神经信号传导的研究，表明大脑和身体通过交流来调节炎症，如果不受控制，炎症可能导致疾病。

Today, engineers, computer scientists, immunologists, neuroscientists, and clinicians develop cutting-edge medicine, including neuroimmune modulation, miniature implants for stimulating and recording the vagus nerve, noninvasive ultrasound neuromodulation to suppress inflammation, and novel brain-computer interfaces to overcome injuries of the nervous system.

今天，工程师、计算机科学家、免疫学家、神经科学家和临床医生开发了尖端医学，包括神经免疫调节、刺激和记录迷走神经的微型植入物、抑制炎症的无创超声神经调节以及克服神经系统损伤的新型脑-计算机接口。

These collaborative efforts converge to create personalized, precise treatments that hold promise in treating acute and chronic diseases, often with fewer side effects compared to current therapies. These treatments have the potential to enhance or replace existing treatments across a range of conditions such as arthritis, heart disease, inflammatory bowel diseases, diabetes, cancer, and autoimmune disorders.

这些合作努力汇集在一起，以创造个性化，精确的治疗方法，有望治疗急性和慢性疾病，与目前的治疗方法相比，副作用通常更少。这些治疗方法有可能增强或替代关节炎、心脏病、炎症性肠病、糖尿病、癌症和自身免疫性疾病等一系列疾病的现有治疗方法。

By producing bioelectronic medicine knowledge, disease and injury could one day be treated by our own nerves without costly and potentially harmful pharmaceuticals..

通过产生生物电子医学知识，疾病和伤害有一天可以由我们自己的神经治疗，而不需要昂贵且潜在有害的药物。。

About the Feinstein Institutes

关于范斯坦学院

The Feinstein Institutes for Medical Research is the home of the research institutes of Northwell Health, the largest health care provider and private employer in New York State. Encompassing 50 research labs, 3,000 clinical research studies and 5,000 researchers and staff, the Feinstein Institutes raises the standard of medical innovation through its six institutes of behavioral science, bioelectronic medicine, cancer, health system science, translational research, and molecular medicine.

范斯坦医学研究院（Feinstein Institutes for Medical Research）是纽约州最大的医疗保健提供者和私人雇主Northwell Health研究院的所在地。范斯坦研究所包括50个研究实验室、3000个临床研究和5000名研究人员和工作人员，通过其行为科学、生物电子医学、癌症、卫生系统科学、转化研究和分子医学六个研究所提高了医学创新的标准。

We make breakthroughs in health condition, including endometriosis, lupus, postpartum depression, schizophrenia, sepsis. We are the global scientific leader in bioelectronic medicine – an innovative field of science that has the potential to revolutionize medicine. For more information about how we produce knowledge to cure disease, visit http://feinstein.northwell.edu and follow us on LinkedIn..

我们在健康状况方面取得了突破，包括子宫内膜异位症、狼疮、产后抑郁症、精神分裂症、败血症。我们是生物电子医学领域的全球科学领导者，这是一个有可能彻底改变医学的创新科学领域。有关我们如何产生治疗疾病的知识的更多信息，请访问http://feinstein.northwell.edu并在LinkedIn上关注我们。。