宾夕法尼亚牙医学院研究显示含抗病毒蛋白的口香糖可减少流感和疱疹传播-动脉网

Penn Dental Medicine Study Shows Gum Containing Antiviral Protein Reduces Flu, Herpes Transmission

CISION 等信源发布 2025-04-03 01:32

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PHILADELPHIA

费城

，

April 2, 2025

2025年4月2日

/PRNewswire/ -- In today's interconnected world, viral diseases contribute to significant global health challenges and economic costs. Seasonal influenza epidemics cause substantial disease burden and economic losses exceeding

/PRNewswire/ -- 在当今互联互通的世界中，病毒性疾病给全球健康带来重大挑战，并造成巨大的经济损失。季节性流感流行导致沉重的疾病负担，经济损失超过

$11.2 billion

112亿美元

annually in

每年在

the United States

美国

alone. Meanwhile, herpes simplex virus-1 (HSV-1), spread primarily through oral contact, infects over two-thirds of the global population and is the leading cause of infectious blindness in Western countries.

单独存在。同时，单纯疱疹病毒1型（HSV-1）主要通过口腔接触传播，感染了全球超过三分之二的人口，并且是西方国家感染性失明的主要原因。

Low vaccination rates for influenza viruses and the lack of an HSV vaccine underscore the need for a new approach—one that targets reducing viral loads at the sites where transmission occurs. Now, in a study published in

低流感病毒疫苗接种率以及缺乏HSV疫苗凸显了对新方法的需求——这种方法旨在减少传播发生部位的病毒载量。现在，在一项发表于

Molecular Therapy

分子治疗

, researchers at

，研究人员在

Penn Dental Medicine

宾夕法尼亚大学牙医学院

and collaborators in

和合作者在

Finland

芬兰

, have done just that.

，已经做到了。

Building on their

基于他们的

previous work

以前的工作

—now in

——现在在

clinical trial

临床试验

—showing that a similar approach was able to reduce SARS-CoV-2 in COVID-19 patient saliva or swab samples by more than 95%,

——表明类似的方法能够将COVID-19患者唾液或拭子样本中的SARS-CoV-2减少95%以上，

Henry Daniell

亨利·丹尼尔

, W.D. Miller Professor at Penn Dental Medicine, and collaborators tested the ability of a chewing gum made from lablab beans,

宾夕法尼亚牙科医学院的W.D.米勒教授及其合作者测试了一种由扁豆制成的口香糖的能力，

Lablab purpureus—

紫花扁豆——

that naturally contain an antiviral trap protein (FRIL)—to neutralize two herpes simplex viruses (HSV-1 and HSV-2) and two influenza. They prepared clinical grade chewing gum to comply with FDA specifications and demonstrated safety and efficacy. Forty mg of a two-gram bean gum tablet was adequate to reduce viral loads by more than 95%, and antiviral efficacy was maintained up to 823 days when chewing gums were stored at room temperature..

天然含有抗病毒陷阱蛋白（FRIL）——能够中和两种单纯疱疹病毒（HSV-1和HSV-2）以及两种流感病毒。他们制备了符合FDA规格的临床级口香糖，并证明了其安全性和有效性。两克豆胶片中仅需40毫克就足以将病毒载量减少95%以上，且在室温下存放时，口香糖的抗病毒效力可维持长达823天。

Daniell and his colleagues are now looking to use lablab bean powder to tackle bird flu, currently having a significant impact in

丹尼尔和他的同事现在正寻求使用扁豆粉来应对禽流感，目前禽流感正在产生重大影响。

North America

北美

. In the past three months,

。在过去的三个月里，

54 million birds

5400万只鸟

have been affected by H5N1, and several human infections have been reported in the U.S. and

已受到H5N1的影响，并且在美国和

Canada

加拿大

。

Previously,

之前，

bean powder has been shown

豆粉已经显示出

by a collaborating laboratory to effectively neutralize H5N1 and H7N9—two strains of influenza A known to cause bird flu. Daniell and colleagues are currently looking to test its use in bird feed to help control bird flu.

通过合作实验室有效中和 H5N1 和 H7N9——这两种已知会导致禽流感的甲型流感病毒株。丹尼尔及其同事目前正在研究将其用于禽类饲料中，以帮助控制禽流感。

'A broad-spectrum antiviral protein (FRIL) present in a natural food product (bean powder) to neutralize not only human flu viruses but also avian (bird) flu is a timely innovation to prevent their infection and transmission,' says Daniell.

“一种存在于天然食品（豆粉）中的广谱抗病毒蛋白（FRIL），能够中和不仅人类流感病毒，还包括禽流感（鸟流感）病毒，这是预防其感染和传播的及时创新，”丹尼尔说道。

Research performed in the Daniell lab was supported by NIH grant R01 HL 107904.

丹尼尔实验室进行的研究得到了美国国立卫生研究院（NIH）R01 HL 107904拨款的支持。

Media contact:

媒体联系人：

Beth Adams

贝丝·亚当斯

，

adamsnb@upenn.edu

SOURCE PENN DENTAL MEDICINE

来源：宾夕法尼亚大学牙医学院

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