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Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immunosurveillance mechanisms. Dura-derived immunosuppressive macrophages are now shown to migrate to the cerebrospinal fluid, limiting anti-tumor CD8+ T cell responses in models of leptomeningeal metastasis..
实体瘤的软脑膜转移与预后不良,治疗选择有限和免疫监视机制不明确有关。。。
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Fig. 1: Dura-associated macrophages migrate to the CSF following LM seeding and inhibit T cell functions.
图1:LM接种后,硬脑膜相关巨噬细胞迁移至CSF并抑制T细胞功能。
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Rights and permissionsReprints and permissionsAbout this articleCite this articleKilian, M., Quintana, F.J. Immunosuppressive dura-derived macrophages in leptomeningeal metastasis.
权利和许可本文引用本文Kilian,M.,Quintana,F.J。软脑膜转移中的免疫抑制性硬脑膜衍生巨噬细胞。
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