Akadeum Life Sciences has previewed its Alerion cell separation system, an instrument that provides a closed system for separating T cells from a leukopak using the company’s Buoyancy Activated Cell Sorting (BACS) microbubble technology. The instrument promises to speed up the cell separation process, increase cell recovery, automate several manual steps, improve sample processing robustness, decrease user error incidence, and reduce cell exhaustion.  .

Akadeum生命科学公司（Akadeum Life Sciences）预览了其Alerion细胞分离系统，该仪器提供了一个封闭系统，使用该公司的浮力激活细胞分选（BACS）微泡技术将T细胞与白细胞分离。该仪器有望加快细胞分离过程，提高细胞回收率，自动化几个手动步骤，提高样品处理的稳健性，减少用户错误发生率，并减少细胞耗竭。（笑声）。。

Currently, revolutionary treatments like CAR T cell therapy can cost more than $500,000, partly because current technology is difficult to scale up in manufacturing processes. With few options in the market, customers are forced to settle for mediocre performance from dated technology. Akadeum’s microbubble technology addresses these challenges and offers a shift in the field of cell separation, activation, and expansion, promising higher performance, and lower prohibitive costs to improve accessibility.

目前，CAR T细胞疗法等革命性疗法的成本可能超过50万美元，部分原因是目前的技术难以在制造过程中扩大规模。由于市场上几乎没有选择，客户被迫接受过时技术的平庸性能。Akadeum的微泡技术解决了这些挑战，并在细胞分离，激活和扩增领域提供了转变，有望获得更高的性能和更低的高昂成本，以提高可及性。

The new Alerion system brings even more robust cell separation workflows compared to legacy magnetic-activated cell separation (MACS) and fluorescence-activated cell sorting (FACS) instruments. Akadeum’s new instrument enables unmatched scalability and productivity for T cell separation by processing more healthy cells per isolation and more isolations during a manufacturing shift, according to the company..

与传统的磁激活细胞分离（MACS）和荧光激活细胞分选（FACS）仪器相比，新的Alerion系统带来了更强大的细胞分离工作流程。据该公司称，Akadeum的新仪器通过每次分离处理更多健康细胞以及在生产转移过程中进行更多分离，为T细胞分离提供了无与伦比的可扩展性和生产力。。

“This instrument marks an important step in bringing the performance advantages of our products into clinical manufacturing workflows. The instrument provides gentle separation, fast protocols, flexible workflows and does so in a closed system,” Akadeum Life Sciences Founder/CEO Brandon McNaughton said.  .

Akadeum Life Sciences创始人/首席执行官布兰登·麦克诺顿（Brandon McNaughton）说：“该仪器标志着将我们产品的性能优势引入临床制造工作流程的重要一步。该仪器提供了温和的分离，快速的协议，灵活的工作流程，并且在一个封闭的系统中实现了这一点。”。（笑声）。。

Akadeum’s instrument utilizes a two-chamber consumable. In the bottom chamber, the leukopak material is mixed with an antibody cocktail and microbubble solution. Using cell-specific binding properties, the microbubbles adhere to a predetermined cell population. Next, a channel between the two chambers is opened, allowing the naturally buoyant microbubbles to float the T cells to the top chamber, leaving the unwanted cells behind in the lower chamber.

Akadeum的仪器使用两室消耗品。在底室中，将leukopak材料与抗体混合物和微泡溶液混合。使用细胞特异性结合特性，微泡粘附于预定的细胞群。接下来，打开两个腔室之间的通道，使自然漂浮的微泡将T细胞漂浮到顶部腔室，将不需要的细胞留在下部腔室中。

This automated process can be applied to Akadeum’s negative or positive selection kits and takes less than 60 minutes to complete.  .

这个自动化过程可以应用于Akadeum的阴性或阳性选择试剂盒，完成不到60分钟。（笑声）。。

“For the first time, customers will have a choice of the cell separation technology they use. With the many features of our microbubbles, we believe many will now choose the Akadeum solution. Additionally, with the Alerion achieving cell recovery rates of 90% and above, they will experience more healthy cells for use in cell and gene therapy, as compared to other technologies,' Akadeum R&D Vice PresidentCasey Wegner stated. 'Finally, microbubble technology is highly scalable and eco-friendly as opposed to the contamination associated with magnets.

“这是第一次，客户可以选择他们使用的细胞分离技术。凭借我们微泡的许多功能，我们相信许多人现在会选择Akadeum解决方案。此外，随着Alerion的细胞回收率达到90%以上，与其他技术相比，他们将体验到更多用于细胞和基因治疗的健康细胞，”Akadeum研发副总裁总统凯西·韦格纳表示。最后，微泡技术具有高度的可扩展性和环保性，而不是与磁铁相关的污染。

We’re thrilled with the work that our team has done to bring this instrument to researchers and developers.”  .

我们的团队为将该仪器带给研究人员和开发人员所做的工作让我们感到兴奋。”（笑声）。。

Akadeum is currently signing up customers interested in being a Beta testing site, in advance of a full product launch.

在全面推出产品之前，Akadeum目前正在与有兴趣成为Beta测试站点的客户签约。

Akadeum Life Sciences was formed to solve long-standing sample preparation problems in research, diagnostics, and cell therapy markets with a flotation-based target isolation platform technology. Without the critical step of separation (isolating biological targets like DNA, proteins, or cells from biological samples), many diagnostics and therapies are not possible.

成立Akadeum Life Sciences是为了利用基于浮选的目标分离平台技术解决研究，诊断和细胞治疗市场中长期存在的样品制备问题。如果没有关键的分离步骤（从生物样品中分离出DNA，蛋白质或细胞等生物靶标），许多诊断和治疗是不可能的。

More than a solution to a single problem, this simple platform is disrupting the separation market—from nucleic acid extraction to cell isolation. Akadeum was the first to commercialize BACS (buoyancy activated cell sorting) microbubble kits for cell isolation applications. In parallel, Akadeum is actively establishing industry partnerships and collaborations.

这个简单的平台不仅仅是一个问题的解决方案，它正在破坏从核酸提取到细胞分离的分离市场。Akadeum是第一个将用于细胞分离应用的BACS（浮力激活细胞分选）微泡试剂盒商业化的公司。与此同时，Akadeum正在积极建立行业伙伴关系和合作。

Akadeum's kits are available for research only and as GMP-grade configurations.  .

Akadeum的试剂盒仅用于研究和GMP级配置。。