Cala Health获得5000万美元用于家庭震颤缓解治疗-动脉网

Cala Health Snags $50M for At-Home Tremor Relief Therapy

MedCity News 等信源发布 2024-12-10 07:00

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388813 01: A photo illustration depicts a person typing May 4, 2001 in Denver, CO. National Academy of Sciences estimates that musculoskeletal disorders such as carpal-tunnel syndrome, tendinitis, and lower back pain cost the nation $45 billion to $54 billion in compensation, lost wages, and lower productivity each year.

388813 01:2001年5月4日，在科罗拉多州丹佛市，一张照片描绘了一个人在打字。美国国家科学院估计，腕管综合征、肌腱炎和腰痛等肌肉骨骼疾病每年给国家造成450亿至540亿美元的补偿、工资损失和生产力下降。

(Photo by Michael Smith/Newsmakers) .

（迈克尔·史密斯/新闻工作者合影）。

On Monday, a Silicon Valley-based bioelectronic medicine company raised tens of millions of dollars to help the more than 7 million Americans who struggle with essential tremor (ET).

周一，一家总部位于硅谷的生物电子医药公司筹集了数千万美元，以帮助700多万与特发性震颤（ET）作斗争的美国人。

The company, named Cala Health, closed a $50 million funding round co-led by Vertex Growth Fund and Nexus NeuroTech Ventures. All of the company’s existing investors also participated in the round, including GV, Johnson & Johnson, Lux Capital, OSF Ventures and Ascension Ventures.

该公司名为Cala Health，结束了由Vertex Growth Fund和Nexus NeuroTech Ventures共同领导的5000万美元的融资回合。该公司的所有现有投资者也参加了本轮投资，包括GV、强生、卢森堡资本、OSF Ventures和Ascension Ventures。

Cala was founded in 2014 as a Stanford University spinout. Its main goal is to give patients a better option for treating their ET — which is a neurological disorder characterized by involuntary shaking that usually affects the hands, head or voice.

Cala成立于2014年，是斯坦福大学的分支机构。它的主要目标是为患者提供更好的治疗ET的选择，ET是一种神经系统疾病，其特征是不自主的颤抖，通常会影响手，头或声音。

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As technology advances, AI-powered tools will increasingly reduce the administrative burdens on healthcare providers.

随着技术的进步，人工智能工具将越来越多地减轻医疗保健提供者的行政负担。

By Dr. Michael Blackman, Chief Medical Officer at Greenway Health

由Dr。Greenway Health首席医疗官迈克尔·布莱克曼（MichaelBlackman）

The condition can have a significant effect on people’s essential abilities, such as writing, eating and speaking, pointed out Cala CEO Deanna Harshbarger.

Cala首席执行官迪安娜·哈什巴格（DeannaHarshbarger）指出，这种情况会对人们的基本能力产生重大影响，如写作、饮食和口语。

“As a result, these tremors can impact mental health and discourage people from doing what they love. Clinical studies estimate 50% of ET patients suffer from social phobia, and 80% of ET patients suffer from depression that can severely impact quality of life,” she stated.

她说：“因此，这些震颤会影响心理健康，阻止人们做自己喜欢的事。临床研究估计，50%的ET患者患有社交恐惧症，80%的ET患者患有抑郁症，这会严重影响生活质量。”。

The drugs used most often to treat ET include beta-blockers such as propranolol and an epilepsy drug called primidone. While these medications are effective for some patients, they can also induce a range of undesirable side effects such as fatigue, nausea and depression — and some patients might not be able to take these drugs due to contraindications with comorbidity, Harshbarger noted..

最常用于治疗ET的药物包括β受体阻滞剂，如普萘洛尔和一种名为primidone的癫痫药物。Harshbarger指出，虽然这些药物对某些患者有效，但它们也会引起一系列不良副作用，例如疲劳，恶心和抑郁，并且一些患者可能由于合并症的禁忌症而无法服用这些药物。。

There are also surgical options, like deep brain stimulation or ablation — but not all patients are keen on invasive procedures, she added.

她补充说，也有手术选择，如脑深部刺激或消融，但并非所有患者都热衷于侵入性手术。

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医疗保健数字转型中的卫生管理人员

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听取来自Quantum Health、Surescripts、EY、Clinical Architecture和Personify Health的高管分享他们对医疗保健数字转型的看法。

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By√9；：<9MedCity News

Last year, Cala gave ET patients a new option through the commercial launch of its kIQ system, which the company says is the first noninvasive wearable device cleared by the FDA to temporarily relieve tremors in people with ET and Parkinson’s disease.

去年，Cala通过其kIQ系统的商业推出为ET患者提供了一个新的选择，该公司表示，该系统是FDA批准的第一个非侵入性可穿戴设备，可暂时缓解ET和帕金森病患者的震颤。

“Our goal is to leverage bioelectronic medicine to transform the standard of care for chronic disease and allow patients to live life fully,” Harshbarger declared.

哈什巴格宣布：“我们的目标是利用生物电子医学来改变慢性病的护理标准，使患者能够充分生活。”。

The kIQ system is a wrist-worn device prescribed by physicians to manage a patient’s hand tremors. It senses each patient’s unique tremor signature and individualizes stimulation, Harshbarger said.

kIQ系统是医生开的一种手腕佩戴设备，用于管理患者的手部震颤。Harshbarger说，它可以感知每个患者独特的震颤特征，并个性化刺激。

The at-home therapy system delivers transcutaneous afferent patterned stimulation (TAPS) therapy, meaning it applies specific patterns of electrical stimulation through the skin to modulate neural activity and promote therapeutic effects. Using TAPS, the device noninvasively counteracts the patient’s tremor through the nerves on the wrist, she explained..

家庭治疗系统提供经皮传入模式刺激（TAPS）治疗，这意味着它通过皮肤应用特定的电刺激模式来调节神经活动并促进治疗效果。她解释说，使用水龙头，该装置可以通过手腕上的神经无创地抵消患者的震颤。。

Once a patient completes an at-home therapy session, they can view their body’s responses via Cala’s online patient portal. Nine out of 10 patients experience tremor reduction with a complete 40-minute session, Harshbarger noted.

一旦患者完成家庭治疗，他们可以通过Cala的在线患者门户查看身体的反应。Harshbarger指出，每10名患者中就有9名经历了40分钟的震颤缓解。

Medicare, the VA and several commercial health plans pay for the therapy, she said.

她说，医疗保险、弗吉尼亚州和一些商业健康计划为治疗付费。

She also said that Cala has no direct competitors, given there are no other companies selling FDA-cleared, noninvasive neurostimulation devices for the relief of hand tremor. There are some other companies developing devices to treat ET using noninvasive neurostimulation, including Allevion Therapeutics and Encora Therapeutics, but they haven’t cleared regulatory hurdles yet in the U.S..

她还说，Cala没有直接竞争对手，因为没有其他公司销售FDA批准的无创神经刺激装置来缓解手部震颤。还有一些其他公司正在开发使用无创神经刺激治疗ET的设备，包括Allevion Therapeutics和Encora Therapeutics，但他们尚未在美国清除监管障碍。。

Cala is also currently in the process of developing TAPS therapy-based solutions for other indications, such as cardiology and psychiatry, Harshbarger said.

哈什巴格说，Cala目前也在为其他适应症（如心脏病学和精神病学）开发基于TAPS疗法的解决方案。

Photo: Michael Smith, Newsmakers

照片：迈克尔·史密斯，新闻制作人

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