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)--TAE Life Sciences, in collaboration with Kyoto University and Principal Investigator Dr. Fuyuhiko Tamanoi, is pleased to announce groundbreaking preclinical results in Boron Neutron Capture Therapy (BNCT). Utilizing TAE Life Science’s novel boron-10 drugs and Kyoto University Research Reactor (KURR) neutron source has generated significant pre-clinical data that may redefine the potential of BNCT in cancer treatment..

)--TAE Life Sciences与京都大学和首席研究员Tamanoi Fuyuhiko博士合作，很高兴宣布硼中子俘获疗法（BNCT）的开创性临床前结果。利用TAE Life Science的新型硼-10药物和京都大学研究堆（KURR）中子源产生了重要的临床前数据，可能会重新定义BNCT在癌症治疗中的潜力。。

Recently published in the

最近发表在

Journal of Medicinal Chemistry

药物化学杂志

(J. Med. Chem. 2023, 66, 13809−13820) our research highlights a remarkable phenomenon known as the

（J.Med。Chem。2023,6613809-13820）我们的研究突出了一种称为

abscopal effect

. This effect, where localized radiation treatment results in the shrinkage of tumors at untreated sites, holds profound implications for treating metastatic and micro-metastatic cancer.

这种效应，局部放射治疗导致未治疗部位的肿瘤缩小，对治疗转移性和微转移性癌症具有深远的意义。

In a key study using immune-competent balb/c mice, BNCT treatment of subcutaneous tumors on one leg completely inhibited tumor growth when the same tumor cells were reintroduced to the opposite leg two weeks post-treatment. These results, some of the most impressive preclinical data seen to date, suggest that BNCT can stimulate an immune response capable of generating memory cells to prevent tumor recurrence at distant sites..

在一项使用免疫活性balb/c小鼠的关键研究中，当治疗后两周将相同的肿瘤细胞重新引入对侧腿时，BNCT治疗一条腿上的皮下肿瘤完全抑制了肿瘤生长。这些结果是迄今为止最令人印象深刻的临床前数据，表明BNCT可以刺激能够产生记忆细胞的免疫反应，以防止远处肿瘤复发。。

In one experiment, a mouse colon tumor was grown in the leg of a mouse and a second tumor was grown in its shoulder. BNCT was applied to the tumor in the leg, while the shoulder tumor was shielded from treatment. Remarkably, the untreated shoulder tumor exhibited a 34% reduction and slower growth rate compared to the control group, highlighting a potential systemic effect of BNCT..

在一个实验中，一只小鼠的腿上长出了一个小鼠结肠肿瘤，而另一个肿瘤长在了它的肩膀上。BNCT应用于腿部肿瘤，而肩部肿瘤被屏蔽治疗。值得注意的是，与对照组相比，未经治疗的肩部肿瘤减少了34%，生长速度较慢，突出了BNCT的潜在全身作用。。

“While the abscopal effect is not new in radiation oncology, these results with BNCT represent a significant step forward,” said Dr. Sunil Krishnan, Radiation Oncologist and Professor at the Center for Translational Cancer Research at UT Health Houston. “What’s particularly exciting is that this level of immune response and tumor control has not traditionally been observed with standard x-ray-based radiation therapy.

“虽然远隔效应在放射肿瘤学中并不新鲜，但BNCT的这些结果代表了一个重要的进步，”休斯顿大学健康中心转化癌症研究中心的放射肿瘤学家兼教授SunilKrishnan博士说。“特别令人兴奋的是，这种水平的免疫反应和肿瘤控制传统上没有用标准的基于x射线的放射疗法观察到。

It underscores the potential for BNCT to not only address primary tumors but also impact metastatic disease in a way we haven’t seen before.”.

它强调了BNCT不仅可以解决原发性肿瘤，还可以以我们以前从未见过的方式影响转移性疾病。”。

Further investigations are underway to explore the mechanisms behind these results, focusing on the role of dendritic cells, T-cells, and macrophages in immune memory. Additionally, TAE Life Sciences is evaluating the combination of BNCT with immune checkpoint inhibitors, such as anti-CTLA4, anti-PD1, and anti-PDL1, to enhance outcomes in tumors with both “hot” (active immune profile) and “cold” (inactive immune profile) immune phenotypes..

正在进行进一步的研究以探索这些结果背后的机制，重点是树突状细胞，T细胞和巨噬细胞在免疫记忆中的作用。此外，TAE生命科学正在评估BNCT与免疫检查点抑制剂（如抗CTLA4，抗PD1和抗PDL1）的组合，以增强具有“热”（主动免疫谱）和“冷”（非活性免疫谱）免疫表型的肿瘤的结果。。

'We are excited to demonstrate both the vaccine effect and the abscopal effect in preclinical BNCT experiments,' said Kendall Morrison, Chief Scientific Officer at TAE Life Sciences. 'This research reinforces BNCT's potential not only as a localized therapy but also as a treatment capable of addressing metastatic cancer.

TAE生命科学首席科学官肯德尔·莫里森（KendallMorrison）说：“我们很高兴在临床前BNCT实验中证明疫苗效应和远隔效应。”这项研究增强了BNCT的潜力，不仅可以作为局部治疗，还可以作为治疗转移性癌症的治疗方法。

Combining BNCT with immunotherapy agents could significantly transform cancer treatment outcomes.'.

将BNCT与免疫治疗剂相结合可以显着改变癌症治疗结果。”。

If these preclinical results can be translated to clinical applications, it could pave the way for improved responses to immune checkpoint blockade therapies, particularly for challenging “cold” tumors.

如果这些临床前结果可以转化为临床应用，则可以为改善对免疫检查点阻断疗法的反应铺平道路，特别是对于具有挑战性的“冷”肿瘤。

About TAE Life Sciences

关于TAE生命科学

TAE Life Sciences is dedicated to pioneering advancements in Boron Neutron Capture Therapy (BNCT), a unique cancer treatment modality. Through innovative compounds, cutting-edge neutron sources, and collaborations with leading institutions, TAE Life Sciences aims to offer patients a targeted, effective, and minimally invasive cancer treatment option..

TAE生命科学致力于硼中子俘获疗法（BNCT）的开创性进展，这是一种独特的癌症治疗方式。通过创新化合物、尖端中子源以及与领先机构的合作，TAE生命科学旨在为患者提供靶向、有效和微创的癌症治疗选择。。