THURSDAY, May 15, 2025 -- Individuals with

星期四，2025年5月15日——

Down syndrome

唐氏综合症

are at increased risk of poor cardiovascular outcomes, according to a study published online May 7 in the

根据5月7日在线发表的一项研究，心血管结局不佳的风险增加。

Journal of Internal Medicine

内科杂志

.

。

Annie Pedersen, Ph.D., from the Institute of Biomedicine at the University of Gothenburg in Sweden, and colleagues used national registries to identify 5,155 individuals born in Sweden between 1946 and 2000 with Down syndrome, as well as matched controls (1:50). Cardiovascular risk was compared between the groups..

瑞典哥德堡大学生物医学研究所的安妮·彼得森博士及其同事利用国家登记册，确定了 1946 年至 2000 年间出生于瑞典的 5155 名唐氏综合症患者，以及匹配的对照组（1：50）。心血管风险在各组之间进行了比较。

The researchers found that Down syndrome was associated with increased risk of ischemic stroke (hazard ratio [HR], 4.41) and hemorrhagic stroke (HR, 5.14). Risk of acute myocardial infarction was similar between the groups, overall, but was increased in younger individuals (under 40 years) with Down syndrome.

研究人员发现，唐氏综合症与缺血性中风（风险比 [HR]，4.41）和出血性中风（HR，5.14）的风险增加相关。总体而言，两组的心肌梗死风险相似，但在患有唐氏综合症的较年轻个体（40岁以下）中风险增加。

In people with Down syndrome with selected atherosclerotic (HR, 12.67) and embolic (HR, 10.35,) risk factors, risk of ischemic stroke was even higher, compared to controls without risk factors..

在具有特定动脉粥样硬化（HR，12.67）和栓塞（HR，10.35）风险因素的唐氏综合症患者中，与没有风险因素的对照组相比，缺血性中风的风险更高。

'Our results indicate a different spectrum of cardiovascular risk factors in Down syndrome, which might have implications for screening measures as well as primary and secondary prevention strategies,' the authors write. 'These findings should inform future studies that aim to further investigate the pathophysiological mechanisms of cardiovascular diseases in Down syndrome, as well as health care systems developing guidelines fitted for the unique needs of the Down syndrome population.'.

“我们的研究结果显示，唐氏综合征患者的心血管风险因素有不同的特征，这可能对筛查措施以及一级和二级预防策略产生影响，”作者写道。“这些发现应为未来的研究提供参考，旨在进一步探讨唐氏综合征中心血管疾病的病理生理机制，同时帮助医疗系统制定适合唐氏综合征人群特殊需求的指南。”

Abstract/Full Text

摘要/全文

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