DALLAS--(

达拉斯--(

BUSINESS WIRE

商业热线

)--Colossal Biosciences, the world’s first de-extinction company, has today announced $200M in a Series C financing by TWG Global, a diversified holding company with operating businesses and investments in technology/AI, financial services, private lending and sports and media, jointly led by Mark Walter and Thomas Tull.

)--世界上第一家灭绝物种公司巨无霸生物科学（Colossal Biosciences）今天宣布，由马克·沃尔特（Mark Walter）和托马斯·图尔（Thomas Tull）共同领导的多元化控股公司TWG Global在C系列融资中提供2亿美元。TWG Global是一家多元化控股公司，在技术/人工智能、金融服务、私人贷款以及体育和媒体领域拥有经营业务和投资。

Since launching in September 2021, Colossal has raised $435M in total funding. This latest round of capital places the company at a $10.2 billion valuation. Colossal will leverage this latest infusion of capital to continue to advance its genetic engineering technologies while pioneering new revolutionary software, wetware and hardware solutions, which have applications beyond de-extinction including species preservation and human healthcare..

自2021年9月推出以来，巨像已经筹集了4.35亿美元的总资金。最新一轮资本金使该公司估值102亿美元。巨无霸将利用这一最新注入的资金，继续推进其基因工程技术，同时开创新的革命性软件、软件和硬件解决方案，这些解决方案具有超越灭绝的应用，包括物种保护和人类保健。。

“Our recent successes in creating the technologies necessary for our end-to-end de-extinction toolkit have been met with enthusiasm by the investor community. TWG Global and our other partners have been bullish in their desire to help us scale as quickly and efficiently as possible,” said CEO and co-founder of Colossal Ben Lamm.

“我们最近在创造端到端消除灭绝工具包所需的技术方面取得的成功受到了投资者界的热情欢迎。TWG Global和我们的其他合作伙伴一直看好帮助我们尽快高效地扩大规模的愿望，”巨人Ben Lamm的首席执行官兼联合创始人表示。

“This funding will grow our team, support new technology development, expand our de-extinction species list, while continuing to allow us to carry forth our mission to make extinction a thing of the past.”.

“这笔资金将壮大我们的团队，支持新技术的开发，扩大我们的灭绝物种名单，同时继续使我们能够履行使灭绝成为过去的使命。”。

Colossal employs over 170 scientists and partners with labs in Boston, Dallas, and Melbourne, Australia. In addition, Colossal sponsors over 40 full time postdoctoral scholars and research programs in 16 partner labs at some of the most prestigious universities around the globe. Colossal’s scientific advisory board has grown to include over 95 of the top scientists working in genomics, ancient DNA, ecology, conservation, developmental biology, and paleontology.

Colossal在波士顿、达拉斯和澳大利亚墨尔本的实验室拥有170多名科学家和合作伙伴。此外，在全球一些最负盛名的大学的16个合作实验室中，有40多名全职博士后学者和研究项目得到了巨额赞助。巨像的科学顾问委员会已经发展到包括95多名在基因组学、古代DNA、生态学、保护学、发育生物学和古生物学领域工作的顶尖科学家。

Together, these teams are tackling some of the hardest problems in biology, including mapping genotypes to traits and behaviors, understanding developmental pathways to phenotypes like craniofacial shape, tusk formation, and coat color patterning, and developing new tools for multiplex and large-insert genome engineering..

这些团队正在共同解决生物学中一些最困难的问题，包括将基因型映射到性状和行为，了解颅面形状，象牙形成和皮毛颜色图案等表型的发育途径，以及开发用于多重和大插入基因组工程的新工具。。

“Colossal is the leading company working at the intersection of AI, computational biology and genetic engineering for both de-extinction and species preservation,” said Mark Walter, CEO of TWG Global. “Colossal has assembled a world-class team that has already driven, in a short period of time, significant technology innovations and impact in advancing conservation, which is a core value of TWG Global.

TWG Global首席执行官马克·沃尔特（Mark Walter）表示：“巨无霸是人工智能、计算生物学和基因工程交叉领域的领先公司，致力于消除灭绝和物种保护。”。“巨无霸组建了一支世界级的团队，在短时间内推动了重大的技术创新，并在推进保护方面产生了重大影响，这是TWG Global的核心价值。

We are thrilled to support Colossal as it accelerates and scales its mission to combat the animal extinction crisis.”.

我们很高兴能够支持巨无霸，因为它加速并扩大了其抗击动物灭绝危机的使命。”。

“Colossal is a revolutionary genetics company making science fiction into science fact. We are creating the technology to build de-extinction science and scale conservation biology particularly for endangered and at-risk species. I could not be more appreciative of the investor support for this important mission,” said George Church, Ph.D, Colossal Co-founder, Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and the Massachusetts Institute of Technology (MIT)..

“Colossal是一家革命性的遗传学公司，它将科幻小说变成了科学事实。我们正在创造技术，以建立灭绝科学和规模保护生物学，特别是针对濒危和高危物种。我非常感谢投资者对这项重要使命的支持，”Colossal联合创始人、哈佛医学院遗传学教授、哈佛大学和麻省理工学院（MIT）健康科学与技术教授George Church博士表示。。

In October 2024, the

2024年10月

Colossal Foundation

巨大的基础

was launched, a sister 501(c)(3) focused on overseeing the deployment and application of Colossal-developed science and technology innovations. The organization currently supports 48 conservation partners and their global initiatives around the world. This includes partners like Re:wild, Save The Elephants, Biorescue, Birdlife International, Conservation Nation, Sezarc, Mauritian Wildlife Foundation, Aussie Ark, International Elephant Foundation, and Saving Animals From Extinction.

成立时，一个姐妹501（c）（3）专注于监督巨大的发达科技创新的部署和应用。该组织目前在世界各地支持48个保护伙伴及其全球倡议。这包括Re：野生、拯救大象、Biorescue、国际鸟盟、保护国家、Sezarc、毛里求斯野生动物基金会、澳大利亚方舟、国际大象基金会和拯救濒临灭绝的动物等合作伙伴。

Currently the Colossal Foundation is focused on supporting conservation partners who are working on new innovative technologies that can be applied to conservation and those who benefit from the development and deployment of new genetic rescue and de-extinction technologies to help combat the biodiversity extinction crisis..

目前，巨无霸基金会专注于支持正在研究可应用于保护的新创新技术的保护合作伙伴，以及那些受益于开发和部署新的基因拯救和灭绝技术以帮助应对生物多样性灭绝危机的合作伙伴。。

Tracking Progress on Colossal’s De-Extinction Projects

跟踪巨无霸灭绝计划的进展

The first step in every de-extinction project is to recover and analyze preserved genetic material and use that data to identify each species’ core genomic components. In addition to recruiting Dr. Beth Shapiro, a global leader in ancient DNA research, as Colossal’s Chief Science Officer, Colossal has built a team of Ph.D experts in ancient DNA among its scientific advisors, including Love Dalen, Andrew Pask, Tom Gilbert, Michael Hofreiter, Hendrik Poinar, Erez Lieberman Aiden, and Matthew Wooler.

每个消除灭绝项目的第一步是恢复和分析保存的遗传物质，并利用这些数据来识别每个物种的核心基因组成分。除了聘请全球古代DNA研究领导者贝思·夏皮罗博士担任巨像的首席科学官外，巨像还在其科学顾问中建立了一支古代DNA博士专家团队，其中包括洛夫·戴伦、安德鲁·帕斯克、汤姆·吉尔伯特、迈克尔·霍夫雷特、亨德里克·波伊纳、埃里兹·利伯曼·艾登和马修·伍勒。

With this team, Colossal continues to push advances in ancient DNA through support to academic labs and internal scientific research. All three core species - mammoth, thylacine, and dodo - have already benefited from this coalescence of expertise. As an example, Colossal now has the most contiguous and complete ancient genomes to date for each of these three species; these genomes are the blueprints from which these species’ core traits will be engineered..

凭借这个团队，巨像公司通过支持学术实验室和内部科学研究，继续推动古代DNA的进步。所有三个核心物种——猛犸、类囊虫和渡渡鸟——都已经从这种专业知识的融合中受益。例如，巨像现在拥有迄今为止这三个物种中最连续和完整的古代基因组；这些基因组是设计这些物种核心性状的蓝图。。

The path from ancient genome to living species requires a systems model approach to innovation across computational biology, cellular engineering, genetic engineering, embryology, and animal husbandry, with refinement and tuning in each step along the de-extinction pipeline occurring simultaneously.

从古代基因组到活物种的道路需要一种系统模型方法来创新计算生物学，细胞工程，基因工程，胚胎学和畜牧业，同时在灭绝管道的每个步骤中进行改进和调整。

To date, Colossal’s scientists have achieved monumental breakthroughs at each step for each of the three flagship species..

迄今为止，巨像的科学家们在这三个旗舰物种的每一步都取得了重大突破。。

In the last three years, Colossal’s first major project to be announced, the

在过去的三年中，Colossal宣布的第一个重大项目

woolly mammoth project

长毛象项目

, generated new genomic resources, made breakthroughs in cell biology and genome engineering, and explored the ecological impact of de-extinction, with implications for mammoths, elephants, and species across the vertebrate tree of life.

，产生了新的基因组资源，在细胞生物学和基因组工程方面取得了突破，并探索了灭绝对生态的影响，对猛犸象，大象和脊椎动物生命树上的物种产生了影响。

Woolly Mammoth De-extinction Project Progress:

猛犸象灭绝项目进展：

The mammoth team has:

猛犸队拥有：

Generated chromosome-scale reference genomes for the African elephant, Asian elephant, and rock hyrax, all of which have been released on the National Center for Biotechnology Information database;

生成了非洲象、亚洲象和岩石鬣狗的染色体规模参考基因组，所有这些基因组都已在国家生物技术信息中心数据库中发布；

Generated the first

生成了第一个

de novo

从头开始

assembled mammoth genome - that is, a genome generated using only the ancient DNA reads rather than mapped to a reference genome. This genome identified several genetic loci that are missing in reference-guided assemblies;

组装的猛犸基因组-即仅使用古代DNA读数而不是映射到参考基因组产生的基因组。该基因组确定了参考引导组件中缺失的几个遗传基因座；

Acquired and aligned 60+ ancient genomes for woolly mammoth and Columbian mammoth in collaboration with key scientific advisor, Love Dalen and Tom van der Valk. This data, in combination with 30+ genomes for extant elephant species including Asian, African, and Bornean elephants, have dramatically increased the accuracy of mammoth-specific variant calling;.

与关键科学顾问Love Dalen和Tom van der Valk合作，获得并比对了长毛象和哥伦比亚长毛象的60多个古代基因组。这些数据与包括亚洲、非洲和婆罗洲大象在内的现存大象物种的30多个基因组相结合，大大提高了猛犸象特定变异呼叫的准确性；。

Derived, characterized, and biobanked 10+ primary cell lines from acquired tissue for Asian elephants, rock hyrax, and aardvark for use in company conservation and de-extinction pipelines;

从亚洲象，岩鬣狗和土豚的获得组织中衍生，表征和生物库化的10+原代细胞系，用于公司保护和灭绝管道；

Became the first to derive pluripotent stem cells for Asian elephants. These cells are essential for in-vitro embryogenesis and gametogenesis;

成为第一个为亚洲大象获得多能干细胞的人。；

Generated neuronal and cardiac precursor cells from elephant iPSCs, demonstrating the potential of these stem cell populations;

从大象iPSC产生神经元和心脏前体细胞，证明了这些干细胞群的潜力；

Fine-tuned and redesigned transcription factors using state-of-the-art machine algorithms to generate novel proteins with increased capacity for cellular reprogramming;

使用最先进的机器算法对转录因子进行微调和重新设计，以生成具有更高细胞重编程能力的新型蛋白质；

Generated TP53 mutant variants and reversibly integrated over-expression cassettes to facilitate immortalization of elephant cells that can be used in downstream editing efficiency screening;

产生TP53突变体变体并可逆地整合过表达盒，以促进大象细胞的永生化，可用于下游编辑效率筛选；

Optimized media to facilitate proliferation of immortalized cell lines and enhance viability of biosamples following cryo-preservation, which is a critical aspect of biobanking effort

优化培养基以促进永生化细胞系的增殖，并在冷冻保存后增强生物样品的活力，这是生物库工作的一个关键方面

Demonstrated multiplex gene editing at 20+ target sites of high impact genes associated with core cold adaptation mammoth phenotypes;

在与核心冷适应猛犸表型相关的高影响基因的20多个靶位点证明了多重基因编辑；

Established a hair organoid model to assess the impact of key genetic targets on formation capacity and development of hair follicles as a means to validate edit target selection;

建立了毛发类器官模型，以评估关键遗传靶标对毛囊形成能力和发育的影响，作为验证编辑靶标选择的手段；

Built a leading embryology lab for endangered species work and started the process of refining protocols for elephant somatic cell nuclear transfer process

为濒危物种工作建立了领先的胚胎学实验室，并开始完善大象体细胞核移植过程的方案

'These mammoth milestones mark a pivotal step forward for de-extinction technologies,” said Love Dalen, Professor at the Centre for Paleogenetics, University of Stockholm, and a key advisor to the mammoth project. “The dedication of the team at Colossal to precision and scientific rigor is truly inspiring, and I have no doubt they will be successful in resurrecting core mammoth traits.'.

斯德哥尔摩大学古遗传学中心教授、猛犸象项目关键顾问Love Dalen说：“这些巨大的里程碑标志着灭绝技术向前迈出了关键的一步。”。“巨人队对精确性和科学严谨性的奉献真的令人鼓舞，我相信他们将成功复活猛犸象的核心特征。”。

Thylacine De-extinction Project Progress:

乙基消光项目进展：

The Colossal

巨人

thylacine

乙酰乙酸

team recently made

团队最近制作

announcements

公告

demonstrating progress on the various work streams critical for the de-extinction of the thylacine. Since that team’s inception two years ago the Australia and Texas-based teams have:

展示了对乙基化物灭绝至关重要的各种工作流程的进展。自该团队两年前成立以来，澳大利亚和德克萨斯州的团队已经：

Generated the highest-quality ancient genome to date for a Thylacine, at 99.9% complete, using ancient long reads and ancient RNA – a world’s first and once thought to be an impossible goal – creating the genomic blueprint for Thylacine de-extinction;

使用古老的长读物和古老的RNA（这是世界上第一个，曾经被认为是不可能的目标）生成了迄今为止最高质量的类囊体古代基因组，完成率为99.9%，为类囊体灭绝创造了基因组蓝图；

Generated ancient genomes for 11 individuals thylacines, thereby gaining understanding of fixed variants versus population-level variation in thylacines pre-extinction and enabling more accurate prediction of de-extinction targets;

产生了11个类囊体个体的古代基因组，从而了解了类囊体灭绝前的固定变异与种群水平变异，并能够更准确地预测灭绝目标；

Assembled telomere-to-telomere genome sequences for all dasyurid species – the evolutionary cousins of thylacines– providing resources both to improve Colossal’s understanding thylacine evolution and underpin thylacine engineering efforts, and to aid in the conservation of threatened marsupial species;.

；。

Became the first to derive pluripotent stem cells in fat-tailed dunnarts, propelling the company on the path towards advanced

成为第一个在肥尾邓纳特（dunnarts）中获得多能干细胞的公司，推动公司朝着先进的方向发展

in vitro

体外

functional workflows as well as establishing state of the art conservation and genomic preservation capabilities in marsupials;

功能工作流程，以及建立有袋动物的最先进保护和基因组保存能力；

Identified regions of the genome driving the development of the thylacine’s unique craniofacial shape and demonstrated, using genetic engineering in mice, that these regions drive morphological similarities between thylacines and wolves;

确定了驱动类囊体独特颅面形状发育的基因组区域，并在小鼠中使用基因工程证明了这些区域驱动类囊体和狼之间的形态相似性；

Established multiplex editing pipelines in dunnart fibroblast cell lines for the first identified edits which provide the framework for the Thylacine hypercarnivore craniofacial morphology;

在dunnart成纤维细胞系中建立了多重编辑管道，用于首次确定的编辑，为类囊体-超食肉动物颅面形态提供了框架；

Made over 300 unique genetic edits into a cell line of a fat-tailed dunnart, which is the species that is the foundation for Colossal’s future thylacines and future surrogate of thylacine embryos;

对厚尾dunnart的细胞系进行了300多个独特的遗传编辑，该物种是庞然大物未来类囊体和类囊体胚胎未来替代物的基础；

Prototyped artificial ex-utero development for early-stage marsupial gestation;

用于早期有袋动物妊娠的原型人工子宫外发育；

Discovered and optimized an approach to induce ovulation in a dunnart, which is a vital first for both marsupial conservation and thylacine de-extinction;

发现并优化了一种在dunnart中诱导排卵的方法，这是有袋动物保护和类囊体灭绝的重要首次；

Fertilized single-cell marsupial embryos and cultured them over half way through pregnancy in an artificial uterus device

受精的单细胞有袋类胚胎，并在人工子宫装置中在怀孕的一半以上进行培养

“These milestones put us ahead of schedule on many of the critical technologies needed to underpin de-extinction efforts. At the same time, it creates major advances in genomics, stem cell generation and engineering, and marsupial reproductive technologies that are paving the way for the de-extinction of the thylacine and is revolutionizing conservation science for marsupials.

“这些里程碑使我们在支持灭绝努力所需的许多关键技术上提前完成。与此同时，它在基因组学、干细胞生成和工程以及有袋动物生殖技术方面取得了重大进展，为类囊虫的灭绝铺平了道路，并正在彻底改变有袋动物的保护科学。

Colossal’s work demonstrates that with innovation and perseverance, we can offer groundbreaking solutions to safeguard biodiversity— and the team is already doing this in many visionary ways,” said Andrew Pask, Ph.D..

Colossal的工作表明，凭借创新和毅力，我们可以提供开创性的解决方案来保护生物多样性，团队已经在以许多富有远见的方式进行这项工作，”安德鲁·帕斯克博士说。。

Dodo De-extinction Project Progress:

The Colossal Avian Genomics Group is currently focused on the

庞大的鸟类基因组学小组目前专注于

Dodo

渡渡鸟

project as well as building a distinct suite of tools for avian genome engineering which differs from some of the company’s mammalian projects. The dodo specific team’s progress includes:

该项目还为禽类基因组工程构建了一套独特的工具，这与该公司的一些哺乳动物项目不同。dodo特定团队的进展包括：

Generated a complete, high coverage genome for the dodo, its sister extinct species the solitaire, and the critically endangered manumea (also known as the “tooth-billed pigeon” and “little dodo”);

为渡渡鸟、其姊妹灭绝物种纸牌和极度濒危的曼努美亚（也称为“齿嘴鸽”和“小渡渡鸟”）生成了一个完整的、高覆盖率的基因组；

Generated and published a chromosome-scale assembly of the Nicobar pigeon (the dodo’s closest relative) as well as developed a population-scale data set of Nicobar pigeon genomes for computational identification of dodo-specific traits;

生成并发布了尼科巴鸽（渡渡鸟的近亲）的染色体规模组装，并开发了尼科巴鸽基因组的种群规模数据集，用于计算鉴定渡渡鸟特有的性状；

Developed a machine learning approach to identify genes associated with craniofacial shape in birds for gene-editing targets toward resurrecting the dodo’s unique bill morphology;

开发了一种机器学习方法来识别与鸟类颅面形状相关的基因，用于基因编辑目标，以恢复渡渡鸟独特的喙形态；

Processed more than 10,000 eggs and optimized culture conditions for growing primordial germ cells (PGCs) for four bird species;

处理了10000多个鸡蛋，并优化了培养条件，以培养四种鸟类的原始生殖细胞（PGC）；

Developed a new approach to isolate editable cells from feather pulls;

开发了一种新方法，将可编辑细胞与羽毛拉分离；

Established a flock of Nicobar pigeons that will act as donors for PGCs that will be edited into Colossal’s dodos;

建立了一群尼科巴鸽子，作为PGC的捐赠者，将被编辑成巨兽渡渡鸟；

Demonstrated that the RNA-binding protein

证明了RNA结合蛋白

La

洛杉矶

consistently enhances precision editing efficiency in avian genomes, leading to improved efficiency in gene-editing;

始终如一地提高禽类基因组的精确编辑效率，从而提高基因编辑的效率；

Validated that newly reported integrase variants exhibit higher enzymatic activity, which is being leveraged to establish a method for large-fragment DNA exchange;

验证了新报道的整合酶变体表现出更高的酶活性，这被用于建立大片段DNA交换的方法；

Used genome-editing tools to alter the DNA sequence in chicken PGCs, injected these edited PGCs into embryos, and successfully hatched Colossal’s first chimeric chicks - the offspring of these birds will be Colossal’s surrogates for de-extinct dodos

使用基因组编辑工具改变鸡PGC中的DNA序列，将这些编辑过的PGC注射到胚胎中，并成功孵化出Colossal的第一只嵌合小鸡-这些鸟的后代将成为Colossal灭绝的渡渡鸟的替代品

'As we advance our understanding of avian genomics and developmental biology, we're seeing remarkable progress in the tools and techniques needed to restore lost bird species,” said Colossal’s Chief Science Officer Beth Shapiro. “The unique challenges of avian reproduction require bespoke approaches to genetic engineering, for example, and our dodo team has had impressive success translating tools developed for chickens to tools that have even greater success in pigeons.

Colossal首席科学官贝思·夏皮罗（BethShapiro）说：“随着我们对鸟类基因组学和发育生物学的深入了解，我们看到恢复丢失鸟类物种所需的工具和技术取得了显着进展。”。“例如，鸟类繁殖的独特挑战需要定制的基因工程方法，我们的dodo团队已经取得了令人印象深刻的成功，将为鸡开发的工具转化为在鸽子中取得更大成功的工具。

While work remains, the pace of discovery within our dodo team has exceeded expectations.”.

尽管仍有工作要做，但我们的dodo团队的发现速度已经超出了预期。”。

Colossal’s Support of Global Conservation and De-Extinction Efforts

巨兽对全球保护和灭绝努力的支持

By 2050, it is projected that over 50% of the world’s animal species may be extinct. Now

预计到2050年，世界上超过50%的动物物种可能会灭绝。现在

around 27,000 species

per year go extinct, compared to the natural rate of 10 to 100 species per year. Over the past 50 years (1970–2020),

与每年10到100个物种的自然灭绝率相比，每年都会灭绝。在过去50年（1970年至2020年），

the average size of monitored wildlife populations

受监测野生动物种群的平均规模

has shrunk by 73%. That extinction crisis will have

缩水了73%。灭绝危机将产生

cascading, negative impacts

级联、负面影响

on human health and wellbeing including reductions in drinkable water, increases in land desertification and increases in food insecurity. While current conservation efforts are imperative to protecting species, more and newer technologies and techniques are required that can scale in response to the speed humanity is changing the planet and destroying ecosystems.

对人类健康和福祉的影响，包括饮用水减少、土地荒漠化加剧和粮食不安全加剧。虽然目前的保护工作对于保护物种至关重要，但需要更多更新的技术和技术来应对人类改变地球和破坏生态系统的速度。

Colossal was created to respond to this crisis. And, Colossal’s growing de-extinction and species preservation toolkit of software, wetware and hardware solutions provides new, scalable approaches to this systems-level existential threat and biodiversity crisis..

巨无霸是为了应对这场危机而创建的。此外，巨无霸不断增长的软件、软件和硬件解决方案的灭绝和物种保护工具包为这种系统级的生存威胁和生物多样性危机提供了新的、可扩展的方法。。

'The technological advances we're seeing in genetic engineering and synthetic biology are rapidly transforming our understanding of what's possible in species restoration,” said Shapiro. “While the path to de-extinction is complex, each step forward brings us closer to understanding how we might responsibly reintroduce traits from lost species.

夏皮罗说：“我们在基因工程和合成生物学方面看到的技术进步正在迅速改变我们对物种恢复可能的理解。”。“虽然消除灭绝的道路很复杂，但每向前迈出一步，都会使我们更加了解如何负责任地重新引入丢失物种的特征。

The real promise lies not just in the technology, but also in how we might apply these tools to protect and restore endangered species and ecosystems.”.

。

The breakthroughs in Colossal’s core projects create a ripple effect across species conservation. Each Colossal core species is tied to conservation efforts that support other endangered and at-risk species in the respective animal’s family group. The company’s work toward mammoth restoration has simultaneously advanced reproductive and genetic technologies that can help preserve endangered elephant species, while the dodo program is pioneering avian genetic tools that will benefit threatened bird species worldwide.

巨无霸核心项目的突破在物种保护方面产生了连锁反应。每个巨大的核心物种都与保护工作有关，这些保护工作支持各自动物家族中的其他濒危和风险物种。该公司在猛犸象恢复方面的工作同时拥有先进的生殖和遗传技术，可以帮助保护濒危的大象物种，而渡渡鸟计划则开创了鸟类遗传工具的先河，这将使全世界受威胁的鸟类受益。

Through the Colossal Foundation and its partnerships with leading conservation organizations, Colossal is transforming these scientific advances into practical solutions that can help protect and restore vulnerable species across multiple taxonomic families. Key initiatives include:.

通过Colossal基金会及其与主要保护组织的合作关系，Colossal正在将这些科学进步转化为实用的解决方案，以帮助保护和恢复多个分类学家族中的脆弱物种。关键举措包括：。

Colossal’s $7.5M in new donations to fund ancient DNA research across a diverse selection of species;

巨像公司（Colossal）新捐款750万美元，用于资助各种物种的古代DNA研究；

The development of a gene-engineering solution to create cane toad toxin resistance for Australia’s endangered northern quoll;

开发一种基因工程解决方案，为澳大利亚濒危的北卡罗尔创造甘蔗蟾蜍毒素抗性；

A partnership with the international conservation organization Re:wild on a suite of initiatives to preserve the world's most threatened species, including:

与国际保护组织（international conservation organization Re：wild）合作，采取一系列举措保护世界上最受威胁的物种，包括：

A joint 10-year conservation strategy to save some of the world’s most threatened species by leveraging the power of Colossal’s genetic technologies and Re:wild’s experience and partnerships for species conservation across the world;

；

The Lost Species project where the companies have partnered to find the world's most wanted lost species and catalyze conservation for those rediscovered;

这是一个物种丢失项目，两家公司合作寻找世界上最想要的丢失物种，并促进对那些被重新发现的物种的保护；

The Species Reintroduction Fund which was designed to support the reintroduction of threatened species back to the wild; and

物种再引入基金，旨在支持将受威胁物种重新引入野外；和

The development of a distributed genetic repository of endangered species (a biobank) which will act as an insurance policy for species on the edge of extinction while building local capacity to provide a safety net for species facing extinction.

开发濒危物种分布式基因库（生物库），作为濒临灭绝物种的保险单，同时建设当地能力，为面临灭绝的物种提供安全网。

Joining the BioRescue consortium in the fight to save the world's most endangered rhino species: the northern white rhino. Through a novel technological platform, Colossal Foundation and BioRescue will provide the tools needed to create a genetically healthy population which can be reintroduced to the wild;.

加入BioRescue联盟，拯救世界上最濒危的犀牛物种：北方白犀牛。通过一个新的技术平台，巨无霸基金会和BioRescue将提供创造基因健康人群所需的工具，这些人群可以重新引入野外；。

A partnership with the Mauritius Wildlife Foundation to use the company’s novel genetic rescue platform to restore genetic diversity with the heavily threatened pink pigeon;

与毛里求斯野生动物基金会（Mauritis Wildlife Foundation）合作，利用该公司的新型基因拯救平台，恢复受到严重威胁的粉红鸽子的遗传多样性；

A partnership with Save the Elephants to create an artificial intelligence platform to detect, identify and track African elephants' movements in Samburu National Park to identify, analyze, and even predict elephant behaviors and movements;

与拯救大象组织合作，创建一个人工智能平台，以检测、识别和跟踪桑布鲁国家公园中非洲大象的活动，从而识别、分析甚至预测大象的行为和活动；

An AI-powered bird call detector to help partners at the Samoa Conservation Society, BirdLife International, and the IUCN's Pigeon and Dove Specialist Group to identify the lost tooth-billed pigeon which led to the first sighting of the tooth-billed pigeon in several years;

一个人工智能驱动的鸟叫声探测器，帮助萨摩亚保护协会、国际鸟盟和IUCN的鸽子和鸽子专家组的合作伙伴识别丢失的齿嘴鸽，这导致了几年来首次发现齿嘴鸽；

The distribution of critical funding to Zoos Victoria to kickstart the rapid rescue of the once-thought to be extinct Victorian grassland earless dragon upon its rediscovery after more than fifty-four years of being lost;

；

Joining forces with Pronatura Noroeste in support of Mexico's National Commission of Natural Protected Areas Mexico (CONANP) and their Vaquita Monitoring Group's efforts to protect the world's most endangered marine mammal;

与Pronatura Noroeste联手支持墨西哥国家自然保护区委员会（CONANP）及其Vaquita监测小组保护世界上最濒危海洋哺乳动物的努力；

Hosting an international meeting of the world's leading voices in Sumatran rhino rescue effort that led to the development of a partnership between Colossal and IPB University in Indonesia to use advanced assisted reproduction and cutting edge genetic technologies to save this critically endangered species;.

主办了苏门答腊犀牛救援工作世界领先声音的国际会议，促成了Colossal和印尼IPB大学之间的合作关系，利用先进的辅助生殖和尖端遗传技术来拯救这种极度濒危的物种；。

Committing to reignite the search for America's most infamous lost species, the ivory-billed woodpecker;

致力于重新启动对美国最臭名昭著的失传物种象牙喙啄木鸟的搜索；

Forming Colossal's Indigenous Council to a focus on wolf and buffalo conservation, and enhance and accelerate the conservation initiatives of the indigenous peoples of North America;

成立巨人土著委员会，重点关注狼和水牛的保护，并加强和加速北美土著人民的保护举措；

A partnership with Dr. Paul Ling, Ph.D. at Baylor College of Medicine, who collaborated on the development of a vaccine for EEHV, the deadliest disease in elephants;

与贝勒医学院（BaylorCollege of Medicine）博士保罗·林（Paul Ling）博士（Dr.Paul Ling）合作开发大象最致命疾病EEHV疫苗；

A partnership with Dr. Andrew Pask at University of Melbourne including one of the largest investments ever into the creation of an avian genomics toolkit to develop conservation and de-extinction tools.

与墨尔本大学安德鲁·帕斯克博士的合作，包括有史以来最大规模的投资之一，用于创建鸟类基因组学工具包，以开发保护和消除灭绝工具。

'Colossal is advancing the development of genetic technologies for conservation at a rapid pace. Their cutting-edge technologies are changing what is possible in species conservation and are permitting us to envision a world where many more Critically Endangered species not only survive but thrive,” said Barney Long, PhD, Senior Director of Conservation Strategies for Re:wild..

“巨像正在快速推进保护基因技术的发展。他们的尖端技术正在改变物种保护的可能性，并使我们能够设想一个世界，在这个世界上，更多的极度濒危物种不仅存活下来，而且茁壮成长，”Re：wild.保护战略高级主管Barney Long博士说。。

Colossal’s additional strategic investors include funds such as USIT, Animal Capital, Breyer Capital, At One Ventures, In-Q-Tel, BOLD Capital, Peak 6, and Draper Associates among others and private investors including Robert Nelsen, Peter Jackson, Fran Walsh, Ric Edelman, Brandon Fugal, Paul Tudor Jones, Richard Garriott, Giammaria Giuliani, Sven-Olof Lindblad, Victor Vescovo, and Jeff Wilke..

Colossal的其他战略投资者包括USIT、Animal Capital、Breyer Capital、At One Ventures、In-Q-Tel、BOLD Capital、Peak 6和Draper Associates等基金，以及包括Robert Nelsen、Peter Jackson、Fran Walsh、Ric Edelman、Brandon Fugal、Paul Tudor Jones、Richard Garriott、Giammaria Giuliani、Sven Olof Lindblad、Victor Vescovo和Jeff Wilke在内的私人投资者。。

For more information on the company’s progress, please visit:

有关公司进展的更多信息，请访问：

www.colossal.com

www.conossal.com

to sign up for the newsletter and follow along on social media.

注册新闻稿并在社交媒体上跟进。

ABOUT COLOSSAL

Colossal was founded by emerging technology and software entrepreneur Ben Lamm and world-renowned geneticist and serial biotech entrepreneur George Church, Ph.D., and is the first to apply CRISPR technology for the purposes of species de-extinction. Colossal creates innovative technologies for species restoration, critically endangered species protection and the repopulation of critical ecosystems that support the continuation of life on Earth.

Colossal由新兴技术和软件企业家Ben Lamm和世界著名遗传学家和系列生物技术企业家George Church博士创立，是第一个将CRISPR技术应用于物种灭绝目的的公司。巨无霸为物种恢复、极度濒危物种保护和支持地球生命延续的关键生态系统的重新繁殖创造了创新技术。

Colossal is accepting humanity's duty to restore Earth to a healthier state, while also solving for the future economies and biological necessities of the human condition through cutting-edge science and technologies. To follow along, please visit: .

巨像正在接受人类的责任，将地球恢复到一个更健康的状态，同时也通过尖端科学和技术解决未来经济和人类状况的生物必需品。如需了解详情，请访问：。

www.colossal.com

www.conossal.com

WEBSITE & SOCIALS

网站和社交

Website:

www.colossal.com

www.conossal.com

Twitter:

推特：

https://x.com/colossal

https://x.com/colossal

Instagram: ​​

Instagram：​​

https://www.instagram.com/itiscolossal/

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LinkedIn:

LinkedIn：

https://www.linkedin.com/company/itiscolossal/

https://www.linkedin.com/company/itiscolossal/

Facebook:

脸书：

https://www.facebook.com/itiscolossal

https://www.facebook.com/itiscolossal