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ONI

ONI

(Oxford Nanoimaging), a life science tools company focused on developing super-resolution microscopy, announced today the launch of the Aplo Scope, a single molecule super-resolution microscope that enables scientists to observe and measure molecular interactions within cells and tissues with unparalleled precision..

专注于开发超分辨率显微镜的生命科学工具公司（Oxford Nanoimaging）今天宣布推出Aplo Scope，这是一种单分子超分辨率显微镜，使科学家能够以无与伦比的精度观察和测量细胞和组织内的分子相互作用。。

The Aplo Scope addresses a critical challenge in single-molecule research—capturing the intricate details of biological systems in real-time and at super-resolution. Traditional imaging methods often struggle to capture nanoscale structures and the molecular interactions needed to fully understand drug efficacy and biomarker dynamics.

Aplo范围解决了单分子研究中的一个关键挑战，即实时和超分辨率地捕获生物系统的复杂细节。传统的成像方法通常难以捕获纳米级结构和充分了解药物功效和生物标志物动力学所需的分子相互作用。

ONI’s Aplo Scope is a comprehensive, all-in-one platform that delivers unparalleled clarity and precision for researchers..

ONI的Aplo Scope是一个全面的多功能平台，为研究人员提供了无与伦比的清晰度和精确度。。

“The next wave of innovation in biology and drug development is about visualizing molecular interactions with unprecedented precision,” said Paul Scagnetti, CEO, ONI. “The Aplo Scope provides the clarity, speed, and nanoscale precision researchers need to accelerate breakthroughs in medicine. By overcoming the limitations of traditional microscopy, it reveals hidden molecular interactions and unlocks insights previously thought impossible.

ONI首席执行官保罗·斯加内蒂（PaulScagnetti）表示：“生物学和药物开发的下一波创新浪潮是以前所未有的精度可视化分子相互作用。”。“Aplo示波器提供了研究人员加速医学突破所需的清晰度、速度和纳米级精度。通过克服传统显微镜的局限性，它揭示了隐藏的分子相互作用，并解开了以前认为不可能的见解。

This next-generation imaging technology is a bridge to enabling scientific breakthroughs that were previously out of reach, and will power the next era of scientific breakthroughs.”.

这种下一代成像技术是实现以前遥不可及的科学突破的桥梁，并将推动下一个科学突破时代。”。

The Aplo Scope seamlessly transitions from low-power live-cell imaging to high-power super-resolution imaging at an impressive 20 nm resolution, eliminating the need for hardware reconfiguration and streamlining the imaging process. Its compact benchtop design integrates advanced imaging technology with automated workflows, empowering researchers to explore cellular structures in depth and uncover critical insights in drug delivery, biomarker discovery, and antibody therapeutics..

Aplo示波器以令人印象深刻的20 nm分辨率从低功率活细胞成像无缝过渡到高功率超分辨率成像，无需硬件重新配置并简化成像过程。其紧凑的台式设计将先进的成像技术与自动化工作流程相结合，使研究人员能够深入探索细胞结构，并揭示药物输送，生物标志物发现和抗体治疗方面的关键见解。。

“Directly visualizing biological and chemical phenomena at the molecular level has completely transformed our research and allowed us to solve critical challenges in biomedical science,” said Lorenzo Albertazzi, associate professor, TU/e Department of Biomedical Engineering. “The potential of this technique extends far beyond its current applications and single-molecule localization microscopy (SMLM) helps us understand disease mechanisms, advance drug discovery, and enabling patient stratification.”.

TU/e生物医学工程系副教授Lorenzo Albertazzi说：“在分子水平上直接可视化生物和化学现象已经完全改变了我们的研究，并使我们能够解决生物医学科学中的关键挑战。这项技术的潜力远远超出了其当前的应用，单分子定位显微镜（SMLM）有助于我们了解疾病机制，推进药物发现，并实现患者分层。”。

Featuring a custom-engineered laser module that provides precise control across a wide power range (0.01 kW/cm² to 4.0 kW/cm²), this enables a seamless transition from live-cell imaging to super-resolution with just a click. Paired with a carefully selected filter set and user-friendly software design, the Aplo Scope simplifies complex assays, such as multi-color imaging and time-lapse videos of biological events like particle uptake or cell-to-cell interactions.

采用定制设计的激光模块，可在宽功率范围（0.01 kW/cm²至4.0 kW/cm²）内提供精确控制，只需轻轻一按，即可实现从活细胞成像到超分辨率的无缝过渡。与精心挑选的过滤器组和用户友好的软件设计相结合，Aplo Scope简化了复杂的分析，例如多色成像和生物事件（如颗粒摄取或细胞间相互作用）的延时视频。

Its versatility, ease of use, and plug-and-play design allow even non-experts to achieve high-quality results without the time-consuming setup required by traditional imaging systems..

它的多功能性、易用性和即插即用设计使即使是非专家也能获得高质量的结果，而无需传统成像系统所需的耗时设置。。

“SMLM microscopy has transformative potential for drug discovery by providing nanoscale insights into biomolecular interactions, mechanisms, and dynamics,” said Alexey Rak, Department Head, Bio Structure and Biophysics, Integrated Drug Discovery, Sanofi. “Its incredible resolution, combined with single-molecule sensitivity, enables drug hunters to characterize targets and molecules with exceptional precision that is close to the structural biology one.

赛诺菲综合药物发现生物结构与生物物理学部门负责人Alexey Rak说：“SMLM显微镜通过提供对生物分子相互作用，机制和动力学的纳米级见解，具有药物发现的变革潜力。”。“它令人难以置信的分辨率，结合单分子灵敏度，使药物猎手能够以接近结构生物学的异常精度表征目标和分子。

While challenges remain in live-cell imaging and high-throughput scalability, emerging technologies and AI-driven approaches will further elevate the role of SMLM in developing the next generation of therapeutics..

虽然活细胞成像和高通量可扩展性仍面临挑战，但新兴技术和人工智能驱动的方法将进一步提高SMLM在开发下一代疗法中的作用。。

Understanding how biology works at the smallest scales - inside individual cells - is essential to solving the world’s most pressing health challenges, from identifying relevant biomarkers to designing better medicines. Single-molecule imaging is pivotal for uncovering the mechanisms that drive disease and therapeutic response in drug development.

从识别相关生物标志物到设计更好的药物，了解生物学如何在最小规模上（在单个细胞内）发挥作用，对于解决世界上最紧迫的健康挑战至关重要。单分子成像对于揭示药物开发中驱动疾病和治疗反应的机制至关重要。

These insights are crucial for advancing everything from cancer treatments to vaccines, helping researchers solve mysteries that were previously hidden due to blind spots left undiscovered from existing technologies..

这些见解对于推进从癌症治疗到疫苗的一切都至关重要，有助于研究人员解决以前由于现有技术未发现的盲点而隐藏的谜团。。

“I started using SMLM to study chromatin structure in somatic and stem cells several years ago. I have been extensively applying it to investigate 3D genome organization and chromatin fiber looping, which are fundamental features underlying various cell phenotypes, including normal, diseased, or drug-induced states,” said Maria Pia Cosma, Senior Scientist and ICREA Research Professor, Center for Genomic Regulation (CRG) in Barcelona, Spain.

“几年前，我开始使用SMLM研究体细胞和干细胞中的染色质结构。我一直在广泛应用它来研究3D基因组组织和染色质纤维环，这是各种细胞表型的基本特征，包括正常，患病或药物诱导状态，”西班牙巴塞罗那基因组调控中心（CRG）高级科学家兼ICREA研究教授Maria Pia Cosma说。

“Recently, we utilized SMLM data of chromatin signatures to train a deep-learning model capable of identifying induced pluripotent stem cells, cancer cells, and virus-infected cells. This approach shows great potential for future cancer diagnosis and patient monitoring, as it requires very few cells to train the model.”.

“最近，我们利用染色质特征的SMLM数据来训练能够识别诱导多能干细胞，癌细胞和病毒感染细胞的深度学习模型。这种方法显示出未来癌症诊断和患者监测的巨大潜力，因为它需要很少的细胞来训练模型。”。

Named after the Greek word for simplicity, “Aplo” reflects ONI’s mission to make super-resolution microscopy both accessible and powerful. As the cornerstone of ONI’s Aplo Platform, the Aplo Scope integrates application-specific kits and cloud-based software into a seamless, end-to-end solution. By streamlining workflows and simplifying data analysis, it empowers researchers to uncover molecular details that drive scientific discovery and therapeutic innovation..

“Aplo”以希腊语“简单”一词命名，反映了ONI的使命，即使超分辨率显微镜既方便又强大。作为ONI Aplo平台的基石，Aplo Scope将特定于应用程序的工具包和基于云的软件集成到无缝的端到端解决方案中。通过简化工作流程和简化数据分析，它使研究人员能够揭示推动科学发现和治疗创新的分子细节。。

About the Aplo Platform

关于Aplo平台

The Aplo platform revolutionizes the world of super-resolution microscopy through the combination of application specific kits and chemistry with fully automated fluidic control via Aplo Flow, class leading SMLM hardware with Aplo Scope, and innovative, user centric, and automated CODI software capable of delivering a truly seamless sample to answer experience..

Aplo平台通过将特定于应用的试剂盒和化学试剂与通过Aplo Flow进行的全自动流体控制相结合，以及具有Aplo范围的一流SMLM硬件，以及能够提供真正无缝样品到答案体验的创新、以用户为中心的自动化CODI软件，彻底改变了超分辨率显微镜的世界。。

About ONI

关于ONI

ONI is a private, venture backed life sciences tools company transforming therapeutic discovery with accessible, high-performance super-resolution microscopy and funded by ARCH Venture Partners, Casdin Capital, Oxford Science Enterprises (OSE) and more. The company’s first product, the Nanoimager, introduced the world’s first desktop platform for single-molecule imaging, offering 20 nm resolution to study individual molecules in living cells, tissue, and nanoparticles.

ONI是一家由风险投资支持的私人生命科学工具公司，通过可访问的高性能超分辨率显微镜改造治疗发现，并由ARCH venture Partners，Casdin Capital，Oxford Science Enterprises（OSE）等资助。该公司的第一款产品Nanoimager推出了世界上第一个单分子成像桌面平台，提供20纳米分辨率，用于研究活细胞、组织和纳米颗粒中的单个分子。

ONI’s latest innovation, the Aplo Scope, is a compact, end-to-end imaging platform that delivers unmatched clarity, precision, and speed. Designed to empower researchers, the Aplo Scope provides real-time insights into complex biological systems, enabling breakthroughs in drug delivery, biomarker discovery, and antibody therapeutics.

ONI的最新创新Aplo示波器是一种紧凑的端到端成像平台，可提供无与伦比的清晰度、精度和速度。Aplo Scope旨在增强研究人员的能力，提供对复杂生物系统的实时见解，从而在药物输送，生物标志物发现和抗体治疗方面取得突破。

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