FRIDAY, April 25, 2025 -- Doctors can accurately predict a person’s risk of fatty liver disease as early as 16 years before symptoms develop, a new study says.

2025年4月25日，星期五——一项新研究表明，医生可以早在症状出现前16年准确预测一个人患脂肪肝疾病的风险。

A blood test looking for five specific proteins can predict metabolic dysfunction-associated steatotic liver disease (MASLD), more commonly known as fatty liver disease, researchers are scheduled to report at the upcoming Digestive Diseases Week meeting in San Diego.

研究人员计划在即将于圣地亚哥举行的消化疾病周会议上报告，一种寻找五种特定蛋白质的血液测试可以预测与代谢功能障碍相关的脂肪肝病（MASLD），这种疾病更常见的名称是脂肪肝病。

The five-protein test was 84% accurate at predicting fatty liver disease five years from onset and 76% accurate at predicting 16 years ahead of diagnosis, researchers report.

研究人员报告说，这种五蛋白测试在预测脂肪肝疾病方面，从发病前五年预测的准确率为84%，而在诊断前16年预测的准确率为76%。

“Too often, people do not find out they are at risk for liver disease before they are diagnosed and coping with symptoms,” lead researcher

“人们往往在被诊断出肝病并开始应对症状之前，并不知道自己有患病风险，”首席研究员表示。

Dr. Shiyi Yu

俞世宜博士

said in a news release. Yu is a resident physician of gastroenterology at Guangdong Provincial People's Hospital in China.

新闻发布会上表示。余是中国广东省人民医院的胃肠病学住院医师。

“The field urgently needs effective biomarkers and predictive models, and our research shows that plasma proteins offer novel potential strategies for early prediction and intervention,” Yu added.

“该领域迫切需要有效的生物标志物和预测模型，我们的研究表明，血浆蛋白为早期预测和干预提供了新的潜在策略，”余补充道。

Fatty liver disease occurs when fat starts to accumulate in the liver, eventually causing

脂肪肝病是指当脂肪开始在肝脏中积累时，最终导致

inflammation and scarring

炎症和疤痕形成

. People with the disorder face up to twice the risk of premature death as those without fatty liver disease, researchers said in background notes.

研究人员在背景资料中说，患有此病的人面临的早死风险是那些没有脂肪肝疾病的人的两倍。

For the study, researchers analyzed blood samples from more than 50,000 people participating in the UK Biobank, a long-term U.K. health research study.

在该项研究中，研究人员分析了参与英国生物样本库（UK Biobank）这一英国长期健康研究项目的5万多人的血样。

The team screened for more than 2,700 blood-borne proteins and found five that appear to be early warning signals for fatty liver disease.

该团队筛查了2700多种血源性蛋白质，发现了五个似乎是脂肪肝疾病早期预警信号的蛋白质。

Adding other clues of fatty liver disease, like body mass index (an estimate of body fat based on height and weight) and daily exercise, boosted the blood test’s accuracy even more – more than 90% at five years and 82% at 16 years.

添加脂肪肝疾病的其他线索，如身体质量指数（基于身高和体重估算的身体脂肪量）和每日运动，可进一步提高血液检测的准确性——五年内超过90%，16年内达到82%。

“We achieved similar results when we tested this predictive model in a separate cohort of people in China, further supporting the robustness of the model and showing it can be effective across diverse populations,” Yu said.

“当我们在一个独立的中国人群体中测试这个预测模型时，我们得到了类似的结果，这进一步证明了该模型的稳健性，并表明它可以适用于不同的人群，”余教授说。

Yu is scheduled to present these findings on May 4. Findings presented at medical meetings are considered preliminary until published in a peer-reviewed journal.

余定于 5 月 4 日展示这些研究成果。在医学会议上展示的成果通常被视为初步成果，直到它们被发表在经同行评议的期刊上。

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