THURSDAY, May 8, 2025 -- Live zoster vaccination is associated with a lower risk for overall cardiovascular events when compared with no vaccination, according to a study published online May 5 in the

2025年5月8日，星期四——一项5月5日在线发表于《美国医学会杂志》的研究显示，与未接种疫苗相比，接种活带状疱疹疫苗可降低总体心血管事件的风险。

European Heart Journal

欧洲心脏杂志

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Sooji Lee, from the Kyung Hee University Medical Center in Seoul, South Korea, and colleagues conducted a large-scale cohort study with long-term follow-up to examine the association between live zoster vaccination and the risk for various cardiovascular events. The risk for incident cardiovascular outcomes was assessed for individuals aged 50 years or older who had undergone live zoster vaccination versus unvaccinated individuals.

韩国首尔庆熙大学医学中心的李秀智（Sooji Lee）及其同事进行了一项大规模队列研究，并进行了长期随访，以探讨活水痘带状疱疹疫苗接种与各种心血管事件风险之间的关联。研究评估了50岁及以上接种活水痘带状疱疹疫苗的人群与未接种人群中新发心血管疾病的风险。

After applying propensity score-based overlap weighting, data were included for 1,271,922 individuals, with a median follow-up of 6.0 years..

应用基于倾向评分的重叠权重后，纳入了1,271,922名个体的数据，中位随访时间为6.0年。

The researchers found associations for live zoster vaccination with lower risks for overall cardiovascular events (hazard ratio [HR], 0.77), especially major adverse cardiovascular events, heart failure, cerebrovascular disorders, ischemic heart disease, thrombotic disorders, and dysrhythmia (HRs, 0.74, 0.74, 0.76, 0.78, 0.78, and 0.79, respectively).

研究人员发现，接种活带状疱疹疫苗与总体心血管事件风险降低相关（风险比 [HR]，0.77），尤其是主要不良心血管事件、心力衰竭、脑血管疾病、缺血性心脏病、血栓性疾病和心律失常（HR 分别为 0.74、0.74、0.76、0.78、0.78 和 0.79）。

The restricted mean survival time difference was 95.14 days per decade for overall cardiovascular events following live zoster vaccination. The protective association lasted for up to eight years, with the reduction greatest at two to three years postvaccination. Men, those aged younger than 60 years, those with unhealthy lifestyle habits, and those from low-income households and rural residents had a more pronounced decrease in cardiovascular disease risk..

活疹疫苗接种后，整体心血管事件的限制性平均生存时间差异为每十年95.14天。这种保护作用持续长达八年，其中接种疫苗后两到三年内的减少幅度最大。男性、60岁以下人群、有不健康生活习惯的人群、低收入家庭以及农村居民的心血管疾病风险下降更为显著。

'The findings suggest that implementing live zoster vaccination strategies may be associated with favorable cardiovascular outcomes across different population groups,' the authors write.

“研究结果表明，实施带状疱疹活疫苗接种策略可能与不同人群的良好心血管结局相关，”作者写道。

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