The Cultivated B, a Heidelberg, Germany-based company, reports the discovery of a chemical class of FGFR1 agonists mimicking basic fibroblast growth factor’s (bFGF) effect on cell proliferation, an essential component of cell-culture media. A preprint of the study is published on

总部位于德国海德堡的公司The Cultured B报道发现了一类化学FGFR1激动剂，模仿碱性成纤维细胞生长因子（bFGF）对细胞增殖的影响，细胞增殖是细胞培养基的重要组成部分。这项研究的预印本发表在

bioRxiv

生物Rxiv

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“This class of small molecules offers a stable, highly cost-effective alternative, poised to transform cultivated meat, biopharmaceuticals, regenerative medicine, and large-scale cell manufacturing by addressing key challenges,” said Hamid Noori, PhD, CEO and founder of The Cultivated B and a Forbes Councils member..

“这类小分子提供了一种稳定、高成本效益的替代品，有望通过应对关键挑战来改变养殖肉类、生物制药、再生医学和大规模细胞制造，”养殖B的首席执行官兼创始人哈米德·努里博士（Hamid Noori）说，他也是福布斯理事会成员。。

The discovery revolutionizes cell production by overcoming key bottlenecks such as rapid degradation, high production costs, batch variability, and complex storage requirements, according to Noori, who added that, unlike traditional bFGF, small molecules remain active for over 13 days, thus providing where stability, consistency, and scalability..

Noori说，这一发现通过克服关键瓶颈（如快速降解，高生产成本，批次可变性和复杂的存储要求）彻底改变了细胞生产，他补充说，与传统的bFGF不同，小分子在13天内保持活性，从而提供稳定性，一致性和可扩展性。。

“We are unlocking new possibilities for entire industries,” he continued. “This breakthrough has the potential to revolutionize the scalability, consistency, and cost-effectiveness of cell-based product manufacturing, including applications in cultivated meat and cell therapy.”

“我们正在为整个行业释放新的可能性，”他继续说道。“这一突破有可能彻底改变基于细胞的产品制造的可扩展性、一致性和成本效益，包括在养殖肉类和细胞疗法中的应用。”

The Cultivated B was founded in 2009 and develops technologies involved in cellular agriculture, precision fermentation, and bioreactor engineering. The German Institute for Innovation in Sustainability and Digitalization named The Cultivated B the “2024 Employer of the Future.”

栽培B成立于2009年，开发涉及细胞农业、精密发酵和生物反应器工程的技术。德国可持续发展和数字化创新研究所将栽培B命名为“2024年未来雇主”

News

新闻

Cell culture

细胞培养

Cell proliferation

细胞增殖

Fibroblast growth factor

Small molecules

小分子