FRIDAY, May 16, 2025 -- Sedentary time is associated with an increased risk for Alzheimer disease (AD), according to a study published online May 13 in

2025年5月16日，星期五——根据5月13日在线发表的一项研究，久坐时间与阿尔茨海默病（AD）风险增加相关。

Alzheimer's & Dementia

阿尔茨海默病与痴呆症

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Marissa A. Gogniat, Ph.D., from the Vanderbilt Memory and Alzheimer's Center in Nashville, Tennessee, and colleagues examined how sedentary behavior relates to longitudinal brain structure and cognitive changes in older adults in a study involving 404 participants from the Vanderbilt Memory and Aging Project.

田纳西州纳什维尔范德比尔特记忆与阿尔茨海默病中心的马丽莎·A·戈尼亚特博士及其同事在一项涉及范德比尔特记忆与衰老项目404名参与者的研究中，调查了久坐行为如何与老年人纵向脑结构和认知变化相关联。

Participants completed seven days of actigraphy, neuropsychological assessment, and 3 Tesla brain magnetic resonance imaging during a seven-year period. Sedentary time was examined in relation to brain structure and cognition..

参与者在七年时间内完成了为期七天的体动记录、神经心理学评估和3特斯拉脑磁共振成像。久坐时间与大脑结构和认知功能的关系被进行了研究。

The researchers found that greater sedentary time was associated with a smaller AD-neuroimaging signature and worse episodic memory in cross-sectional models. The associations varied based on apolipoprotein E

研究人员发现，在横断面模型中，更长的久坐时间与较小的阿尔茨海默病神经影像特征和更差的情节记忆有关。这些关联因载脂蛋白E的不同而有所变化。

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4 status. Greater sedentary time related to faster hippocampal volume reductions and declines in naming and processing speed in longitudinal models.

4种状态。在纵向模型中，更长的久坐时间与海马体积减少加快以及命名和处理速度下降有关。

“Our study showed that reducing sitting time could be a promising strategy for preventing neurodegeneration and subsequent cognitive decline,' study coauthor Angela Jefferson, Ph.D., also from the Vanderbilt Memory and Alzheimer's Center, said in a press release. 'This research highlights the importance of reducing sitting time, particularly among aging adults at increased genetic risk for Alzheimer's disease.

“我们的研究表明，减少坐着的时间可能是一种预防神经退化和随后认知能力下降的有前景的策略，”该研究的共同作者、同样来自范德堡记忆与阿尔茨海默病中心的安吉拉·杰斐逊博士在新闻稿中表示。“这项研究强调了减少久坐时间的重要性，特别是对于患阿尔茨海默病遗传风险增加的老年人群。”

It is critical to our brain health to take breaks from sitting throughout the day and move around to increase our active time.”.

“为了我们的大脑健康，全天候坐着时休息一下并四处走动以增加我们的活动时间是至关重要的。”

One author disclosed ties to Vivid Genomics.

一名作者披露了与Vivid Genomics的关系。

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