by Mark Chiang

作者：蒋马克

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A recent study presented at the ASCO 2025 conference highlights findings on the safety and efficacy of a combination therapy involving encorafenib and binimetinib for patients with resected stage II melanoma. The research focuses specifically on individuals with high-risk BRAF-mutated melanoma, a subgroup known to face increased chances of recurrence following surgical removal of tumors..

一项在2025年ASCO会议上发表的最新研究强调了关于恩科拉非尼和比尼替尼联合疗法在治疗已切除的II期黑色素瘤患者中的安全性和有效性结果。该研究特别聚焦于携带高风险BRAF突变的黑色素瘤患者，这一亚组在手术切除肿瘤后复发的可能性较高。

The study reports that the dual-drug regimen demonstrates promising results in improving outcomes for this patient population. Encorafenib, a BRAF inhibitor, and binimetinib, a MEK inhibitor, target specific pathways associated with tumor growth in BRAF-mutated melanoma. Researchers evaluated both the safety profile and therapeutic effectiveness of this approach, noting enhanced tolerability alongside improved efficacy compared to existing treatment options.

该研究报告称，这种双药方案在改善这一患者群体的治疗效果方面表现出可喜的成果。Encorafenib是一种BRAF抑制剂，而binimetinib是一种MEK抑制剂，二者针对与BRAF突变黑色素瘤肿瘤生长相关的关键通路。研究人员评估了这种方案的安全性与治疗效果，指出与现有治疗方案相比，其耐受性增强且疗效提高。

These findings aim to address an unmet need in managing high-risk stage II melanoma cases post-surgery. Further details regarding trial design, patient demographics, and statistical outcomes were shared during the presentation..

这些研究结果旨在解决术后管理高风险 II 期黑色素瘤病例中未满足的需求。关于试验设计、患者人口统计和统计结果的更多细节在报告中进行了分享。

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Source: GO-AI-ne1

来源：GO-AI-ne1

Date: June 9, 2025

日期：2025年6月9日

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Mark Chiang

蒋志光

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