In 2024, it was estimated that 26,890 individuals in the U.

2024年，据估计在美国有26,890人

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S. would be diagnosed with stomach cancer, and 10,880 would succumb to the disease. For many, stomach cancer is diagnosed too late, by which time it has already metastasized throughout the abdomen. Recent advances in chemotherapy and immunotherapy have allowed patients with advanced stomach cancer to live for an average of 10 to 17 months following diagnosis.

S.会被诊断出患有胃癌，而10,880人将死于该疾病。对许多人来说，胃癌的诊断来得太晚，此时癌细胞已经扩散到整个腹部。近年来，化疗和免疫疗法的进步使得晚期胃癌患者在确诊后平均可以存活10到17个月。

Now, researchers are working on an innovative light-activated immunotherapy technique that could eventually treat patients with stomach cancer that has spread throughout the abdomen..

现在，研究人员正在研究一种创新的光激活免疫疗法技术，该技术最终可以用于治疗已扩散至整个腹部的胃癌患者。

The approach, developed by bioengineers at University of Texas at Dallas (Dallas, TX, USA), in collaboration with researchers at UT Southwestern Medical Center (Dallas, TX, USA), leverages specially designed molecules and far-red or near-infrared light to “prime” the immune system, encouraging it to target stubborn cancer cells.

该方法由德克萨斯大学达拉斯分校（美国德克萨斯州达拉斯）的生物工程师与德克萨斯大学西南医学中心（美国德克萨斯州达拉斯）的研究人员合作开发，利用特别设计的分子和远红光或近红外光“激发”免疫系统，促使其靶向顽固的癌细胞。

These novel engineered proteins, when injected into the patient’s abdomen, are designed to bind to cancer cells. Once this binding occurs, a small fiber-optic light is used to apply near-infrared light, activating the engineered proteins to block cancer cell growth and activate immune cells that destroy the cancer cells.

这些新型工程蛋白被注射到患者的腹部后，会与癌细胞结合。一旦结合发生，使用光纤导管施加近红外光，激活这些工程蛋白以阻止癌细胞生长，并激活摧毁癌细胞的免疫细胞。

When the proteins are activated by light, they capture oxygen and convert it into reactive molecules capable of killing the cancer cells while simultaneously stimulating the immune system..

当这些蛋白质被光激活时，它们会捕获氧气并将其转化为能够杀死癌细胞的活性分子，同时刺激免疫系统。

The lab-engineered molecules, known as betabodies, specifically target tumor cells, leaving healthy tissues unharmed to minimize side effects. By combining the light-activated method with engineered protein technology, this approach utilizes both techniques to effectively eliminate tumors. While the researchers believe this method could work for a range of tumor types, it has not yet been fully tested in humans.

这些被称为β体的实验室工程分子专门靶向肿瘤细胞，不会伤害健康组织，从而将副作用降到最低。通过将光激活方法与工程蛋白技术相结合，这种方法利用了两种技术来有效消除肿瘤。尽管研究人员认为这种方法可能适用于多种类型的肿瘤，但尚未在人体中进行全面测试。

The researchers are optimistic that this enhanced therapy could significantly improve patient outcomes..

研究人员乐观地认为，这种增强型疗法可以显著改善患者预后。

“There is a dire need for treatments to help people with advanced stomach cancer live longer,” said Dr. Girgis Obaid, assistant professor of bioengineering in the Erik Jonsson School of Engineering and Computer Science. “If successful, our approach ultimately can help patients with stomach cancer live longer after the cancer has spread.”.

“迫切需要治疗来帮助晚期胃癌患者延长生命，”埃里克·乔纳森工程与计算机科学学院生物工程助理教授吉尔吉斯·奥贝德博士说。“如果成功，我们的方法最终可以帮助胃癌患者在癌症扩散后延长生存时间。”

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