THURSDAY, May 22, 2025 -- Herpes simplex virus type 1 (HSV-1) is associated with an increased risk for Alzheimer disease (AD) based on real-world data from the United States, according to a study published online May 20 in

2025年5月22日星期四——根据5月20日在线发表的一项研究，基于美国的真实世界数据，单纯疱疹病毒1型（HSV-1）与阿尔茨海默病（AD）风险增加相关。

BMJ Open

BMJ开放期刊

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Yunhao Liu, from Gilead Sciences Inc. in Foster City, California, and colleagues conducted a matched case-control study involving patients with AD aged 50 years and older diagnosed between 2006 and 2021 identified from the IQVIA PharMetrics Plus claims database to examine the association between HSV-1 and AD.

来自加利福尼亚州福斯特城吉利德科学公司的刘云浩及其同事进行了一项匹配病例对照研究，研究对象为2006年至2021年间从IQVIA PharMetrics Plus索赔数据库中识别出的50岁及以上的AD患者，以探讨HSV-1与AD之间的关联。

Controls were matched with individuals with AD on age, sex, region, database entry year, and health care visit numbers in a 1:1 ratio (344,628 AD case-control pairs)..

对照组与阿尔茨海默病（AD）患者在年龄、性别、地区、数据库录入年份和医疗访问次数上以1:1的比例进行匹配（344,628对AD病例对照组）。

The researchers found that 0.44 and 0.24 percent of patients with AD and controls, respectively, had a history of HSV-1 diagnosis. There was an association for HSV-1 diagnosis with an increased risk for AD (adjusted odds ratio, 1.80). Compared with those who did not use antiherpetics, patients with HSV-1 who used antiherpetics were less likely to develop AD (adjusted hazard ratio, 0.83)..

研究人员发现，分别有 0.44% 和 0.24% 的 AD 患者和对照组有过 HSV-1 诊断史。HSV-1 诊断与 AD 风险增加存在关联（调整后的比值比为 1.80）。与未使用抗疱疹病毒药物的人相比，使用抗疱疹病毒药物的 HSV-1 患者发展为 AD 的可能性较小（调整后的风险比为 0.83）。

'These findings place an even greater emphasis on viewing the prevention of herpesviruses as a public health priority,' the authors write. 'Further research to determine whether suppression of neurotropic viruses can alter the natural history of AD and AD-related dementia is warranted based on the consistent observational studies.'.

“这些发现更加突出了将预防疱疹病毒视为公共卫生优先事项的重要性，”作者写道。“基于一致的观察性研究，有必要进一步研究抑制神经嗜性病毒是否可以改变阿尔茨海默病（AD）和AD相关痴呆的自然病程。”

Several authors disclosed ties to the pharmaceutical industry, including Gilead Sciences, which funded the study.

数名作者透露了与制药行业的关系，包括资助这项研究的吉利德科学公司。

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