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The retina is a simple window to reflect the changes of brain nerves. The aim of this study was to investigate the association between retinal status and white matter lesions (WMLs) in 143 patients aged 50-80 years, utilizing Optical Coherence Tomography Angiography (OCTA) and the Fazekas Visual Scale for assessment.Methods: A total of 143 subjects underwent MRI scanning to assess the degree of WMLs using the Fazekas scale.

视网膜是反映大脑神经变化的简单窗口。本研究的目的是利用光学相干断层扫描血管造影（OCTA）和Fazekas视觉量表进行评估，调查143名50-80岁患者的视网膜状态与白质病变（WML）之间的关系。方法：共有143名受试者接受了MRI扫描，以使用Fazekas量表评估WML的程度。

Retinal imaging was conducted utilizing OCTA. Multivariate logistic regression analysis was employed to determine the odds ratios and 95% confidence intervals associated with the Fazekas score for each factor. The relationship between cognitive function and various OCTA parameters was assessed using quadratic and cubic simulation curve models.

利用OCTA进行视网膜成像。。使用二次和三次模拟曲线模型评估认知功能与各种OCTA参数之间的关系。

Data following a normal distribution are presented as means, while non-normally distributed data are reported as medians. Qualitative data are expressed as percentages.Results: As Fazekas grades increased, ILM-IPL thickness (OR = 3.267, OR = 8.436), vessel density in the parafoveal region of the macula, retinal vessel densities (OR = 2.058, OR = 2.363), and RNFL thickness significantly reduced (P < 0.05).

服从正态分布的数据以均值表示，而非正态分布的数据以中位数表示。定性数据以百分比表示。结果：随着Fazekas分级的增加，ILM-IPL厚度（OR=3.267，OR=8.436），黄斑中心凹旁区域的血管密度，视网膜血管密度（OR=2.058，OR=2.363）和RNFL厚度显着降低（P＜0.05）。

With increasing Fazekas scores, the bilateral foveal avascular zone showed a significant increase (OR = 0.362, OR = 0.458)(P < 0.05).Retinal thickness and vascular density were negatively correlated with WMLs, and positively correlated with cognitive function (P < 0.05).The severity of WMLs increases as retinal thickness and vascular density decrease.OCTA examination has a degree of role in screening for WMLs caused by cerebral microvascular disease.

随着Fazekas评分的增加，双侧中央凹无血管区显著增加（OR=0.362，OR=0.458）（P<0.05）。视网膜厚度和血管密度与WML呈负相关，与认知功能呈正相关（P＜0.05）。WML的严重程度随着视网膜厚度和血管密度的降低而增加。OCTA检查在筛查由脑微血管疾病引起的WML方面具有一定程度的作用。

Its effectiveness in screening early asymptomatic individuals or those with mild cognitive impairment is somewhat limited..

它在筛查早期无症状个体或轻度认知障碍患者方面的有效性有些有限。。