/PRNewswire/ -- Plasmidsaurus, the company that sequences while you sleep, today announced the launch of a new product update that delivers full-length AAV genome sequences, including subgenomic variants, in just three days. The new service is already being used by academic labs, CDMOs, and gene therapy researchers frustrated by slow timelines, unclear results, and high sample requirements from legacy sequencing vendors..

/PRNewswire/ -- Plasmidsaurus，这家在您睡眠时进行测序的公司，今天宣布推出一项新的产品更新，该服务能够在短短三天内提供全长AAV基因组序列，包括亚基因组变异。这项新服务已经被学术实验室、CDMO以及对传统测序供应商缓慢的时间表、不明确的结果和高样本需求感到沮丧的基因治疗研究人员所使用。

What's really in your capsid?

你的衣壳里到底有什么？

Gene therapy scientists have always known that what you design isn't always what you get. Truncated genomes, snapback variants, and inverted payloads are common pitfalls, yet many sequencing methods still miss them entirely. Plasmidsaurus's AAV genome sequencing service gives researchers a clear and complete picture of their sequence with a turnaround time fast enough to matter for real experiments..

基因治疗科学家们一直都知道，设计出来的并不总是得到的结果。截短的基因组、回弹变异和倒置的有效载荷是常见的隐患，然而许多测序方法仍然完全遗漏了它们。Plasmidsaurus 的 AAV 基因组测序服务为研究人员提供了清晰且完整的序列图谱，其周转时间足以满足真实实验的需求。

All it takes is 1×10

只需要 1×10 就够了。

vector genomes of purified capsid—up to 10× less than what other long-read services require, preserving precious samples for more research. From that, Plasmidsaurus delivers full-length consensus sequences, annotated variant assemblies, and interactive genome maps. Most AAV sequencing protocols use end-repair, annealing, amplification, and/or fragmentation steps that can generate artifacts.

纯化衣壳的载体基因组——比其他长读长服务所需量少10倍，保存了珍贵样品用于更多研究。基于此，Plasmidsaurus提供全长一致性序列、注释变异组装和交互式基因组图。大多数AAV测序方案使用末端修复、退火、扩增和/或片段化步骤，这些步骤可能会产生伪影。

Plasmidsaurus's method directly ligates and sequences intact genomes, preserving ITRs and genome configurations as they exist in your prep. Just the native genome, exactly as it exists in your prep..

Plasmidsaurus 的方法直接连接并测序完整的基因组，保留 ITR 和基因组配置，如同它们在您的制备中存在的一样。仅仅是天然基因组，完全如其在您的制备中的状态。

Innovating to empower researchers

创新赋能研究者

Plasmidsaurus's AAV genome sequencing service is enabled by Oxford Nanopore's capabilities for fast long-read sequencing. Through innovation in sample preparation, bioinformatics, and speed of service, Plasmidsaurus works to accelerate the work of every biomedical scientist.

Plasmidsaurus的AAV基因组测序服务依托于Oxford Nanopore的快速长读长测序技术。通过在样本制备、生物信息学和服务速度方面的创新，Plasmidsaurus致力于加速每位生物医学科学家的研究工作。

'Our team requires fast and reliable long-read genome sequencing as part of our AAV QC process,' said

'我们的团队在AAV质量控制流程中需要快速且可靠的长读长基因组测序，'表示

Lily Jewel

莉莉·珠尔

, PhD of Tevard Biosciences, a Plasmidsaurus AAV sequencing customer. 'We have consistently found Plasmidsaurus's Oxford Nanopore sequencing service to be of higher quality with more rapid turnaround times than comparable offerings from other CROs.'

Tevard Biosciences的博士，Plasmidsaurus AAV测序的客户说道：“我们始终认为Plasmidsaurus的Oxford Nanopore测序服务相比其他CRO提供的类似服务，质量更高且周转时间更快。”

'The rapid pace of innovation in gene therapy demands tools that are just as fast and agile,' said

“基因治疗领域的快速创新步伐要求工具同样快速且灵活，”

Gordon Sanghera

戈登·桑赫拉

, CEO of Oxford Nanopore Technologies. 'We're proud that Oxford Nanopore Technologies is enabling Plasmidsaurus to deliver breakthrough services that not only reduce time-to-insight but also provide a new gold standard in plasmid and vector characterisation.'

牛津纳米孔科技公司首席执行官表示：“我们为牛津纳米孔科技公司能够助力Plasmidsaurus提供突破性的服务感到自豪，这些服务不仅缩短了获得洞察的时间，还为质粒和载体表征树立了新的黄金标准。”

The core to better science

更好的科学核心

Despite remarkable progress in the last decade, cell and gene therapy R&D remains extremely challenging. When vector validation takes weeks and returns ambiguous results, projects stall. Plasmidsaurus developed this service to help scientists move faster and with more confidence. Researchers can order directly through the website with no need for quote generation or onboarding delays..

尽管在过去十年中取得了显著的进展，细胞和基因治疗的研发仍然极具挑战性。当载体验证需要数周时间并返回模棱两可的结果时，项目就会停滞不前。Plasmidsaurus 开发了这项服务，以帮助科学家更快、更自信地推进研究。研究人员可以直接通过网站订购，无需生成报价或经历繁琐的上手流程。

'We're thrilled to see how Plasmidsaurus is empowering the gene therapy community with fast, unprecedented insight into their critical biological materials with innovative sequencing solutions,' said

“我们很高兴看到Plasmidsaurus如何通过创新的测序解决方案，为基因治疗界提供快速且前所未有的对其关键生物材料的洞察，”

Aaron Pomerantz

亚伦·波默兰茨

, Market Segment Associate Director for Infectious Disease and Applied Markets at Oxford Nanopore Technologies. 'By providing a clearer picture of vector genome composition in real time, researchers can be confident in the quality of their gene therapy products.'

牛津纳米孔技术公司传染病和应用市场部门的市场总监表示：“通过实时提供更清晰的载体基因组组成图谱，研究人员可以对其基因治疗产品的质量充满信心。”

'Our goal is to accelerate science,' said Plasmidsaurus cofounder and CEO

“我们的目标是加速科学发展，”Plasmidsaurus联合创始人兼首席执行官表示。

Mark Budde

马克·布德

. 'There is massive potential and progress happening with new AI tools, but researchers are still left with slow lab workflows and inconclusive results when they build their sequences in the real world. We work to make sequencing as fast and accurate as possible because innovation in biology can't wait for slow sequencing.'.

“新的AI工具有着巨大的潜力和进展，但研究人员在现实世界中构建序列时，仍然面临实验室工作流程缓慢和结果不明确的问题。我们致力于使测序尽可能快速和准确，因为生物学的创新不能等待缓慢的测序。”

About Plasmidsaurus

关于Plasmidsaurus

Plasmidsaurus is on a mission to accelerate new cures and promote a healthier planet by unlocking new levels of productivity for scientists. The company's DNA sequencing services are used daily by thousands of innovators, including Nobel Prize winners, dynamic biotech startups, pharmaceutical companies, research labs, and DIY biohackers, and have been cited in thousands of publications.

Plasmidsaurus 致力于通过提升科学家的生产力来加速新疗法的开发，推动地球健康。该公司提供的 DNA 测序服务每天被数千名创新者使用，包括诺贝尔奖获得者、充满活力的生物技术初创公司、制药公司、研究实验室以及 DIY 生物黑客，并已被数千篇出版物引用。

Plasmidsaurus's global network of labs operates day and night to enable world-changing discoveries..

Plasmidsaurus 的全球实验室网络昼夜不停地运作，以实现改变世界的发现。