EN
登录

软脑膜转移瘤中的免疫抑制硬脑膜来源巨噬细胞

Immunosuppressive dura-derived macrophages in leptomeningeal metastasis

Nature 等信源发布 2024-12-20 20:50

可切换为仅中文


Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immunosurveillance mechanisms. Dura-derived immunosuppressive macrophages are now shown to migrate to the cerebrospinal fluid, limiting anti-tumor CD8+ T cell responses in models of leptomeningeal metastasis..

实体瘤的软脑膜转移与预后不良,治疗选择有限和免疫监视机制不明确有关。。。

Access through your institution

通过您的机构访问

Buy or subscribe

购买或订阅

This is a preview of subscription content, access via your institution

这是订阅内容的预览,可通过您的机构访问

Access options

访问选项

Access through your institution

通过您的机构访问

Access through your institution

通过您的机构访问

Change institution

变革机构

Buy or subscribe

购买或订阅

Access Nature and 54 other Nature Portfolio journals

Access Nature和54种其他Nature投资组合期刊

Get Nature+, our best-value online-access subscription

获取Nature+,我们最具价值的在线访问订阅

24,99 € / 30 days

24,99欧元/30天

cancel any time

随时取消

Learn more

了解更多信息

Subscribe to this journal

订阅此日记

Receive 12 digital issues and online access to articles

接收12期数字期刊并在线访问文章

111,21 € per year

每年111,21欧元

only 9,27 € per issue

每期仅9.27欧元

Learn more

了解更多信息

Buy this article

购买这篇文章

Purchase on SpringerLink

在SpringerLink上购买

Instant access to full article PDF

即时访问全文PDF

Buy now

立即购买

Prices may be subject to local taxes which are calculated during checkout

价格可能需要缴纳结帐时计算的地方税

Additional access options:

其他访问选项:

Log in

登录

Learn about institutional subscriptions

了解机构订阅

Read our FAQs

阅读我们的常见问题

Contact customer support

联系客户支持

Fig. 1: Dura-associated macrophages migrate to the CSF following LM seeding and inhibit T cell functions.

图1:LM接种后,硬脑膜相关巨噬细胞迁移至CSF并抑制T细胞功能。

ReferencesLe Rhun, E. et al. Neuro. Oncol. 23, 1100–1112 (2021).Article

参考Rhun,E.等人,Neuro。肿瘤。231100-1112(2021)。文章

PubMed

PubMed

Google Scholar

谷歌学者

Brastianos, P. K. et al. Nat. Commun. 12, 5954 (2021).Article

Brastianos,P.K.等人,Nat.Commun。125954(2021)。文章

CAS

中科院

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Zhao, J. et al. Nat. Cancer https://doi.org/10.1038/s43018-024-00858-2 (2024).Article

赵,J。等。自然癌症https://doi.org/10.1038/s43018-024-00858-2(2024年)。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Whiteley, A. E. et al. Science 384, eadh5548 (2024).Article

怀特利,A.E.等人,《科学》384,第5548页(2024)。文章

CAS

中科院

PubMed

PubMed

Google Scholar

谷歌学者

Chi, Y. et al. Science 369, 276–282 (2020).Article

Chi,Y.等人,《科学》369276-282(2020)。文章

CAS

中科院

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Kessenbrock, K., Plaks, V. & Werb, Z. Cell 141, 52–67 (2010).Article

Kessenbrock,K.,Plaks,V.&Werb,Z.细胞141,52-67(2010)。文章

CAS

中科院

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Castello, L. M. et al. Mediators Inflamm. https://doi.org/10.1155/2017/4049098 (2017).Article

Castello,L.M.等人。https://doi.org/10.1155/2017/4049098(2017).文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Klement, J. D. et al. J. Clin. Invest. 128, 5549–5560 (2018).Article

Klement,J.D.等人,J.Clin。投资。1285549–5560(2018)。文章

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Rustenhoven, J. et al. Cell 184, 1000–1016.e27 (2021).Article

Rustenhoven,J.等人,细胞1841000–1016.E27(2021)。文章

CAS

中科院

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Louveau, A. et al. Nat. Neurosci. 21, 1380–1391 (2018).Article

Louveau,A.等人,《神经科学》。211380–1391(2018)。文章

CAS

中科院

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Mildenberger, W., Stifter, S. A. & Greter, M. Curr. Opin. Immunol. 76, 102181 (2022).Article

米登伯格,W.,斯蒂夫特,S.A。和格雷特,M.Curr。奥平。免疫。76102181(2022)。文章

CAS

中科院

PubMed

PubMed

Google Scholar

谷歌学者

Pietras, A. et al. Cell Stem Cell 14, 357–369 (2014).Article

Pietras,A.等人,《细胞干细胞》14357–369(2014)。文章

CAS

中科院

PubMed

PubMed

PubMed Central

公共医学中心

Google Scholar

谷歌学者

Wei, J. et al. J. Clin. Invest. 129, 137–149 (2019).Article

Wei,J.等人,J.Clin。投资。129137-149(2019)。文章

PubMed

PubMed

Google Scholar

谷歌学者

Kilian, M. et al. Cancer Cell 41, 235–251.e9 (2023).Article

Kilian,M.等人,《癌细胞》41235–251.e9(2023)。文章

CAS

中科院

PubMed

PubMed

Google Scholar

谷歌学者

Remsik, J. et al. Preprint at bioRxiv https://doi.org/10.1101/2023.03.17.533041 (2023).Download referencesAuthor informationAuthors and AffiliationsAnn Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAMichael Kilian & Francisco J.

Remsik,J.等人,bioRxiv预印本https://doi.org/10.1101/2023.03.17.533041。下载参考文献作者信息作者和附属机构美国马萨诸塞州波士顿哈佛医学院布莱根妇女医院罗姆尼神经系统疾病中心Michael Kilian&Francisco J。

QuintanaBroad Institute of MIT and Harvard, Cambridge, MA, USAMichael Kilian & Francisco J. QuintanaGene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAFrancisco J. QuintanaAuthorsMichael KilianView author publicationsYou can also search for this author in.

麻省理工学院和哈佛大学金塔纳布罗德研究所,马萨诸塞州剑桥,美国迈克尔·基利安和弗朗西斯科·J·金塔涅·莱伊免疫学和炎症研究所,马萨诸塞州总医院,哈佛医学院,马萨诸塞州波士顿,美国弗朗西斯科·J·金塔纳作家迈克尔·基利安观点作者出版物你也可以在中搜索这位作者。

PubMed Google ScholarFrancisco J. QuintanaView author publicationsYou can also search for this author in

PubMed谷歌学者Francisco J.QuintanaView作者出版物您也可以在

PubMed Google ScholarCorresponding authorCorrespondence to

PubMed谷歌学者通讯社

Francisco J. Quintana.Ethics declarations

Francisco J.Quintana。道德宣言

Competing interests

相互竞争的利益

The authors declare no competing interests.

作者声明没有利益冲突。

Rights and permissionsReprints and permissionsAbout this articleCite this articleKilian, M., Quintana, F.J. Immunosuppressive dura-derived macrophages in leptomeningeal metastasis.

权利和许可本文引用本文Kilian,M.,Quintana,F.J。软脑膜转移中的免疫抑制性硬脑膜衍生巨噬细胞。

Nat Cancer 5, 1791–1792 (2024). https://doi.org/10.1038/s43018-024-00859-1Download citationPublished: 20 December 2024Issue Date: December 2024DOI: https://doi.org/10.1038/s43018-024-00859-1Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

Nat Cancer 51791-1792(2024)。https://doi.org/10.1038/s43018-024-00859-1Download引文发布日期:2024年12月20日发布日期:2024年12月OI:https://doi.org/10.1038/s43018-024-00859-1Share本文与您共享以下链接的任何人都可以阅读此内容:获取可共享链接对不起,本文目前没有可共享的链接。复制到剪贴板。

Provided by the Springer Nature SharedIt content-sharing initiative

由Springer Nature SharedIt内容共享计划提供