NEW YORK – Complete Genomics highlighted efforts to bring multiomics and spatial biology capabilities to its sequencing customers at the American Society of Human Genetics annual meeting last week.

纽约——上周，在美国人类遗传学学会年会上，Complete Genomics强调了为其测序客户带来多组学和空间生物学功能的努力。

The US subsidiary of Chinese next-generation sequencing instrument maker MGI Tech is already offering products based on Stereo-seq, a spatial transcriptomics technology originally developed by researchers affiliated with BGI Group.

中国下一代测序仪器制造商MGI Tech的美国子公司已经在提供基于Stereo-seq的产品，Stereo-seq是一种空间转录组学技术，最初由BGI集团下属的研究人员开发。

At the meeting, it unveiled Go Spatial, an automated sample processing platform for the Stereo-seq workflow, as well as FluoXpert, which promises to give its DNBSeq-G400 sequencer protein analysis capabilities with a software upgrade.

在会议上，它推出了用于Stereo-seq工作流程的自动样品处理平台Go Spatial，以及FluoXpert，它承诺通过软件升级提供其DNBSeq-G400测序仪蛋白质分析功能。

'Obviously, multiomics is not just the genome,' said Rob Tarbox, Complete Genomics' VP of product and marketing. 'We want our technology to be able to work with and generate all the kinds of data that our customers want to generate.'

“显然，多组学不仅仅是基因组学，”Complete Genomics的产品和营销副总裁罗伯·塔博克斯（RobTarbox）说我们希望我们的技术能够处理并生成客户想要生成的各种数据。”

Stereo-seq

立体声序列

According to Tarbox, Complete Genomics became the exclusive US distributor of STOmics Tech — a BGI Group subsidiary that has commercialized the Stereo-seq technology — in early July. Despite both being affiliated with BGI, Complete Genomics' relationship with STOmics is 'very much a distributorship in every facet,' Tarbox said, though he declined to disclose financial details.

。Tarbox说，尽管两者都隶属于BGI，但Complete Genomics与STOmics的关系“在各个方面都是一种分销关系”，尽管他拒绝透露财务细节。

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Currently, STOmics carries products for analyzing fresh frozen and formalin-fixed paraffin-embedded (FFPE) tissue samples. For fresh frozen and FFPE samples, the company offers 1 cm x 1 cm chips, as well as 2 cm x 3 cm chips for fresh frozen samples.

目前，STOmics携带用于分析新鲜冷冻和福尔马林固定石蜡包埋（FFPE）组织样品的产品。对于新鲜冷冻和FFPE样品，该公司提供1厘米x 1厘米的芯片，以及用于新鲜冷冻样品的2厘米x 3厘米芯片。

According to a Complete Genomics spokesperson, the cost for the Stereo-seq workflow, including sequencing, is $56 for the first run and $49 for the second run on the smaller chips and $81 for the first and $67 for the second run on the larger chip.

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STOmics also offers Stereo-seq Analysis Workflow (SAW) software, a suite of pipelines that enables spatial data analysis, expression quantification, and data visualization.

STOmics还提供Stereo-seq Analysis Workflow（SAW）软件，这是一套管道，可实现空间数据分析，表达量化和数据可视化。

Compared to existing products in the market, Tarbox said one advantage of Stereo-seq is the large field of view for fresh frozen samples. In addition, the technology employs a non-targeted, species-agnostic, and non-probed-based approach, enabling researchers to achieve hypothesis-free spatial transcriptomics analysis.

Tarbox表示，与市场上现有产品相比，Stereo-seq的一个优势是新鲜冷冻样品的视野较大。此外，该技术采用了非靶向，物种不可知和非探测的方法，使研究人员能够实现无假设的空间转录组学分析。

The technology has also shown to be competitive in an independent benchmarking study. .

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The company plans to target researchers who hope to study larger tissue samples or organ slices with its fresh frozen products and oncology researchers with its FFPE kit, he said.

他说，该公司计划瞄准那些希望用新鲜冷冻产品研究较大组织样本或器官切片的研究人员，以及用FFPE试剂盒研究肿瘤学研究人员。

Given that Stereo-seq is based on Complete Genomics' DNB-seq technology, Tarbox said, the STOmics products are also 'synergistic' with the company's sequencers and could potentially boost instrument sales.

Tarbox说，鉴于Stereo-seq基于Complete Genomics的DNB-seq技术，STOmics产品也与该公司的测序仪“协同”，并可能促进仪器销售。

Complete Genomics has also established a spatial certified service provider program for Stereo-seq services. Providers include South Plainfield, NJ-based Admera Health and the Technology Center for Genomics & Bioinformatics (TCGB) of the University of California, Los Angeles, according to its website..

Complete Genomics还为Stereo-seq服务建立了空间认证服务提供商计划。据其网站介绍，提供商包括位于新泽西州南普莱恩菲尔德的Admera Health和加利福尼亚大学洛杉矶分校基因组学与生物信息学技术中心（TCGB）。。

'We hope that over time, as people experience what the technology can do, that will allow them perhaps to either bring it on in their own lab or to maybe push for their local core or shared service group to bring on the technology,' Tarbox said.

Tarbox说：“我们希望随着时间的推移，随着人们对这项技术的体验，这将允许他们要么在自己的实验室中实现，要么推动他们当地的核心或共享服务团队实现这项技术。”。

Meanwhile, it remains somewhat nebulous how STOmics fits in the BGI universe. An STOmics spokesperson noted previously that the company has been 'authorized to productize Stereo-seq technology' but turned down interview requests and declined to answer questions before deadline about the company's commercial roadmap, funding, IP, and relationship with BGI Group.

与此同时，STOmics在BGI宇宙中的适用性仍然有些模糊。STOmics发言人此前表示，该公司已被“授权生产Stereo-seq技术”，但拒绝了采访要求，并拒绝在截止日期前回答有关该公司商业路线图、资金、知识产权以及与BGI集团关系的问题。

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According to STOmics' website, its products are 'commercialized by GCATbio,' a synthetic biology company based in Changzhou, a city in eastern China. The company similarly declined to clarify its relationship with GCATbio in an email.

根据STOmics的网站，其产品由总部位于中国东部城市常州的合成生物公司GCATbio“商业化”。该公司同样拒绝在电子邮件中澄清其与GCATbio的关系。

GCATbio has a subsidiary in the UK, which was incorporated in March 2023 and previously did business as STOmics UK, according to a UK government website. GCATbio UK lists Jiang Wang, cofounder and chairman of BGI Group, as 'a person with significant control' and has appointed Yue Shen, chief scientist of synthetic biology at BGI Research, as a director.

据英国政府网站称，GCATbio在英国拥有一家子公司，该公司于2023年3月成立，之前作为STOmics UK开展业务。GCATbio UK将BGI集团联合创始人兼董事长江旺列为“具有重大控制权的人”，并任命BGI Research合成生物学首席科学家岳深为董事。

GCATbio's US subsidiary, meanwhile, shares the same address as Complete Genomics. .

与此同时，GCATbio的美国子公司与Complete Genomics拥有相同的地址。

Go Spatial

转到空间

During the ASHG meeting, Complete Genomics also unveiled Go Spatial, an automation platform developed by MGI for the Stereo-seq workflow. A benchtop instrument, Go Spatial automates crosslinking, tissue fixation, permeabilization, reverse transcription, tissue removal, as well as cDNA release and the collection steps for Stereo-seq.

在ASHG会议期间，Complete Genomics还推出了Go Spatial，这是MGI为Stereo-seq工作流程开发的自动化平台。Go Spatial是一种台式仪器，可自动交联，组织固定，透化，逆转录，组织去除以及cDNA释放和Stereo-seq的收集步骤。

It can process12 samples per 12-hour run, according to the company. .

据该公司称，它每12小时可以处理12个样品。

Pricing for Go Spatial is not yet available but it is slated for commercial launch in Q2 of 2025, according to a spokesperson.

一位发言人表示，Go Spatial的定价尚未公布，但预计将于2025年第二季度商业推出。

'Ever since we got the machine, we never do manual [preparations] again,' Joe Yeong Poh Sheng, a spatial immuno-pathologist at Singapore General Hospital who presented at a Complete Genomics-sponsored workshop during ASHG, told GenomeWeb.

新加坡总医院的空间免疫病理学家JoeYeongPoh-Sheng在ASHG期间参加了一个由完整基因组学赞助的研讨会，他告诉GenomeWeb：“自从我们拥有了这台机器以来，我们就再也不需要手动（准备）了。”。

Sheng, an early-access customer for Go Spatial, said his lab can process up to 24 slides a day using the platform instead of just four samples per day manually.

盛是Go Spatial的早期访问客户，他说他的实验室可以使用该平台每天处理多达24张幻灯片，而不是每天手动处理四个样本。

FluoXpert

FluoXpert

Complete Genomics also showcased FluoXpert, an add-on to the DNB-seq G400 sequencer that enables multiplex immunofluorescence (mIF) staining for protein analysis. 'Basically, what we do is take one of our sequencers and use the same optics and fluidic delivery [to] make it a fluorescent imager,' Tarbox explained.

Complete Genomics还展示了FluoXpert，它是DNB-seq G400测序仪的附加组件，可用于蛋白质分析的多重免疫荧光（mIF）染色。”Tarbox解释说：“基本上，我们所做的是使用我们的测序仪之一，并使用相同的光学和流体输送，使其成为荧光成像仪。”。

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The FluoXpert staining module can detect up to 24 protein targets on a single tissue section with an imaging resolution of 360 nm per pixel. The workflow comes with a multiplex immunofluorescence reagent kit that supports both fresh frozen and FFPE samples.

FluoXpert染色模块可以在单个组织切片上检测多达24个蛋白质靶标，每个像素的成像分辨率为360 nm。该工作流程配有一个多重免疫荧光试剂盒，可支持新鲜冷冻和FFPE样品。

Three flow cells are avialable for FluoXpert: solo small, which supports one sample and has a scanning region of 15 mm x 15 mm; solo large, which comes with a scanning region of 15 mm x 20 mm; and dual large, which can fit two tissue sections, each with a scanning area of 15 mm x 20 mm.

FluoXpert可以使用三个流通池：solo small，它支持一个样品，扫描区域为15 mm x 15 mm；solo large，扫描区域为15毫米x 20毫米；和双大，可以容纳两个组织切片，每个切片的扫描面积为15毫米x 20毫米。

Sheng, who is also an early-access customer for FluoXpert, received the technology in September and has performed a few dozens of runs so far. The workflow is 'very easy to use' and the lab can 'easily' analyze close to 40 slides a week, he said, with a turnaround time of about 10 hours for a 24-target run.

Sheng也是FluoXpert的早期访问客户，他在9月份收到了这项技术，到目前为止已经进行了几十次运行。。

Since FluoXpert generates signals from secondary antibodies, off-the-shelf antibodies can be used, he added. .

他补充说，由于FluoXpert从二抗产生信号，因此可以使用现成的抗体。

Existing G400 customers can upgrade to the FluoXpert for an undisclosed price, according to a company spokesperson. While there is no commercial launch date available, Complete Genomics plans to make the technology available to US customers on an early-access basis 'very soon,' she said,

公司发言人表示，现有G400客户可以升级到FluoXpert，价格未透露。她说，虽然目前还没有商业上市日期，但Complete Genomics计划“很快”将该技术尽早提供给美国客户，