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DDW:系统性项目提高结直肠癌筛查的最新可能性

DDW: Systematic Program Increases Likelihood of Up-to-Date Colorectal Cancer Screening

Drugs 等信源发布 2025-04-26 02:34

可切换为仅中文


FRIDAY, April 25, 2025 -- A systematic program of monitoring colorectal cancer (CRC) screening status increases up-to-date screening status, according to a study presented at the 2025 Digestive Disease Week, held from May 3 to 6 in San Diego.

2025年4月25日星期五——在2025年5月3日至6日于圣地亚哥举行的消化疾病周上发布的一项研究表明,系统性监测结直肠癌(CRC)筛查状态的计划可以提高最新的筛查率。

Douglas Corley, M.D., Ph.D., from Kaiser Permanente Northern California in Pleasanton, and colleagues analyzed data from nearly 1.1 million adults aged 50 to 75 years across 22 medical centers from 2000 to 2019 to examine screening and CRC-related outcomes. Programmatic screening was introduced in 2006 to 2008, with annual ascertainment of up-to-date status by colonoscopy, sigmoidoscopy, or fecal immunochemical testing (FIT); for those not up-to-date, mailed outreach was performed using FIT..

来自加州普莱森顿凯撒医疗集团北加州分部的道格拉斯·科利医学博士及其同事分析了2000年至2019年间,来自22个医疗中心的近110万名50至75岁成年人的数据,以研究筛查与结直肠癌(CRC)相关的结果。项目化筛查在2006年至2008年引入,通过结肠镜、乙状结肠镜或粪便免疫化学检测(FIT)来确定最新筛查状态;对于未及时筛查的人群,则通过邮寄方式进行FIT推广。

The researchers found that after introduction of systematic FIT-based screening, up-to-date screening status more than doubled, from 37.4 to 79.8 percent between 2000 and 2019, with similar patterns seen across all racial and ethnic groups. CRC incidence rates increased in these groups from 109.1 to 126.4 cases per 100,000 in 2002, concordant with increased screening prevalence.

研究人员发现,在引入基于粪便免疫化学测试(FIT)的系统性筛查后,最新的筛查率从2000年的37.4%增加到2019年的79.8%,增加了两倍多,所有种族和族裔群体都呈现出相似的趋势。在这些群体中,结直肠癌(CRC)的发病率从2002年的每10万人109.1例增加到126.4例,与筛查普及率的提高一致。

Rates then peaked during 2008 to 2010, consistent with increased early detection of cancers, and then decreased gradually, in accordance with cancer prevention resulting from polyp detection and removal, to 66.3, 78.3, 78.4, and 87.1 cases per 100,000 in Asian, Hispanic, White, and Black members, respectively, in 2019.

随后,2008年至2010年期间,发病率达到了峰值,这与癌症的早期检测增加一致,然后随着由息肉检测和切除带来的癌症预防效果逐渐下降,分别为每10万亚洲人、西班牙裔、白人和黑人成员中66.3例、78.3例、78.4例和87.1例,在2019年。

From 2002 to 2019, there was a decrease noted in CRC-related deaths to 15.3, 20.7, 21.9, and 23.5 per 100,000 in Asian, White, Hispanic, and Black members, respectively..

从2002年到2019年,亚洲、白人、西班牙裔和黑人群体中与结直肠癌相关的死亡率分别下降至每10万人中的15.3、20.7、21.9和23.5。

'Ten years ago, there were big gaps in cancer risk and death, especially among our Black patients,' Corley said in a statement. 'Now, those differences are nearly gone.'

“十年前,癌症风险和死亡率存在很大差距,尤其是在我们的黑人患者中,”科利在一份声明中说。“现在,这些差异几乎消失了。”

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