THURSDAY, May 15, 2025 -- In a clinical report published in the May issue of

2025年5月15日，星期四——在五月份发表的临床报告中

Pediatrics

儿科

, the American Academy of Pediatrics presents updated guidance on the evaluation and treatment of

美国儿科学会提供了关于评估和治疗的最新指南

patent ductus arteriosus

动脉导管未闭

(PDA) in preterm infants.

早产儿中的（PDA）。

Namasivayam Ambalavanan, M.D., from the University of Alabama at Birmingham, and colleagues reviewed the available evidence to develop guidelines for evaluation and treatment of preterm infants with prolonged ductal patency.

来自阿拉巴马大学伯明翰分校的Namasivayam Ambalavanan博士及其同事审查了现有证据，以制定针对动脉导管未闭延长的早产儿的评估和治疗指南。

The authors note that delayed closure of PDA is common in preterm infants, especially at more extreme immaturity. Echocardiography is essential for confirming PDA presence and assessing its hemodynamic significance. For a hemodynamically significant PDA (hsPDA), medical closure using ibuprofen or acetaminophen is an option.

作者指出，早产儿动脉导管未闭 (PDA) 的延迟闭合是常见的，尤其是在极不成熟的情况下。超声心动图对于确认 PDA 的存在及其血流动力学意义的评估至关重要。对于具有血流动力学显著性的 PDA（hsPDA），使用布洛芬或对乙酰氨基酚进行药物闭合是一种选择。

Recent data indicate the lack of benefits of prophylactic or early (age <2 weeks) medical PDA closure versus expectant management and, consequently, they are not recommended. Since the relative benefits and risks of expectant management with close monitoring, attempted pharmacologic closure, or procedural (transcatheter/surgical) closure have not been adequately defined, data are insufficient to support firm recommendations on management of infants with an hsPDA beyond 2 weeks of age.

最近的数据表明，预防性或早期（年龄＜2周）药物关闭动脉导管未闭（PDA）相较于期待疗法并没有益处，因此不推荐使用。由于对期待疗法密切监测、尝试药物关闭或程序性（经导管/手术）关闭的相对益处和风险尚未得到充分界定，目前的数据不足以支持对超过2周大的患有hsPDA婴儿的管理提出明确建议。

Medical closure of an hsPDA beyond 2 weeks of age is attempted by many clinicians. Infants may be considered for transcatheter closure or surgical ligation if the hsPDA persists despite medical therapy (or if medical therapy is contraindicated). Surgical closure of the PDA has become less frequent in recent years, and in many centers, transcatheter closure is more common..

许多临床医生尝试在婴儿出生两周后进行hsPDA的药物闭合。如果hsPDA在药物治疗后仍然存在（或药物治疗禁忌），可以考虑对婴儿进行经导管闭合或手术结扎。近年来，PDA的手术闭合频率有所降低，在许多中心，经导管闭合更为常见。

'There is a lack of evidence to guide management, necessitating equipoise regarding treatment options and support for parents to permit enrollment of their infants in trials that can expand the available body of evidence,' the authors write.

“缺乏指导管理的证据，因此需要对治疗方案保持不确定态度，并支持父母允许将其婴儿纳入可扩大现有证据基础的试验中，”作者写道。

Abstract/Full Text

摘要/全文

THURSDAY, May 15, 2025 -- Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may cut the risk of obesity-related cancer (ORC) in patients being treated for diabetes and...

2025年5月15日，星期四——胰高血糖素样肽-1受体激动剂（GLP-1 RAs）可能会降低正在接受糖尿病治疗的患者患上与肥胖相关的癌症（ORC）的风险，并且...

THURSDAY, May 15, 2025 -- Shorter breastfeeding duration and younger age at first birth are known risk factors for triple negative breast cancer (TNBC) and vary by race, according...

2025年5月15日，星期四——较短的母乳喂养时间和较年轻的首次生育年龄是三阴性乳腺癌（TNBC）的已知风险因素，并且因种族而异，根据...

THURSDAY, May 15, 2025 -- There is no association between COVID-19 vaccination in pregnancy and spontaneous abortion, according to a study published online May 2...

2025年5月15日，星期四——根据5月2日在线发表的一项研究，孕期接种新冠疫苗与自然流产之间不存在关联。

Whatever your topic of interest,

无论你感兴趣的话题是什么，

subscribe to our newsletters

订阅我们的新闻通讯

to get the best of Drugs.com in your inbox.

获取 Drugs.com 的最新资讯到您的收件箱。