新研究显示，带状疱疹疫苗与痴呆风险降低20%有关，GSK股价上涨-动脉网

New Study Shows Shingles Vaccine Linked To 20% Lower Dementia Risk, GSK Stock Pops

benzinga 等信源发布 2025-04-03 15:17



可切换为仅中文







Researchers investigated whether the shingles (herpes zoster) vaccine can help prevent dementia. Previous studies suggest that certain herpes viruses may contribute to dementia, and vaccines might have

研究人员调查了带状疱疹（herpes zoster）疫苗是否有助于预防痴呆。先前的研究表明，某些疱疹病毒可能会导致痴呆，而疫苗可能具有作用。

immune benefits

免疫益处

。

The new research, published on Wednesday, Nature analyzed data from 282,541 older adults in Wales and found that people who received the original shingles live virus vaccine were 20% less likely to develop dementia than non-vaccinated participants.

周三发表在《自然》上的新研究分析了威尔士 282,541 名老年人的数据，发现接种原始带状疱疹活病毒疫苗的人患痴呆症的可能性比未接种疫苗的参与者低 20%。

Also Read:

另请阅读：

Trump Administration Weighs Deep Cuts To Domestic HIV Prevention Programs, Gilead Stock Slides

特朗普政府考虑大幅削减国内艾滋病预防项目，吉利德股票下滑。

Shingles, also known as herpes zoster, is a painful rash illness caused by the varicella-zoster virus, the same virus that causes chickenpox, which reactivates in the body after a person has had chickenpox.

带状疱疹，也称为疱疹性神经痛，是由水痘-带状疱疹病毒引起的痛苦的皮疹疾病，这种病毒与导致水痘的病毒相同，在人体内患过水痘后会重新激活。

The

study

学习

found that getting the zoster vaccine lowered the chance of being diagnosed with dementia over seven years by 3.5 percentage points, or about 20% relative risk reduction.

发现接种带状疱疹疫苗可将七年内被诊断出痴呆症的几率降低3.5个百分点，相对风险减少约20%。

The protective effect was stronger in women than men. The findings were confirmed in another population (England and Wales) using death certificate data, showing fewer dementia-related deaths among vaccinated individuals.

女性的保护作用比男性更强。在另一人群（英格兰和威尔士）中使用死亡证明数据确认了这一发现，显示接种疫苗的个体中与痴呆相关的死亡更少。

Previous research in July 2024

2024年7月的先前研究

hinted

暗示了

that the older live shingles vaccine might offer some protection, but that vaccine has been discontinued in favor of the recombinant version.

旧的活带状疱疹疫苗可能提供一些保护，但该疫苗已被重组版本取代。

Researchers found that people who received the recombinant vaccine had a 17% longer period without a dementia diagnosis—equal to about 164 extra days dementia-free for those who eventually developed the condition.

研究人员发现，接种重组疫苗的人在没有痴呆症诊断的时间上延长了17%——相当于那些最终患病的人多出了大约164天的无痴呆期。

The recombinant vaccine also appeared to reduce dementia risk more than flu and tetanus–diphtheria–pertussis vaccines. The effect was seen in both men and women but was stronger in women.

重组疫苗似乎也比流感和白喉-破伤风-百日咳疫苗更有助于降低痴呆风险。这种效果在男性和女性中都有体现，但在女性中更为明显。

Last year,

去年，

GSK plc

葛兰素史克公司

GSK

revealed data from the ZOSTER-049 long-term follow-up phase 3 trial, which followed participants for up to approximately 11 years following initial vaccination with Shingrix

揭示了ZOSTER-049三期长期随访试验的数据，该试验在参与者初次接种Shingrix疫苗后进行了长达约11年的随访。

(Recombinant Zoster Vaccine or RZV)

（重组带状疱疹疫苗或RZV）

。

The final trial data demonstrate that RZV has maintained efficacy against shingles in adults over 50 for over a decade.

最终试验数据表明，RZV 在 50 岁以上成人中对带状疱疹的有效性已维持了十多年。

Shingrix sales for 2024 reached 3.36 billion pounds, down 2% (+1% at

Shingrix的2024年销售额达到33.6亿英镑，下降了2%（+1%

constant currency)

固定货币

。

Price Action