AbstractObjectiveTo estimate inter-center variation (ICV) in hospital length of stay (LOS) and oral feeding at discharge among infants with gastroschisis.Study designThe Children’s Hospitals Neonatal Consortium’s (CHNC) database was used to identify hospitalized survivors with gastroschisis. Two outcomes were evaluated: LOS and discharge without tube feedings.

摘要目的评估腹裂患儿住院时间（LOS）和出院时口服喂养的中心间变异（ICV）。研究设计儿童医院新生儿协会（CHNC）的数据库用于识别腹裂住院幸存者。评估了两个结果：LOS和无管喂养的出院。

Hospital outcomes were evaluated in unadjusted and adjusted analyses. Generalized linear models with log link for gamma distribution were used to model LOS and logistic regression for discharge without tube feeds.ResultsFor 3987 surviving infants with gastroschisis, LOS and discharge within 70 days with exclusively oral feeding both exhibited significant ICV.

在未经调整和调整的分析中评估了医院的结果。伽马分布具有对数链接的广义线性模型用于模拟无管进料流量的服务水平和逻辑回归。结果对于3987名存活的腹裂婴儿，仅口服喂养的LOS和70天内出院均表现出显着的ICV。

Differences persisted in multivariable analyses. Risk-adjusted LOS (68% difference) and oral feeding at discharge (6.4-fold difference) varied significantly between centers.ConclusionHospital of care was independently associated with LOS and exclusive oral feeding at discharge rates for infants with gastroschisis.

多变量分析中仍然存在差异。风险调整后的LOS（差异68%）和出院时的口服喂养（差异6.4倍）在中心之间差异显着。结论医院护理与腹裂婴儿出院率的LOS和独家口服喂养独立相关。

Management differences, potentially influenced by parental preferences, contributed to variation..

管理差异可能会受到父母偏好的影响，从而导致差异。。

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Fig. 1: Inter-center variation of risk-adjusted outcomes of surviving infants with gastroschisis.

图1：存活的腹裂婴儿风险调整结果的中心间变化。

Data availability

数据可用性

CHNC is a consortium of multiple hospitals, each with a formal legal agreement between the hospital and the CHNC organization. Because the data registry collects multiple elements of protected health information (PHI), the legal agreements strictly prohibit the sharing of data among member hospitals or outside the organization..

。由于数据登记处收集受保护健康信息（PHI）的多个元素，因此法律协议严格禁止成员医院之间或组织外部共享数据。。

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Download referencesAcknowledgementsBeverly Brozanski, Jacquelyn Evans, Theresa Grover, Karna Murthy, Michael Padula, Eugenia Pallotto, Anthony Piazza, Kristina Reber, Billie Short, and ex-officio David Durand, Francine Dyes, Jeanette Asselin, are executive members of the Children’s Hospitals Neonatal Consortium, Inc., who developed and managed the CHND (thechnc.org).

下载参考文献致谢Beverly Brozanski，Jacquelyn Evans，Theresa Grover，Karna Murthy，Michael Padula，Eugenia Pallotto，Anthony Piazza，Kristina Reber，Billie Short和当然的David Durand，Francine Dyes，Jeanette Asselin是开发和管理CHND的儿童医院新生儿协会（thechnc.org）的执行成员。

For more information, please contact exec@thechnc. We appreciate Mr. John Mallett and Ms. Evelyn Werbaneth’s contribution to data collection, curation, and security for this analysis.We are indebted to the following CHNC participating institutions that serve the infants and their families; these institutions (and their site sponsors) also have invested in and continue to participate in the CHND:Children’s Healthcare of Atlanta – Egleston, Atlanta, GA, USA (Anthony Piazza); Children’s Healthcare of Atlanta - Scottish Rite, Atlanta, GA, USA (Gregory Sysyn); Dell Children’s, Austin, TX, USA (Ashley Lucke, Molly Pont); Children’s of Alabama, Birmingham, AL, USA (Allison Black, Carl Coghill); Boston Children’s Hospital, Boston, MA, USA (Anne Hansen) Levine Children’s Hospital, Charlotte, NC, USA (Eugenia Pallotto); Ann & Robert H.

有关更多信息，请联系exec@thechnc.我们感谢John Mallett先生和Evelyn Werbaneth女士对数据收集，管理和安全性的贡献。我们感谢以下CHNC参与机构为婴儿及其家人提供服务；这些机构（及其网站赞助商）也投资并继续参与CHND：美国佐治亚州亚特兰大市埃格尔斯顿的亚特兰大儿童保健（Anthony Piazza）；亚特兰大儿童保健中心-苏格兰仪式，美国佐治亚州亚特兰大（Gregory Sysyn）；戴尔儿童百货，美国德克萨斯州奥斯汀（Ashley Lucke，Molly Pont）；美国阿拉巴马州伯明翰阿拉巴马州儿童（Allison Black，Carl Coghill）；美国马萨诸塞州波士顿波士顿儿童医院（Anne Hansen）美国北卡罗来纳州夏洛特市莱文儿童医院（Eugenia Pallotto）；安和罗伯特H。

Lurie Children’s Hospital, Chicago, IL, USA (Karna Murthy, Gustave Falciglia); Cincinnati, Children’s Hospital, Cincinnati, OH, USA (Beth Haberman); Cleveland Clinic, Cleveland, OH, USA (Tetyana Nesterenko); Nationwide Children’s Hospital, Columbus, OH, USA (Thomas Bartman); Children’s Medical Center Dallas, Dallas, TX, USA (Sushmita Yallapragada, Lina Chalak); Children’s Hospital Colorado, Denver, CO, USA (Danielle Smith, Stephanie Bourque); Children’s Hospital Michigan, Detroit, MI, USA (Girija Natarajann); Cook Children’s Healthcare System, Ft.

美国伊利诺伊州芝加哥鲁里儿童医院（Karna Murthy，Gustave Falciglia）；美国俄亥俄州辛辛那提市辛辛那提儿童医院（Beth Haberman）；克利夫兰诊所，美国俄亥俄州克利夫兰（Tetyana Nesterenko）；美国俄亥俄州哥伦布全国儿童医院（Thomas Bartman）；美国德克萨斯州达拉斯市达拉斯儿童医学中心（Sushmita Yallapragada，Lina Chalak）；美国科罗拉多州丹佛市科罗拉多儿童医院（Danielle Smith，Stephanie Bourque）；美国密歇根州底特律市密歇根儿童医院（Girija Natarajann）；库克儿童保健系统。

Worth, TX, USA (Annie .

沃思，德克萨斯州，美国（安妮。

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PubMed Google ScholarConsortiaOn behalf of Children’s Hospitals Neonatal Consortium Gastroschisis Focus GroupContributionsTheresa Grover, Mike Padula, Karna Murthy, Jackie Evans, Stephanie Riddle, and Elizabeth Jacobsen contributed to data acquisition and curation, formulating the analytic question and data interpretations.

PubMed Google ScholarConsortiaOn代表儿童医院新生儿协会腹裂焦点小组贡献Theresa Grover，Mike Padula，Karna Murthy，Jackie Evans，Stephanie Riddle和Elizabeth Jacobsen为数据采集和管理做出了贡献，制定了分析问题和数据解释。

Isabella Zaniletti completed statistical analyses and interpretations. Con Yee Ling and Karna Marthy drafted the first version of the manuscript. Stephanie Korff, Angela Chandler, and Corbin Downey participated in the data interpretation and editing of the manuscript.Corresponding authorCorrespondence to.

伊莎贝拉·扎尼莱蒂完成了统计分析和解释。Con Yee Ling和Karna Marthy起草了手稿的第一版。斯蒂芬妮·科尔夫，安吉拉·钱德勒和科尔宾·唐尼参与了手稿的数据解释和编辑。对应作者对应。

Con Yee Ling.Ethics declarations

Con Yee Ling。道德宣言

Competing interests

相互竞争的利益

Authors affiliated with CHNC serve as executive directors of CHNC and members of the CHNC board.

隶属于CHNC的作者担任CHNC的执行董事和CHNC董事会成员。

Ethics approval and consent to participate

道德批准和同意参与

Each participating CHNC hospital retains IRB and administrative oversight for participation in the work and all associated studies. Subsequent secondary analyses were reviewed and exempted as non-human subject research by the Stanley Manne Research Institute (Chicago, IL: 2009-14982) Institutional Review Board..

每个参与的CHNC医院都保留IRB和行政监督，以参与工作和所有相关研究。随后的二次分析由斯坦利·曼恩研究所（伊利诺伊州芝加哥：2009-14982）机构审查委员会审查并豁免为非人类受试者研究。。

Additional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Supplementary informationSupplementary Table 1: Comorbidity Definitions41372_2024_2160_MOESM2_ESM.docxSupplementary Table 2: Unadjusted Characteristics of Infants with Gastroschisis by Hospital of Care Considered for AnalysisThe Children’s Hospital Neonatal Consortium Gastroschisis Focus Group includes the following members:Rights and permissionsSpringer Nature or its licensor (e.g.

Additional informationPublisher的注释Springer Nature在已发布的地图和机构隶属关系中的管辖权主张方面保持中立。补充信息补充表1：合并症定义41372\u 2024\u 2160\u MOESM2\u ESM.docx补充表2：考虑用于分析的护理医院对腹裂婴儿的未调整特征儿童医院新生儿协会腹裂焦点小组包括以下成员：权利和许可Pringer Nature或其许可人（例如。

a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.Reprints and permissionsAbout this articleCite this articleLing, C.Y., Zaniletti, I., Riddle, S.

协会或其他合作伙伴）根据与作者或其他权利持有人的出版协议对本文拥有专有权；本文接受稿件版本的作者自行存档仅受此类出版协议和适用法律的条款管辖。转载和许可本文引用本文Ling，C.Y.，Zaniletti，I.，Riddle，S。

et al. Inter-center variations in inpatient outcomes for infants with gastroschisis from the Children’s Hospitals Neonatal Consortium..

等。儿童医院新生儿协会腹裂婴儿住院结局的中心间差异。。

J Perinatol (2024). https://doi.org/10.1038/s41372-024-02160-6Download citationReceived: 16 August 2024Revised: 22 October 2024Accepted: 24 October 2024Published: 11 December 2024DOI: https://doi.org/10.1038/s41372-024-02160-6Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

J Perinatol（2024）。https://doi.org/10.1038/s41372-024-02160-6Download引文收到日期：2024年8月16日修订日期：2024年10月22日接受日期：2024年10月24日发布日期：2024年12月11日OI：https://doi.org/10.1038/s41372-024-02160-6Share本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

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Outcomes researchPaediatricsRisk factorsSurgery

结果研究儿科风险因素手术