Inter-organ interactions are critical for homeostasis and proper organ functioning. Several studies published in 2024 have provided insights into the mechanisms underlying reciprocal interactions of the kidney with the brain, gut and liver.Key advances

器官间相互作用对于体内平衡和适当的器官功能至关重要。2024年发表的几项研究深入了解了肾脏与大脑，肠道和肝脏相互作用的机制。主要进展

Microglial potassium efflux via the calcium-dependent channel KCa3.1 promotes the microglial release of IL-1β and IL-1β receptor 1-mediated neuronal dysfunction in chronic kidney disease, highlighting the importance of kidney–brain crosstalk3

通过钙依赖性通道KCa3.1的小胶质细胞钾外流促进慢性肾脏疾病中小胶质细胞释放IL-1β和IL-1β受体1介导的神经元功能障碍，突出了肾-脑串扰的重要性3

Group 3 innate lymphoid cells (ILC3s) contribute to kidney fibrosis following their migration from the small intestine to the kidney via a CXCR6–CXCL16 signalling axis. In the kidney, PD-1 expressed on ILC3s mediates the IL-17A-induced activation of fibroblasts by inhibiting IL-23R endocytosis, thereby amplifying IL-23-induced JAK2–STAT3–RORγt–IL-17A signalling in ILC3s, highlighting the importance of kidney–gut crosstalk5..

第3组先天淋巴细胞（ILC3s）通过CXCR6-CXCL16信号轴从小肠迁移到肾脏后，会导致肾纤维化。在肾脏中，ILC3s上表达的PD-1通过抑制IL-23R内吞作用介导IL-17A诱导的成纤维细胞活化，从而扩增IL-23诱导的ILC3s中JAK2-STAT3-RORγt-IL-17A信号传导，突出了肾脏-肠道串扰的重要性5。。

Mice with non-alcoholic steatohepatitis develop progressive glomerulosclerosis and interstitial fibrosis through mechanisms that involve mitochondrial dysfunction, lipid metabolism and insulin signalling pathways in the kidney, highlighting the importance of liver–kidney crosstalk6

患有非酒精性脂肪性肝炎的小鼠通过涉及肾脏线粒体功能障碍，脂质代谢和胰岛素信号通路的机制发展为进行性肾小球硬化和间质纤维化，突显了肝肾串扰的重要性6

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Fig. 1: A variety of mechanisms underlie kidney crosstalk with distant organs.

图1：肾脏与远处器官串扰的各种机制。

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Download referencesAuthor informationAuthors and AffiliationsDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of KoreaMyung-Gyu Kim

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(김명규) & Sang Kyung Jo

（[UNK]명；）[UNK]&#160；Sang Kyung Jo

(조상경)AuthorsMyung-Gyu Kim

（조상경）作者Myung Gyu Kim

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PubMed Google ScholarSang Kyung Jo

PubMed谷歌奖学金Sang Kyung Jo

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PubMed Google ScholarCorresponding authorCorrespondence to

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Sang Kyung Jo

桑庆乔

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Rights and permissionsReprints and permissionsAbout this articleCite this articleKim, MG., Jo, S.K. New insights into kidney crosstalk with distant organs.

权利和许可打印和许可本文引用本文Kim，MG。，Jo，S.K。对肾脏与远处器官串扰的新见解。

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Chronic kidney diseaseNephrology

慢性肾脏病肾脏病