爱茉莉太平洋研究证实微藻衍生的PDRNs在皮肤再生和伤口愈合中的潜力-动脉网

Amorepacific Research Confirms Potential of Microalgal-Derived PDRNs in Skin Regeneration and Wound Healing

CISION 等信源发布 2025-04-29 09:00

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New findings suggest 'BluePDRN™' offers a sustainable, scalable alternative to traditional animal-derived PDRNs

新发现表明，“BluePDRN™”提供了一种可持续、可扩展的传统动物源PDRN替代方案。

SEOUL, South Korea

韩国首尔

，

April 28, 2025

2025年4月28日

/PRNewswire/ -- Amorepacific revealed research findings confirming the skin-regenerative effects of polydeoxyribonucleotides (PDRNs) extracted from a microalgal source,

/PRNewswire/ -- 爱茉莉太平洋公布了从微藻来源提取的多脱氧核糖核苷酸（PDRNs）在促进皮肤再生效果方面的研究结果，

Chlorella protothecoides

小球藻属原壳体藻

. The findings were published in the international journal

研究结果发表在国际期刊上

Archives of Dermatological Research

皮肤病学研究档案

under the title, 'Effects of

标题为《影响》

Chlorella protothecoides

普通小球藻

-derived polydeoxyribonucleotides on skin regeneration and wound-healing.'

衍生的多脱氧核苷酸在皮肤再生和伤口愈合中的作用。

继续阅读

Images from a reconstructed human epidermis test, showing increased levels of protein marker expression during BluePDRN™-induced skin regeneration when compared to that of a control group

来自重建的人类表皮测试的图像，显示在BluePDRN™诱导的皮肤再生过程中，蛋白质标志物表达水平增加，相对于对照组

Visual representation of test results from Amorepacific R&I Center paper published in Archives of Dermatological Research, indicating that BluePDRN™ activates cell proliferation and angiogenesis pathways through A2AR-dependent mechanisms

发表在《皮肤病学研究档案》上的爱茉莉太平洋R&I中心论文的测试结果的可视化表示，表明BluePDRN™通过A2AR依赖性机制激活细胞增殖和血管生成途径。

PDRNs have been garnering attention in recent years for its efficacy in enhancing skin regeneration and wound healing. In Korea, PDRNs that have been purified can be found in various applications, including pharmaceuticals, medical devices and cosmetics. Traditionally, PDRNs are extracted from animal-derived sources like salmon or trout, but Amorepacific turned its attention to .

近年来，PDRN因其在促进皮肤再生和伤口愈合方面的功效而备受关注。在韩国，经过纯化的PDRN已应用于多个领域，包括医药品、医疗器械和化妆品。传统上，PDRN通常从鲑鱼或鳟鱼等动物来源中提取，但爱茉莉太平洋将目光转向了其他方向。

Chlorella protothecoides

蛋白核小球藻

to develop an animal-free alternative that is sustainable and scalable.

开发一种可持续且可扩展的无动物替代品。

The pioneering research on

开创性研究

Chlorella

小球藻

-derived PDRNs, led by Amorepacific's R&I Center, was conducted as part of the Ministry of Oceans and Fisheries' project to develop marine biomaterial formulation technology. Through this initiative, Amorepacific successfully developed a production process for high-yield, low-molecular-weight, microalgal-derived PDRNs dubbed 'BluePDRN™', consequently shedding light on its mechanism of action and skin regenerative effects..

由爱茉莉太平洋R&I中心主导的衍生PDRNs研究，是作为韩国海洋水产部开发海洋生物材料配方技术项目的一部分进行的。通过这一举措，爱茉莉太平洋成功开发出一种高产量、低分子量的微藻衍生PDRNs生产流程，这种物质被称为“BluePDRN™”，并揭示了其作用机制和皮肤再生效果。

Research results showed BluePDRN™ displayed wound closure effects equivalent to those of salmon-derived PDRN

研究结果显示，BluePDRN™表现出与鲑鱼来源的PDRN相当的伤口闭合效果。

[1]

, with each molecule being approximately 1/20th the size of a salmon-derived PDRN molecule

，每个分子的大小约为鲑鱼源PDRN分子的1/20

[2]

. It also promoted the expression of collagen accumulation and angiogenesis, both of which are essential for healthy skin. Like traditional animal-derived PDRNs, BluePDRN™ demonstrated skin regeneration efficacy through an adenosine A2A receptor (A2AR)-dependent mechanism.

它还促进了胶原积累和血管生成的表达，这两者对健康皮肤都至关重要。与传统的动物源性PDRN一样，BluePDRN™通过腺苷A2A受体（A2AR）依赖性机制展示了皮肤再生功效。

Notably, the regenerative benefits of BluePDRN

值得注意的是，BluePDRN 的再生益处

商标

were also observed in skin tissue with epidermal damage caused by photoaging, as demonstrated in experiments conducted by Outer Biosciences Inc., a biotechnology company in

也在由光老化引起的表皮损伤的皮肤组织中被观察到，正如生物技术公司Outer Biosciences Inc.进行的实验所展示的那样。

Boston, MA

马萨诸塞州波士顿市

, USA that researches ingredients for skin health.

，美国一家研究皮肤健康成分的公司。

Byung-Fhy Suh

, CTO of Amorepacific R&I Center, said, 'This research is highly significant as it reveals the efficacy of sustainable, vegan PDRNs derived from microalgae. Amorepacific will continue its efforts to deliver safer and more effective products to customers around the world.'

爱茉莉太平洋R&I中心的首席技术官表示：“这项研究具有重要意义，因为它揭示了从微藻中提取的可持续、纯素PDRN的功效。爱茉莉太平洋将继续努力，为全球客户提供更安全、更有效的产品。”

Amorepacific has applied for a patent on the production technology behind BluePDRN™, 'Manufacturing technology for low-molecular-weight PDRN isolated from microalgae (

爱茉莉太平洋已申请了关于BluePDRN™背后生产技术的专利，“从微藻中分离的低分子量PDRN的制造技术（”

Chlorella

小球藻

) using a continuous modular process.' The company has also received a New Excellent Technology (NET) certification and a minister's commendation from the Ministry of Oceans and Fisheries.

) 使用连续模块化流程。”该公司还获得了新的优秀技术 (NET) 认证以及海洋和渔业部长的嘉奖。

[1]

Results from Amorepacific R&I Center tests on ex vivo skin and reconstructed human epidermis

来自爱茉莉太平洋研发中心关于离体皮肤和重建的人类表皮的测试结果

[2]

Each BluePDRN™ being approximately 24 kDa in size (1/20

每个 BluePDRN™ 的大小约为 24 kDa（1/20）。

the size of a salmon-derived PDRN molecule), according to measurement of molecular weight by Korea Polymer Testing & Research Institute

根据韩国聚合物测试与研究所的分子量测量结果，鲑鱼来源的PDRN分子的大小）。

SOURCE Amorepacific

来源：爱茉莉太平洋

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