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register hereHelicobacter pylori (H. pylori), a globally prevalent pathogen Group I carcinogen, presents a formidable challenge in gastric cancer prevention due to its increasing antimicrobial resistance and strain diversity. This comprehensive review critically analyzes the limitations of conventional antibiotic-based therapies and explores cutting-edge approaches to combat H.

在这里登记幽门螺杆菌（H.pylori）是一种全球流行的病原体I组致癌物，由于其抗菌耐药性和菌株多样性的增加，在胃癌预防方面提出了巨大的挑战。这篇全面的综述批判性地分析了传统抗生素疗法的局限性，并探索了对抗H的前沿方法。

pylori infections and associated gastric carcinogenesis. We emphasize the pressing need for innovative therapeutic strategies, with a particular focus on precision medicine and tailored vaccine development. Despite promising advancements in enhancing host immunity, current Helicobacter pylori vaccine clinical trials have yet to achieve long-term efficacy or gain approval regulatory approval.

幽门螺杆菌感染和相关的胃癌发生。我们强调迫切需要创新的治疗策略，特别关注精准医学和量身定制的疫苗开发。尽管在增强宿主免疫力方面取得了有希望的进展，但目前的幽门螺杆菌疫苗临床试验尚未取得长期疗效或获得监管部门的批准。

We propose an paradigm-shifting approach leveraging artificial intelligence (AI) to design precision-targeted, multiepitope vaccines tailored to multiple H. pylori subtypes. This AI-driven strategy has the potential to revolutionize antigen selection and optimize vaccine efficacy, addressing the critical need for personalized interventions in H.

我们提出了一种利用人工智能（AI）设计针对多种幽门螺杆菌亚型的精确靶向多表位疫苗的范式转换方法。这种人工智能驱动的策略有可能彻底改变抗原选择并优化疫苗功效，从而解决H中个性化干预的关键需求。

pylori eradication efforts. By leveraging AI in vaccine design, we propose a revolutionary approach to precision therapy that could significantly reduce H. pylori -associated gastric cancer burden..

根除幽门螺杆菌的努力。通过在疫苗设计中利用AI，我们提出了一种革命性的精确治疗方法，可以显着降低幽门螺杆菌相关的胃癌负担。。