AT2细胞中Fbxo45的缺失导致组蛋白供应不足并引发肺腺癌-动脉网

Loss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma

Nature 等信源发布 2024-12-13 23:45

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AbstractDysregulation of histone supply is implicated in various cancers, including lung adenocarcinoma (LUAD), although the underlying mechanisms remain poorly understood. Here, we demonstrate that knockout of Fbxo45 in mouse alveolar epithelial type 2 (AT2) cells leads to spontaneous LUAD. Our findings reveal that FBXO45 is a novel cell-cycle-regulated protein that is degraded upon phosphorylation by CDK1 during the S/G2 phase.

摘要组蛋白供应失调与包括肺腺癌（LUAD）在内的各种癌症有关，尽管其潜在机制仍然知之甚少。在这里，我们证明敲除小鼠肺泡上皮2型（AT2）细胞中的Fbxo45会导致自发性LUAD。我们的研究结果表明，FBXO45是一种新型的细胞周期调节蛋白，在S/G2期被CDK1磷酸化后降解。

During the S phase or DNA damage repair, FBXO45 binds to UPF1 and recruits the phosphatase PPP6C, thereby inhibiting UPF1 phosphorylation. This process is crucial for preventing the degradation of replication-dependent (RD) histone mRNAs and ensuring an adequate histone supply. In the absence of FBXO45, the impaired interaction between PPP6C and UPF1 results in sustained hyperphosphorylation of UPF1 throughout the cell cycle, leading to an insufficient histone supply, chromatin relaxation, genomic instability, and an increased rate of gene mutations, ultimately culminating in malignant transformation.

在S期或DNA损伤修复过程中，FBXO45与UPF1结合并募集磷酸酶PPP6C，从而抑制UPF1磷酸化。这个过程对于防止复制依赖性（RD）组蛋白mRNA的降解和确保足够的组蛋白供应至关重要。在没有FBXO45的情况下，PPP6C和UPF1之间的相互作用受损导致UPF1在整个细胞周期中持续过度磷酸化，导致组蛋白供应不足，染色质松弛，基因组不稳定和基因突变率增加，最终导致恶性转化。

Notably, analysis of clinical LUAD specimens confirms a positive correlation between the loss of FBXO45 and genomic instability, which is consistent with our findings in the mouse model. These results highlight the critical role of FBXO45 as a genomic guardian in coordinating histone supply and DNA replication, providing valuable insights into potential therapeutic targets and strategies for the treatment of LUAD..

值得注意的是，对临床LUAD标本的分析证实了FBXO45的丢失与基因组不稳定性之间存在正相关，这与我们在小鼠模型中的发现一致。这些结果突出了FBXO45作为基因组监护人在协调组蛋白供应和DNA复制中的关键作用，为治疗LUAD的潜在治疗靶点和策略提供了有价值的见解。。

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Fig. 1: Fbxo45 deficiency in AT2 cells leads to LUAD.Fig. 2: Fbxo45 deficiency reduces the supply of RD-histones.Fig. 3: FBXO45 prevents rapid degradation of RD-histone mRNAs.Fig. 4: FBXO45 binds to UPF1 and inhibits pS/TQ-UPF1.Fig. 5: FBXO45 reduces the phosphorylation level of UPF1 by recruiting PPP6C to UPF1.Fig.

图1:AT2细胞中Fbxo45缺乏导致LUAD。图2:Fbxo45缺乏会减少RD组蛋白的供应。图3:FBXO45防止RD组蛋白mRNA的快速降解。图4:FBXO45与UPF1结合并抑制pS/TQ-UPF1。图5:FBXO45通过将PPP6C募集到UPF1来降低UPF1的磷酸化水平。

6: FBXO45 is a cell-cycle regulated protein and highly expressed in the S phase.Fig. 7: Fbxo45 deficiency leads to loosened chromatin and impaired DDR.Fig. 8: Fbxo45 deficiency leads to accumulation of gene mutations..

6： FBXO45是一种细胞周期调节蛋白，在S期高度表达。图7:Fbxo45缺乏会导致染色质松动和DDR受损。。。

Data availability

数据可用性

The RNA-Seq data generated in this study were provided as EXCEL profiles in Supplementary Data and have been deposited in the Gene Expression Omnibus (GEO) repository under the accession number GSE218662. The whole-exome sequencing (WES) data generated in this study were provided as EXCEL profiles in Supplementary Data and have been deposited in the Sequence Read Archive (SRA) database under the accession number PRJNA905170.

本研究中生成的RNA-Seq数据在补充数据中以EXCEL配置文件的形式提供，并已以登录号GSE218662保存在Gene Expression Omnibus（GEO）存储库中。本研究中产生的全外显子组测序（WES）数据在补充数据中以EXCEL配置文件的形式提供，并已以登录号PRJNA905170保存在序列读取档案（SRA）数据库中。

The mass spectrometry data generated in this study were provided as EXCEL profiles in Supplementary Data and have been uploaded to the Integrated Proteome Resources (iProX) database under the accession number IPX0005469000 and IPX0010103000. All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.

本研究中产生的质谱数据在补充数据中以EXCEL配置文件的形式提供，并已上传到综合蛋白质组资源（iProX）数据库，登录号为IPX0005469000和IPX0010103000。评估论文结论所需的所有数据均包含在论文和/或补充材料中。

All data are also available from the corresponding author (J.Y.) upon reasonable request..

根据合理要求，通讯作者（J.Y.）也可以提供所有数据。。

ReferencesSung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49.Article

ReferencesSung H，Ferlay J，Siegel RL，Laversanne M，Soerjomataram I，Jemal A等。2020年全球癌症统计：全球185个国家36种癌症的全球发病率和死亡率估计。CA癌症J临床。2021年；71:209–49.文章

PubMed

Google Scholar

谷歌学者

Chevallier M, Borgeaud M, Addeo A, Friedlaender A. Oncogenic driver mutations in non-small cell lung cancer: Past, present and future. World J Clin Oncol. 2021;12:217–37.Article

Chevallier M，Borgeaud M，Addeo A，Friedlaender A.非小细胞肺癌中的致癌驱动突变：过去，现在和未来。世界J临床肿瘤学。2021年；12： 217-37.文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Nair N, Shoaib M, Sorensen CS. Chromatin dynamics in genome stability: roles in suppressing endogenous DNA damage and facilitating DNA repair. Int J Mol Sci. 2017;18:1486.Article

Nair N，Shoaib M，Sorensen CS。染色质动力学在基因组稳定性中的作用：抑制内源性DNA损伤和促进DNA修复。国际分子科学杂志。2017年；18：第1486条

PubMed

PubMed Central

PubMed 中心

Google Scholar

谷歌学者

Zhao S, Allis CD, Wang GG. The language of chromatin modification in human cancers. Nat Rev Cancer. 2021;21:413–30.Article

赵S，Allis CD，Wang GG。人类癌症中染色质修饰的语言。Nat Rev癌症。2021年；21:413–30.文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

O’Sullivan RJ, Kubicek S, Schreiber SL, Karlseder J. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat Struct Mol Biol. 2010;17:1218–25.Article

O'Sullivan RJ，Kubicek S，Schreiber SL，Karlseder J.减少了端粒损伤信号引起的组蛋白生物合成和染色质变化。Nat Struct Mol Biol。2010年；17： 1218-25.文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Pal S, Tyler JK. Epigenetics and aging. Sci Adv. 2016;2:e1600584.Article

。表观遗传学和衰老。Sci Adv.2016；2： e1600584。文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Feser J, Truong D, Das C, Carson JJ, Kieft J, Harkness T, et al. Elevated histone expression promotes life span extension. Mol Cell. 2010;39:724–35.Article

Feser J，Truong D，Das C，Carson JJ，Kieft J，Harkness T等。组蛋白表达升高可促进寿命延长。摩尔细胞。2010年；39:724–35.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Mejlvang J, Feng Y, Alabert C, Neelsen KJ, Jasencakova Z, Zhao X, et al. New histone supply regulates replication fork speed and PCNA unloading. J Cell Biol. 2014;204:29–43.Article

Mejlvang J，Feng Y，Alabert C，Neelsen KJ，Jasencakova Z，Zhao X等。新的组蛋白供应调节复制叉速度和PCNA卸载。J细胞生物学。2014年；204:29–43.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Singh RK, Liang D, Gajjalaiahvari UR, Kabbaj MH, Paik J, Gunjan A. Excess histone levels mediate cytotoxicity via multiple mechanisms. Cell Cycle. 2010;9:4236–44.Article

Singh RK，Liang D，Gajjalaiahvari UR，Kabbaj MH，Paik J，Gunjan A.过量的组蛋白水平通过多种机制介导细胞毒性。细胞周期。2010年；9： 4236-44.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Li L, Zhang X, Tian T, Pang L. Mathematical modelling the pathway of genomic instability in lung cancer. Sci Rep. 2019;9:14136.Article

Li L，Zhang X，Tian T，Pang L.肺癌基因组不稳定途径的数学建模。Sci代表2019；9：第14136条

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Marzluff WF, Koreski KP. Birth and Death of Histone mRNAs. Trends Genet. 2017;33:745–59.Article

Marzluff WF，Koreski KP。组蛋白mRNA的产生和死亡。趋势Genet。2017年；33:745-59.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Davila Lopez M, Samuelsson T. Early evolution of histone mRNA 3’ end processing. RNA. 2008;14:1–10.Article

Davila Lopez M，Samuelsson T.组蛋白mRNA 3'末端加工的早期进化。RNA。2008年；14： 1-10.文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Kaygun H, Marzluff WF. Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat Struct Mol Biol. 2005;12:794–800.Article

Kaygun H，Marzluff WF。复制依赖性组蛋白mRNA的调节降解需要ATR和Upf1。Nat Struct Mol Biol。2005年；12： 794-800.文章

CAS

PubMed

Google Scholar

谷歌学者

Kaufman PD. Toxicity and lifespan extension: complex outcomes of histone overexpression in budding yeast. Cell Cycle. 2010;9:4611–2.Article

考夫曼PD。毒性和寿命延长：发芽酵母中组蛋白过表达的复杂结果。细胞周期。2010年；9：

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Marzluff WF, Wagner EJ, Duronio RJ. Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail. Nat Rev Genet. 2008;9:843–54.Article

Marzluff WF，Wagner EJ，Duronio RJ。经典组蛋白mRNA的代谢和调节：没有poly（a）尾巴的生命。Nat Rev Genet。2008年；9： 843-54.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Meaux SA, Holmquist CE, Marzluff WF. Role of oligouridylation in normal metabolism and regulated degradation of mammalian histone mRNAs. Philos Trans R Soc Lond B Biol Sci. 2018;373:20180170.Article

Meaux SA，Holmquist CE，Marzluff WF。寡尿酰化在哺乳动物组蛋白mRNA正常代谢和调节降解中的作用。Philos Trans R Soc Lond B Biol Sci。2018年；373:20180170.文章

PubMed

PubMed Central

PubMed 中心

Google Scholar

谷歌学者

Choe J, Ahn SH, Kim YK. The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA. Nucleic Acids Res. 2014;42:9334–49.Article

Choe J，Ahn SH，Kim YK。由UPF1介导的mRNP重塑促进复制依赖性组蛋白mRNA的快速降解。Nucleic Acids Res.2014；42:9334–49.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Gowravaram M, Bonneau F, Kanaan J, Maciej VD, Fiorini F, Raj S, et al. A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner. Nucleic Acids Res. 2018;46:2648–59.Article

Gowravaram M，Bonneau F，Kanaan J，Maciej VD，Fiorini F，Raj S等。RNA解旋酶UPF1中的保守结构元件以同工型特异性方式调节其催化活性。核酸研究2018；46:2648–59.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Chakrabarti S, Jayachandran U, Bonneau F, Fiorini F, Basquin C, Domcke S, et al. Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2. Mol Cell. 2011;41:693–703.Article

Chakrabarti S，Jayachandran U，Bonneau F，Fiorini F，Basquin C，Domcke S等。Upf1的RNA依赖性ATPase活性及其受Upf2调节的分子机制。摩尔细胞。2011年；41:693–703.文章

CAS

PubMed

Google Scholar

谷歌学者

Fiorini F, Bonneau F, Le Hir H. Biochemical characterization of the RNA helicase UPF1 involved in nonsense-mediated mRNA decay. Methods Enzymol. 2012;511:255–74.Article

Fiorini F，Bonneau F，Le Hir H.参与无义介导的mRNA衰变的RNA解旋酶UPF1的生化表征。方法酶法。2012年；511:255–74.文章

CAS

PubMed

Google Scholar

谷歌学者

Kim YK, Maquat LE. UP Front and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond. RNA. 2019;25:407–22.Article

Kim YK，Maquat LE。RNA衰变的前沿和中心：UPF1在无义介导的mRNA衰变及其后。RNA。2019年；25:407–22.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Choe J, Kim KM, Park S, Lee YK, Song OK, Kim MK, et al. Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20. Nucleic Acids Res. 2013;41:1307–18.Article

Choe J，Kim KM，Park S，Lee YK，Song OK，Kim MK等。复制依赖性组蛋白mRNA的快速降解主要发生在由核帽结合蛋白80和20结合的mRNA上。核酸研究2013；41:1307-18.文章

CAS

PubMed

Google Scholar

谷歌学者

Muller B, Blackburn J, Feijoo C, Zhao X, Smythe C. DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication. J Cell Biol. 2007;179:1385–98.Article

Muller B，Blackburn J，Feijoo C，Zhao X，Smythe C.DNA激活的蛋白激酶在新观察到的S期检查点中起作用，该检查点将组蛋白mRNA丰度与DNA复制联系起来。J细胞生物学。2007年；179:1385–98.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Xu M, Zhu C, Zhao X, Chen C, Zhang H, Yuan H, et al. Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors. Oncotarget. 2015;6:979–94.Article

Xu M，Zhu C，Zhao X，Chen C，Zhang H，Yuan H等。非典型泛素E3连接酶复合物Skp1-Pam-Fbxo45控制核心上皮-间质转化诱导转录因子。Oncotarget。2015年；6： 979-94.文章

PubMed

Google Scholar

谷歌学者

Yoshida K. Characterization of estrogen-induced F-box protein FBXO45. Oncol Rep. 2005;14:531–5.CAS

吉田K.雌激素诱导的F-box蛋白FBXO45的表征。Oncol Rep.2005；14： 531–5.CAS

PubMed

Google Scholar

谷歌学者

Yoon KA, Park JH, Han J, Park S, Lee GK, Han JY, et al. A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. Hum Mol Genet. 2010;19:4948–54.Article

Yoon KA，Park JH，Han J，Park S，Lee GK，Han JY等。一项全基因组关联研究揭示了韩国人群中非小细胞肺癌的易感性变异。哼，摩尔基因。2010年；19： 4948-54.文章

CAS

PubMed

Google Scholar

谷歌学者

Tuominen R, Jonsson G, Enerback C, Appelqvist F, Olsson H, Ingvar C, et al. Investigation of a putative melanoma susceptibility locus at chromosome 3q29. Cancer Genet. 2014;207:70–4.Article

Tuominen R，Jonsson G，Enerback C，Appelqvist F，Olsson H，Ingvar C等。染色体3q29上推定的黑色素瘤易感基因座的研究。癌症基因。2014年；207:70–4.文章

CAS

PubMed

Google Scholar

谷歌学者

Wu C, Miao X, Huang L, Che X, Jiang G, Yu D, et al. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet. 2011;44:62–6.Article

Wu C，Miao X，Huang L，Che X，Jiang G，Yu D等。全基因组关联研究确定了中国人群中与胰腺癌易感性相关的五个基因座。纳特·吉内特。2011年；44:62–6.文章

PubMed

Google Scholar

谷歌学者

Feng M, Ye X, Chen B, Zhang J, Lin M, Zhou H, et al. Detection of circulating genetically abnormal cells using 4-color fluorescence in situ hybridization for the early detection of lung cancer. J Cancer Res Clin Oncol. 2021;147:2397–405.Article

冯敏，叶X，陈B，张J，林M，周H，等。使用四色荧光原位杂交检测循环遗传异常细胞用于肺癌的早期检测。J癌症研究临床肿瘤学。2021年；147:2397–405.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Katz RL, Zaidi TM, Pujara D, Shanbhag ND, Truong D, Patil S, et al. Identification of circulating tumor cells using 4-color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low-dose computed tomography-detected lung nodules.

Katz RL，Zaidi TM，Pujara D，Shanbhag ND，Truong D，Patil S等。使用四色荧光原位杂交鉴定循环肿瘤细胞：验证低剂量计算机断层扫描检测到的肺结节患者排除肺癌的无创辅助手段。

Cancer Cytopathol. 2020;128:553–62.Article .

癌症细胞病理学。2020年；128:553-62。文章。

CAS

PubMed

Google Scholar

谷歌学者

Willatt L, Cox J, Barber J, Cabanas ED, Collins A, Donnai D, et al. 3q29 microdeletion syndrome: clinical and molecular characterization of a new syndrome. Am J Hum Genet. 2005;77:154–60.Article

Willatt L，Cox J，Barber J，Cabanas ED，Collins A，Donnai D等。3q29微缺失综合征：一种新综合征的临床和分子表征。我是J Hum Genet。2005年；

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Glassford, M.R., R.H. Purcell, S. Pass, M.M. Murphy, G.J. Bassell, J.G. Mulle, et al., Caregiver perspectives on a Child’s diagnosis of 3q29 Deletion: “We Can’t Just Wish This Thing Away”. J Dev Behav Pediatr, 2022;43:e94–e102.Saiga T, Fukuda T, Matsumoto M, Tada H, Okano HJ, Okano H, et al.

Glassford，M.R.，R.H.Purcell，S.Pass，M.M.Murphy，G.J.Bassell，J.G.Mulle等人，照顾者对儿童3q29缺失诊断的观点：“我们不能只希望这件事消失”。J Dev Behav Pediatr，2022年；43:e94-e102.Saiga T，Fukuda T，Matsumoto M，Tada H，Okano HJ，Okano H等。

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009;29:3529–43.Article .

Fbxo45形成一种新型泛素连接酶复合物，是神经元发育所必需的。摩尔细胞生物学。2009年；29:3529–43。文章。

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014;507:190–4.Article

Desai TJ，Brownfield DG，Krasnow MA。肺泡祖细胞和干细胞在肺发育，更新和癌症中的作用。自然。2014年；507:190–4.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Zheng HC, Takano Y. NNK-induced lung tumors: a review of animal model. J Oncol. 2011;2011:635379.Article

Zheng HC，Takano Y.NNK诱导的肺肿瘤：动物模型的综述。J Oncol。2011年；2011:635379.文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Wikenheiser KA, Vorbroker DK, Rice WR, Clark JC, Bachurski CJ, Oie HK, et al. Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice. Proc Natl Acad Sci USA. 1993;90:11029–33.Article

Wikenheiser KA，Vorbroker DK，Rice WR，Clark JC，Bachurski CJ，Oie HK等。从表面活性蛋白C/猿猴病毒40大肿瘤抗原转基因小鼠产生永生化远端呼吸道上皮细胞系。美国国家科学院院刊1993；90:11029–33.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ. The human and mouse replication-dependent histone genes. Genomics. 2002;80:487–98.Article

。人和小鼠复制依赖性组蛋白基因。基因组学。2002年；80:487–98.文章

CAS

PubMed

Google Scholar

谷歌学者

Sittman DB, Graves RA, Marzluff WF. Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation. Proc Natl Acad Sci USA. 1983;80:1849–53.Article

Sittman DB，Graves RA，Marzluff WF。组蛋白mRNA浓度在转录和mRNA降解水平受到调节。美国国家科学院院刊1983；

CAS

PubMed

PubMed Central

PubMed 中心

Google Scholar

谷歌学者

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10:1523.Article

Zhou Y，Zhou B，Pache L，Chang M，Khodabakhshi AH，Tanaseichuk O等。Metascape为系统级数据集的分析提供了面向生物学家的资源。纳特公社。2019年；10：第1523条

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Dou Y, Kalmykova S, Pashkova M, Oghbaie M, Jiang H, Molloy KR, et al. Affinity proteomic dissection of the human nuclear cap-binding complex interactome. Nucleic Acids Res. 2020;48:10456–69.Article

Dou Y，Kalmykova S，Pashkova M，Oghbaie M，Jiang H，Molloy KR等。人核帽结合复合物相互作用组的亲和蛋白质组学解剖。核酸Res.2020；48:10456–69.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Hoefig KP, Heissmeyer V. Degradation of oligouridylated histone mRNAs: see UUUUU and goodbye. Wiley Interdiscip Rev RNA. 2014;5:577–89.Article

Hoefig KP，Heissmeyer V.寡尿酸化组蛋白mRNA的降解：参见UUUUU和再见。Wiley Interdiscip Rev RNA。2014；5： 577-89.文章

CAS

PubMed

Google Scholar

谷歌学者

Hammond D, Zeng K, Espert A, Bastos RN, Baron RD, Gruneberg U, et al. Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A. J Cell Sci. 2013;126:3429–40.CAS

Hammond D，Zeng K，Espert A，Bastos RN，Baron RD，Gruneberg U等。蛋白磷酸酶6中与黑色素瘤相关的突变由于Aurora-A失调而导致染色体不稳定和DNA损伤。J细胞科学。2013年；126:3429–40.CAS

PubMed

Google Scholar

谷歌学者

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6:pl1.Article

Gao J，Aksoy BA，Dogrusoz U，Dresdner G，Gross B，Sumer SO等。使用cBioPortal对复杂癌症基因组学和临床概况进行综合分析。Sci信号。2013年；6： pl1.文章

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Maskin CR, Raman R, Houvras Y. PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity. Sci Rep. 2022;12:5573.Article

Maskin CR，Raman R，Houvras Y.PPP6C是一种丝氨酸-苏氨酸磷酸酶，可调节黑素细胞分化，并通过调节MITF活性促进黑色素瘤的发生。Sci代表2022；12：第5573条

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Sobajima T, Kowalczyk KM, Skylakakis S, Hayward D, Fulcher LJ, Neary C, et al. PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. J Cell Biol. 2023;222:e202205117.Article

Sobajima T，Kowalczyk KM，Skylakakis S，Hayward D，Fulcher LJ，Neary C等人。Aurora A-TPX2的PP6调节限制了NDC80的磷酸化和有丝分裂纺锤体的大小。J细胞生物学。2023年；222:e202205117.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Chen X, Miragaia RJ, Natarajan KN, Teichmann SA. A rapid and robust method for single cell chromatin accessibility profiling. Nat Commun. 2018;9:5345.Article

Chen X，Miragaia RJ，Natarajan KN，Teichmann SA。一种快速可靠的单细胞染色质可及性分析方法。纳特公社。2018年；9：第5345条

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Rizzo JM, Bard JE, Buck MJ. Standardized collection of MNase-seq experiments enables unbiased dataset comparisons. BMC Mol Biol. 2012;13:15.Article

里佐JM，巴德JE，巴克MJ。MNase-seq实验的标准化收集可以实现无偏数据集比较。BMC摩尔生物学。2012年；13： 15、条款

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Frew AJ, Johnstone RW, Bolden JE. Enhancing the apoptotic and therapeutic effects of HDAC inhibitors. Cancer Lett. 2009;280:125–33.Article

Frew AJ，Johnstone RW，Bolden JE。增强HDAC抑制剂的凋亡和治疗作用。癌症Lett。2009年；280:125–33.文章

CAS

PubMed

Google Scholar

谷歌学者

Igaz N, Kovacs D, Razga Z, Konya Z, Boros IM, Kiricsi M. Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles. Colloids Surf B Biointerfaces. 2016;146:670–7.Article

Igaz N，Kovacs D，Razga Z，Konya Z，Boros IM，Kiricsi M.通过脱乙酰酶抑制调节染色质结构和DNA可及性增强了银纳米颗粒的抗癌活性。胶体表面B生物界面。2016年；146:670–7.文章

CAS

PubMed

Google Scholar

谷歌学者

Luzhna L, Kathiria P, Kovalchuk O. Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond. Front Genet. 2013;4:131.Article

Luzhna L，Kathiria P，Kovalchuk O.遗传毒性评估中的微核：从遗传学到表观遗传学等。前Genet。2013年；4： 131、条款

CAS

PubMed

PubMed Central

PubMed 中心

Google Scholar

谷歌学者

Kinner A, Wu W, Staudt C, Iliakis G. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res. 2008;36:5678–94.Article

Kinner A，Wu W，Staudt C，Iliakis G.Gamma-H2AX在染色质背景下识别和信号传导DNA双链断裂。；36:5678–94.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Griesbach E, Schlackow M, Marzluff WF, Proudfoot NJ. Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle. Nat Commun. 2021;12:359.Article

Griesbach E，Schlackow M，Marzluff WF，Proudfoot NJ。H2A的双RNA 3'末端加工。X信使RNA在整个细胞周期中维持DNA损伤修复。纳特公社。2021年；12：第359条

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Hauer MH, Seeber A, Singh V, Thierry R, Sack R, Amitai A, et al. Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates. Nat Struct Mol Biol. 2017;24:99–107.Article

Hauer MH，Seeber A，Singh V，Thierry R，Sack R，Amitai A等。响应DNA损伤的组蛋白降解增强了染色质动力学和重组率。Nat Struct Mol Biol。2017年；24:99–107.文章

CAS

PubMed

Google Scholar

谷歌学者

Chang KW, Lin CE, Tu HF, Chung HY, Chen YF, Lin SC. Establishment of a p53 null murine oral carcinoma cell line and the identification of genetic alterations associated with this carcinoma. Int J Mol Sci. 2020;21:9354.Article

Chang KW，Lin CE，Tu HF，Chung HY，Chen YF，Lin SC.建立p53缺失的鼠口腔癌细胞系并鉴定与该癌相关的遗传改变。国际分子科学杂志。2020年；21:9354.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Esposito MR, Binatti A, Pantile M, Coppe A, Mazzocco K, Longo L, et al. Somatic mutations in specific and connected subpathways are associated with short neuroblastoma patients’ survival and indicate proteins targetable at onset of disease. Int J Cancer. 2018;143:2525–36.Article

Esposito MR，Binatti A，Pantile M，Coppe A，Mazzocco K，Longo L等。特定和相关亚通路中的体细胞突变与神经母细胞瘤患者的生存期短有关，并表明疾病发作时可靶向的蛋白质。Int J癌症。2018年；143:2525–36.文章

CAS

PubMed

Google Scholar

谷歌学者

Han ZF, Lin ST, Zhong M, Yu DJ. Correlations of UGT1A1 gene polymorphisms with onset and prognosis of non-small cell lung cancer. Eur Rev Med Pharmacol Sci. 2020;24:9973–80.PubMed

韩志福，林士泰，钟敏，余DJ。UGT1A1基因多态性与非小细胞肺癌发病及预后的相关性。Eur Rev Med Pharmacol Sci。2020年；24:9973–80.PubMed

Google Scholar

谷歌学者

Preussner J, Zhong J, Sreenivasan K, Gunther S, Engleitner T, Kunne C, et al. Oncogenic amplification of zygotic dux factors in regenerating p53-deficient muscle stem cells defines a molecular cancer subtype. Cell Stem Cell. 2018;23:794–805 e4.Article

Preussner J，Zhong J，Sreenivasan K，Gunther S，Engleitner T，Kunne C等。合子dux因子在再生p53缺陷型肌肉干细胞中的致癌扩增定义了分子癌症亚型。细胞干细胞。2018年；23:794-805 e4条款

CAS

PubMed

Google Scholar

谷歌学者

Jonckheere N, Van Seuningen I. Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. J Transl Med. 2018;16:259.Article

Jonckheere N，Van Seuningen I.癌症基因组图谱和癌细胞系百科全书大规模基因组数据库的综合分析：MUC4/MUC16/MUC20签名与人类癌症的生存率差有关。J Transl Med。2018；16：第259条

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Reiterova J, Tesar V. Autosomal dominant polycystic kidney disease: from pathophysiology of cystogenesis to advances in the treatment. Int J Mol Sci. 2022;23:3317.Article

Reiterova J，Tesar V.常染色体显性多囊肾病：从囊肿发生的病理生理学到治疗进展。国际分子科学杂志。2022年；23:3317.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, et al. Comprehensive characterization of cancer driver genes and mutations. Cell. 2018;173:371–85 e18.Article

Bailey MH，Tokheim C，Porta Pardo E，Sengupta S，Bertrand D，Weerasinghe A等。癌症驱动基因和突变的综合表征。细胞。2018年；173:371-85 e18。文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Martinez-Jimenez F, Muinos F, Sentis I, Deu-Pons J, Reyes-Salazar I, Arnedo-Pac C, et al. A compendium of mutational cancer driver genes. Nat Rev Cancer. 2020;20:555–72.Article

。Nat Rev癌症。2020年；20： 555-72.文章

CAS

PubMed

Google Scholar

谷歌学者

Dhatchinamoorthy K, Colbert JD, Rock KL. Cancer immune evasion through loss of MHC class I antigen presentation. Front Immunol. 2021;12:636568.Article

Dhatchinamoorthy K，Colbert JD，Rock KL。通过丧失MHC I类抗原呈递来逃避癌症免疫。前免疫。2021年；12： 636568条

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

He Y, Rozeboom L, Rivard CJ, Ellison K, Dziadziuszko R, Yu H, et al. MHC class II expression in lung cancer. Lung Cancer. 2017;112:75–80.Article

He Y，Rozeboom L，Rivard CJ，Ellison K，Dziadziuszko R，Yu H等。MHC II类在肺癌中的表达。肺癌。2017年；112:75–80.文章

PubMed

Google Scholar

谷歌学者

Johnson AM, Bullock BL, Neuwelt AJ, Poczobutt JM, Kaspar RE, Li HY, et al. Cancer cell-intrinsic expression of MHC Class II regulates the immune microenvironment and response to Anti-PD-1 therapy in lung adenocarcinoma. J Immunol. 2020;204:2295–307.Article

Johnson AM，Bullock BL，Neuwelt AJ，Poczobutt JM，Kaspar RE，Li HY等。II类MHC的癌细胞内在表达调节肺腺癌的免疫微环境和对抗PD-1治疗的反应。免疫杂志。2020年；204:2295–307.文章

CAS

PubMed

Google Scholar

谷歌学者

Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr., Kinzler KW. Cancer genome landscapes. Science. 2013;339:1546–58.Article

Vogelstein B，Papadopoulos N，Velculescu VE，Zhou S，Diaz LA Jr.，Kinzler KW。癌症基因组景观。科学。2013年；

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Lin M, Wang ZW, Zhu X. FBXO45 is a potential therapeutic target for cancer therapy. Cell Death Discov. 2020;6:55.Article

Lin M，Wang ZW，Zhu X.FBXO45是癌症治疗的潜在治疗靶点。细胞死亡发现。2020年；6： 55、条款

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Kogure N, Yokobori T, Ogata K, Altan B, Mochiki E, Ohno T, et al. Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis. Anticancer Res. 2017;37:191–6.Article

。抗癌研究2017；37:191–6.文章

CAS

PubMed

Google Scholar

谷歌学者

Abshire CF, Carroll JL, Dragoi AM. FLASH protects ZEB1 from degradation and supports cancer cells’ epithelial-to-mesenchymal transition. Oncogenesis. 2016;5:e254.Article

Abshire CF，Carroll JL，Dragoi AM。FLASH保护ZEB1免受降解，并支持癌细胞的上皮向间充质转化。肿瘤发生。2016年；5： e254条款

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Peschiaroli A, Scialpi F, Bernassola F, Pagano M, Melino G. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene. 2009;28:3157–66.Article

Peschiaroli A，Scialpi F，Bernassola F，Pagano M，Melino G.F-box蛋白FBXO45促进p73的蛋白酶体依赖性降解。致癌基因。2009年；28:3157–66.文章

CAS

PubMed

Google Scholar

谷歌学者

Chen X, Sahasrabuddhe AA, Szankasi P, Chung F, Basrur V, Rangnekar VM, et al. Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival. Cell Death Differ. 2014;21:1535–45.Article

Chen X，Sahasrabuddhe AA，Szankasi P，Chung F，Basrur V，Rangnekar VM等。Fbxo45介导的肿瘤抑制因子Par-4降解调节癌细胞存活。细胞死亡不同。2014年；21:1535–45.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Richter KT, Kschonsak YT, Vodicska B, Hoffmann I. FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation. Cell Death Differ. 2020;27:758–72.Article

Richter KT，Kschonsak YT，Vodicska B，Hoffmann I.FBXO45-MYCBP2通过靶向FBXW7降解来调节有丝分裂细胞的命运。细胞死亡不同。2020年；27:758–72.文章

CAS

PubMed

Google Scholar

谷歌学者

Wu L, Yu K, Chen K, Zhu X, Yang Z, Wang Q, et al. Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation. Cell Death Dis. 2022;13:231.Article

Wu L，Yu K，Chen K，Zhu X，Yang Z，Wang Q等。Fbxo45通过靶向USP49进行泛素化和降解来促进胰腺癌的进展。细胞死亡Dis。2022年；13： 231条

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Wang Q, Wu L, Cao R, Gao J, Chai D, Qin Y, et al. Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation. Oncogene. 2022;41:4795–807.Article

Wang Q，Wu L，Cao R，Gao J，Chai D，Qin Y等。Fbxo45通过靶向GGNBP2进行泛素化和降解来促进食管鳞状细胞癌的恶性发展。致癌基因。2022年；41:4795–807.文章

CAS

PubMed

Google Scholar

谷歌学者

Al Zubaidi T, Gehrisch OHF, Genois MM, Liu Q, Lu S, Kung J, et al. Targeting the DNA replication stress phenotype of KRAS mutant cancer cells. Sci Rep. 2021;11:3656.Article

Al-Zubaidi T，Gehrisch OHF，Genois MM，Liu Q，Lu S，Kung J等。针对KRAS突变癌细胞的DNA复制应激表型。Sci代表2021；11：

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Chung FZ, Sahasrabuddhe AA, Ma K, Chen X, Basrur V, Lim MS, et al. Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation. J Biol Chem. 2014;289:28448–59.Article

Chung FZ，Sahasrabuddhe AA，Ma K，Chen X，Basrur V，Lim MS等。Fbxo45抑制N-钙粘蛋白的钙敏感蛋白水解并促进神经元分化。生物化学杂志。2014年；289:28448–59.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Deem AK, Li X, Tyler JK. Epigenetic regulation of genomic integrity. Chromosoma. 2012;121:131–51.Article

认为AK，李X，泰勒JK。基因组完整性的表观遗传调控。染色体。2012年；121:131–51.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, et al. Genomic instability in mice lacking histone H2AX. Science. 2002;296:922–7.Article

Celeste A，Petersen S，Romanienko PJ，Fernandez Capetillo O，Chen HT，Sedelnikova OA等。缺乏组蛋白H2AX的小鼠的基因组不稳定性。科学。2002年；296:922–7.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Gionchiglia N, Granato A, Merighi A, Lossi L. Association of Caspase 3 Activation and H2AX gamma Phosphorylation in the Aging Brain: Studies on Untreated and Irradiated Mice. Biomedicines. 2021;9:1166.Article

Gionchiglia N，Granato A，Merighi A，Lossi L.衰老大脑中Caspase 3活化和H2AXγ磷酸化的关联：未经治疗和照射的小鼠的研究。。2021年；9：第1166条

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. H2AX: the histone guardian of the genome. DNA Repair. 2004;3:959–67.Article

Fernandez Capetillo O，Lee A，Nussenzweig M，Nussenzweig A.H2AX：基因组的组蛋白守护者。DNA修复。2004年；3： 959–67.文章

CAS

PubMed

Google Scholar

谷歌学者

Martincorena I, Campbell PJ. Somatic mutation in cancer and normal cells. Science. 2015;349:1483–9.Article

。癌症和正常细胞中的体细胞突变。科学。2015年；349:1483-9.文章

CAS

PubMed

Google Scholar

谷歌学者

Sinha M, Lowell CA. Isolation of highly pure primary mouse alveolar epithelial type II cells by flow cytometric cell sorting. Bio Protoc. 2016;6:e2013.Article

Sinha M，Lowell CA。通过流式细胞术细胞分选分离高纯度的原代小鼠肺泡上皮II型细胞。生物协议。2016年；6： 2013年2月

PubMed

Google Scholar

谷歌学者

Zhang H, Zhao X, Guo Y, Chen R, He J, Li L, et al. Hypoxia regulates overall mRNA homeostasis by inducing Met(1)-linked linear ubiquitination of AGO2 in cancer cells. Nat Commun. 2021;12:5416.Article

Zhang H，Zhao X，Guo Y，Chen R，He J，Li L，et al。缺氧通过诱导癌细胞中AGO2的Met（1）连接的线性泛素化来调节整体mRNA稳态。纳特公社。2021年；12：第5416条

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

De Clerck NM, Meurrens K, Weiler H, Van Dyck D, Van G, Houtte, et al. High-resolution X-ray microtomography for the detection of lung tumors in living mice. Neoplasia. 2004;6:374–9.Article

De Clerck NM，Meurrens K，Weiler H，Van Dyck D，Van G，Houtte等。用于检测活体小鼠肺肿瘤的高分辨率X射线显微断层扫描。瘤形成。2004年；6： 374-9.文章

PubMed

PubMed Central

PubMed 中心

Google Scholar

谷歌学者

Dzierzak E, de Bruijn M. Isolation and analysis of hematopoietic stem cells from mouse embryos. Methods Mol Med. 2002;63:1–14.PubMed

Dzierzak E，de Bruijn M.从小鼠胚胎中分离和分析造血干细胞。方法Mol Med。2002；63:1–14.PubMed

Google Scholar

谷歌学者

Buenrostro JD, Giresi PG, Zaba LC, Chang HY, Greenleaf WJ. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat Methods. 2013;10:1213–8.Article

Buenrostro JD，Giresi PG，Zaba LC，Chang HY，Greenleaf WJ。天然染色质的转座，用于快速灵敏地对开放染色质，DNA结合蛋白和核小体位置进行表观基因组分析。。2013年；10： 1213-8.文章

CAS

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Gansauge MT, Meyer M. Single-stranded DNA library preparation for the sequencing of ancient or damaged DNA. Nat Protoc. 2013;8:737–48.Article

Gansauge MT，Meyer M.用于古代或受损DNA测序的单链DNA文库制备。。2013年；8： 737-48.文章

PubMed

Google Scholar

谷歌学者

Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014;505:117–20.Article

。自然。2014年；505:117–20.文章

PubMed

Google Scholar

谷歌学者

Soederberg A, Meissgeier T, Bosserhoff AK, Linck-Paulus L. MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A. Cells. 2022;11:3859.Article

Soederberg A，Meissgeier T，Bosserhoff AK，Linck-Paulus L.MAGOH和MAGOHB在黑色素瘤细胞中的敲低降低了无义介导的衰变活性，并通过上调GADD45A促进了细胞凋亡。细胞。2022年；11： 3859条

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Baird TD, Cheng KC, Chen YC, Buehler E, Martin SE, Inglese J, et al. ICE1 promotes the link between splicing and nonsense-mediated mRNA decay. Elife. 2018;7:e33178.Article

Baird TD，Cheng KC，Chen YC，Buehler E，Martin SE，Inglese J等。ICE1促进剪接和无义介导的mRNA衰变之间的联系。。2018年；7： e33178。条款

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Pereverzev AP, Gurskaya NG, Ermakova GV, Kudryavtseva EI, Markina NM, Kotlobay AA, et al. Method for quantitative analysis of nonsense-mediated mRNA decay at the single cell level. Sci Rep. 2015;5:7729.Article

Pereverzev AP，Gurskaya NG，Ermakova GV，Kudryavtseva EI，Markina NM，Kotlobay AA等。在单细胞水平上定量分析无义介导的mRNA衰变的方法。Sci代表2015；5：第7729条

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Shechter D, Dormann HL, Allis CD, Hake SB. Extraction, purification and analysis of histones. Nat Protoc. 2007;2:1445–57.Article

Shechter D，Dormann HL，Allis CD，Hake SB。组蛋白的提取，纯化和分析。。2007年；2： 1445-57.条

CAS

PubMed

Google Scholar

谷歌学者

Download referencesAcknowledgementsWe thank the Proteomics, Electron microscope and Flow sorting laboratory of Core Facility, Shanghai Jiao Tong University College of Basic Medical Sciences.FundingThis work was supported by grants from the National Natural Science Foundation of China (82230100, 32271310, 82273138) and Natural Science Foundation of Shanghai (23ZR1411500).Author informationAuthor notesThese authors contributed equally: Lian Li, Junya Li, Ran Chen, Caihu Huang, Yong Zuo.Authors and AffiliationsDepartment of Biochemistry and Molecular Cell Biology & Department of Thoracic Surgery Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, ChinaLian Li, Junya Li, Ran Chen, Caihu Huang, Yong Zuo, Runhui Lu, Xiaojia Liu, Jiayi Huang, Yanli Wang, Xian Zhao, Jinke Cheng, Xiaojing Zhao & Jianxiu YuDepartment of Respiratory and Critical Care Medicine, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, 201700, ChinaLian Li, Chunling Du & Jianxiu YuAuthorsLian LiView author publicationsYou can also search for this author in.

下载参考文献致谢我们感谢上海交通大学基础医学院核心设施的蛋白质组学，电子显微镜和流动分选实验室。资助这项工作得到了国家自然科学基金（822301003227131082273138）和上海自然科学基金（23ZR1411500）的资助。作者信息作者注意到这些作者做出了同样的贡献：Lian Li，Junya Li，Ran Chen，Caihu Huang，Yong Zuo。作者和所属单位上海交通大学医学院仁济医院生物化学与分子细胞生物学系和胸外科，上海，200025，李华莲，李俊雅，陈冉，黄彩虎，左勇，卢润辉，刘晓佳，黄家义，王燕丽，赵贤，程金科，赵晓静，余建秀复旦大学附属中山医院青浦分院呼吸与重症监护医学系，上海，201700，李华莲，杜春玲，余建秀作者LiView作者出版物您也可以在中搜索这位作者。

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PubMed Google ScholarContributionsJY and LL conceptualized the project; LL, JL, RC, CH, YZ and JC designed the methods; LL, JL, RC, CH, RL, XL, and JH performed most of experiments; LL, YW, XZ and JY performed formal analyses; LL and JY wrote the manuscript; JY, CD, and XJZ supervised the project.

PubMed Google ScholarContributionsJY和LL将该项目概念化；LL，JL，RC，CH，YZ和JC设计了方法；LL，JL，RC，CH，RL，XL和JH进行了大部分实验；LL，YW，XZ和JY进行了正式分析；LL和JY写了手稿；JY，CD和XJZ监督了该项目。

All authors reviewed and edited the manuscript.Corresponding authorsCorrespondence to.

所有作者都审阅并编辑了手稿。通讯作者通讯。

Xiaojing Zhao, Chunling Du or Jianxiu Yu.Ethics declarations

赵晓静、杜春玲或余建秀。道德宣言

Competing interests

相互竞争的利益

The authors declare no competing interests.

作者声明没有利益冲突。

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Animal experiments were conducted following the general rules for the care and use of experimental animals and approved by the Shanghai Jiao Tong University School of Medicine Animal Care and Use Committee (permission no. A-2022-036). Clinical samples were collected from patients with written informed consent, following a protocol approved by The Affiliated Renji Hospital of Shanghai Jiao Tong University School of Medicine (ethics approval no.

。临床样本是根据上海交通大学医学院附属仁济医院批准的方案（伦理批准号：。

RA-2022-267)..

RA-2022-267）。。

Additional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Supplementary informationSupplemental Figure_S1-8Supplemental_Table_S1Supplemental_Table_S2Supplemental_Table_S3Supplemental_Table_S4Supplemental_Table_S5Supplemental_Table_S6Supplemental_Table_S7Supplemental_Table_S8Supplemental_Table_S9original western blotsRights and permissionsSpringer Nature or its licensor (e.g.

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a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.Reprints and permissionsAbout this articleCite this articleLi, L., Li, J., Chen, R.

协会或其他合作伙伴）根据与作者或其他权利持有人的出版协议对本文拥有专有权；本文接受稿件版本的作者自行存档仅受此类出版协议和适用法律的条款管辖。转载和许可本文引用本文Li，L.，Li，J.，Chen，R。

et al. Loss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma..

AT2细胞中Fbxo45的缺失导致组蛋白供应不足并引发肺腺癌。。

Cell Death Differ (2024). https://doi.org/10.1038/s41418-024-01433-zDownload citationReceived: 14 June 2024Revised: 27 November 2024Accepted: 05 December 2024Published: 13 December 2024DOI: https://doi.org/10.1038/s41418-024-01433-zShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

细胞死亡不同（2024）。https://doi.org/10.1038/s41418-024-01433-zDownload引文收到日期：2024年6月14日修订日期：2024年11月27日接受日期：2024年12月5日发布日期：2024年12月13日OI：https://doi.org/10.1038/s41418-024-01433-zShare本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

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