全圆治疗公司获得美国专利许可，用于使用环状单链DNA进行靶向基因组修饰-动脉网

Full Circles Therapeutics Secures U.S. Patent Allowance for Targeted Genome Modification Using Circular Single-Stranded DNA

CISION 等信源发布 2025-03-07 21:58

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CAMBRIDGE, Mass.

马萨诸塞州剑桥市

，

March 7, 2025

2025年3月7日

/PRNewswire/ -- Full Circles Therapeutics, a leader in next-generation genome engineering, announces that the United States Patent and Trademark Office (USPTO) has allowed its foundational patent titled

/PRNewswire/ -- 全圆治疗公司（Full Circles Therapeutics），作为下一代基因组工程的领导者，宣布美国专利商标局（USPTO）已批准其基础专利，标题为

'TARGETED GENOME MODIFICATION USING CIRCULAR SINGLE-STRANDED DNA.'

使用环状单链DNA进行靶向基因组修饰。

This patent protects Full Circles' innovative platform, which enables

该专利保护了 Full Circles 的创新平台，该平台能够

precise, efficient, and non-viral genome modification

精确、高效且非病毒的基因组修饰

using circular single-stranded DNA (cssDNA), overcoming key challenges in genome engineering.

利用环状单链DNA（cssDNA），克服基因组工程中的关键挑战。

This breakthrough provides a

这一突破提供了

safer, modular, and scalable alternative to viral vectors and traditional double-stranded DNA (dsDNA) donors

更安全、模块化且可扩展的病毒载体和传统双链DNA（dsDNA）供体替代方案

, improving gene integration efficiency while minimizing immunogenicity, cytotoxicity, and off-target effects. With broad applications in

，提高基因整合效率，同时尽量减少免疫原性、细胞毒性和脱靶效应。具有广泛的应用前景在

cell and gene therapy, regenerative medicine, and biomedical research

细胞和基因治疗、再生医学和生物医学研究

, this platform is poised to transform the field of genetic modification.

，该平台有望转变基因修改领域。

Advancing Genome Engineering with cssDNA

利用cssDNA推进基因组工程

The growing demand for

不断增长的需求对于

safe and efficient genome editing technologies

安全高效的基因组编辑技术

has highlighted the limitations of viral-based gene transfer methods, such as lentiviral and adeno-associated virus (AAV) vectors, which present risks of unpredictable genomic integration, immunogenicity, and manufacturing challenges.

突显了基于病毒的基因转移方法的局限性，例如慢病毒和腺相关病毒 (AAV) 载体，这些方法存在不可预测的基因组整合、免疫原性和生产挑战等风险。

Full Circles'

圆满

cssDNA-based technology, dubbed C4DNA

基于cssDNA的技术，称为C4DNA

™

GATALYST

催化剂

™

genome engineering platform, enables targeted transgene integration via homology-directed repair (HDR) without the risks of viral vectors

基因组工程平台，能够通过同源定向修复（HDR）实现靶向转基因整合，且无病毒载体的风险

, improving precision while reducing toxicity. This makes it ideal for

，提高精度同时降低毒性。这使得它非常适合

next-generation, virus-free therapeutic applications

下一代无病毒治疗应用

。

'The allowance of this patent is a significant milestone in advancing non-viral genome editing,' said

“这项专利的批准是推进非病毒基因组编辑的一个重要里程碑，”

Richard Shan

理查德·山

, co-founder and Chairman of Full Circles Therapeutics

Full Circles Therapeutics联合创始人兼董事长

. 'Our proprietary cssDNA platform offers a safer and more precise alternative for gene modification, paving the way for improved allogeneic cell therapies, CAR-NK and CAR-T therapies, and other transformative treatments.'

“我们专有的cssDNA平台为基因修饰提供了一种更安全、更精确的替代方案，为改进同种异体细胞疗法、CAR-NK和CAR-T疗法以及其他革命性治疗铺平了道路。”

Open for Licensing and Collaboration

开放许可和合作

To accelerate innovation,

为了加速创新，

Full Circles Therapeutics is actively seeking licensing and partnership opportunities

全圆治疗公司正在积极寻求许可和合作机会。

for its cssDNA platform across the

为了它的cssDNA平台跨越

biotechnology and pharmaceutical industries

生物技术和制药行业

。

'We believe C4DNA

“我们相信C4DNA

™

GATALYST

催化剂

™

technology has immense potential across oncology, autoimmune diseases, regenerative medicine, and beyond,' said

技术在肿瘤学、自身免疫疾病、再生医学等领域具有巨大的潜力，

Howard Wu

吴霍华德

, co-founder and CSO

联合创始人兼首席战略官

. 'By offering this platform for licensing, we aim to empower other innovators to enhance their gene editing capabilities and advance safer, faster, more affordable and effective therapies.'

“通过提供这一平台的授权，我们旨在赋能其他创新者提升他们的基因编辑能力，并推动更安全、更快速、更经济、更有效的治疗方法的发展。”

Contact for Licensing Inquiries

许可证咨询联系方式

For Media & Licensing Inquiries:

媒体和授权查询：

Flora Zhang

张弗洛拉

Director of Communications, Full Circles Therapeutics

通讯总监，Full Circles Therapeutics公司

Phone: (410) 733-0130

电话：（410）733-0130

Email:

电子邮件：

391251@email4pr.com

About Full Circles Therapeutics

关于富勒圆治疗学

Full Circles Therapeutics is a pioneering biotechnology company advancing genome engineering through innovative, non-viral gene editing technologies. Its proprietary cssDNA platform is designed to

Full Circles Therapeutics是一家通过创新的非病毒基因编辑技术推动基因组工程的先锋生物技术公司。其专有的cssDNA平台旨在

enable safer, more efficient, and scalable genetic modifications

启用更安全、更高效和可扩展的基因改造

, revolutionizing next-generation cell and gene therapies.

，彻底改变下一代细胞和基因疗法。

For more information, visit

欲了解更多信息，请访问

www.fullcirclestx.com

。

SOURCE Full Circles Therapeutics

来源：Full Circles Therapeutics

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