Guardant Health Guardant360 Tissue

Guardant Health Guardant360 组织

Guardant Health has launched Guardant360 Tissue, an updated version of its prior tissue genotyping assay that now incorporates multiomics analysis including DNA, RNA, AI-powered PD-L1 immunohistochemistry, and genome-wide methylation data. The test is intended to provide researchers and care teams with a more comprehensive view of a patient's cancer..

Guardant Health推出了Guardant360 Tissue，这是其先前组织基因分型检测的更新版本，现在结合了多组学分析，包括DNA、RNA、AI驱动的PD-L1免疫组化以及全基因组甲基化数据。该测试旨在为研究人员和医疗团队提供更全面的患者癌症视图。

The test is powered by the Guardant Infinity smart liquid biopsy platform and enables insights beyond what can typically be found using tests that do not incorporate epigenetics. The company said these insights can apply to important classes of therapeutics, such as PARP-inhibitors and immunotherapies, as well as important new classes of therapies in late-stage development.

该测试由Guardant Infinity智能液体活检平台提供支持，能够提供通常使用不包含表观遗传学的测试无法获得的见解。该公司表示，这些见解适用于重要的治疗药物类别，例如PARP抑制剂和免疫疗法，以及处于后期开发阶段的重要新类别疗法。

The test also enables classification and subtyping of each individual tumor at a much higher resolution than previously possible..

该测试还能够以比以前更高的分辨率对每个个体肿瘤进行分类和亚型划分。

According to the company, the test also requires 92 percent less tissue surface area for analysis than the industry norm. Samples can also be analyzed with 40 percent fewer slides. The assay covers 742 DNA genes and fusions in 367 RNA genes, with the ability to add genome-wide analysis of the tumor methylome.

据该公司介绍，与行业标准相比，该测试所需的组织表面分析面积还减少了 92%。样品也可以用少 40% 的切片进行分析。该检测涵盖了 742 个 DNA 基因和 367 个 RNA 基因的融合，并且能够添加对肿瘤甲基化组的全基因组分析。

Test results are available in less than two weeks, and the clinical report is covered by Medicare for eligible patients..

测试结果在两周内即可获得，临床报告由Medicare为符合条件的患者支付。

Karius Focus BAL

卡里乌斯焦点BAL

Karius has launched Karius Focus BAL, a metagenomic sequencing-based microbial cell-free DNA test designed to help physicians identify the pathogens causing pneumonia and other lung infections. Using the same technology as the company's plasma-based Karius Spectrum test, the new assay can detect and classify over 500 pathogens associated with lung infections from 1 mL of bronchoalveolar lavage within a single day of sample receipt at the company's CLIA-certified and CAP-accredited laboratory in Redwood City, California..

Karius 推出了 Karius Focus BAL，这是一款基于宏基因组测序的微生物无细胞 DNA 检测，旨在帮助医生识别导致肺炎和其他肺部感染的病原体。新检测使用与其血浆为基础的 Karius Spectrum 检测相同的技术，可以在加利福尼亚州雷德伍德市公司 CLIA 认证和 CAP 认可的实验室收到样本的一天之内，从 1 毫升支气管肺泡灌洗液中检测并分类超过 500 种与肺部感染相关的病原体。

Tempus Loop

时间循环

Tempus AI has launched Tempus Loop, an oncology-focused platform for target discovery and validation that integrates real-world patient data with human-derived biological models and CRISPR-screens. The platform uses artificial intelligence to uncover insights for preclinical therapeutic development and utilizes the real-world data to identify patient subpopulations with similar clinical, pathologic, and molecular patterns.

Tempus AI 推出了 Tempus Loop，这是一个专注于肿瘤学的靶点发现和验证平台，整合了真实世界患者数据、人类衍生的生物模型以及 CRISPR 筛选技术。该平台利用人工智能揭示临床前治疗开发的见解，并通过真实世界数据识别具有相似临床、病理和分子特征的患者亚群。

It then uses systems biological approaches to determine novel target genes and multimodal signatures, which can then be used to map patient subcohorts to relevant patient-derived organoids. It can then validate targets using high-throughput functional screens. The firm has deployed Loop to prioritize drug targets in patient subpopulations with severe unmet needs for a large pharmaceutical company, it said. .

然后，它使用系统生物学方法来确定新的靶基因和多模式特征，这些特征可以用于将患者亚组映射到相关的患者来源的类器官。之后，它可以使用高通量功能筛选来验证靶点。该公司表示，已经部署了Loop，为一家大型制药公司在具有严重未满足需求的患者亚群中优先考虑药物靶点。

Almac Diagnostics PNPLA3 Genotyping Kit

阿尔马克诊断PNPLA3基因分型试剂盒

Almac Diagnostics has launched the PNPLA3 Genotyping Kit for liver disease research. The qPCR kit can be used to genotype the PNPLA3 gene from blood or buccal swab specimens with a hands-on time of less than 30 minutes. It includes three genotyping assay controls to ensure confidence for researchers in allelic assay calls, Almac said.

阿尔马克诊断公司推出了用于肝病研究的PNPLA3基因分型试剂盒。该qPCR试剂盒可用于从血液或口腔拭子样本中对PNPLA3基因进行基因分型，操作时间不到30分钟。阿尔马克表示，该试剂盒包含三种基因分型检测对照，以确保研究人员对等位基因检测结果的信心。

The kit is designed to enable researchers to identify genetic risk factors to understand the underlying genetic predisposition to metabolic dysfunction-associated steatotic liver disease better, to investigate how the I148M variant of the PNPLA3 gene influences disease severity and fibrosis progression, and to develop future targeted therapies through better disease population understanding, the company said..

该公司表示，该工具旨在使研究人员能够识别遗传风险因素，以更好地了解与代谢功能障碍相关的脂肪肝病的潜在遗传易感性，研究PNPLA3基因的I148M变异如何影响疾病严重程度和纤维化进展，并通过更好地了解疾病人群来开发未来的靶向治疗。

Zeiss Axioscan 7 Spatial Biology

蔡司Axioscan 7空间生物学

Zeiss has launched the Axioscan 7 Spatial Biology slide scanner optimized for multiplex immunofluorescence (mIF) imaging across large cohorts of samples. It allows up to eight fluorescence-stained biomarkers to be studied at the same time and can fully automatically scan up to 100 samples in a single run.

蔡司推出了Axioscan 7空间生物学玻片扫描仪，该扫描仪针对大批量样本的多重免疫荧光（mIF）成像进行了优化。它能够同时研究多达八种荧光染色的生物标记物，并且可以在单次运行中全自动扫描多达100个样本。

A selection of hardware and software solutions contributes to superior reproducibility of images and data for longitudinal and multisite studies, Zeiss said. The platform can be used with OmniVue reagents from Zeiss partner Ultivue, which feature DNA amplification technology designed for high specificity and dynamic range.

蔡司表示，一系列硬件和软件解决方案有助于在纵向和多站点研究中实现更优的图像和数据可重复性。该平台可与蔡司合作伙伴Ultivue提供的OmniVue试剂配合使用，这些试剂采用了专为高特异性和动态范围设计的DNA扩增技术。

Ultivue offers ready-to-use validated assays paired with co-optimized analysis algorithms. The instrument and workflow are fully compatible with a broad range of assays, including various mIF reagents, standard IHC, and H&E, and samples stained with different assays can easily be imaged automatically in the same batch, Zeiss said.

Ultivue 提供即用型验证分析方法，并配有协同优化的分析算法。蔡司表示，该仪器和工作流程完全兼容广泛的分析方法，包括各种多重免疫荧光（mIF）试剂、标准免疫组化（IHC）和苏木精-伊红染色（H&E），并且使用不同分析方法染色的样本可以轻松在同一批次中自动成像。

Finally, an integrated image-analysis solution by Zeiss partner Mindpeak enables the efficient analysis of IHC and mIF-stained tissue images generated on the platform..

最后，蔡司合作伙伴Mindpeak提供的集成图像分析解决方案能够高效分析在该平台上生成的IHC和mIF染色组织图像。

Opentrons Flex NeoSwitch Workstation

Opentrons Flex NeoSwitch 工作站

Opentrons and its Neochromosome subsidiary have launched the Opentrons Flex neoSwitch Workstation powered by the Neochromosome neoSwitch platform for in-house antibody discovery. The workstation enables automation of the neoSwitch antibody discovery workflow including high-throughput purification of binders for rapid characterization, Opentrons said.

奥普特隆及其新染色体子公司推出了由新染色体neoSwitch平台驱动的Opentrons Flex neoSwitch工作站，用于内部抗体发现。奥普特隆表示，该工作站能够自动化neoSwitch抗体发现工作流程，包括用于快速表征的高通量结合物纯化。

The neoSwitch antibody discovery platform is designed to toggle between yeast surface display for binder selection and protein secretion for downstream evaluation of hits. This integration eliminates traditionally labor-intensive and time-consuming subcloning and protein-expression steps, significantly reducing overall process timelines, the company said.

该公司表示，neoSwitch抗体发现平台设计用于在酵母表面展示以进行结合物筛选和蛋白质分泌以进行下游命中评估之间切换。这种整合消除了传统上费力且耗时的亚克隆和蛋白质表达步骤，大幅缩短了整体流程时间。

Users can access ready-to-use, high-diversity antibody libraries built by Neochromosome or Neochromosome's custom DNA library services..

用户可以访问由Neochromosome构建的现成的高多样性抗体库，或Neochromosome的定制DNA库服务。

Metabolon Microbiome Research Solution

代谢组微生物组研究解决方案

Metabolon has launched a microbiome research solution that integrates metagenomics sequencing and bioinformatics tools with a new microbiome metabolite panel. The service includes metagenomic sequencing options whereby customers can select different sequencing methods and depths; a microbiome panel focused on hundreds of metabolites; and an easy-to-use suite of microbiome bioinformatics tools such as pipelines for processing raw shotgun and 16S sequencing data and machine learning-driven integration to uncover multiomic relationships between microbial community composition and metabolic profiles..

Metabolon推出了一种微生物组研究解决方案，该方案整合了宏基因组测序和生物信息学工具，并新增了一个微生物组代谢物检测面板。该服务包括宏基因组测序选项，客户可以选择不同的测序方法和深度；一个专注于数百种代谢物的微生物组检测面板；以及一套易于使用的微生物组生物信息学工具，例如用于处理原始宏基因组和16S测序数据的流程，以及通过机器学习驱动的整合分析，揭示微生物群落组成与代谢特征之间的多组学关系。

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