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5-羟色胺能信号在小鼠皮质锥体细胞和SOM中间神经元中的常见和对比作用
Common and contrasting effects of 5-HTergic signaling in pyramidal cells and SOM interneurons of the mouse cortex
Nature 等信源发布 2024-11-07 22:17
可切换为仅中文
AbstractSerotonin (5-hydroxytryptamine, 5-HT) is a powerful modulator of neuronal activity within the central nervous system and dysfunctions of the serotonergic system have been linked to several neuropsychiatric disorders such as major depressive disorders or schizophrenia. The anterior cingulate cortex (aCC) plays an important role in cognitive capture of stimuli and valence processing and it is densely innervated by serotonergic fibers from the nucleus raphe.
摘要5-羟色胺（5-羟色胺，5-HT）是中枢神经系统内神经元活动的强大调节剂，5-羟色胺能系统的功能障碍与几种神经精神疾病有关，如重度抑郁症或精神分裂症。前扣带回皮层（aCC）在刺激的认知捕获和价处理中起着重要作用，它被中缝核的5-羟色胺能纤维密集支配。
In order to understand how pathophysiological 5-HT signalling can lead to neuropsychiatric diseases, it is important to understand the physiological actions of 5-HT on cortical circuits. Therefore, we combined electrophysiological recordings with pharmacology and immunocytochemistry to investigate the effects of 5-HT on Somatostatin-positive interneurons (SOM-INs) and compared these to supragranular pyramidal cells (PCs).
为了了解病理生理学5-HT信号如何导致神经精神疾病，重要的是要了解5-HT对皮质回路的生理作用。因此，我们将电生理记录与药理学和免疫细胞化学相结合，研究5-HT对生长抑素阳性中间神经元（SOM-INs）的影响，并将其与颗粒上锥体细胞（PC）进行比较。
This comparison allowed us to identify common and contrasting effects of 5-HT on SOM-INs and PCs of the aCC resulting in a specific modulation of the excitation-to-inhibition balance in PCs but not in SOM-INs..
这种比较使我们能够确定5-HT对aCC的SOM-INs和PC的共同和对比作用，从而导致PC中激发-抑制平衡的特定调节，而不是SOM-INs。。
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Fig. 1: Differential effect of 5-HT on cell excitability in SOM-INs and PCs.Fig. 2: 5-HTR expression in SOM-INs and PCs.Fig. 3: 5-HT increases the frequency of spontaneous postsynaptic currents in SOM-INs but not in PCs.Fig. 4: 5-HT enhances GABAergic transmission in SOM-INs and PCs.Fig. 5: 5-HT specifically decreases the E/I balance in PCs but not in SOM-Ins..
图1:5-HT对SOM-INs和PC中细胞兴奋性的不同影响。图2:SOM-INs和PC中的5-HTR表达。图3:5-HT增加SOM-INs中自发突触后电流的频率，但不增加PC中的自发突触后电流。图4:5-HT增强SOM-INs和PC中的GABA能传递。图5:5-HT特异性降低PC中的E/I平衡，但不降低SOM-INs中的E/I平衡。。
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All data analyzed in this study are included in this published article.
本研究中分析的所有数据均包含在本文中。
ReferencesGroenewegen HJ, Uylings HB. The prefrontal cortex and the integration of sensory, limbic and autonomic information. Prog Brain Res. 2000;126:3–28. https://doi.org/10.1016/S0079-6123(00)26003-2.Article
参考文献Groenewegen HJ，Uylings HB。前额叶皮层和感觉，边缘和自主信息的整合。；126:3-28。https://doi.org/10.1016/S0079-6123（00）26003-2.文章
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Rikhye RV, Gilra A, Halassa MM. Thalamic regulation of switching between cortical representations enables cognitive flexibility. Nat Neurosci. 2018;21:1753–63. https://doi.org/10.1038/s41593-018-0269-z.Article
Rikhye RV，Gilra A，Halassa MM。丘脑调节皮层表征之间的转换可以实现认知灵活性。Nat Neurosci。2018年；21:1753-63年。https://doi.org/10.1038/s41593-018-0269-z.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, et al. Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell. 2018;175:472–87.e20. https://doi.org/10.1016/j.cell.2018.07.043.Article
Ren J，Friedmann D，Xiong J，Liu CD，Ferguson BR，Weerakkody T等。解剖学定义和功能不同的中缝背侧血清素亚系统。细胞。2018年；。https://doi.org/10.1016/j.cell.2018.07.043.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC. Cognitive inflexibility after prefrontal serotonin depletion. Science. 2004;304:878–80. https://doi.org/10.1126/science.1094987.Article
Clarke HF，Dalley JW，Crofts HS，Robbins TW，Roberts AC.前额叶血清素耗竭后的认知僵硬。科学。2004年；304:878-80。https://doi.org/10.1126/science.1094987.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Hamani C, Mayberg H, Stone S, Laxton A, Haber S, Lozano AM. The subcallosal cingulate gyrus in the context of major depression. Biol Psychiatry. 2011;69:301–8. https://doi.org/10.1016/j.biopsych.2010.09.034.Article
Hamani C，Mayberg H，Stone S，Laxton A，Haber S，Lozano AM。抑郁症背景下的扣带回。生物精神病学。2011年；69:301-8。https://doi.org/10.1016/j.biopsych.2010.09.034.Article
PubMed
PubMed
Google Scholar
谷歌学者
Miranda L. Antidepressant and anxiolytic effects of activating 5HT2A receptors in the anterior cingulate cortex and the theoretical mechanisms underlying them - A scoping review of available literature. Brain Res. 2024;1846:149226. https://doi.org/10.1016/j.brainres.2024.149226.Article .
Miranda L.激活前扣带回皮层中5HT2A受体的抗抑郁和抗焦虑作用及其潜在的理论机制-现有文献的范围综述。Brain Res.2024；1846:149226年。https://doi.org/10.1016/j.brainres.2024.149226.Article。
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Ghaderi A, Brown EC, Clark DL, Ramasubbu R, Kiss ZHT, Protzner AB. Role of the serotonergic system in subcallosal DBS for treatment-resistant depression. Brain Stimul. 2022;15:211–3. https://doi.org/10.1016/j.brs.2021.12.009.Article
Ghaderi A，Brown EC，Clark DL，Ramasubbu R，Kiss ZHT，Protzner AB.5-羟色胺能系统在性腺下DBS治疗难治性抑郁症中的作用。大脑刺激。2022年；15： 211–3。https://doi.org/10.1016/j.brs.2021.12.009.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Rojas PS, Fiedler JL. What Do We Really Know About 5-HT1A Receptor Signaling in Neuronal Cells? Front Cell Neurosci. 2016;10:272. https://doi.org/10.3389/fncel.2016.00272.Article
罗哈斯PS，菲德勒JL。我们真正了解神经元细胞中的5-HT1A受体信号传导吗？前细胞神经科学。2016年；10： 272页。https://doi.org/10.3389/fncel.2016.00272.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Puig MV, Gulledge AT. Serotonin and prefrontal cortex function: neurons, networks, and circuits. Mol Neurobiol. 2011;44:449–64. https://doi.org/10.1007/s12035-011-8214-0.Article
Puig MV，Gulledge AT。血清素和前额叶皮层功能：神经元，网络和电路。摩尔神经生物学。2011年；44:449-64。https://doi.org/10.1007/s12035-011-8214-0.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Czyrak A, Czepiel K, Mackowiak M, Chocyk A, Wedzony K. Serotonin 5-HT1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex. Brain Res. 2003;989:42–51. https://doi.org/10.1016/s0006-8993(03)03352-3.Article
Czyrak A，Czepiel K，Mackowiak M，Chocyk A，Wedzony K.血清素5-HT1A受体可能控制大鼠扣带回皮层谷氨酸能神经元的输出。Brain Res.2003；989:42-51。https://doi.org/10.1016/s0006-8993（03）03352-3.文章
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
DeFelipe J, Arellano JI, Gomez A, Azmitia EC, Munoz A. Pyramidal cell axons show a local specialization for GABA and 5-HT inputs in monkey and human cerebral cortex. J Comp Neurol. 2001;433:148–55. https://doi.org/10.1002/cne.1132.Article
DeFelipe J，Arellano JI，Gomez A，Azmitia EC，Munoz A.锥体细胞轴突在猴子和人类大脑皮层中显示出GABA和5-HT输入的局部特化。J Comp Neurol。2001年；433:148-55。https://doi.org/10.1002/cne.1132.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Jakab RL, Goldman-Rakic PS. 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci USA. 1998;95:735–40. https://doi.org/10.1073/pnas.95.2.735.Article .
。美国国家科学院院刊1998；95:735-40。https://doi.org/10.1073/pnas.95.2.735.Article。
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E. Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels. Neurochem Int. 1998;32:153–62. https://doi.org/10.1016/s0197-0186(97)00087-9.Article
Hagberg GB，Blomstrand F，Nilsson M，Tamir H，Hansson E.在原代培养中刺激星形胶质细胞上的5-HT2A受体可打开电压无关的Ca2+通道。；32:153-62。https://doi.org/10.1016/s0197-0186（97）00087-9.文章
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Stephens EK, Baker AL, Gulledge AT. Mechanisms Underlying Serotonergic Excitation of Callosal Projection Neurons in the Mouse Medial Prefrontal Cortex. Front Neural Circuits. 2018;12:2. https://doi.org/10.3389/fncir.2018.00002.Article
Stephens EK，Baker AL，Gulledge AT。小鼠内侧前额叶皮层胼胝体投射神经元5-羟色胺能兴奋的机制。前神经回路。2018年；12： 。https://doi.org/10.3389/fncir.2018.00002.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Santello M, Bisco A, Nevian NE, Lacivita E, Leopoldo M, Nevian T. The brain-penetrant 5-HT(7) receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain. Neurobiol Dis. 2017;106:214–21. https://doi.org/10.1016/j.nbd.2017.07.005.Article
Santello M，Bisco A，Nevian NE，Lacivita E，Leopoldo M，Nevian T.脑渗透剂5-HT（7）受体激动剂LP-211可减少神经性疼痛的感觉和情感成分。神经生物学疾病。2017年；106:214-21。https://doi.org/10.1016/j.nbd.2017.07.005.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Puig MV, Watakabe A, Ushimaru M, Yamamori T, Kawaguchi Y. Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptors. J Neurosci. 2010;30:2211–22. https://doi.org/10.1523/JNEUROSCI.3335-09.2010.Article
Puig MV，Watakabe A，Ushimaru M，Yamamori T，Kawaguchi Y.血清素通过5-HT1A和5-HT2A受体调节大鼠前额叶皮层的快速尖峰中间神经元和同步活动。J神经科学。2010年；30:2211-22。https://doi.org/10.1523/JNEUROSCI.3335-09.2010.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Goodfellow NM, Benekareddy M, Vaidya VA, Lambe EK. Layer II/III of the prefrontal cortex: Inhibition by the serotonin 5-HT1A receptor in development and stress. J Neurosci. 2009;29:10094–103. https://doi.org/10.1523/JNEUROSCI.1960-09.2009.Article
Goodfellow NM，Benekareddy M，Vaidya VA，Lambe EK。。J神经科学。2009年；29:10094-103。https://doi.org/10.1523/JNEUROSCI.1960-09.2009.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Araneda R, Andrade R. 5-Hydroxytryptamine2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience. 1991;40:399–412. https://doi.org/10.1016/0306-4522(91)90128-b.Article
Araneda R，Andrade R.5-羟色胺2和5-羟色胺1A受体介导对大鼠缔合皮层膜兴奋性的相反反应。神经科学。1991年；40:399-412。https://doi.org/10.1016/0306-4522（91）90128-b.文章
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Amargos-Bosch M, Bortolozzi A, Puig MV, Serrats J, Adell A, Celada P, et al. Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex. Cereb Cortex. 2004;14:281–99. https://doi.org/10.1093/cercor/bhg128.Article
Amargos Bosch M，Bortolozzi A，Puig MV，Serrats J，Adell A，Celada P等。5-羟色胺1A和5-羟色胺2A受体在前额叶皮层锥体神经元中的共表达和体内相互作用。大脑皮层。2004年；14： 281年至99年。https://doi.org/10.1093/cercor/bhg128.Article
PubMed
PubMed
Google Scholar
谷歌学者
Avesar D, Gulledge AT. Selective serotonergic excitation of callosal projection neurons. Front Neural Circuits. 2012;6:12.Article
Avesar D，Gulledge AT。胼胝体投射神经元的选择性5-羟色胺能激发。前神经回路。2012年；6： 12、条款
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Elliott MC, Tanaka PM, Schwark RW, Andrade R Serotonin Differentially Regulates L5 Pyramidal Cell Classes of the Medial Prefrontal Cortex in Rats and Mice. eNeuro. 2018;5. https://doi.org/10.1523/ENEURO.0305-17.2018.Stephens EK, Avesar D, Gulledge AT. Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex.
Elliott MC，Tanaka PM，Schwark RW，Andrade R血清素差异调节大鼠和小鼠内侧前额叶皮层的L5锥体细胞类别。埃纽罗。2018年；5https://doi.org/10.1523/ENEURO.0305-17.2018.StephensEK，Avesar D，Gulledge AT。小鼠前额叶皮层胼胝体投射神经元的活性依赖性血清素能激发。
Front Neural Circuits. 2014;8:97 https://doi.org/10.3389/fncir.2014.00097.Article .
前神经回路。2014年；8： 九十七https://doi.org/10.3389/fncir.2014.00097.Article。
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Hostetler RE, Hu H, Agmon A Genetically Defined Subtypes of Somatostatin-Containing Cortical Interneurons. eNeuro. 2023;10. https://doi.org/10.1523/ENEURO.0204-23.2023.Tremblay R, Lee S, Rudy B. GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits. Neuron. 2016;91:260–92.
Hostetler RE，Hu H，Agmon是一种遗传定义的含有生长抑素的皮质中间神经元亚型。埃纽罗。2023年；10https://doi.org/10.1523/ENEURO.0204-23.2023.Tremblay。神经元。2016年；91:260-92。
https://doi.org/10.1016/j.neuron.2016.06.033.Article .
https://doi.org/10.1016/j.neuron.2016.06.033.Article .
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
de Filippo R, Rost BR, Stumpf A, Cooper C, Tukker JJ, Harms C, et al. Somatostatin interneurons activated by 5-HT(2A) receptor suppress slow oscillations in medial entorhinal cortex. Elife. 2021;10. https://doi.org/10.7554/eLife.66960.Kim D, Jeong H, Lee J, Ghim JW, Her ES, Lee SH, et al.
de Filippo R，Rost BR，Stumpf A，Cooper C，Tukker JJ，Harms C等。由5-HT（2A）受体激活的生长抑素中间神经元抑制内侧内嗅皮层的缓慢振荡。埃利夫。2021年；10https://doi.org/10.7554/eLife.66960.KimD，Jeong H，Lee J，Ghim JW，Her ES，Lee SH等。
Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory. Neuron. 2016;92:902–15. https://doi.org/10.1016/j.neuron.2016.09.023.Article .
表达小白蛋白和生长抑素的中间神经元在工作记忆中的不同作用。神经元。2016年；92:902-15。https://doi.org/10.1016/j.neuron.2016.09.023.Article。
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Williams GV, Rao SG, Goldman-Rakic PS. The physiological role of 5-HT2A receptors in working memory. J Neurosci. 2002;22:2843–54. https://doi.org/10.1523/JNEUROSCI.22-07-02843.2002.Article
Williams GV，Rao SG，Goldman Rakic PS.5-HT2A受体在工作记忆中的生理作用。J神经科学。2002年；22:2843-54。https://doi.org/10.1523/JNEUROSCI.22-07-02843.2002.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Seney ML, Tripp A, McCune S, Lewis DA, Sibille E. Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression. Neurobiol Dis. 2015;73:213–9. https://doi.org/10.1016/j.nbd.2014.10.005.Article
Seney ML，Tripp A，McCune S，Lewis DA，Sibille E.对抑郁症患者膝下前扣带回皮层生长抑素基因表达降低的层流和细胞分析。神经生物学疾病。2015年；73:213-9。https://doi.org/10.1016/j.nbd.2014.10.005.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Tripp A, Kota RS, Lewis DA, Sibille E. Reduced somatostatin in subgenual anterior cingulate cortex in major depression. Neurobiol Dis. 2011;42:116–24. https://doi.org/10.1016/j.nbd.2011.01.014.Article
Tripp A，Kota RS，Lewis DA，Sibille E.减少了抑郁症患者膝下前扣带回皮层中的生长抑素。神经生物学疾病。2011年；42:116-24。https://doi.org/10.1016/j.nbd.2011.01.014.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Liguz-Lecznar M, Dobrzanski G, Kossut M. Somatostatin and Somatostatin-Containing Interneurons-From Plasticity to Pathology. Biomolecules. 2022;12. https://doi.org/10.3390/biom12020312.Scheggia D, Manago F, Maltese F, Bruni S, Nigro M, Dautan D, et al. Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice.
Liguz-Lecznar M，Dobrzanski G，Kossut M.生长抑素和含有生长抑素的中间神经元从可塑性到病理学。生物分子。2022年；12https://doi.org/10.3390/biom12020312.Scheggia。
Nat Neurosci. 2020;23:47–60. https://doi.org/10.1038/s41593-019-0551-8.Article .
纳特神经科学。2020;23:47–60.https://doi.org/10.1038/s41593-019-0551-8.Article.
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Teissier A, Chemiakine A, Inbar B, Bagchi S, Ray RS, Palmiter RD, et al. Activity of Raphe Serotonergic Neurons Controls Emotional Behaviors. Cell Rep. 2015;13:1965–76. https://doi.org/10.1016/j.celrep.2015.10.061.Article
Teissier A，Chemiakine A，Inbar B，Bagchi S，Ray RS，Palmiter RD等。中缝5-羟色胺能神经元的活动控制情绪行为。Cell Rep.2015；13： 1965年至76年。https://doi.org/10.1016/j.celrep.2015.10.061.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Oliva AA Jr, Jiang M, Lam T, Smith KL, Swann JW. Novel hippocampal interneuronal subtypes identified using transgenic mice that express green fluorescent protein in GABAergic interneurons. J Neurosci. 2000;20:3354–68. https://doi.org/10.1523/JNEUROSCI.20-09-03354.2000.Article
奥利瓦AA Jr，江M，林T，史密斯KL，斯旺JW。使用在GABA能中间神经元中表达绿色荧光蛋白的转基因小鼠鉴定出新的海马中间神经元亚型。J神经科学。；20： 3354-68。https://doi.org/10.1523/JNEUROSCI.20-09-03354.2000.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Riedemann T, Schmitz C, Sutor B. Immunocytochemical heterogeneity of somatostatin-expressing GABAergic interneurons in layers II and III of the mouse cingulate cortex: A combined immunofluorescence/design-based stereologic study. J Comp Neurol. 2016;524:2281–99. https://doi.org/10.1002/cne.23948.Article .
Riedemann T，Schmitz C，Sutor B.小鼠扣带回皮层II层和III层中表达生长抑素的GABA能中间神经元的免疫细胞化学异质性：基于免疫荧光/设计的立体组合研究。J Comp Neurol。2016年；524:2281-99。https://doi.org/10.1002/cne.23948.Article。
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Riedemann T, Straub T, Sutor B. Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex. PLoS One. 2018;13:e0200567. https://doi.org/10.1371/journal.pone.0200567.Article
Riedemann T，Straub T，Sutor B.在小鼠扣带皮层的浅层中表达两种生长抑素的GABA能中间神经元。PLoS One。2018年；13： e0200567。https://doi.org/10.1371/journal.pone.0200567.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Riedemann T, Sutor B Cell-Type-Specific Effects of Somatostatin on Synaptic Transmission in the Anterior Cingulate Cortex. J Neurosci. 2024;44. https://doi.org/10.1523/JNEUROSCI.0598-23.2024.Riedemann T, Polder HR, Sutor B Determination and compensation of series resistances during whole-cell patch-clamp recordings using an active bridge circuit and the phase-sensitive technique.
Riedemann T，Sutor B细胞生长抑素对前扣带回皮层突触传递的特异性作用。J神经科学。2024年；44https://doi.org/10.1523/JNEUROSCI.0598-23.2024.RiedemannT，Polder HR，Sutor B使用有源桥电路和相敏技术在全细胞膜片钳记录过程中确定和补偿串联电阻。
Pflugers Arch. 2016;468:1725-40. https://doi.org/10.1007/s00424-016-1868-8.Rothman JS, Silver RA. NeuroMatic: An Integrated Open-Source Software Toolkit for Acquisition, Analysis and Simulation of Electrophysiological Data. Front Neuroinform. 2018;12:14 https://doi.org/10.3389/fninf.2018.00014.Article .
Pflugers拱门。2016年；468:1725-1740年。https://doi.org/10.1007/s00424-016-1868-8.RothmanJS，银色RA。NeuroMatic：用于采集，分析和模拟电生理数据的集成开源软件工具包。前Neuroinform。2018年；12： 十四https://doi.org/10.3389/fninf.2018.00014.Article。
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Santana N, Artigas F. Laminar and Cellular Distribution of Monoamine Receptors in Rat Medial Prefrontal Cortex. Front Neuroanat. 2017;11:87. https://doi.org/10.3389/fnana.2017.00087.Article
Santana N，Artigas F.大鼠内侧前额叶皮层中单胺受体的层状和细胞分布。前神经解剖。2017年；11： 87页。https://doi.org/10.3389/fnana.2017.00087.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Athilingam JC, Ben-Shalom R, Keeshen CM, Sohal VS, Bender KJ Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife. 2017;6. https://doi.org/10.7554/eLife.31991.Ferezou I, Cauli B, Hill EL, Rossier J, Hamel E, Lambolez B.
Athilingam JC，Ben Shalom R，Keeshen CM，Sohal VS，Bender KJ血清素增强小鼠前额叶快速刺激中间神经元的兴奋性和伽玛频率时间整合。埃利夫。2017年；6https://doi.org/10.7554/eLife.31991.Ferezou我，考利B，希尔EL，罗西尔J，哈梅尔E，兰博雷斯B。
5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons. J Neurosci. 2002;22:7389–97. https://doi.org/10.1523/JNEUROSCI.22-17-07389.2002.Article .
5-HT3受体介导新皮层血管活性肠肽/胆囊收缩素中间神经元的5-羟色胺能快速突触兴奋。J神经科学。2002年；22:7389-97。https://doi.org/10.1523/JNEUROSCI.22-17-07389.2002.Article。
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Higa GSV, Francis-Oliveira J, Carlos-Lima E, Tamais AM, Borges FDS, Kihara AH, et al. 5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development. Sci Rep. 2022;12:21015. https://doi.org/10.1038/s41598-022-23767-9.Article
Higa GSV，Francis Oliveira J，Carlos Lima E，Tamais AM，Borges FDS，Kihara AH等。出生后发育中前额叶皮层的5-HT依赖性突触可塑性。Sci代表2022；12： 21015年。https://doi.org/10.1038/s41598-022-23767-9.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Schmitz D, Gloveli T, Empson RM, Heinemann U. Potent depression of stimulus evoked field potential responses in the medial entorhinal cortex by serotonin. Br J Pharm. 1999;128:248–54. https://doi.org/10.1038/sj.bjp.0702788.Article
Schmitz D，Gloveli T，Empson RM，Heinemann U.5-羟色胺对内侧内嗅皮层刺激诱发的场电位反应的有效抑制。Br J Pharm。1999；128:248-54。https://doi.org/10.1038/sj.bjp.0702788.Article
CAS
中科院
Google Scholar
谷歌学者
Torres-Escalante JL, Barral JA, Ibarra-Villa MD, Perez-Burgos A, Gongora-Alfaro JL, Pineda JC. 5-HT1A, 5-HT2, and GABAB receptors interact to modulate neurotransmitter release probability in layer 2/3 somatosensory rat cortex as evaluated by the paired pulse protocol. J Neurosci Res.
Torres Escalante JL，Barral JA，Ibarra Villa MD，Perez Burgos A，Gongora Alfaro JL，Pineda JC。通过配对脉冲方案评估，5-HT1A，5-HT2和GABAB受体相互作用以调节2/3层体感大鼠皮层中神经递质的释放概率。J Neurosci Res。
2004;78:268–78. https://doi.org/10.1002/jnr.20247.Article .
2004;78:268–78. https://doi.org/10.1002/jnr.20247.Article .
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Tian Z, Yamanaka M, Bernabucci M, Zhao MG, Zhuo M. Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex. Mol Brain. 2017;10:21. https://doi.org/10.1186/s13041-017-0303-1.Article
Tian Z，Yamanaka M，Bernabucci M，Zhao MG，Zhuo M.血清素诱导的前扣带回皮层兴奋性突触传递抑制的表征。摩尔大脑。2017年；10： 21岁。https://doi.org/10.1186/s13041-017-0303-1.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Zhou FM, Hablitz JJ. Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. J Neurophysiol. 1999;82:2989–99. https://doi.org/10.1152/jn.1999.82.6.2989.Article
周FM，Hablitz JJ。血清素受体的激活调节大鼠大脑皮层的突触传递。神经生理学杂志。1999年；82:2989-99。https://doi.org/10.1152/jn.1999.82.6.2989.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Beique JC, Imad M, Mladenovic L, Gingrich JA, Andrade R. Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex. Proc Natl Acad Sci USA. 2007;104:9870–5. https://doi.org/10.1073/pnas.0700436104.Article
Beique JC，Imad M，Mladenovic L，Gingrich JA，Andrade R.5-羟色胺2A受体介导的促进前额叶皮层突触活动的机制。美国国家科学院院刊2007；104:9870-5。https://doi.org/10.1073/pnas.0700436104.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Aghajanian GK, Marek GJ. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 1997;36:589–99. https://doi.org/10.1016/s0028-3908(97)00051-8.Article
Aghajanian GK，Marek GJ。5-羟色胺在新皮层锥体细胞的顶端树突中诱导兴奋性突触后电位。神经药理学。1997年；36:589-99。https://doi.org/10.1016/s0028-3908（97）00051-8.文章
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Aghajanian GK, Marek GJ. Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain Res. 1999;825:161–71. https://doi.org/10.1016/s0006-8993(99)01224-x.Article
Aghajanian GK，Marek GJ。血清素通过5-HT2A受体通过谷氨酸释放的异步模式增加前额叶皮层V层锥体细胞中的EPSC。Brain Res.1999；825:161-71。https://doi.org/10.1016/s0006-8993（99）01224-x.文章
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Barre A, Berthoux C, De Bundel D, Valjent E, Bockaert J, Marin P, et al. Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning. Proc Natl Acad Sci USA. 2016;113:E1382–91. https://doi.org/10.1073/pnas.1525586113.Article
。美国国家科学院院刊2016；113:E1382-91。https://doi.org/10.1073/pnas.1525586113.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Beique JC, Campbell B, Perring P, Hamblin MW, Walker P, Mladenovic L, et al. Serotonergic regulation of membrane potential in developing rat prefrontal cortex: coordinated expression of 5-hydroxytryptamine (5-HT)1A, 5-HT2A, and 5-HT7 receptors. J Neurosci. 2004;24:4807–17. https://doi.org/10.1523/JNEUROSCI.5113-03.2004.Article .
Beique JC，Campbell B，Perring P，Hamblin MW，Walker P，Mladenovic L等。发育中的大鼠前额叶皮层中膜电位的5-羟色胺能调节：5-羟色胺（5-HT）1A，5-HT2A和5-HT7受体的协调表达。J神经科学。2004年；24:4807-17。https://doi.org/10.1523/JNEUROSCI.5113-03.2004.Article。
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Liu Q, Wong-Riley MT. Postnatal changes in cytochrome oxidase expressions in brain stem nuclei of rats: implications for sensitive periods. J Appl Physiol (1985). 2003;95:2285–91. https://doi.org/10.1152/japplphysiol.00638.2003.Article
Liu Q，Wong Riley MT。大鼠脑干核细胞色素氧化酶表达的出生后变化：对敏感期的影响。J Appl Physiol（1985）。2003年；95:2285-91。https://doi.org/10.1152/japplphysiol.00638.2003.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Schwaller F, Kanellopoulos AH, Fitzgerald M. The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord. Sci Rep. 2017;7:2215. https://doi.org/10.1038/s41598-017-02509-2.Article
Schwaller F，Kanellopoulos AH，Fitzgerald M.感觉脊髓差异脑干血清素能控制的发育出现。Sci代表2017；7： 2215年。https://doi.org/10.1038/s41598-017-02509-2.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Zhang ZW. Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development. J Neurosci. 2003;23:3373–84. https://doi.org/10.1523/JNEUROSCI.23-08-03373.2003.Article
张志伟。5-羟色胺在出生后发育过程中诱导大鼠前额叶皮层V层锥体神经元的强直放电。J神经科学。2003年；。https://doi.org/10.1523/JNEUROSCI.23-08-03373.2003.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Hu H, Cavendish JZ, Agmon A. Not all that glitters is gold: off-target recombination in the somatostatin-IRES-Cre mouse line labels a subset of fast-spiking interneurons. Front Neural Circuits. 2013;7:195. https://doi.org/10.3389/fncir.2013.00195.Article
Hu H，Cavendish JZ，Agmon A.并非所有闪闪发光的都是黄金：生长抑素IRES-Cre小鼠系中的脱靶重组标记了快速尖峰中间神经元的一个子集。前神经回路。2013年；7： 195年。https://doi.org/10.3389/fncir.2013.00195.Article
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Large AM, Kunz NA, Mielo SL, Oswald AM. Inhibition by Somatostatin Interneurons in Olfactory Cortex. Front Neural Circuits. 2016;10:62 https://doi.org/10.3389/fncir.2016.00062.Article
Large AM，Kunz NA，Mielo SL，Oswald AM。嗅觉皮层中生长抑素中间神经元的抑制作用。前神经回路。2016年；10： 62个https://doi.org/10.3389/fncir.2016.00062.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Nassar M, Simonnet J, Lofredi R, Cohen I, Savary E, Yanagawa Y, et al. Diversity and overlap of parvalbumin and somatostatin expressing interneurons in mouse presubiculum. Front Neural Circuits. 2015;9:20. https://doi.org/10.3389/fncir.2015.00020.Article
Nassar M，Simonnet J，Lofredi R，Cohen I，Savary E，Yanagawa Y等。小鼠睾丸前叶中表达小白蛋白和生长抑素的中间神经元的多样性和重叠。前神经回路。2015年；9： 二十。https://doi.org/10.3389/fncir.2015.00020.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Nigro MJ, Hashikawa-Yamasaki Y, Rudy B. Diversity and Connectivity of Layer 5 Somatostatin-Expressing Interneurons in the Mouse Barrel Cortex. J Neurosci. 2018;38:1622–33. https://doi.org/10.1523/JNEUROSCI.2415-17.2017.Article
Nigro MJ，Hashikawa Yamasaki Y，Rudy B.小鼠桶皮层中表达第5层生长抑素的中间神经元的多样性和连通性。J神经科学。2018年；38:1622-33年。https://doi.org/10.1523/JNEUROSCI.2415-17.2017.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Andrade R, Nicoll RA. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn Schmiedebergs Arch Pharm. 1987;336:5–10. https://doi.org/10.1007/BF00177743.Article
。新型抗焦虑药区分突触后5-羟色胺受体介导大鼠海马单个神经元的不同生理反应。Naunyn Schmiedebergs Arch Pharm。1987；336:5-10。https://doi.org/10.1007/BF00177743.Article
CAS
中科院
Google Scholar
谷歌学者
Colino A, Halliwell JV. Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin. Nature. 1987;328:73–7. https://doi.org/10.1038/328073a0.Article
科利诺A，哈利维尔合资公司。5-羟色胺对海马CA1神经元中三个独立K电导的差异调节。自然。1987年；328:73-7。https://doi.org/10.1038/328073a0.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
De Vivo M, Maayani S. Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes. J Pharm Exp Ther. 1986;238:248–53.
De Vivo M，Maayani S.豚鼠和大鼠海马膜中5-羟色胺1A受体介导的福司柯林刺激的腺苷酸环化酶活性抑制的表征。J Pharm Exp Ther。1986年；238:248-53。
Google Scholar
谷歌学者
Weiss S, Sebben M, Kemp DE, Bockaert J. Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons. Eur J Pharm. 1986;120:227–30. https://doi.org/10.1016/0014-2999(86)90544-3.Article
Weiss S，Sebben M，Kemp DE，Bockaert J.血清素5-HT1受体介导神经元中环AMP产生的抑制。欧洲药理学杂志，1986年；120:227-30。https://doi.org/10.1016/0014-2999（86）90544-3.文章
CAS
中科院
Google Scholar
谷歌学者
Zgombick JM, Beck SG, Mahle CD, Craddock-Royal B, Maayani S. Pertussis toxin-sensitive guanine nucleotide-binding protein(S) couple adenosine A1 and 5-hydroxytryptamine1A receptors to the same effector systems in rat hippocampus: biochemical and electrophysiological studies. Mol Pharm.
Zgombick JM，Beck SG，Mahle CD，Craddock Royal B，Maayani百日咳毒素敏感的鸟嘌呤核苷酸结合蛋白将腺苷A1和5-羟色胺1A受体偶联到大鼠海马中的相同效应系统：生化和电生理研究。摩尔制药。
1989;35:484–94.CAS .
1989年；35:484-94。科学院。
Google Scholar
谷歌学者
Grunschlag CR, Haas HL, Stevens DR. 5-HT inhibits lateral entorhinal cortical neurons of the rat in vitro by activation of potassium channel-coupled 5-HT1A receptors. Brain Res. 1997;770:10–7. https://doi.org/10.1016/s0006-8993(97)00738-5.Article
Grunschlag CR，Haas HL，Stevens DR.5-HT通过激活钾通道偶联的5-HT1A受体在体外抑制大鼠的外侧内嗅皮层神经元。Brain Res.1997；770:10-7。https://doi.org/10.1016/s0006-8993（97）00738-5.文章
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Deng PY, Poudel SK, Rojanathammanee L, Porter JE, Lei S. Serotonin inhibits neuronal excitability by activating two-pore domain k+ channels in the entorhinal cortex. Mol Pharm. 2007;72:208–18. https://doi.org/10.1124/mol.107.034389.Article
Deng PY，Poudel SK，Rojanathammane L，Porter JE，Lei S.血清素通过激活内嗅皮层中的两个孔结构域k+通道来抑制神经元兴奋性。摩尔制药。2007；72:208-18。https://doi.org/10.1124/mol.107.034389.Article
CAS
中科院
Google Scholar
谷歌学者
Berg KA, Maayani S, Goldfarb J, Scaramellini C, Leff P, Clarke WP. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Mol Pharm. 1998;54:94–104.Article
Berg KA，Maayani S，Goldfarb J，Scaramellini C，Leff P，Clarke WP。5-羟色胺2A型和2C型受体的效应子途径依赖性相对功效：激动剂定向运输受体刺激的证据。Mol Pharm。1998；54:94–104.文章
CAS
中科院
Google Scholar
谷歌学者
Nakaki T, Roth BL, Chuang DM, Costa E. Phasic and tonic components in 5-HT2 receptor-mediated rat aorta contraction: participation of Ca++ channels and phospholipase C. J Pharm Exp Ther. 1985;234:442–6.CAS
Nakaki T，Roth BL，Chuang DM，Costa E.5-HT2受体介导的大鼠主动脉收缩中的相位和张力成分：Ca++通道和磷脂酶C.J Pharm Exp Ther的参与。1985年；234:442–6.CAS
Google Scholar
谷歌学者
Okoro EO. Overlap in the pharmacology of L-type Ca2+-channel blockers and 5-HT2 receptor antagonists in rat aorta. J Pharm Pharm. 1999;51:953–7. https://doi.org/10.1211/0022357991773221.Article
Okoro EO公司。。J Pharm Pharm。1999；51:953-7。https://doi.org/10.1211/0022357991773221.Article
CAS
中科院
Google Scholar
谷歌学者
Baker A, Kalmbach B, Morishima M, Kim J, Juavinett A, Li N, et al. Specialized Subpopulations of Deep-Layer Pyramidal Neurons in the Neocortex: Bridging Cellular Properties to Functional Consequences. J Neurosci. 2018;38:5441–55. https://doi.org/10.1523/JNEUROSCI.0150-18.2018.Article .
Baker A，Kalmbach B，Morishima M，Kim J，Juavinett A，Li N等。新皮层深层锥体神经元的特殊亚群：将细胞特性与功能后果联系起来。J神经科学。2018年；38:5441-55。https://doi.org/10.1523/JNEUROSCI.0150-18.2018.Article。
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Avesar D, Stephens EK, Gulledge AT. Serotonergic Regulation of Corticoamygdalar Neurons in the Mouse Prelimbic Cortex. Front Neural Circuits. 2018;12:63. https://doi.org/10.3389/fncir.2018.00063.Article
Avesar D，Stephens EK，Gulledge AT。小鼠前肢皮层皮质杏仁核神经元的5-羟色胺能调节。前神经回路。2018年；12： 63页。https://doi.org/10.3389/fncir.2018.00063.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
van Aerde KI, Feldmeyer D. Morphological and physiological characterization of pyramidal neuron subtypes in rat medial prefrontal cortex. Cereb Cortex. 2015;25:788–805. https://doi.org/10.1093/cercor/bht278.Article
van Aerde KI，Feldmeyer D.大鼠内侧前额叶皮层锥体神经元亚型的形态学和生理学表征。大脑皮层。2015年；25:788-805。https://doi.org/10.1093/cercor/bht278.Article
PubMed
PubMed
Google Scholar
谷歌学者
Weiler S, Guggiana Nilo D, Bonhoeffer T, Hubener M, Rose T, Scheuss V. Functional and structural features of L2/3 pyramidal cells continuously covary with pial depth in mouse visual cortex. Cereb Cortex. 2023;33:3715–33. https://doi.org/10.1093/cercor/bhac303.Article
Weiler S，Guggiana Nilo D，Bonhoeffer T，Hubener M，Rose T，Scheuss V.L2/3锥体细胞的功能和结构特征与小鼠视觉皮层的软脑膜深度持续共变。大脑皮层。2023年；33:3715-33。https://doi.org/10.1093/cercor/bhac303.Article
PubMed
PubMed
Google Scholar
谷歌学者
Gouwens NW, Sorensen SA, Berg J, Lee C, Jarsky T, Ting J, et al. Classification of electrophysiological and morphological neuron types in the mouse visual cortex. Nat Neurosci. 2019;22:1182–95. https://doi.org/10.1038/s41593-019-0417-0.Article
Gouwens NW，Sorensen SA，Berg J，Lee C，Jarsky T，Ting J等。小鼠视觉皮层中电生理和形态神经元类型的分类。Nat Neurosci。2019年；22:1182年至1995年。https://doi.org/10.1038/s41593-019-0417-0.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Song C, Moyer JR Jr. Layer- and subregion-specific differences in the neurophysiological properties of rat medial prefrontal cortex pyramidal neurons. J Neurophysiol. 2018;119:177–91. https://doi.org/10.1152/jn.00146.2017.Article
Song C，Moyer JR。大鼠内侧前额叶皮层锥体神经元神经生理学特性的层和亚区特异性差异。神经生理学杂志。2018年；119:177-91。https://doi.org/10.1152/jn.00146.2017.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Xiang Z, Prince DA. Heterogeneous actions of serotonin on interneurons in rat visual cortex. J Neurophysiol. 2003;89:1278–87. https://doi.org/10.1152/jn.00533.2002.Article
向子，达王子。5-羟色胺对大鼠视皮层中间神经元的异质作用。神经生理学杂志。2003年；89:1278年至87年。https://doi.org/10.1152/jn.00533.2002.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Karnani MM, Jackson J, Ayzenshtat I, Hamzehei Sichani A, Manoocheri K, Kim S, et al. Opening Holes in the Blanket of Inhibition: Localized Lateral Disinhibition by VIP Interneurons. J Neurosci. 2016;36:3471–80. https://doi.org/10.1523/JNEUROSCI.3646-15.2016.Article
Karnani MM，Jackson J，Ayzenshtat I，Hamzehei Sichani A，Manoocheri K，Kim S等。在抑制毯中打开孔：VIP中间神经元的局部侧向去抑制。J神经科学。2016年；36:3471-80。https://doi.org/10.1523/JNEUROSCI.3646-15.2016.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M. Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nat Neurosci. 2013;16:1068–76. https://doi.org/10.1038/nn.3446.Article
。Nat Neurosci。2013年；16： 1068-76年。https://doi.org/10.1038/nn.3446.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Tokarski K, Kusek M, Hess G. 5-HT7 receptors modulate GABAergic transmission in rat hippocampal CA1 area. J Physiol Pharm. 2011;62:535–40.CAS
Tokarski K，Kusek M，Hess G.5-HT7受体调节大鼠海马CA1区的GABA能传递。J Physiol Pharm。2011；62:535–40.CAS
Google Scholar
谷歌学者
Brys I, Barrientos SA, Ward JE, Wallander J, Petersson P, Halje P. 5-HT2AR and NMDAR psychedelics induce similar hyper-synchronous states in the rat cognitive-limbic cortex-basal ganglia system. Commun Biol. 2023;6:737. https://doi.org/10.1038/s42003-023-05093-6.Article
Brys I，Barrientos SA，Ward JE，Wallander J，Petersson P，Halje P。5-HT2AR和NMDAR迷幻剂在大鼠认知边缘皮层-基底神经节系统中诱导相似的超同步状态。社区生物。2023年；6： 737页。https://doi.org/10.1038/s42003-023-05093-6.Article
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Wood J, Kim Y, Moghaddam B. Disruption of prefrontal cortex large scale neuronal activity by different classes of psychotomimetic drugs. J Neurosci. 2012;32:3022–31. https://doi.org/10.1523/JNEUROSCI.6377-11.2012.Article
Wood J，Kim Y，Moghaddam B.不同类别的拟精神药物对前额叶皮层大规模神经元活动的破坏。J神经科学。2012年；32:3022-31。https://doi.org/10.1523/JNEUROSCI.6377-11.2012.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
McGinty DJ, Harper RM. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res. 1976;101:569–75. https://doi.org/10.1016/0006-8993(76)90480-7.Article
McGinty DJ，Harper RM。背中缝神经元：猫睡眠期间的放电抑制。Brain Res.1976；101:569-75。https://doi.org/10.1016/0006-8993（76）90480-7.文章
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Menon JML, Nolten C, Achterberg EJM, Joosten R, Dematteis M, Feenstra MGP, et al. Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation - a Systematic Review, Network Meta-analysis, and New Primary Data. J Circadian Rhythms. 2019;17:1. https://doi.org/10.5334/jcr.174.Article .
Menon JML，Nolten C，Achterberg EJM，Joosten R，Dematteis M，Feenstra MGP等。脑微透析液单胺与昼夜节律，睡眠和睡眠剥夺的关系-系统评价，网络荟萃分析和新的主要数据。J昼夜节律。2019年；17： 一。https://doi.org/10.5334/jcr.174.Article。
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Oikonomou G, Altermatt M, Zhang RW, Coughlin GM, Montz C, Gradinaru V, et al. The Serotonergic Raphe Promote Sleep in Zebrafish and Mice. Neuron. 2019;103:686–701.e8. https://doi.org/10.1016/j.neuron.2019.05.038.Article
Oikonomou G，Altermatt M，Zhang RW，Coughlin GM，Montz C，Gradinaru V等。血清素能中缝促进斑马鱼和小鼠的睡眠。神经元。2019年；103:686-701.e8。https://doi.org/10.1016/j.neuron.2019.05.038.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Sanchez S, Sanchez C, Paredes SD, Cubero J, Rodriguez AB, Barriga C. Circadian variations of serotonin in plasma and different brain regions of rats. Mol Cell Biochem. 2008;317:105–11. https://doi.org/10.1007/s11010-008-9836-z.Article
Sanchez S，Sanchez C，Paredes SD，Cubero J，Rodriguez AB，Barriga C.大鼠血浆和不同脑区血清素的昼夜节律变化。摩尔细胞生物化学。2008年；317:105-11。https://doi.org/10.1007/s11010-008-9836-z.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, et al. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. 2020;183:1986–2002.e26. https://doi.org/10.1016/j.cell.2020.11.040.Article
Unger EK，Keller JP，Altermatt M，Liang R，Matsui A，Dong C等。通过机器学习指导选择性和敏感性血清素传感器的进化。细胞。2020年；183:1986-2002.e26。https://doi.org/10.1016/j.cell.2020.11.040.Article
CAS
中科院
PubMed
PubMed
PubMed Central
公共医学中心
Google Scholar
谷歌学者
Bridi MCD, Zong FJ, Min X, Luo N, Tran T, Qiu J, et al. Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits. Neuron. 2020;105:621–9.e4. https://doi.org/10.1016/j.neuron.2019.11.011.Article
Bridi MCD，Zong FJ，Min X，Luo N，Tran T，Qiu J等。视觉皮层回路中兴奋-抑制平衡的每日振荡。神经元。2020年；105:621-9.e4。https://doi.org/10.1016/j.neuron.2019.11.011.Article
CAS
中科院
PubMed
PubMed
Google Scholar
谷歌学者
Download referencesAcknowledgementsWe would like to thank Gabi Horn for excellent technical assistance. Friedrich-Baur Stiftung (03/21) and FöFoLe (21/2020) provided funding for this project.Author informationAuthor notesThese authors contributed equally: Nathalie Schmitz, Sadat Hodzic.Authors and AffiliationsDepartment of Physiological Genomics, Institute of Physiology, Biomedical Center, Ludwig-Maximilians-Universität München, 82152, Planegg-Martinsried, GermanyNathalie Schmitz, Sadat Hodzic & Therese RiedemannCenter of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology, Paracelsus Medical University, Strubergasse 22, 5020, Salzburg, AustriaTherese RiedemannAuthorsNathalie SchmitzView author publicationsYou can also search for this author in.
下载参考文献致谢我们要感谢Gabi Horn提供的出色技术援助。Friedrich Baur Stiftung（03/21）和FöFoLe（21/2020）为该项目提供了资金。作者信息作者注意到这些作者做出了同样的贡献：Nathalie Schmitz，Sadat Hodzic。作者和附属机构慕尼黑路德维希·马克西米利安大学生物医学中心生理学研究所生理基因组学系，82152，Planegg Martinsried，GermanyNathalie Schmitz，Sadat Hodzic＆Therese Riedmanncenter of Physiology，Pathologysiology and Biophysics，Paracelsus医科大学生理学和病理生理学研究所，Strubergasse 225020，Salzburg，Australiatherese Riedmanauthorsnathalie SchmitzView作者出版物您也可以在中搜索这位作者。
PubMed Google ScholarSadat HodzicView author publicationsYou can also search for this author in
PubMed Google ScholarSadat HodzicView作者出版物您也可以在
PubMed Google ScholarTherese RiedemannView author publicationsYou can also search for this author in
PubMed Google ScholarTherese RiedemannView作者出版物您也可以在
PubMed Google ScholarContributionsSH: Data collection, analysis, revision of manuscript; NS: Conceptualization, data collection, analysis, writing of initial draft; TR: Funding acquisition, conceptualization, supervision, data collection, writing of initial draft, revision of manuscript.Corresponding authorCorrespondence to.
PubMed谷歌学术贡献SSH：数据收集，分析，稿件修订；NS：概念化，数据收集，分析，初稿撰写；TR：资金获取，概念化，监督，数据收集，初稿撰写，稿件修订。对应作者对应。
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Additional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Supplementary informationSupplemental MaterialRights and permissionsSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.Reprints and permissionsAbout this articleCite this articleSchmitz, N., Hodzic, S.
Additional informationPublisher的注释Springer Nature在已发布的地图和机构隶属关系中的管辖权主张方面保持中立。补充信息补充材料权利和许可Pringer Nature或其许可方（例如协会或其他合作伙伴）根据与作者或其他权利持有人的出版协议对本文拥有专有权；本文接受稿件版本的作者自行存档仅受此类出版协议和适用法律的条款管辖。转载和许可本文引用本文Schmitz，N.，Hodzic，S。
& Riedemann, T. Common and contrasting effects of 5-HTergic signaling in pyramidal cells and SOM interneurons of the mouse cortex..
&Riedemann，T。5-HTergic信号在小鼠皮层锥体细胞和SOM中间神经元中的常见和对比作用。。
Neuropsychopharmacol. (2024). https://doi.org/10.1038/s41386-024-02022-xDownload citationReceived: 14 July 2024Revised: 03 October 2024Accepted: 26 October 2024Published: 07 November 2024DOI: https://doi.org/10.1038/s41386-024-02022-xShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.
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