THURSDAY, April 24, 2025 -- Metabolic syndrome (MetS) and its individual components are associated with an increased risk for young-onset dementia (YOD), according to a study published online April 23 in

2025年4月24日星期四——根据4月23日在线发表的一项研究，代谢综合征（MetS）及其各个组成部分与早发性痴呆（YOD）风险增加相关。

Neurology

神经病学

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Jeong-Yoon Lee, M.D., from Soonchunhyang University Seoul Hospital in South Korea, and colleagues conducted a nationwide population-based cohort study using data from the Korean National Insurance Service to examine whether MetS, defined according to established guidelines, and its individual components increase the risk for YOD, defined as dementia diagnosis before age 65 years..

韩国首尔顺天乡大学医院的李正允（Jeong-Yoon Lee）博士及其同事利用韩国国家健康保险服务的数据进行了一项全国性基于人群的队列研究，以探讨根据既定指南定义的代谢综合征（MetS）及其各个组分是否增加了早发性痴呆（YOD，定义为65岁之前诊断的痴呆）的风险。

Data were included for 1,979,509 participants; 8,921 (0.45 percent) developed YOD during an average follow-up of 7.75 years. The researchers found that MetS was associated with an increased risk for all-cause YOD, Alzheimer disease, and vascular dementia (adjusted hazard ratios, 1.24, 1.12, and 1.21, respectively).

研究共纳入了1,979,509名参与者；在平均7.75年的随访期间，有8,921人（0.45%）发展为年轻发病痴呆（YOD）。研究人员发现，代谢综合征（MetS）与全因YOD、阿尔茨海默病和血管性痴呆的风险增加相关（调整后的风险比分别为1.24、1.12和1.21）。

There were significant interactions noted with younger age (40 to 49 versus 50 to 59 years), female sex, drinking status, obesity, and depression..

注意到与较年轻年龄（40至49岁对比50至59岁）、女性、饮酒状态、肥胖和抑郁存在显著的交互作用。

'Our findings suggest that lifestyle changes to reduce the risk of metabolic syndrome, such as eating a healthy diet, exercising regularly, maintaining a healthy weight, quitting smoking, and reducing stress, may help reduce the risk of young-onset dementia,' coauthor Minwoo Lee, M.D., Ph.D., of Hallym University Sacred Heart Hospital in Anyang, South Korea, said in a statement.

“我们的研究结果表明，通过生活方式的改变来降低代谢综合征的风险，例如健康饮食、定期锻炼、保持健康体重、戒烟和减轻压力，可能有助于降低早发性痴呆的风险，”韩国安养市韩林大学圣心医院的李敏宇博士在一份声明中说道。

'Future research that follows people over longer periods of time and uses brain scans to look for biomarkers of dementia is needed to confirm and expand upon our findings.'.

“未来需要进行更长时间的跟踪研究，并使用脑扫描来寻找痴呆症的生物标志物，以确认并扩展我们的研究结果。”

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